Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose

American Journal of Chinese Medicine

Volumn 39, Issue 3, 2011, Pages 551-563

  Chiu, Chuan Sung ^a,c   Chiu, Yung Jia ^a   Wu, Lung Yuan ^a   Lu, Tsung Chun ^d   Huang, Tai Hung ^b   Hsieh, Ming Tsuen ^a   Lu, Chung Yen ^e   Peng, Wen Huang ^a  

^a School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c HSIN SHENG COLLEGE OF MEDICAL CARE AND MANAGEMENT   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e CARDINAL TIEN COLLEGE OF HEALTHCARE AND MANAGEMENT   (Taiwan)

Author keywords

Aging; Cognition Deficit; D gal; Diosgenin

Indexed keywords

DIOSGENIN; GALACTOSE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; LEARNING; MALE; MAZE TEST; MEMORY; MENTAL CAPACITY; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; SENESCENCE; TREATMENT OUTCOME;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; COGNITION DISORDERS; DIOSCOREA; DIOSGENIN; GALACTOSE; GLUTATHIONE PEROXIDASE; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; SUPEROXIDE DISMUTASE;

EID: 79957497980     PISSN: 0192415X     EISSN: 0192415X     Source Type: Journal    
DOI: 10.1142/S0192415X11009020     Document Type: Article

References (56)

