Regional alterations of JNK3 and CaMKIIα subunit expression in the rat brain after soman poisoning

Human and Experimental Toxicology

Volumn 30, Issue 6, 2011, Pages 448-459

  Ramarao, G ^a   Waghmare, C K ^a   Srivastava, Nalini ^a   Bhattacharya, B K ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

c Jun N terminal kinases (JNKs); calcium calmodulin dependent protein kinase II (CaMKII); immunoreactivity; neurotoxic effects; soman

Indexed keywords

ACETYLCHOLINESTERASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; JANUS KINASE 3; PROTEIN KINASE; SOMAN;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HIPPOCAMPUS; IMMUNOREACTIVITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THALAMUS; WESTERN BLOTTING;

ACETYLCHOLINESTERASE; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN MAPPING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CHEMICAL WARFARE AGENTS; FEMALE; INJECTIONS, SUBCUTANEOUS; MITOGEN-ACTIVATED PROTEIN KINASE 10; RATS; RATS, WISTAR; SOMAN; SUBCELLULAR FRACTIONS; TIME FACTORS;

RATTUS;

EID: 79957457383     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110386814     Document Type: Article

References (54)

1. Edwards DR Cell signaling and the control of gene transcription. Trends Pharmocol Sci 1994 ; 15: 239-244. (Pubitemid 24210729)
2. Dragunow M., Preston K. The role of inducible transcription factors in apoptotic nerve cell death. Brain Res Rev 1995 ; 21: 1-28.
3. Herdegen T., Waetzig V. The JNK and p38 signal transduction following axotomy. Restor Neurol Neurosci 2001 ; 19: 29-39. (Pubitemid 35025920)
4. Miller SG, Kennedy MB Regulation of brain type II Ca2+/calmodulin- dependent protein kinase by autophosphorylation: a Ca2+ -triggered molecular switch. Cell 1985 ; 44: 861-870.
5. Braun AP, Schulman H. The multifunctional calcium/ calmodulin dependent protein kinase II: from form to function. Ann Rev Phys 1995 ; 57: 417-445.
6. Kanaseki T., Ikeuchi Y., Sugiura H., and Yamauchi T. Structural features of Ca2+ /calmodulin-dependent protein kinase II revealed by electron microscopy. J Cell Biol 1991 ; 115: 1049-1060. (Pubitemid 21909952)
7. Hidding U., Mielke K., Waetzig V., Brecht S., Hanisch U., Behrens A., et al. The c-Jun N-terminal kinases in cerebral microglia: immunological functions in the brain. Biochem Pharmacol 2002 ; 64: 781.
8. Waetzig V., Herdegen T. Neurodegenerative physiological actions of c-Jun N-terminal kinases in the mammalian brain. Neurosci Lett 2004 ; 361: 64-67. (Pubitemid 38609217)
9. Rincon M., Flavell RA, and Davis RJ Signal transduction by MAP kinases in T lymphocytes. Oncogene 2001 ; 20: 2490-2497. (Pubitemid 32531305)
10. Kassa J., Pecka M., Tichy M., Bajgar J., Koupilova M., Herink J., et al. Toxic effects of sarin in rats at three months following single and repeated low-level inhalation exposure. Pharmacol Toxicol 2001 ; 88: 209-219.
11. Bajgar J. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 2004 ; 38: 151-216.
12. Chebabo S., Santos M., and Albequerque E. Organophosphate Sarin, at low- concentrations, inhibits the evoked release of GABA in rat hippocampal slices. Neurotoxicology 1999 ; 20: 871-872.
13. Ward TR, Ferris DJ, Tilson HA, and Mundy WR Correlation of anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors. Toxicol Appl Pharmacol 1993 ; 122: 300-307. (Pubitemid 23314955)
14. Miyaki K., Nishiwaki Y., Maekawa K., Ogawa Y., Asukai N., Yoshimura K., et al. Effects of sarin on the nervous system of subway workers seven years after the Tokyo subway sarin attack. J Occup Health 2005 ; 47: 299-304. (Pubitemid 41359222)
