Isolation and characterization of anti-diabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part

Asian Pacific Journal of Tropical Medicine

Volumn 4, Issue 4, 2011, Pages 278-282

  Patil, Raju ^a   Patil, Ravindra ^b   Ahirwar, Bharati ^c   Ahirwar, Dheeraj ^a  

^a CEC School of Pharmacy   (India)

^b S U College of Pharmaceutical Sciences and Research   (India)

^c GURU GHASIDAS UNIVERSITY   (India)

Author keywords

Bioactivity guided fractionation; Diabetes; Ocimum sanctum

Indexed keywords

16 HYDROXY 4,4,10,13 TETRAMETHYL 17 (4 METHYLPENTYL) HEXADECAHYDRO CYCLOPENTA[A]PHENANTHREN 3 ONE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OCIMUM SANCTUM EXTRACT; TOLBUTAMIDE; TRIACYLGLYCEROL; TRITERPENOID; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHOLESTEROL BLOOD LEVEL; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG ISOLATION; DRUG SCREENING; GLUCOSE BLOOD LEVEL; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; BIOLOGICAL ASSAY; BLOOD GLUCOSE; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; LIPIDS; MALE; OCIMUM; PLANT EXTRACTS; PLANT STRUCTURES; RATS; TRITERPENES;

EID: 79957546707     PISSN: 19957645     EISSN: 19957645     Source Type: Journal    
DOI: 10.1016/S1995-7645(11)60086-2     Document Type: Article

References (43)