1. Accatino, L., M. Pizarro, N. Solis and C.S. Koenig. Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat. Hepatology 28: 129-140, 1998. (Pubitemid 28299994)
2. Aquino, R., C. Conti, F. De Simone, N. Orsi, C. Pizza and M.L. Stein. Antiviral activity of constituents of Tamus Communis. J. Chemother. 3: 305-309, 1991.
3. Barnes, C.A., L. Nadel and W.K. Honig. Spatial memory deficit in senescent rats. Can. J. Psychol. 34: 29-39, 1980.
4. Cayen, M.N. and D. Dvornik. Effect of Diosgenin on lipid metabolism in rats. J. Lipid Res. 20: 162-174, 1979. (Pubitemid 9150664)
5. Chen, Y. and Y. Wu. Progress in research and manufacturing of steroidal sapogenins in China. J. Herb. Spic. Med. Plants 2: 59-70, 1994.
6. Chiang, C.T., T.D. Way, S.J. Tsai and J.K. Lin. Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in her2-overexpressing breast cancer cells through modulating Akt, Mtor and Jnk phosphorylation. FEBS Lett. 581: 5735-5742, 2007.
7. Chiu, C.S., J.S. Deng, M.T. Hsieh, M.J. Fan, M.M. Lee, F.S. Chueh, C.K. Han, Y.C. Lin and W.H. Peng. Yam (Dioscorea pseudojaponica Yamamoto) ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose. Am. J. Chin. Med. 37: 889-902, 2009.
8. Cini, M., R.G. Fariello, A. Bianchetti and A. Moretti. Studies on lipid peroxidation in the rat brain. Neurochem. Res. 19: 283-288, 1994. (Pubitemid 24054798)
9. Cui, X., P. Zuo, Q. Zhang, X. Li, Y. Hu, J. Long, L. Packer and J. Liu. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of r-alpha-lipoic acid. J. Neurosci. Res. 84: 647-654, 2006. (Pubitemid 44196705)
10. D'Hooge, R. and P.P. De Deyn. Applications of the Morris water maze in the study of learning and memory. Brain Res. Rev. 36: 60-90, 2001. (Pubitemid 32763130)
11. De Iuliis, A., J. Grigoletto, A. Recchia, P. Giusti and P. Arslan. A proteomic approach in the study of an animal model of parkinson's disease. Clin. Chim. Acta 357: 202-209, 2005. (Pubitemid 40894638)
12. Djerassi, C. Drugs from third world plants: the future. Science 258: 203-204, 1992.
13. Flohe, L. and W.A. Gunzler. Assays of glutathione peroxidase. Methods Enzymol. 105: 114-121, 1984. (Pubitemid 14165378)
14. Fukui, K., N.O. Omoi, T. Hayasaka, T. Shinnkai, S. Suzuki, K. Abe and S. Urano. Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Ann. NY Acad. Sci. 959: 275-284, 2002. (Pubitemid 34457568)
15. Harman, D. Free radical theory of aging. Mutat. Res. 275: 257-266, 1992.
16. Hayakawa, M., K. Hattori, S. Sugiyama and T. Ozawa. Age-Associated oxygen damage and mutations in mitochondrial dna in human hearts. Biochem. Biophys. Res. Commun. 189: 979-985, 1992. (Pubitemid 23032471)
17. Hu, K., A. Dong, X.S. Yao, H. Kobayashi and S. Iwasaki. Antineoplastic agents. I. Three spirostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca. Planta Med. 62: 573-575, 1996. (Pubitemid 27006703)
18. Hu, K., X. Yao, H. Kobayashi and S. Iwasaki. Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea Collettii Var. Hypoglauca. Planta Med. 63: 161-165, 1997. (Pubitemid 27196087)
19. Jayachandran, K.S., H.R. Vasanthi and G.V. Rajamanickam. Antilipoperoxidative and membrane stabilizing effect of diosgenin, in experimentally induced myocardial infarction. Mol. Cell Biochem. 327: 203-210, 2009.
20. Kamisako, T. and H. Ogawa. Regulation of Biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: effects of diosgenin and ethinyl estradiol. Hepatol. Res. 26: 348-352, 2003. (Pubitemid 37184526)
21. Kato, A., T. Miura and T. Fukunaga. Effects of steroidal glycosides on blood glucose in normal and diabetic mice. Biol. Pharm. Bull. 18: 167-168, 1995.
22. Liu, S.Y., J.Y. Wang, Y.T. Shyu and L.M. Song. Studies on yams {Dioscorea Spp.) in Taiwan. J. Chin. Med. 6: 111-126, 1995.
23. Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
24. Lu, J., Y.L. Zheng, L. Luo, D.M. Wu, D.X. Sun and Y.J. Feng. Quercetin reverses D-galactose induced neurotoxicity in mouse brain. Behav. Brain Res. Ill: 251-260, 2006. (Pubitemid 43946498)
25. Ma, H.Y., Z.T. Zhao, L.J. Wang, Y. Wang, Q.L. Zhou, B.X., Wang. Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of dioscorea panthaica. Zhongguo Zhong Yao Za Zhi 27: 528-531, 2002.
26. Malinow, M.R. Effects of synthetic glycosides on cholesterol absorption. Ann. NY Acad. Sci. 454: 23-27, 1985. (Pubitemid 16198834)
27. McCord, J.M. and I. Fridowich. An enzymic function for erythrocuprein. J. Biol. Chem. 244: 6044-6055, 1969.
28. Mihara, M. and M. Uchiyama. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 86: 271-278, 1978. (Pubitemid 9050395)
29. Morgan, B.P. and M.S. Morynihan. Steroids in Kirk-Othmer Encyclopedia of Chemical Technology, 4th ed. John Wiley & Sons, New York, USA, 1997, pp. 851-921.
