Ubiquitin sorts proteins into the intralumenal degradative compartment of the late-endosome/vacuole

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Volumn 2, Issue 9, 2001, Pages 622-630

  Urbanowski, J L ^a   Piper, R C ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Degradation; Down regulation; Late endosome; Lysosome; MVB; MVE; Ubiquitin; Vacuole; Vesicle budding

Indexed keywords

CELL SURFACE PROTEIN; PHOSPHATIDYLINOSITOL; UBIQUITIN;

ARTICLE; CELL MEMBRANE; CELL VACUOLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENDOSOME; GOLGI COMPLEX; INFORMATION; INTERNALIZATION; LYSOSOME; MEMBRANE; MOLECULAR RECOGNITION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN TARGETING; SIGNAL TRANSDUCTION; YEAST;

BIOLOGICAL TRANSPORT; CYTOSOL; DOWN-REGULATION; ENDOSOMES; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; LYSOSOMES; MICROSCOPY, FLUORESCENCE; PHOSPHATIDYLINOSITOL PHOSPHATES; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBCELLULAR FRACTIONS; TIME FACTORS; TRYPSIN; UBIQUITIN; YEASTS;

EID: 0034852403     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.20905.x     Document Type: Article

References (36)

1. Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae
2. Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors
3. Fab1p Ptdlns (3) P 5-kinase function is essential for protein sorting in the multivesicular body
4. The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants
5. Autophagy as a regulated pathway of cellular degradation
6. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane
7. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking
8. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain
9. Recycling of the yeast a-factor receptor
10. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
11. Gettin' down with Ubiquitin: Turning off cell-surface receptors, transporters and channels
12. The ubiquitin-proteasome system and endocytosis
13. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis
14. Monoubiquitin carries a novel internalization signal that is appended to activated receptors
15. A function for monoubiquitination in the internalization of a G protein-coupled receptor
16. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases
17. The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization
18. Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products
19. VPS27 controls vascuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae
20. Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane
21. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
22. Yeast mutants affecting possible quality control of plasma membrane proteins
23. Two separate signals act independently to localize a yeast late Golgi membrane protein through a combination of retrieval and retention
24. Aggresomes, inclusion bodies and protein aggregation
25. A syntaxin homolog encoded by VAM3 mediates down-regulation of a yeast G protein-coupled receptor
26. Ubiquitin in chains
27. Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators. PDR1 and PDR3
28. Polar transmembrane domains target proteins to the interior of the yeast vacuole
29. Sorting in the endosomal system in yeast and animal cells
30. C-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
31. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
32. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
33. Endocytosis is required for the growth of vacuolar H (+) -ATPase-defective yeast: Identification of six new END genes
34. The breast cancer gene product TSG101. A regulator of ubiquitination?
35. Ubiquitin in retrovirus assembly: Actor or bystander?
36. Chemical synthesis and expression of a cassette adapted ubiquitin gene