Transport activity-dependent intracellular sorting of the yeast general amino acid permease

Molecular Biology of the Cell

Volumn 22, Issue 11, 2011, Pages 1919-1929

  Cain, Natalie E ^a   Kaiser, Chris A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; CARRIER PROTEIN; CITRULLINE; GAP1P PROTEIN; GLUTAMIC ACID; GLYCINE; LYSINE; PERMEASE; PHENYLALANINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CYTOPLASM VESICLE; ENZYME ACTIVITY; MULTIVESICULAR ENDOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; TRANS GOLGI NETWORK;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; CELL MEMBRANE; MULTIVESICULAR BODIES; MUTANT PROTEINS; MUTATION, MISSENSE; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION;

SACCHAROMYCES CEREVISIAE;

EID: 79957597366     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-10-0800     Document Type: Article

References (35)

1. Abramoff MD, Magelhaes PJ, Ram SJ (2004). Image processing with Image J. Biophotonics Int 11, 36-42.
2. Blondel MO, Morvan J, Dupre S, Urban-Grimal D, Haguenauer-Tsapis R, Volland C (2004). Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Mol Biol Cell 15, 883-895. (Pubitemid 38146501)
3. Chen EJ, Kaiser CA (2002). Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 99, 14837-14842. (Pubitemid 35334570)
4. Chen EJ, Kaiser CA (2003). LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol 161, 333-347. (Pubitemid 36529851)
5. Cheng Y, Prusoff WH (1973). Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22, 3099-3108.
6. Didion T, Regenberg B, Jorgensen MU, Kielland-Brandt MC, Andersen HA (1998). The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae. Mol Microbiol 27, 643-650. (Pubitemid 28045745)
7. Donaton MC, Holsbeeks I, Lagatie O, Van Zeebroeck G, Crauwels M, Winderickx J, Thevelein JM (2003). The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae. Mol Microbiol 50, 911-929. (Pubitemid 37372253)
8. Forsberg H, Gilstring CF, Zargari A, Martinez P, Ljungdahl PO (2001). The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42, 215-228. (Pubitemid 34212174)
9. Gao X, Lu F, Zhou L, Dang S, Sun L, Li X, Wang J, Shi Y (2009). Structure and mechanism of an amino acid antiporter. Science 324, 1565-1568.
10. Gao X, Zhou L, Jiao X, Lu F, Yan C, Zeng X, Wang J, Shi Y (2010). Mechanism of substrate recognition and transport by an amino acid antiporter. Nature 463, 828-832.
11. Grenson M, Hou C, Crabeel M (1970). Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. IV. Evidence for a general amino acid permease. J Bacteriol 103, 770-777.
12. Helliwell SB, Losko S, Kaiser CA (2001). Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J Cell Biol 153, 649-662. (Pubitemid 34286099)
13. Hundal HS, Taylor PM (2009). Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am J Physiol Endocrinol Metab 296, E603-E613.
14. Iraqui I, Vissers S, Bernard F, de Craene JO, Boles E, Urrestarazu A, Andre B (1999). Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease. Mol Cell Biol 19, 989-1001. (Pubitemid 29046843)
15. Jack DL, Paulsen IT, Saier MH (2000). The amino acid/polyamine/ organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Microbiol (Reading, Engl). 146, 1797-1814. (Pubitemid 30639257)
16. Jardetzky O (1966). Simple allosteric model for membrane pumps. Nature 211, 969-970.
17. Jensen LT, Carroll MC, Hall MD, Harvey CJ, Beese SE, Culotta VC (2009). Down-regulation of a manganese transporter in the face of metal toxicity. Mol Biol Cell 20, 2810-2819.
18. Kaiser CA, Chen EJ, Losko S (2002). Subcellular fractionation of secretory organelles. Methods Enzymol 351, 325-338. (Pubitemid 34614996)
19. Liu XF, Culotta VC (1999). Mutational analysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters. J Mol Biol 289, 885-891. (Pubitemid 29306657)
20. Nelissen B, Wachter R, Goffeau A (1997). Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol Rev 21, 2113-2134.
21. Poulsen P, Gaber RF, Kielland-Brandt MC (2008). Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor. Mol Membr Biol 25, 164-176. (Pubitemid 351317501)
22. Risinger AL, Cain NE, Chen EJ, Kaiser CA (2006). Activity-dependent reversible inactivation of the general amino acid permease. Mol Biol Cell 17, 4411-4419. (Pubitemid 44522059)
23. Roberg KJ, Rowley N, Kaiser CA (1997). Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae. J Cell Biol 137, 1469-1482. (Pubitemid 27282230)
24. Rubio-Texeira M, Kaiser CA (2006). Amino acids regulate retrieval of the yeast general amino acid permease from the vacuolar targeting pathway. Mol Biol Cell 17, 3031-3050. (Pubitemid 43993507)
25. Seron K, Blondel MO, Haguenauer-Tsapis R, Volland C (1999). Uracil-induced down-regulation of the yeast uracil permease. J Bacteriol 181, 1793-1800. (Pubitemid 29138610)
26. Shaywitz DA, Orci L, Ravazzola M, Swaroop A, Kaiser CA (1995). Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum. J Cell Biol 128, 769-777.
27. Singh SK, Piscitelli CL, Yamashita A, Gouaux E (2008). A competitive inhibitor traps LeuT in an open-to-out conformation. Science 322, 1655-1661.
28. Soetens O, De Craene JO, Andre B (2001). Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1. J Biol Chem 276, 43949-43957.
29. Stanbrough M, Magasanik B (1995). Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae. J Bacteriol 177, 94-102.
30. Sumrada RA, Cooper TG (1982). Isolation of the CAR1 gene from Saccharomyces cerevisiae and analysis of its expression. Mol Cell Biol 2, 1514-1523. (Pubitemid 13169045)
31. Tang HY, Munn A, Cai M (1997). EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae. Mol Cell Biol 17, 4294-4304. (Pubitemid 27318105)
32. Urbanowski JL, Piper RC (2001). Ubiquitin sorts proteins into the intralumenal degradative compartment of the late-endosome/vacuole. Traffic 2, 622-630. (Pubitemid 32825701)
33. Van Zeebroeck G, Bonini BM, Versele M, Thevelein JM (2009). Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nat Chem Biol 5, 45-52.
34. Wu B, Ottow K, Poulsen P, Gaber RF, Albers E, Kielland-Brandt MC (2006). Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p. J Cell Biol 173, 327-331.
35. --dependent neurotransmitter transporters. Nature 437, 215-223.