30. Morris, R. Developments of a water-maze procedure for studying spatial learning in the rat./. Neurosci. Methods 11: 47-60, 1984. (Pubitemid 14088970)
31. Olanow, C.W. A radical hypothesis for neurodegeneration. Trends Neurosci. 16: 439 W, 1993.
32. Oyanagui, Y. Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal. Biochem. 142: 290-296, 1984. (Pubitemid 15177262)
33. Parle, M. and D. Dhingra. Ascorbic acid: a promising memory-enhancer in mice. J. Pharmacol. Sci. 93: 129-135, 2003. (Pubitemid 37390873)
34. Peng, J.P., H. Chen, Y.Q. Qiao, L.R. Ma, T. Narui, H. Suzuki, T. Okuyama and H. Kobayashi. Two new steroidal saponins form Allium sativum and their inhibitory effects on blood coagulability. Acta Pharm. Sinica 31: 613-616, 1996.
35. Raju, J. and R.P. Bird. Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl coa reductase expression and induces apoptosis in Hct-116 human colon carcinoma cells. Cancer Lett. 255: 194-204, 2007. (Pubitemid 47268640)
36. Raju, J. and R. Mehta. Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin. Nutr. Cancer 61: 27-35, 2009.
37. Ravikumar, P.R., P. Hammesfahr and C.J. Sih. Cytotoxic saponins form the Chinese herbal drug Yunnan Bai Yao. J. Pharm. Sci. 68: 900-903, 1979. (Pubitemid 9224269)
38. Santos, W.N., R.R. Bernardo, L.M.T. Pecanha, M. Palbtnik, J.P. Parente and C.B. de Sousa. Hae-molytic activities of plant saponins and agjuvants. Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovani. Vaccine 15: 1024-1029, 1997. (Pubitemid 27308581)
39. Sauvaire, Y., G. Ribes, J.C. Baccou, M.M. Loubatier'es-Mariani. Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek. Lipids 26: 191-197, 1991.
40. Sharps, M.J. and E.S. Gollin, Memory for object locations in young and elderly adults. J. Gerontol. 42: 336-341, 1987. (Pubitemid 17167507)
41. Shen, Y.X., SY. Xu, W. Wei, X.X. Sun, J. Yang, L.H. Liu and C. Dong. Melatonin reduces memory changes and neural oxidative damage in mice treated with D-galactose. J. Pineal. Res. 32: 173-178, 2002. (Pubitemid 34309884)
42. Socci, D.J., B.M. Crandall and G.W. Arendash. Chronic antioxidant treatment improves the cognitive performance of aged rats. Brain Res. 693: 88-94, 1995.
43. Son, I.S., J.H. Kim, HY. Sohn, K.H. Son, J.S. Kim and C.S. Kwon. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (dioscorea spp.), on high-cholesterol fed rats. Biosci. Biotechnol. Biochem. 71: 3063-3071, 2007.
44. Song, X., M. Bao, D. Li and Y.M. Li. Advanced glycation in d-galactose induced mouse aging model. Mech. Ageing Dev. 108: 239-251, 1999. (Pubitemid 29240629)
45. Sung, M.K., C.W. Kendall and A.V. Rao. Effect of saponins and Gypsophila saponin on morphology of colon carcinoma cells in culture. Food Chem. Toxic. 33: 357-366, 1995.
46. Tian, J., K. Ishibashi, K. Reiser, R. Grebe, S. Biswal, P. Gehlbach and J.T. Handa. Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response. Proc. Natl. Acad. Sci. USA 102: 11846-11851, 2005. (Pubitemid 41170813)
47. Uchida, K, H. Takase, Y. Nomura, K. Takeda, N. Takeuchi and Y. Ishikawa. Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol. J. Lipid Res. 25: 236-245, 1984. (Pubitemid 14165023)
48. Uchiyama, M. and M. Mihara. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 86: 271-278, 1978. (Pubitemid 9050395)
49. Valko, M., D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur and J. Telser. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39: 44-84, 2007. (Pubitemid 44566469)
50. Villarreal, J.S., F. Gonzalez-Lima, J. Berndt and E.J. Barea-Rodriguez. Water maze training in aged rats: effects on brain metabolic capacity and behavior. Brain Res. 939: 43-51, 2002. (Pubitemid 34518588)
51. Wang, L.J., Y. Wang, S.W. Chen, J.S. Ma, Q. Fu and B.X. Wang. Antitumor activity of diosgenin in vivo and in vitro. Zhongguo Zhong Yao Za Zhi 27: 777-779, 2002.
52. Wei, H., L. Li, Q. Song, H. Ai, J. Chu and W. Li. Behavioural study of the D-galactose induced aging model in C57bl/6j mice. Behav. Brain Res. 157: 245-251, 2005. (Pubitemid 40082567)
53. Yang, D.J., T.J. Lu and L.S. Hwang. Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto). J. Agric. Food Chem. 51: 6438-6444, 2003.
54. Zhang, J., Z. Meng, M. Zhang, D. Ma, S. Xu and H. Kodama. Effect of six steroidal saponins isolated from Anemarrhenae rhizoma on platelet aggregation and hemolysis in human blood. Clin. Chim. Acta 289: 79-88, 1999. (Pubitemid 29505201)
55. Zhang, Q., X. Li, X. Cui and P. Zuo. D-galactose injured neurogenesis in the hippocampus of adult mice. Neurol. Res. 27: 552-556, 2005. (Pubitemid 41040845)
56. Zhang, XL., B. Jiang, Z.B. Li, S. Hao and L.J. An. Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Pharmacol. Biochem. Behav. 88: 64-72, 2007. (Pubitemid 47379823)