The protective effect of boric acid on aluminum-induced hepatotoxicity and genotoxicity in rats;Sıçanda alüminyum ile uyarılmış hepatotoksisite ve genotoksisite üzerine borik asidin koruyucu etkisi

Turkish Journal of Biology

Volumn 35, Issue 3, 2011, Pages 293-301

  Türkez, Hasan ^a   Geyikoǧlu, Fatime ^a   Çolak, Suat ^a  

^a ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Aluminum; Boric acid; Liver; Micronucleus assay; Rat; Serum enzymes

Indexed keywords

ANIMALIA; RATTUS;

EID: 79957528684     PISSN: 13000152     EISSN: None     Source Type: Journal    
DOI: 10.3906/biy-0902-11     Document Type: Article

References (74)

1. Kaur A, Joshi K, Minz R W et al. Neurofilament phosphorylation and disruption: a possible mechanism of chronic aluminium toxicity in Wistar rats. Toxicol 219: 1-10, 2006.
2. Suay Llopis L, Ballester Díez F. Review of studies on exposure to aluminum and Alzheimer's disease. Rev Esp Salud Publica 76: 645-58, 2002.
3. Reinke CM, Breitkreutz J, Leuenberger H. Aluminium in overthe-counter drugs: risks outweigh benefits? Drug Saf 26: 1011-25, 2003.
4. Exley C. The pro-oxidant activity of aluminum. Free Radic Biol Med 36: 380-87, 2004.
5. Sushma NJ, Rao KJ. Total ATPases activity in diff erent tissues of albino mice exposed to aluminium acetate. J Environ Biol 28: 483-84, 2007.
6. Wedrychowski A, Schmidt WN, Hnilica LS. The in-vivo crosslinking of proteins and DNA by heavy metals. J Biol Chem 261: 3370-76, 1986.
7. Migliore L, Cocchi L, Nesti C et al. Micronuclei assay and FISH analysis in human lymphocytes treated with six metal salts. Environ Mol Mutagen 34: 279-84, 1999.
8. Geyikoǧlu F, Türkez H, Keles MS. The role of fruit juices in the prevention of aluminum sulphate toxicity in human blood in vitro. Fres Environ Bull 14: 878-83, 2005.
9. Banasik A, Lankoff A, Piskulak A et al. Aluminum-induced micronuclei and apoptosis in human peripheral-blood lymphocytes treated during diff erent phases of the cell cycle. Environ Toxicol 20: 402-406, 2005.
10. Gonzalez MA, Alvarez ML, Pisani GB et al. Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats. Biol Trace Elem Res 116: 329-48, 2007.
11. Devirian TA, Volpe SL. The physiological effects of dietary boron. Crit Rev Food Sci Nutr 43: 219-31, 2003.
12. Pawa S, Ali S. Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress. Chem Biol Interact 160: 89-98, 2006.
13. Hunt CD. The biochemical effects of physiologic amounts of dietary boron in animal nutrition models. Environ Health Perspect 102: 35-43, 1994.
14. Moore JA. An assessment of boric acid and borax using the IEHR Evaluative Process for Assessing Human Developmental and Reproductive Toxicity of Agents. Expert Scientific Committee. Reprod Toxicol 11: 123-60, 1997.
15. Usuda K, Kono K, Orita Y et al. Serum and urinary boron levels in rats after single administration of sodium tetraborate. Arch Toxicol 72: 468-44, 1998.
16. Barranco WT, Hudak PF, Eckhert CD et al. Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States). Cancer Causes Control 18: 71-77, 2007.
17. Benson W, Birge W, Dorough H. Absence of mutagenic activity of sodium borate (borax) and boric acid in the Salmonella preincubation test. Environ Toxicol Chem 3: 209-14, 1984.
18. NTP. Toxicology and carcinogenesis studies of boric acid (CAS No. 10043-35-3) in B6C3F1 mice (feed studies). Research Triangle Park, North Carolina, US Department of Health and Human Services, National Toxicology Program, 1987.
19. Bakke JP. Evaluation of the potential of boric acid to induce unscheduled DNA synthesis in the in vitro hepatocyte DNA repair assay using the male F-344 rat. (Unpublished study) Submitted by U.S. Borax Corp. MRID No. 42038903, 1991.
20. McGregor D, Brown A, Cattanach P et al. Responses of the L5178Y tk-/tk-mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen 12: 85-154, 1988.
21. Landolph J. Cytotoxicity and negligible genotoxicity of borax and borax ores to cultured mammalian cells. Am J Ind Med 7: 31-43, 1985.
22. O'Loughlin KG. Bone marrow erythrocyte micronucleus assay of boric acid in Swiss-Webster mice. (Unpublished study) Submitted by U.S. Borax Corp. MRID No. 42038904, 1991.