15. Niijima H., Nagaom I., Nakajima M., Takatori T., Matsuda Y., and Iwase H. Sarin-like and soman-like organophosphorous agents activate PLC gamma in rat brains. Toxicol Appl Pharmacol 1999 ; 156: 64-69. (Pubitemid 29181700)
16. Niijima H., Nagao M., Nakajima M., Takatori T., Iwasa M., and Maeno Y. The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains. Forensic Sci Int 2000 ; 112 (2-3). 171-178. (Pubitemid 30625039)
17. Lallement G., Carpentier P., Collet A., and Baubichon D. Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain Res 1991 ; 563: 234-240.
18. Solberg Y., Belkin M. The role of excitotoxicity in organophosphorous nerve agents central poisoning. Trends Pharmacol 1997 ; 18: 183-185. (Pubitemid 27283644)
19. Olney JW, De Gubareff T., and Labruyere J. Seizure-related brain damage induced by cholinergic agents. Nature 1983 ; 301: 520-522. (Pubitemid 13160572)
20. Bansal I., Waghmare CK, Anand T., Gupta AK, and Bhattacharya BK Differential mRNA expression of acetylcholinesterase in the central nervous system of rats with acute and chronic exposure of sarin & physostistigmine. J Appl Toxicol 2009 ; 29: 386-394.
21. Damodaran TV, Patel AG, Greenfield ST, Dressman HK, Lin SM, and Abou-Donia MB Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. Biochem Pharmacol 2006 ; 71: 497-520. (Pubitemid 43077084)
22. Dillman JF 3rd, Phillips CS, Kniffin DM, Tompkins CP, Hamilton TA, and Kan RK Gene expression profile of rat hippocampus following exposure to the acetylcholinesterase inhibitor soman. Chem Res Toxicol 2009 ; 18: 28-34.
23. Svensson I., Waara L., Johansson L., Bucht A., and Cassel G. Soman-induced interleukin-1 beta mRNA and protein in rat brain. Neurotoxicology 2005 ; 22: 355-362.
24. Williams AJ, Berti R., Yao C., Price RA, Velarde LC, Koplovitz I., et al. Central neuro-inflammatory gene response following soman exposure in the rat. Neurosci Lett 2003 ; 349: 147-150. (Pubitemid 37297799)
25. Dixon WJ The Up and Down method of small samples. J Am Stat Assoc 1965 ; 60: 967-978.
26. Somani SM, Solana RP, and Dube SN Toxicodynamics of nerve agents. In: Somani SM (ed) Chemical warfare agents. San Diego, CA: Academic press, 1992, p. 67.
27. Due AH, Trap HC, Langenberg JP, and Benschop HP Toxicokinetics of soman sterioisomers after subcutenaneous administration to atropinized guinea pigs. Arch Toxicol 1994 ; 68: 60.
28. Ellman GL, Courtney KD, Andres V. Jr, and Feather-Stone RM A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961 ; 7: 88-95.
29. Steck TL, Kant JA Preparation of impermeable ghosts and inside out vesicles from human erythrocyte membranes. Methods Enzymol 1974 ; 31: 172-180.
30. Bradford MM A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 ; 72: 248-254.
31. Wang QS, Zhang CL, Hou LY, Zhao XL, Yang XW, and Xie KQ 2, 5-hexanedione (HD) treatment alters calmodulin, Ca2+/calmodulin-dependent protein kinase II, and protein kinase C in rats' nerve tissues. Toxicol Appl Pharmacol 2008 ; 232: 60-68.
32. Zhao J., Pei DS, Zhang QG, and Yizhang G. Down regulation of Cdc42 attenuates neuronal apoptosis through inhibiting MCK3/JNK3 cascade during ischemic reperfusion in rat hippocampus. Cell Signal 2007 ; 19: 831-843. (Pubitemid 46275373)
33. Ochiishi Y., Yamauchi T., and Terashima T. Regional differences between the immunohistochemical distribution of Ca2+/calmodulin-dependent protein kinase II a and b isoforms in the brainstem of the rat. Brain Res 1998 ; 790: 129-140.
34. McNamara RK, Wees EA, and Lenox RH Differential subcellular redistribution of protein kinase C isozymes in the rat hippocampus induced by kainic acid. J Neurochem 1999 ; 72: 1735-1743. (Pubitemid 29140851)
