Indole-3-carbinol inhibits prostate cancer cell migration via degradation of β-catenin

Oncology Research

Volumn 19, Issue 5, 2011, Pages 237-243

  Jeong, Yun Mi ^a   Li, Hailan ^a   Kim, Su Yeon ^a   Yun, Hye Young ^a   Baek, Kwang Jin ^a   Kwon, Nyoun Soo ^a   Myung, Soon Chul ^a   Kim, Dong Seok ^a  

^a Chung Ang University College of Medicine   (South Korea)

Author keywords

Indole 3 carbinol; Migration; Prostate cancer; catenin

Indexed keywords

3 INDOLEMETHANOL; ANDROGEN RECEPTOR; BETA CATENIN; EPIDERMAL GROWTH FACTOR; MESSENGER RNA; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; INDOLE-3-CARBINOL;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL MOTION; DRUG EFFECT; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR;

ANTICARCINOGENIC AGENTS; BETA CATENIN; CELL MOVEMENT; EPIDERMAL GROWTH FACTOR; HUMANS; INDOLES; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS;

EID: 79957526330     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504011X12970940207922     Document Type: Article

References (25)

1. Jemal, A.; Siegel, R.; Ward, E.; Murray, T.; Xu, J.; Thun, M. J. Cancer statistics, 2007. CA Cancer J. Clin. 57:43-66; 2007.
2. Ye, X. C.; Choueiri, M.; Tu, S. M.; Lin, S. H. Biology and clinical management of prostate cancer bone metastasis. Front. Biosci. 12:3273-3286; 2007.
3. Mimeault, M.; Batra, S. K. Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies. Carcinogenesis 27:1-22; 2006.
4. Zhou, W.; Grandis, J. R.; Wells, A. Stat3 is required but not sufficient for egf receptor-mediated migration and invasion of human prostate carcinoma cell lines. Br. J. Cancer 95:164-171; 2006.
5. Wells, A.; Kassis, J.; Solava, J.; Turner, T.; Lauffenburger, D. A. Growth factor-induced cell motility in tumor invasion. Acta Oncol. 41:124-130; 2002.
6. Xie, H.; Pallero, M. A.; Gupta, K.; Chang, P.; Ware, M. F.; Witke, W.; Kwiatkowski, D. J.; Lauffenburger, D. A.; Murphy-Ullrich, J. E.; Wells, A. Egf receptor regulation of cell motility: Egf induces disassembly of focal adhesions independently of the motility-associated plcgamma signaling pathway. J. Cell Sci. 111(Pt. 5):615-624; 1998.
7. Nelson, W. J.; Nusse, R. Convergence of wnt, beta- catenin, and cadherin pathways. Science 303:1483-1487; 2004.
8. Terry, S.; Yang, X.; Chen, M. W.; Vacherot, F.; Buttyan, R. Multifaceted interaction between the androgen and wnt signaling pathways and the implication for prostate cancer. J. Cell Biochem. 99:402-410; 2006.
9. Heinlein, C. A.; Chang, C. Androgen receptor in prostate cancer. Endocr. Rev. 25:276-308; 2004.
10. Chunthapong, J.; Seftor, E. A.; Khalkhali-Ellis, Z.; Seftor, R. E.; Amir, S.; Lubaroff, D. M.; Heidger, Jr., P. M.; Hendrix, M. J. Dual roles of e-cadherin in prostate cancer invasion. J. Cell Biochem. 91:649-661; 2004.
11. Sarkar, F. H.; Li, Y. Indole-3-carbinol and prostate cancer. J. Nutr. 134:3493S-3498S; 2004.
12. Weng, J. R.; Tsai, C. H.; Kulp, S. K.; Chen, C. S. Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett. 262:153-163; 2008.
13. Chinnakannu, K.; Chen, D.; Li, Y.; Wang, Z.; Dou, Q. P.; Reddy, G. P.; Sarkar, F. H. Cell cycle-dependent effects of 3,3∋-diindolylmethane on proliferation and apoptosis of prostate cancer cells. J. Cell Physiol. 219:94-99; 2009.
14. Chinni, S. R.; Li, Y.; Upadhyay, S.; Koppolu, P. K.; Sarkar, F. H. Indole-3-carbinol (i3c) induced cell growth inhibition, g1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene 20:2927-2936; 2001.
15. Chinni, S. R.; Sarkar, F. H. Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in pc-3 cells. Clin. Cancer Res. 8:1228-1236; 2002.
16. Brew, C. T.; Aronchik, I.; Kosco, K.; McCammon, J.; Bjeldanes, L. F.; Firestone, G. L. Indole-3-carbinol inhibits mda-mb-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of rho kinase activity. Int. J. Cancer 124:2294-2302; 2009.
17. Kim, D. S.; Jeong, Y. M.; Moon, S. I.; Kim, S. Y.; Kwon, S. B.; Park, E. S.; Youn, S. W.; Park, K. C. Indole-3-carbinol enhances ultraviolet b-induced apoptosis by sensitizing human melanoma cells. Cell. Mol. Life Sci. 63: 2661-2668; 2006.
18. Festuccia, C.; Angelucci, A.; Gravina, G. L.; Biordi, L.;Millimaggi, D.; Muzi, P.; Vicentini, C.; Bologna, M. Epidermal growth factor modulates prostate cancer cell invasiveness regulating urokinase-type plasminogen activator activity. Egf-receptor inhibition may prevent tumor cell dissemination. Thromb. Haemost. 93:964-975; 2005.
19. Kharait, S.; Dhir, R.; Lauffenburger, D.; Wells, A. Protein kinase cdelta signaling downstream of the egf receptor mediates migration and invasiveness of prostate cancer cells. Biochem. Biophys. Res. Commun. 343:848-856; 2006.
20. Verras, M.; Sun, Z. Roles and regulation of wnt signaling and beta-catenin in prostate cancer. Cancer Lett. 237:22-32; 2006.
21. Kwon, G. T.; Cho, H. J.; Chung, W. Y.; Park, K. K.; Moon, A.; Park, J. H. Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: Possible mediation by decreased jnk/ap-1 signaling. J. Nutr. Biochem. 20: 663-676; 2009.
22. Hung, W. C.; Chang, H. C. Indole-3-carbinol inhibits sp1- induced matrix metalloproteinase-2 expression to attenuate migration and invasion of breast cancer cells. J. Agric. Food Chem. 57:76-82; 2009.
23. Lu, Z.; Jiang, G.; Blume-Jensen, P.; Hunter, T. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol. Cell. Biol. 21:4016-4031; 2001.
24. Moiseeva, E. P.; Fox, L. H.; Howells, L. M.; Temple, L. A.; Manson, M. M. Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment. Apoptosis 11:799-812; 2006.
25. Li, Y.; Wang, Z.; Kong, D.; Murthy, S.; Dou, Q. P.; Sheng, S.; Reddy, G. P.; Sarkar, F. H. Regulation of foxo3a/beta-catenin/gsk-3beta signaling by 3,3∋-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J. Biol. Chem. 282:21542-21550; 2007.