23. Turkez H, Geyikoglu F, Tatar A et al. Effects of some boron compounds on peripheral human blood. Z Naturforsch C 62: 889-96, 2007.
24. Arslan M, Topaktas M, Rencuzogullari E. The effects of boric acid on sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes. Cytotechnology 56: 91-6, 2008.
25. Ornat ST, Konuk M. Cytogenetic Evaluations of Peripheral Blood Samples of Boron (Kirka-EsMşehir) Workers. The proceedings of 2nd International Boron Symposium Eskişehir, Turkey, 559-62, 2004.
26. Dodds-Smith ME, Johnson MS, Thompson DJ. Trace metal accumulation by the shrew Sorex araneus. II. Tissue distribution in kidney and liver. Ecotoxicol Environ Saf 24: 118-30, 1992.
27. Kurutas EB, Sahan A, Altun T. Oxidative stress biomarkers in liver and gill tissues of spotted barb (Capoeta barroisi Lortet, 1894) living in the river Ceyhan, Adana, Turkey. Turk J Biol 33: 275-82, 2009.
28. Greger JL, Sutherland JE. Aluminum exposure and metabolism. Crit Rev Clin Lab Sci 34: 439-74, 1997.
29. Akpanabiatu MI, Uboh FE, Ekanem TB, et al. The effect of interaction of Rauwolfia vomitoria root bark extract with vitamin E on rats' liver enzymes. Turk J Biol 33: 189-94, 2009.
30. Toulah FH, Al-Rawi MM. Efficacy of garlic extract on hepatic coccidiosis in infected rabbits (Oryctolagus cuniculus): histological and biochemical studies. J Egypt Soc Parasitol 37: 957-68, 2007.
31. Suzuki H, Takasawa H, Kobayashi K et al. Evaluation of a liver micronucleus assay with 12 chemicals using young rats (II): a study by the Collaborative Study Group for the Micronucleus Test/Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group. Mutagenesis 24: 9-16, 2009.
32. National Research Council. Guide for the Care and Use of Laboratory Animals. National Academy Press. Washington; 1996.
33. Weir RJ Jr, Fisher RS. Toxicologic studies on borax and boric acid. Toxicol Appl Pharmacol 23: 351-64, 1972.
34. Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect 102: 65-72, 1994.
35. Van Ginkel MF, van der Voet GB, D'Haese PC et al. Effect of citric acid and maltol on the accumulation of aluminum in rat brain and bone. J Lab Clin Med 121: 453-60, 1993.
36. Wang HX, Ma XC, Deng QL et al. Cytotoxicity of flutamide and 2-hydroxyflutamide and their effects on CYP1A2 mRNA in primary rat hepatocytes. Acta Pharmacol Sin 23: 562-6, 2002.
37. Bowman KO, Kastenbaum MA. Sample size requirement: Single and double classification experiments. In: Owen DB, Harter HL. eds. Selected Tables in Mathematical Statistics. American Mathematical Society and Institute of Mathematical Statistics; 1975: pp. 111-232.
38. Nikolova P, Softova E, Kavaldzhieva B et al. The functional and morphological changes in the liver and kidneys of white rats treated with aluminum. Eksp Med Morfol 32: 52-61, 1994.
39. Gowri Shankar NL, Manavalan R, Venkappayya D et al. Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl(4)-induced oxidative damage in rats. Food Chem Toxicol 46: 3182-185, 2008.
40. Sinha US, Kapoor AK, Singh AK. Histopathological changes in cases of aluminium phosphide poisoning. Indian J Pathol Microbiol 48: 177-80, 2005.
41. Bogdanovic M, Janeva AB, Bulat P. Histopathological changes in rat liver after a single high dose of aluminium. Arh Hig Rada Toksikol 59: 97-101, 2008.
42. Tripathi S, Somashekar BS, Mahdi AA. Aluminum-mediated metabolic changes in rat serum and urine: a proton nuclear magnetic resonance study. J Biochem Mol Toxicol 22: 119-27, 2008.
43. Rahman MF, Siddiqui MK, Jamil K. Acid and alkaline phosphatase activities in a novel phosphorothionate (RPR-11) treated male and female rats. Evidence of dose and timedependent response. Drug Chem Toxicol 23: 497-509, 2000.
44. Sujatha R, Jayakumar AR, Krishnamoorthy MS et al. Behavioural and biochemical changes after simultaneous and post-treatment of vitamin A and D on cadmium toxicity. Environ Toxicol Pharmacol 7: 189-97, 1999.
45. Ninh T, Nguyen MD, Scott Braley MD et al. Comparison of postoperative hepatic function after laparoscopic versus open gastric bypass. Am J Surg 186: 40-44, 2003.
46. Singhal RL, Merali Z. Biochemical toxicity of cadmium. In: Mennear JH. ed. Cadmium toxicity. Marcel Dekker; 1977, pp. 61-112.
