Drug discrimination analysis of partial agonists at the benzodiazepine site. I. Differential effects of U-78875 across training conditions in baboons and rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 3, 1999, Pages 1434-1446

  Ator, Nancy A ^a,b   Griffiths, Roland R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR STIMULATING AGENT; DIAZEPAM; FLUMAZENIL; LORAZEPAM; PANADIPLON; PENTOBARBITAL;

ANIMAL EXPERIMENT; ARTICLE; BABOON; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG DISCRIMINATION; DRUG EFFECT; DRUG POTENTIATION; DRUG RECEPTOR BINDING; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ACOUSTIC STIMULATION; ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; CONDITIONING, OPERANT; DIAZEPAM; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; LORAZEPAM; MALE; OXADIAZOLES; PAPIO; PENTOBARBITAL; PHOTIC STIMULATION; QUINOXALINES; RATS; RATS, LONG-EVANS; RECEPTORS, GABA-A;

EID: 0033061207     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ator NA (1990) Drug discrimination and drug stimulus generalization with anxiolytics. Drug Dev Res 20:189-204.
2. Ator NA (1991) Subjects and instrumentation, in Techniques in the Behavioral and Neural Sciences: Experimental Analysis of Behavior (Iversen IH and Lattal KA eds) pp 1-60, Elsevier, Amsterdam.
3. Ator NA, Grant KA, Purdy RH, Paul SM and Griffiths RR (1993) Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241: 237-243.
4. Ator NA and Griffiths RR (1985) Lorazepam and pentobarbital discrimination: Interactions with CGS 8216 and caffeine. Eur J Pharmacol 107:169-181.
5. Ator NA and Griffiths RR (1986) Discriminative stimulus effects of atypical anxiolytics in baboons and rats. J Pharmacol Exp Ther 237:393-407.
6. Ator NA and Griffiths RR (1989a) Asymmetrical cross-generalization in drug discrimination with lorazepam and pentobarbital training conditions. Drug Dev Res 16:355-364.
7. Ator NA and Griffiths RR (1989b) Differential generalization to pentobarbital in rats trained to discriminate lorazepam, chlordiazepoxide, diazepam or triazolam. Psychopharmocology 98:20-30.
8. Ator NA and Griffiths RR (1997) Selectivity in the generalization profile in baboons trained to discriminate lorazepam: Benzodiazepines, barbiturates and other sedative/anxiolytics. J Pharmacol exp Ther 282:1442-1457.
9. Ator NA, Kautz MA, Sannerud CA and Griffiths RR (1995) Drug discrimination analysis of partial agonists at the benzodiazepine (BZ) modulatory site. Soc Neurosci Abstr 21:2099.
10. Barry H III (1974) Classification of drugs according to their discriminable effects in rats. Fed Proc 33:1814-1824.
11. 3H]flunitrazepam binding throughout the rat brain: An autoradiographic study. J Pharmacol Exp Ther 263;1401-1414.
12. Clarke WP and Bond RA (1998) The elusive nature of intrinsic efficacy. Trends Pharmacol Sci 19:270-276.
13. Costa E and Guidotti A (1996) Benzodiazepines on trial: A research strategy for their rehabilitation. Trends Pharm Sci 17:192-200.
14. Griffiths RR, Sannerud CA, Ator NA and Brady JV (1992) Zolpidem behavioral pharmacology in baboons: Self-injection, discrimination, tolerance and withdrawal. J Pharmacol Exp Ther 260:1199-1208.
15. A receptor subtypes. Br J Pharmacol 115:19-24.
16. A receptors but with the opposite functionality. Br J Pharmacol 123:1490-1494.
17. A receptor ligand of dual functionality. Brain Res 714:165-168.
18. Kenakin T (1993) Pharmacologic Analysis of Drug-Receptor Interaction, 2nd ed, Raven Press, New York.
19. Leff P (1987) An analysis of amplifying and potentiating interactions between agonists. J Pharmacol Exp Ther 243:1035-1042.
20. Miller LG, Deutsch SI, Greenblatt DJ, Paul SM and Shader RI (1988) Acute barbiturate administration increases benzodiazepine receptor binding in vivo. Psychopharmacology 96:385-390.
21. Morse WH and Kelleher RT (1977) Determinants of reinforcement and punishment, in Handbook of Operant Behavior (Honig WK and Staddon JER eds) pp 174-200, Prentice-Hall, Englewood Cliffs, NJ.
22. Overton DA (1979) Influence of shaping procedures and schedules of reinforcement on performance in the two-bar drug discrimination task: A methodological report. Psychopharmacology 65:291-298.
23. A receptors. Mol Pharmacol 42:294-301.
24. Rowlett JK and Woolverton WL (1998) Discriminative stimulus effects of benzodiazepine agonists and partial agonists in pentobarbital-trained rhesus monkeys. Behav Pharmacol 9:81-92.
25. Sannerud CA, Ator NA and Griffiths RR (1992) Behavioral pharmacology of abecarnil in baboons: Self-injection, drug discrimination and physical dependence. Behav Pharmacol 3:507-516.
26. Shannon HE and Herling S (1983) Discriminative stimulus effects of diazepam in rats: Evidence for a maximal effect. J Pharmacol Exp Ther 227:160-166.
27. Sidman M (1960) Tactics of Scientific Research. Basic Books, New York.
28. Sidman, M (1980) A note on the measurement of conditional discrimination. J Exp Anal Behav 33:285-289.
29. Skolnick P, Moncada V, Barker JL and Paul SM (1981) Pentobarbital: Dual actions to increase brain benzodiazepine receptor affinity. Science 211:1448-1450.
30. Tang AH and Franklin SR (1991) The discriminative stimulus effects of diazepam in rats at two training doses. J Pharmacol Exp Ther 258:926-931.
31. Tang AH, Code RA and Himes CS (1993) Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice. Eur J Pharmacol 236:1-5.
32. Tang AH, Franklin SR, Himes CS and Ho PM (1991) Behavioral effects of U-78875, a quinoxalinone anxiolytic with potent benzodiazepine antagonist activity. J Pharmacol Exp Ther 259:248-254.