35. Sidell FR Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates. Clin Toxicol 1974 ; 7: 1-17.
36. Wess J. Molecular biology of muscarinic acetylcholine receptors. Critical Rev Neurobiol 1996 ; 10: 69-99. (Pubitemid 26283956)
37. Kuan CY, Whitmarsh AJ, Yang DD, Liao G., and Schloemer AJ A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A 2003 ; 100: 15184-15189. (Pubitemid 37518037)
38. Yang DD, Kuan CY, Whitmarsh AJ, Rincon M., and Zheng TS Absence of excitotoxicity induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997 ; 389: 865-870. (Pubitemid 27462982)
39. Caughlan A., Newhouse K., Namgung UK, and Xia Z. Chloropyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/ JNK MAP Kinases. Toxicol Sci 2004 ; 78: 125-134. (Pubitemid 38351431)
40. Zimmer LA, Ennis M., Wiley RG, and Shipley MT Nerve gas induced seizure: role of acetylcholine in the rapid induction of fos and glial fibrillary acidic protein in piriform cortex. J Neurosci 1998 ; 18: 3897-3908. (Pubitemid 28225694)
41. Young W. Role of calcium in central nervous system injuries. J Neurotrauma 1992 ; 9: 9-25.
42. Abou-Donia MB, Lapadula DM, and Suwita E. Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity. Toxicology 1988 ; 49: 469-477.
43. LoPachin RM, Lehning EJ Mechanism of calcium entry during axon injury and degeneration. Toxicol Appl Pharmacol 1997 ; 143: 233-244. (Pubitemid 27183542)
44. Wang YJ, Chen GH, Hu XY, Lu YP, Zhou JN, and Liu RY The expression of calcium/calmodulin-dependent protein kinase II-a in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Brain. Research. 2005. 1031, 101-108.
45. Pachiappan A., Thwin MM, Manikandan J., Keong LW, Lee FK, Sivakumar V., et al. ETS2 regulating neurodegenerative signaling pathway of human neuronal (SH-SY5Y) cells exposed to single and repeated low-dose sarin (GB). Chem Res Toxicol 2009 ; 22: 990-996.
46. Abou-Donia MB, Viana ME, Gupta RP, and Anderson JK Enhanced calmodulin binding concurrent with increased kinase-dependent phosphorylation of cytoskeletal proteins following a single subcutaneous injection of diisopropyl phosphorofluoridate in hens. Neurochem Int 1993 ; 22: 165-173.
47. Heck D., Sultan F. Cerebellar structure and function: Making sense of parallel fibers. Hum Mov Sci 2002 ; 21: 411-421.
48. Day T., Greenfield SA A peptide derived from acetylcholinesterase induces neuronal cell death: characterization of possible mechanisms. Exp Brain Res 2003 ; 153: 334-342. (Pubitemid 37463975)
49. Haeusgen W., Boehm R., Zhao Y., Herdegen T., and Waetzig V. Specific activities of individual c-jun n-terminal kinases in the brain. Neuroscience 2009 ; 161: 951-959.
50. Takano H., Fukushi H., Morishima Y., and Shirasaki Y. Ca2+/calmodulin-dependent protein kinase II mediate neuronal death induced by depolarization. Brain Res 2003 ; 962: 41-47. (Pubitemid 36126320)
51. Waetzig V., Herdegen T. A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death. J Biol Chem 2003 ; 278: 567-572. (Pubitemid 36043610)
52. Kadar T., Cohen G., Sahar R., Alkalai D., and Shapira S. Long-term study of brain lesions following soman, in comparison to DFP and metrazol poisoning. Hum Exp Toxicol 1992 ; 11: 517-523. (Pubitemid 23023517)
53. Martin LJ, Doebler JA, Wall TJ, Shih TM, and Anthony A. Brain neuronal chromatin responses in acute soman intoxicated rats. Neurochem Res 1986 ; 11: 1203-1215. (Pubitemid 16027670)
54. Dulaney MD, Hoskins B., and Ho IK Studies on low dose subacute administration of soman, sarin and tabun in the rat. Acta Pharmacol et Toxicol 1985 ; 57: 234-241. (Pubitemid 16234952)