47. Salvatore F, Sacchetti L, Castaldo G. Multivariate discriminant analysis of biochemical parameters for the diff erentiation of clinically confounding liver diseases. Clin Chim Acta 257: 41-58, 1997.
48. Suzuki KT, Kano S, Misawa S et al. Copper-metabolism leading to and following acute hepatitis in lec rats. Toxicol 97: 81-92, 1995.
49. Koh JY, Choi D W. Quantitative-determination of glutamate mediated cortical neuronal injury in cell-culture by lactatedehydrogenase efflux assay. J Neurosci Methods 20: 83-90, 1987.
50. Shen HM, Ong CN, Shi CY. Involvement of reactive oxygen species in aflatoxin b-1-induced cell injury in cultured rat hepatocytes. Toxicol 99: 115-23, 1995.
51. Lindell SL, Hansen T, Rankin M et al. Donor nutritional status-A determinant of liver preservation injury. Transplant 61: 239-247, 1996.
52. Anane R, Creppy EE. Lipid peroxidation as pathway of aluminium cytotoxicity in human skin fibroblast cultures: prevention by superoxide dismutase+catalase and vitamins E and C. Hum Exp Toxicol 20: 477-81, 2001.
53. Price CJ, Marr MC, Myers CB et al. The developmental toxicity of boric acid in rabbits. Fundam Appl Toxicol 34: 176-87, 1996.
54. Pushpavalli G, Veeramani C, Pugalendi KV. Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats. J Basic Clin Physiol Pharmacol 19: 131-50, 2008.
55. Turkez H. Effects of boric acid and borax on titanium dioxide genotoxicity. J Appl Toxicol 28: 658-64, 2008.
56. Kelly GS. Boron: a review of its nutritional interactions and therapeutic uses. Altern Med Rev 2: 48-56, 1997.
57. Hunt CD, Idso JP. Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress. J Trace Elem Exp Med 12: 221-33, 1999.
58. Perez G, Pregi N, Vittori D et al. Aluminum exposure aff ects transferrin-dependent and-independent iron uptake by K562 cells. Biochim Biophys Acta 1745: 124-30, 2005.
59. Kim Y, Olivi L, Cheong JH. Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Toxicol Appl Pharmacol 220: 349-56, 2007.
60. Drobnik M, Latour T. Investigation of the pharmacodynamic properties of the solution of boric acid. Rocz Panstw Zakl Hig 52: 329-36, 2001.
61. Flaten TP, Garruto RM. Polynuclear ions in aluminum toxicity. J Theor Biol 156: 129-32, 1992.
62. Hernandez G, Bollini A, Huarte M et al. In vitro effect of aluminium upon erythrocyte membrane properties. Clin Hemorheol Microcirc 40: 191-205, 2008.
63. Padi SS, Chopra K. Salvage of cyclosporine A-induced oxidative stress and renal dysfunction by carvedilol. Nephron 92: 685-92, 2002.
64. Sethi P, Jyoti A, Singh R. Aluminium-induced electrophysiological, biochemical and cognitive modifications in the hippocampus of aging rats. Neurotoxicol 29: 1069-79, 2008.
65. Barr RD, Barton SA, Schull WJ. Boron levels in man: preliminary evidence of genetic regulation and some implications for human biology. Med Hypothses 46: 286-89, 1996.
66. Zhurkov VS, Sycheva LP, Salamatova O et al. Selective induction of micronuclei in the rat/mouse colon and liver by 1,2-dimethylhydrazine: a seven-tissue comparative study. Mutat Res 368: 115-20, 1996.
67. Kada T, Hirano K, Shirasu Y. Screening of environmental chemical mutagens by the rec-assay system with Bacillus subtilis. Chem Mutagen 6: 149-73, 1980.
68. Oberly TJ, Piper CE, McDonald DS. Mutagenicity of metal salts in the L5178Y mouse lymphoma assay. J Toxicol Environ Health 9: 367-76, 1982.
69. Roy AK, Talukder G, Sharma A. Effects of aluminium sulphate on human leukocyte chromosomes in vitro. Mutat Res 244: 179-83, 1990.
70. Manna GK, Das RK. Chromosome aberrations in mice induced by aluminum chloride. Nucleus 15: 180-86, 1972.
71. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Aluminum. U.S. Department of Health and Human Services, Division of Toxicology and Environmental Medicine/Applied Toxicology Branch. Atlanta; 2008.
72. World Health Organization (WHO). International Programme on Chemical Safety, Environmental Health Criteria 204, Boron. Geneva, 1998
73. Park M, Li Q, Shcheynikov N et al. Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle 4: 24-26, 2005.
74. Abubakar MG, Taylor A, Ferns GA. Aluminium administration is associated with enhanced hepatic oxidant stress that may be off set by dietary vitamin E in the rat. Int J Exp Pathol 84: 49-54, 2003.