Pomegranate juice increases levels of paraoxonase1 (PON1) expression and enzymatic activity in streptozotocin-induced diabetic mice fed with a high-fat diet

Food Research International

Volumn 44, Issue 5, 2011, Pages 1381-1385

  Betanzos Cabrera, G ^a   Guerrero Solano, J A ^a   Martinez Perez M M ^a   Calderon Ramos Z G ^a   Belefant Miller, H ^b   Cancino Diaz, J C ^c  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO   (Mexico)

^b Dale Bumpers Natl Rice Res Center   (United States)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Cardiovascular disease; Diabetes; Paraoxonase1; Pomegranate juice

Indexed keywords

ANTI-INFLAMMATORIES; ANTIBIOTIC RESISTANCE; BACTERIAL INFECTIONS; BLOOD GLUCOSE; BODY WEIGHT; CARDIO-VASCULAR DISEASE; CHOLESTEROL LEVELS; CLINICAL INVESTIGATION; DIABETES; DIABETIC MICE; ENZYMATIC ACTIVITIES; HIGH-FAT DIET; HYPOGLYCEMIC EFFECT; IN-VITRO; LDL OXIDATION; MURINE MODEL; PARAOXONASE1; POMEGRANATE JUICES; TRIACYLGLYCEROLS;

ANIMALS; FRUIT JUICES; FRUITS; GENE EXPRESSION; GLUCOSE; GLYCEROL; NUTRITION; PLANTS (BOTANY);

DISEASES;

ANIMALIA; BACTERIA (MICROORGANISMS); LYTHRACEAE; MURINAE; MUS; PUNICA GRANATUM;

EID: 79957623555     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2011.01.042     Document Type: Article

References (43)

