Brain systems underlying anxiety disorders: A view from neuroimaging

Anxiety Disorders: Theory, Research, and Clinical Perspectives

Volumn , Issue , 2010, Pages 192-203

  Etkin, Amit ^a   Wager, Tor D ^b,c  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Department of Psychology Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79957566457     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511777578.019     Document Type: Chapter

References (67)

1. American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn, text revision (DSM-IV-TR). Washington, DC: American Psychiatric Association.
2. Bandler, R., & Shipley, M. T. (1994). Columnar organization in the midbrain periaqueductal gray: modules for emotional expression? Trends in Neuroscience, 17, 379-389.
3. Baxter, L. R., Schwartz, J. M., Bergman, K. S., et al. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Archives of General Psychiatry, 49,681-689.
4. Behbehani, M. M. (1995). Functional characteristics of the midbrain periaqueductal gray. Progress in Neurobiology, 46,575-605.
5. Bishop, S. J., Duncan, J., & Lawrence, A. D. (2004). State anxiety modulation of the amygdala response to unattended threat-related stimuli. Journal of Neuroscience, 24,10364-10368.
6. Botvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S., & Cohen, J. D. (1999). Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature, 402,179-181.
7. Bryant, R. A., Kemp, A. H., Felmingham, K. L., et al. (2008a). Enhanced amygdala and medial prefrontal activation during nonconscious processing of fear in posttraumatic stress disorder: An fMRI study. Human Brain Mapping, 29, 517-523.
8. Bryant, R. A., Felmingham, K., Kemp, A., et al. (2008b). Amygdala and ventral anterior cingulate activation predicts treatment response to cognitive behaviour therapy for post-traumatic stress disorder. Psychology and Medicine, 38, 555-561.
9. Buchel, C., & Dolan, R. J. (2000). Classical fear conditioning in functional neuroimaging. Current Opinions in Neurobiology, 10,219-223.
10. Buckner, R. L., & Carroll, D. C. (2007). Self-projection and the brain. Trends in Cognitive Sciences, 11,49-57.
11. Corcoran, K. A., Desmond, T. J., Frey, K. A., & Maren, S. (2005). Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction. Journal of Neuroscience, 25,8978-8987.
12. Courtney, S. M., Ungerleider, L. G., Keil, K., & Haxby, J. V. (1997). Transient and sustained activity in a distributed neural system for human working memory. Nature, 386, 608-611.
13. Critchley, H. D., Wiens, S., Rotshtein, P, Ohman, A., & Dolan, R. J. (2004). Neural systems supporting interoceptive awareness. Nature Neuroscience, 7,189-195.
14. Delgado, M. R., Nearing, K. I., Ledoux, J. E., & Phelps, E. A. (2008). Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron, 59, 829-838.
15. D’Esposito, M., Postle, B. R., & Rypma, B. (2000). Prefrontal cortical contributions to working memory: Evidence from event-related fMRI studies. Experimental Brain Research, 133,3-11.
16. Egner, T., & Hirsch, J. (2005a). Cognitive control mechanisms resolve conflict through cortical amplification of task-relevant information. Nature Neuroscience, 8,1784-1790.
17. Egner, T., & Hirsch, J. (2005b). The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage, 24,539-547.
18. Egner, T., Etkin, A., Gale, S., & Hirsch, J. (2008). Dissociable neural systems resolve conflict from emotional versus nonemotional distracters. Cerebral Cortex, 18,1475-1484.
19. Eisenberg, M., Kobilo, T., Berman, D. E., & Dudai, Y. (2003). Stability of retrieved memory: inverse correlation with trace dominance. Science, 301,1102-1104.
20. Etkin, A., & Wager, T. D. (2007). Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164,1476-1488.
21. Etkin, A., Klemenhagen, K. C., Dudman, J. T., et al. (2004). Individual differences in trait anxietypredict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron, 44,1043-1055.
22. Etkin, A., Pittenger, C., Polan, H. J., & Kandel, E. R. (2005). Toward a neurobiology of psychotherapy: basic science and clinical applications. Journal of Neuropsychiatry and Clinical Neuroscience, 17,145-158.
23. Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006). Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron, 51,871-882.
24. Furmark, T., Tillfors, M., Marteinsdottir, I., et al. (2002). Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Archives of General Psychiatry, 59,425-433.
25. Gabbott, P. L., Warner, T. A., Jays, P. R., Salway, P., & Busby, S. J. (2005). Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers. Journal of Computational Neurology, 492,145-177.
26. Gratton, G., Coles, M. G., & Donchin, E. (1992). Optimizing the use of information: strategic control of activation of responses. Journal of Experimental Psychology: General, 121,480-506.
27. Gross, J. J. (1998). The emerging field of emotion regulation: An integrative review. Review of General Psychology, 2,271-299.
28. Gusnard, D. A., & Raichle, M. E. (2001). Searching for a baseline: functional imaging and the resting human brain. NatureReviewsNeuroscience, 2, 685-694.
29. Kalisch, R., Korenfeld, E., Stephan, K. E., et al. (2006). Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. Journal of Neuroscience, 26,9503-9511.
30. Karl, A., Schaefer, M., Malta, L. S., et al. (2006). A metaanalysis of structural brain abnormalities in PTSD. Neuroscience and Biobehavioral Review, 30,1004-1031.
31. Kasai, K., Yamasue, H., Gilbertson, M. W., et al. (2008). Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biological Psychiatry, 63, 550-556.
32. Kerns, J. G., Cohen, J. D., MacDonald, A. W., et al. (2004). Anterior cingulate conflict monitoring and adjustments in control. Science, 303,1023-1026.
