ETS2 regulating neurodegenerative signaling pathway of human neuronal (SH-SY5Y) cells exposed to single and repeated low-dose sarin (GB)

Chemical Research in Toxicology

Volumn 22, Issue 6, 2009, Pages 990-996

  Pachiappan, Arjunan ^a,c   Maung, Maung Thwin ^a   Loke, Weng Keong ^b   Fook, Kay Lee ^b   Manikandan, Jayapal ^a   Sivakumar, Viswanathan ^a   Gopalakrishnakone, Ponnampalam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DSO NATIONAL LABORATORIES   (Singapore)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; APOLIPOPROTEIN E; CD9 ANTIGEN; PRESENILIN 1; SARIN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DDC GENE; DEGENERATIVE DISEASE; DOWN REGULATION; ENZYME ACTIVITY; ETS2 GENE; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE TEST; MICROARRAY ANALYSIS; NERVE CELL; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ACETYLCHOLINESTERASE; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICROARRAY ANALYSIS; NEURONS; PROTO-ONCOGENE PROTEIN C-ETS-2; SARIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 67449095308     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx8003467     Document Type: Article

References (23)

1. Niijima, H., Nagao, M., Nakajima, M., Takatori, T., Matsuda, Y., Iwase, H., and Kobayashi, M. (1999) Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains. Toxicol. Appl. Pharmacol. 156, 64-69. (Pubitemid 29181700)
2. Taylor, P., and Brown, J. H. (1999) Acetylcholine. In Basic Neurochemistry: Molecular Cellular and Medical Aspects (Siegel, G. J., Agranoff, B. W., Alberts, R. W., Fisher, S. K., and Uhler, S. K., Eds.) pp 213-242, Lippincott-Raven Publishers, Philadelphia.
3. Yokoyama, K., Araki, S., Murata, K., Nishikitani, M., Okumura, T., Ishimatsu, S., Takasu, N., and White, R. F. (1998) Chronic neurobehavioral effects of Tokyo subway sarin poisoning in relation to posttraumatic stress disorder. Arch. Environ. Health 53, 249-256. (Pubitemid 28361511)
4. Duffy, F. H., and Burchfield, J. L. (1980) Long term effects of the organophosphate sarin on EEGs in monkeys, and humans. Neurotoxicology 1, 667-689. (Pubitemid 10134686)
5. Kadar, T., Shapira, S., Cohen, G., Sahar, R., Alkalay, D., and Raveh, L. (1995) Sarin-induced neuropathology in rats. Hum. Exp. Toxicol. 14, 252-259.
6. Afshari, C. A. (2002) Perspective: Microarray technology, seeing more than spots. Endocrinology 143, 1983-1989. (Pubitemid 34521541)
7. Damodaran, T. V., Jones, K. H., Patel, A. G., and Abou-Donia, M. B. (2003) Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Biochem. Pharmacol. 65, 2041-2047. (Pubitemid 36637081)
8. Damodaran, T. V., Greenfield, S. T., Patel, A. G., Dressman, H. K., Lin, S. K., and Abou-Donia, M. B. (2006) Toxicogenomic studies of the rat brain at an early time point following acute sarin exposure. Neurochem. Res. 31, 367-381. (Pubitemid 43829326)
9. Damodaran, T. V., Patel, A. G., Greenfield, S. T., Dressman, H. K., Lin, S. M., and Abou-Donia, M. B. (2006) Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. Biochem. Pharmacol. 71, 497-520. (Pubitemid 43077084)
10. Pachiappan, A., Thwin, M. M., Manikandan, J., and Gopalakrishnakone, P. (2005) Glial inflammation and neurodegeneration induced by candoxin, a novel neurotoxin from Bungarus candidus venom: Global gene expression analysis using microarray. Toxicon 46, 883-899. (Pubitemid 41735139)
11. Jamsa, A., Hasslund, K., Cowburn, R. F., Backstrom, A., and Vasange, M. (2004) The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. Biochem. Biophys. Res. Commun. 319, 993-1000. (Pubitemid 38739418)
12. Bobashev, G., Das, S., and Das, A. (2002) In Methods of Microarray Data Analysis II (Lin, S. M., and Johnson, K. F., Eds.) Kluwer Academic Publishers, Boston, MA.
13. Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25, 402-408. (Pubitemid 34164012)
14. Yuryev, A., Mulyukov, Z., Kotelnikova, E., Maslov, S., Egorov, S., Nikitin, A., Daraselia, N., and Mazo, I. (2006) Automatic pathway building in biological association networks. BMC Bioinf. 7, 171-183.
15. Richards, P., Johnson, M., Ray, D., and Walker, C. (1999) Novel protein targets for organophosphorus compounds. Chem.-Biol. Interact. 119-120, 503-511. (Pubitemid 29278589)
16. Huang, Y. (2006) Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies. Curr. Opin. Drug Discovery Dev. 9, 627-641. (Pubitemid 44378831)
17. Christenson, J. G., Dairman, W., and Udenfriend, S. (1972) On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine- norepinephrine). Proc. Natl. Acad. Sci. U.S.A. 69, 343-347.
18. Redmond, L., Oh, S. R., Hicks, C., Weinmaster, G., and Ghosh, A. (2000) Nuclear Notch1 signaling and the regulation of dendritic development. Nat. Neurosci. 3, 30-40. (Pubitemid 30126345)
19. Raux, G., Gantier, R., Thomas-Anterion, C., Boulliat, J., Verpillat, P., Hannequin, D., Brice, A., Frebourg, T., and Campion, D. (2000) Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation. Neurology 55, 1577-1578.
20. Pastorcic, M., and Das, H. K. (2000) Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene. J. Biol. Chem. 275, 34938-34945. (Pubitemid 30832504)
21. Sumarsono, S. H., Wilson, T. J., Tymms, M. J., Venter, D. J., Corrick, C. M., Kola, R., Lahoud, M. H., Papas, T. S., Seth, A., and Kola, I. (1996) Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice. Nature 379, 534-537. (Pubitemid 26049578)
22. Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., and Busciglio, J. (2005) Ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. J. Neurosci. 25, 2295-2303. (Pubitemid 40322270)
23. McDonough, J. H., Jr., and Shih, T. M. (1997) Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci. Biobehav. Rev. 21, 559-579. (Pubitemid 27458800)