1. Aviram M., Dornfeld L. Consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001, 158:195-198.
2. Aviram M., Dornfeld L., Kaplan M., Coleman R., Gaitini D., Nitecki S., et al. Pomegranate juice flavonoids inhibit LDL oxidation and cardiovascular disease: studies in atherosclerotic mice and in humans. Drugs under Experimental and Clinical 2002, 28:49-62.
3. Aviram M., Dornfeld L., Rosenblatm M., Volkova N., Kaplan M., Coleman R., et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. American Journal of Clinical Nutrition 2000, 71:1062-1076.
4. Aviram M., Rosenblat M., Bisgaier C.L., Newton R.S., Primo-Parmo S.L., La Du B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. Journal of Clinical Investigation 1998, 101:1581-1590.
5. Aviram M., Rosenblat M., Gaitini D., Nitecki S., Hoffman A., Dornfeld L., et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clinical Nutrition 2004, 23:423-433.
6. Aviram M., Volkova N., Coleman R., Dreher M., Reddy M.K., Ferreira D., et al. Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins. Journal of Agricultural Food Chemistry 2008, 56:1148-1157.
7. Azadzoi K.M., Schulman R.N., Aviram M., Siroky M.B. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. Journal of Urology 2005, 174:386-393.
8. Basu A., Penugonda K. Pomegranate juice: a heart-healthy fruit juice. Nutrition Reviews 2009, 67:49-56.
9. Betanzos-Cabrera G., Guerrero-Solano A., Cruz-Mayorga D., Calderon Z., Villanueva-Sanchez J., Peña-Irecta A., et al. Effect of pomegranate juice on paraoxonase1 (PON1) gene expression and enzymatic activity in a streptozotocin induced diabetes and diet-induced obese model. 20th World Diabetes Congress. Montreal, Canada 2009.
10. Charlton-Menys V., Liu Y., Durrington P.N. Semiautomated method for determination of serum paraoxonase activity using paraoxon as substrate. Clinical Chemistry 2006, 52:453-457.
11. de Nigris F., Balestrieri M.L., Williams-Ignarro S., D'Armiento F.P., Fiorito C., Ignarro L.J., et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide 2007, 17:50-54.
12. Fuhrman B., Aviram M. Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation. Annals of the New York Academy of Sciences 2002, 957:321-324.
13. Furlong C.E., Richter R.J., Seidel S.L., Motulsky A.G. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon. The American Journal of Human Genetics 1988, 43:230-238.
14. Gil M.I., Tomás-Barberán F.A., Hess-Pierce B., Holcroft D.M., Kader A.A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural and Food Chemistry 2000, 48:4581-4589.
15. Gouédard C., Barouki R., Morel Y. Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Molecular and Cellular Biology 2004, 24:5209-5222.
16. Ignarro L.J., Byrns R.E., Sumi D., de Nigris F., Napoli C. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide 2006, 15:93-102.
17. Ikeda Y., Inoue M., Suehiro T., Arii K., Kumon Y., Hashimoto K. Low human paraoxonase predicts cardiovascular events in Japanese patients with type 2 diabetes. Acta Diabetologica 2009, 46:239-242.
18. Jakubowski H. Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. Journal of Biological Chemistry 2000, 275:3957-3962.
19. Jurenka J.S. Therapeutic applications of pomegranate (Punica granatum L.): a review. Alternative Medicine Review 2008, 13:128-144.
20. Kaplan M., Hayek T., Raz A., Coleman R., Dornfeld L., Vaya J., et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. Journal of Nutrition 2001, 131:2082-2089.
21. Khateeb J., Gantman A., Kreitenberg A.J., Aviram M., Fuhrman B. Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway. Atherosclerosis 2010, 208:119-125.
22. Lansky E.P., Newman R.A. Punica granatum (pomegranate) and its potential for preventionand treatment of inflammation and cancer. Journal of Ethnopharmacol 2007, 109:177-206.
23. Leckey L.C., Garige M., Varatharajalu R., Gong M., Nagata T., Spurney C.F., et al. Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR-/- mice. Alcoholism: Clinical and Experimental Research 2010, 34:1535-1542.
24. Mackness B., Durrington P., McElduff P., Yarnell J., Azam N., Watt M., et al. Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study. Circulation 2003, 107:2775-2779.
25. Mackness M.I., Hallam S.D., Peard T., Warner S., Walker C.H. The separation of sheep and human serum "A"-esterase activity into the lipoprotein fraction by ultracentrifugation. Comparative Biochemistry and Physiology 1985, 82(B:675-677.
26. Mackness M.I., Mackness B.M., Durrington P.N. Paraoxonase and coronary heart disease. Atherosclerosis Supplements 2002, 3:49-55.
27. Mackness B., Mackness M.I., Durrington P.N., Arrol S., Evans A.E., McMaster D., et al. Paraoxonase activity in two healthy populations with differing rates of coronary heart disease. European Journal of Clinical Investigation 2000, 30:4-10.
28. Mertens-Talcott S.U., Jilma-Stohlawetz P., Rios J., Hingorani L., Derendorf H. Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers. Journal of Agriculrural Food Chemistry 2006, 54:8956-8961.
29. Mochizuki H., Scherer S.W., Xi T., Nickle D.C., Majer M., Huizenga J.J., et al. Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence. Gene 1998, 213:149-157.
30. Mooradian A.D. Dyslipidemia in type 2 diabetes mellitus. Nature Clinical Practice Endocrinology & Metabolism 2009, 5:150-159.
31. Primo-Parmo S.L., Sorenson R.C., Teiber L., La Du B.N. The human serum paraoxonase/arylesterase gene (PON1) is one member of multigene family. Genomics 1996, 33:498-507.
32. Reddy S.T., Wadleigh D.J., Grijalva V., Ng C., Hama S., Gangopadhyay A., et al. Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. Arteriosclerosis, Thrombosis and Vascular Biology 2001, 21:542-547.
33. Rock W., Rosenblat M., Miller-Lotan R., Levy A.P., Elias M., Aviram M. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. Journal of Agricultural and Food Chemistry 2008, 56:8704-8713.
34. Rodrigo L., Mackness B., Durrington P.N., Hernandez A., Mackness M.I. Hydrolysis of platelet activating factor by human serum paraoxonase. Biochemical Journal 2001, 354:1-7.
35. Rosenblat M., Aviram M. Antioxidative properties of pomegranate: in vitro studies. Pomegranates: Ancient Roots to Modern Medicine 2006, 31-43. Taylor and Francis Group, New York, NY. N.P. Seeram, D. Heber (Eds.).
36. Rosenblat M., Hayek T., Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006, 187:363-371.
37. Rozenberg O., Rosenblat M., Coleman R., Shih D.M., Aviram M. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Radical Biology & Medicine 2003, 34:774-784.
38. Seeram N.P., Aviram M., Zhang Y., Henning S.M., Feng L., Dreher M., et al. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. Journal of Agricultural Food and Chemistry 2008, 56:1415-1422.
39. Shih D.M., Gu L., Hama S., Xia Y.R., Navab M., Fogelman A.M. Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. Journal of Clinical Investigation 1996, 97:1630-1639.
40. Shukla M., Gupta K., Rasheed Z., Khan K.A., Haqqi T.M. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition 2008, 24:733-743.
41. Sumner M.D., Elliott-Eller M., Weidner G., Daubenmier J.J., Chew M.H., Marlin R., et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. American Journal of Cardiology 2005, 96:810-814.
42. Tward A., Xia Y.R., Wang X.P., Shi Y.S., Park C., Castellani L.W., et al. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation 2002, 106:484-490.
43. van Himbergen T.M., van Tits L.J., Roest M., Stalenhoef A.F. The story of PON1: how an organophosphate-hydrolysing enzyme is becoming a player in cardiovascular medicine. Netherlands Journals of Medicine 2006, 64:34-38.