1. Bhavna S, Chandrajeet B, Partha R Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol 2008, 46:2376-2383.
2. Desai A, Tandon N Challenges in prevention and management of diabetes mellitus and metabolic syndrome in India. Curr Sci 2009, 97(3):356-366.
3. Cheng AYY, Josse RG Intestinal absorption inhibitors for type 2 diabetes mellitus: Prevention and treatment. Drug Discov Today Ther Strat 2004, 1:201-206.
4. Krentz AJ, Bailey CJ Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005, 65:385-411.
5. Kapoor S Ocimum sanctum: a therapeutic role in diabetes and the metabolic syndrome. Horm Metab Res 2008, 40(4):44-49.
6. Okwu DE Flavouring properties on Cassava fufu. Afr J Roots Tuber Crops 1999, 3(2):19-21.
7. Okwu DE Evaluation of the chemical composition of indigenous spices and flavoring agents. Glob J Pure App Sci 2001, 7(3):455-459.
8. Chattopadhyay RR A comparative evaluation of some blood sugar lowering agents of plant origin. J Ethnopharmacol 1999, 67(3):367-372.
9. Joshi H, Parle M Evaluation of nootropic potential Ocimum sanctum L. in mice. Indian J Exp Bio 2006, 44(2):133-136.
10. Kirtikar KR, Basu BD The Indian medicinal plants 1987, International Book Distributor, Dehradun. 2nd ed.
11. Suanarunsawat T, Devakul N, Ayutthaya W, Songsak T, Thirawarapan S, Poungshompoo S Antioxidant activity and lipid-lowering effect of essential oils extracted from Ocimum sanctum L. leaves in rats fed with a high cholesterol diet. J Clin Biochem Nutr 2010, 46(1):52-59.
12. Kim SC, Magesh V, Jeong SJ, Lee HJ, Ahn KS, Lee HJ, et al. Ethanol extract of Ocimum sanctum exerts anti-metastatic activity through inactivation of matrix metalloproteinase-9 and enhancement of anti-oxidant enzymes. Food Chem Toxicol 2010, 48(6):1478-1482.
13. Khan A, Ahmad A, Manzoor N, Khan LA Antifungal activities of Ocimum sanctum essential oil and its lead molecules. Nat Prod Commun 2010, 5(2):345-349.
14. Sharma A, Chandraker S, Patel VK, Ramteke P Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J Pharm Sci 2009, 71(2):136-139.
15. Agarwal P, Nagesh L, Murlikrishnan Evaluation of the antimicrobial activity of various concentrations of Tulsi (Ocimum sanctum) extract against Streptococcus mutans: an in vitro study. Indian J Dent Res 2010, 21(3):357-359.
16. Goel A, Kumar S, Singh DK, Bhatia AK Wound healing potential of Ocimum sanctum Linn. with induction of tumor necrosis factor-alpha. Indian J Exp Biol 2010, 48(4):402-406.
17. Patil RN, Patil RY, Ahirwar D Study of some medicinal plants for antidiabetic activity in alloxan induced diabetes. Pharmacologyonline 2010, 1:53-60.
18. Al-Shamaony L, Al-Khazraji SM, Twaiji HA Hypoglycaemic effect of Artemisia herba alba II. Effect of a valuable extract on some blood parameters in diabetic Animals. J Ethnopharmacol 1994, 43:167-171.
19. Grover JK, Vats V, Rathi SS Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000, 73:461-470.
20. Stanley P, Menon VP Hypoglycemic and other related actions of Tinospora cordifolia Roots in alloxan induced diabetic rats. J Ethnopharmacol 2000, 70(1):9-15.
21. Claudia EN, Momo JE Antidiabetic and hypolipidemic effects of Laportea ovalifolia (Urticaceae) in alloxan induced diabetic rats. Afr J Trad CAM 2006, 3(1):36-43.
22. Ajit K, Choudhary BK, Bandopadhay NG Comparative evaluation of hypoglycemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnopharmacol 2003, 84:105-108.
23. Kim SH, Hyun SH, Choung SY Anti-diabetic effect of cinnamon extract on blood glucose in mice. J Ethnopharmacol 2006, 104:119-123.
24. Bhatena SJ, Velasquez MT Beneficial role of dietary phytoesrogens in obesity and diabetes. Am J Clin Nat 2002, 76:1191-1201.
25. Takemoto K, Tanaka M, Iwata H, Nishihara R, Ishihara K, Wang DH, et al. Low catalase activity in blood is associated with the diabetes caused by alloxan. Clinica Chimica Acta 2009, 407:43-46.
26. Lenzen S, Tiedge M, Jorns A, Munday R Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan. Lessons from animal diabetes 1996, 113-122. Birkhäuser, Boston. E. Shafrir (Ed.).
27. Zhang X, Liang W, Mao Y, Li H, Yang Y, Tan H Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice. Biomed Pharmacother 2009, 63:180-186.
28. Haro-Hernandez RD, Cabrera-Munoz L, Mendeza JD Regeneration of β-Cells and neogenesis from small ducts or acinar cells promote recovery of endocrine pancreatic function in Alloxan-treated rats. Arch Med Res 2004, 35:114-120.
29. Jorns A, Munday R, Tiedge M, Lenzen S Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro. J Endocrinol 1997, 155:283-293.
30. Salil G, Nevina KG, Rajamohana T Arginine rich coconut kernel protein modulates diabetes in alloxan treated rats. Chem Biol Interact 2011, 189:107-111.
31. Jain S, Bhatiaa G, Barika R, Kumar P, Jain A, Dixit VK Antidiabetic activity of Paspalum scrobiculatum Linn. in alloxan induced diabetic rats. J Ethnopharmacol 2010, 127:325-328.
32. Elsner M, Convey EG, Lenzen S Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells. Free Radical Biol Med 2006, 41:825-834.
33. Duarte TL, Almeida GM, Jones GDD Investigation of the role of extracellular H2O2 and transition metal ions in the genotoxic action of ascorbic acid in cell culture models. Toxicol Lett 2007, 170:57-65.
34. Nakamura U, Iwase M, Uchizono Y, Sonoki K, Sasaki N Rapid intracellular acidification and cell death by H2O2and alloxan in pancreatic β cells. Free Radical Biol Med 2006, 40:2047-2055.
35. Hegde PS, Rajasekaran NS, Chandra TS Effects of the antioxidant properties of millet species on oxidative stress and glycemic status in alloxan-induced rats. Nutr Res 2005, 25:1109-1120.
36. Tzu HL, Chia CH, Cicero LT, Chang, Wen CY Anti-hyperglycemic properties of crude extract and triterpenes from poria cocos. Evid Based CAM 2009, 14:1-8.
37. Seung HJ, Yun JH, Eun KS, Soo YC, Jing LJ, Hye S, et al. Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator. Biochem J 2007, 403:243-250.
38. Patel DK, Kumar R, Prasad SK, Sairam K, Hemalatha S Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus (Linn) F. Muell in streptozotocin-induced diabetic rats. Asian Pac J Trop Biomed 2011, 1(4):316-322.
39. Thirumalai T, Therasa SV, Elumalai EK, David E Hypoglycemic effect of Brassica juncea (seeds) on streptozotocin induced diabetic male albino rat. Asian Pac J Trop Biomed 2011, 1(4):323-325.
40. Girija K, Lakshman K, Chandrika U, Ghosh SS, Divya T Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus. Asian Pac J Trop Biomed 2011, 1(2):133-138.
41. Min JT, Ji MY, Nigel T, Cordula HB, Chang QK, Chun PT, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 2008, 15:263-273.
42. Bhavana S, Chandrajeet B, Partha Roy Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol 2008, 46:2376-2383.
43. Kashivishwanath R, Ramesh A, Kumar KE Hypoglycemic and antihyperglycemic effect of Gmelina asaistica Linn. In normal and alloxan induced rats. Biological Pharm Bull 2005, 28(4):729-732.