33. Kim, J. J., Rison, R. A., & Fanselow, M. S. (1993). Effects of amygdala, hippocampus, and periaqueductal gray lesions on short-and long-term contextual fear. Behavioral Neuroscience, 107,1093-1098.
34. Kober, H., Barrett, L. F., Joseph, J., et al. (2008). Functional grouping and cortical-subcortical interactions in emotion: A meta-analysis of neuroimaging studies. Neuroimage, 42, 998-1031.
35. Kringelbach, M. L., & Rolls, E. T. (2004). The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology. Progress in Neurobiology, 72, 341-372.
36. LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998). Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron, 20, 937-945.
37. Lanius, R. A., Williamson, P. C., Hopper, J., et al. (2003). Recall of emotional states in posttraumatic stress disorder: An fMRI investigation. Biological Psychiatry, 53,204-210.
38. Maren, S., Aharonov, G., & Fanselow, M. S. (1997). Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behavioral Brain Research, 88,261-274.
39. Milad, M. R., & Quirk, G. J. (2002). Neurons in medial prefrontal cortex signal memory for fear extinction. Nature, 420,70-74.
40. Milad, M. R., Vidal-Gonzalez, I., & Quirk, G. J. (2004). Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behavioral Neuroscience, 118,389-394.
41. Milad, M. R., Wright, C. I., Orr, S. P, et al. (2007). Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biological Psychiatry, 62, 446-454.
42. Nee, D. E., Wager, T. D., & Jonides, J. (2007). Interference resolution: Insights from a meta-analysis of neuroimaging tasks. Cognitive, Affective, and Behavioral Neuroscience, 7,1-17.
43. Northoff, G., Heinzel, A., de Greck, M., et al. (2006). Selfreferential processing in our brain: A meta-analysis of imaging studies on the self. Neuroimage, 31,440-457.
44. Ochsner, K. N., & Gross, J. J. (2005). The cognitive control of emotion. Trends in Cognitive Sciences, 9, 242-249.
45. Ochsner, K. N., & Gross, J. J. (2008). Cognitive emotion regulation: Insights from social cognitive and affective neuroscience. Current Directions in Psychological Science, 17,153-158.
46. Paxinos, G. (2003). TheHuman NervousSystem, 2ndedn. San Diego, CA: Academic Press.
47. Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002). Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage, 16,331-348.
48. Phan, K. L., Britton, J. C., Taylor, S. F., Fig, L. M., & Liberzon, I. (2006). Corticolimbic bloodflowduringnontraumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry, 63,184-192.
49. Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004). Extinction learning in humans: role of the amygdala and vmPFC. Neuron, 43,897-905.
50. Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000). The role of ventromedial prefrontal cortex in the recovery of extinguished fear. Journal of Neuroscience, 20, 6225-6231.
51. Raichle, M. E., MacLeod, A. M., Snyder, A. Z., et al. (2001). A default mode of brain function. Proceedings of the National Academy of Sciences of the USA, 98, 676-682.
52. Rauch, S. L., Whalen, P J., Shin, L. M., et al. (2000). Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biological Psychiatry, 47, 769-776.
53. Schienle, A., Schafer, A., Hermann, A., Rohrmann, S., & Vaitl, D. (2007). Symptom provocation and reduction in patients suffering from spider phobia: An fMRI study on exposure therapy. European Archives of Psychiatry and Clinical Neuroscience, 257,486-493.
54. Shin, L. M., Whalen, P. J., Pitman, R. K., et al. (2001). An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biological Psychiatry, 50,932-942.
55. Shin, L. M., Wright, C. I., Cannistraro, P. A., et al. (2005). A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Archives of General Psychiatry, 62,273-281.
56. Simmons, A., Stein, M. B., Matthews, S. C., Feinstein, J. S., & Paulus, M. P (2006). Affective ambiguity fora group recruits ventromedial prefrontal cortex. Neuroimage, 29, 655-661.
57. Straube, T., Glauer, M., Dilger, S., Mentzel, H. J., & Miltner, W. H. (2006). Effects of cognitive-behavioraltherapy on brain activation in specific phobia. Neuroimage, 29, 125-135.
58. Tillfors, M., Furmark, T., Marteinsdottir, I., et al. (2001). Cerebral blood flow in subjects with social phobia during stressful speaking tasks: A PET study. American Journal of Psychiatry, 158,1220-1226.
59. Vertes, R. P. (2004). Differentialprojections of the infralimbic and prelimbic cortex in the rat. Synapse, 51,32-58.
60. Wager, T. D., & Smith, E. E. (2003). Neuroimaging studies of working memory: A metaanalysis. Cognitive, Affective, and Behavioral Neuroscience, 3,255-274.
61. Wager, T. D., Barrett, L. F., Bliss-Moreau, E., et al. (2008a). The neuroimaging of emotion. In M. Lewis, J. M. Haviland-Jones, & L. F. Barrett, eds., Handbook of Emotions, 3rd edn. New York, NY: Guilford Press.
62. Wager, T. D., Hughes, B., Davidson, M., Lindquist, M. L., & Ochsner, K. N. (2008b). Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron, 59, 1037-1050.
63. Whalen, P. J., Kagan, J., Cook, R. G., et al. (2004). Human amygdala responsivity to masked fearful eye whites. Science, 306,2061.
64. Whalen, P. J., Johnstone, T., Somerville, L. H., et al. (2008). A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder. Biological Psychiatry, 63,858-863.
65. Williams, L. M., Kemp, A. H., Felmingham, K., et al. (2006). Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage, 29, 347-357.
66. Wright, C. I., Martis, B., McMullin, K., Shin, L. M., & Rauch, S. L. (2003). Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. Biological Psychiatry, 54,1067-1076.
67. Yamasue, H., Kasai, K., Iwanami, A., et al. (2003). Voxelbased analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism. Proceedings of the National Academy of Sciences of the USA, 100,9039-9043.