Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective α1d-adrenergic receptor antagonists

Journal of Medicinal Chemistry

Volumn 48, Issue 8, 2005, Pages 3076-3079

  Konkel, Michael J ^a   Wetzel, John M ^a   Cahir, Marie ^a,b   Craig, Douglas A ^a   Noble, Stewart A ^a,c   Gluchowski, Charles ^a,d  

^a LUNDBECK RESEARCH USA   (United States)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c Kalypsys Inc   (United States)

^d Life Science Solutions   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 [2 [4 (2,4,5 TRIFLUOROPHENYL)PIPERAZIN 1 YL] 1 METHYLETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 8 [2 [4 (2,4,5 TRIFLUOROPHENYL)PIPERAZIN 1 YL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; 8 [2 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; AORTA, THORACIC; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SPIRO COMPOUNDS; SPLEEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 17444425758     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0491391     Document Type: Article

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