Mutational analysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters

Journal of Molecular Biology

Volumn 289, Issue 4, 1999, Pages 885-891

  Liu, Xiu Fen ^a   Culotta, Valeria Cizewski ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Metals; Nramp; Smf1; Transporter; Yeast

Indexed keywords

CARRIER PROTEIN; METAL; MUTANT PROTEIN;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; GENETIC COMPLEMENTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

SACCHAROMYCES CEREVISIAE;

EID: 0033021618     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2815     Document Type: Article

References (23)

1. Agranoff D. D., Krishna S. Metal ion homeostasis and intracellular parasitism. Mol. Microbiol. 28:1998;403-412.
2. Archibald F. S., Fridovich I. Manganese, superoxide dismutase and oxygen tolerance in some lactic acid bacteria. J. Bacteriol. 146:1981a;928-936.
3. Archibald F. S., Fridovich I. J. Manganese and defenses against oxygen toxicity in Lactobacillus plantarum. J. Bacteriol. 145:1981b;422-451.
4. Archibald F. S., Fridovich I. The scavenging of superoxide radical by manganous complexes in vitro. Arch. Biochem. Biophys. 214:1982;452-463.
5. Atkinson P. G., Blackwell J. M., Barton C. H. Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages. Biochem. J. 325:1997;779-786.
6. Becker D., Guarente L. High-efficiency transformation of yeast by electroporation. Methods Enzymol. 194:1991;182-187.
7. Cellier M., Prive G., Belouchi A., Kwan T., Rodrigues V., Chia W., Gros P. Nramp defines a family of membrane proteins. Proc. Natl Acad. Sci. USA. 92:1995;10089-10093.
8. Cellier M., Belouchi A., Gros P. Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet. 12:1996;201-204.
9. Fleming M. D., Trenor C. C., Su M. A., Foernzler D., Beier D. R., Dietrich W. F., Andrews N. C. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet. 16:1997;383-386.
10. Fleming M. D., Romano M. A., Su M. A., Garrick L. M., Garrick M. D., Andrews N. C. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl Acad. Sci. USA. 95:1998;1148-1153.
11. Govoni G., Gros P. Microphage NRAMP1 and its role in resistance to microbial infections. Inflamm. Res. 47:1998;277-284.
12. Govoni G., Vidal S. M., Gauthier S., Skamene E., Malo D., Gros P. The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6j mice transgenic for Nramp1. Infect. Immun. 64:1996;2923-2929.
13. Gruenheid S., Pinner E., Desjardins M., Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185:1997;717-730.
14. Gunshin H., Mackenzie B., Berger U. V., Gushin Y., Romero M. F., Boron W. F., Nussberger S., Gollan J. L., Hediger M. A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:1997;482-488.
15. Jones E. Three proteolytic systems in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 266:1991;7963-7966.
16. Lapinskas P. J., Lin S. J., Culotta V. C. The role of the Saccharomyces cerevisiaeCCC1 gene in the homeostasis of manganese ions. Mol. Microbiol. 21:1996;519-528.
17. Liu X. F., Culotta V. C. Post-translational control of Nramp metal transport in yeast: role of metal ions and the BSD2 gene. J. Biol. Chem. 274:1999;4863-4868.
18. Liu X. F., Supek F., Nelson N., Culotta V. C. Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. J. Biol. Chem. 272:1997;11763-11769.
19. Pinner E., Gruenheid S., Raymond M., Gros P. Functional complementation of the yeast divalent cation transporter family SMF1 by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. J. Biol. Chem. 272:1997;28933-28938.
20. Sikorski R. S., Hieter P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces ceresiviae. Genetics. 122:1989;19-27.
21. Su M. A. III, C C. T., Fleming J. C., Andrews N. A. The G185R mutation disrupts function of the iron transporter Nramp2. Blood. 92:1998;2157-2163.
22. Supek F., Supekova L., Nelson H., Nelson N. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc. Natl Acad. Sci. USA. 93:1996;5105-5110.
23. West A. H., Clark D. J., Martin J., Neupert W., Hart F. U., Horwich A. L. Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein. J. Biol. Chem. 267:1992;24625-24633.