Identification of succinate exporter in Corynebacterium glutamicum and its physiological roles under anaerobic conditions

Journal of Biotechnology

Volumn 154, Issue 1, 2011, Pages 25-34

  Fukui, Keita ^a   Koseki, Chie ^a   Yamamoto, Yoko ^a   Nakamura, Jun ^a   Sasahara, Ayako ^b   Yuji, Reiko ^a   Hashiguchi, Kenichi ^a   Usuda, Yoshihiro ^a   Matsui, Kazuhiko ^a   Kojima, Hiroyuki ^a   Abe, Keietsu ^b  

^a AJINOMOTO CO INC   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

AAE family; Anaerobic condition; Corynebacterium glutamicum; Microaerobic condition; Succinate exporter; Succinate production

Indexed keywords

AAE FAMILY; ANAEROBIC CONDITIONS; CORYNEBACTERIUM GLUTAMICUM; MICROAEROBIC CONDITIONS; SUCCINATE EXPORTER; SUCCINATE PRODUCTION;

AMINO ACIDS; BIOLOGICAL MEMBRANES; GENE EXPRESSION; GLUCOSE; LIPOSOMES; PHOSPHOLIPIDS; PRODUCTIVITY;

STRAIN RATE;

ANTIPORTER; FRUCTOSE 1,6 BISPHOSPHATE; PROTEIN SUCE1; SUCCINIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; CORYNEBACTERIUM GLUTAMICUM; FERMENTATION; GENE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE OVEREXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SUCE 1 GENE;

AEROBIOSIS; ANAEROBIOSIS; BACTERIAL PROTEINS; BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; BIOREACTORS; CORYNEBACTERIUM GLUTAMICUM; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRACELLULAR SPACE; METABOLOME; PHYLOGENY; PROTEOLIPIDS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; SUCCINIC ACID;

CORYNEBACTERIUM GLUTAMICUM;

EID: 79957451359     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.03.010     Document Type: Article

References (53)

1. Abe K., Ohnishi F., Yagi K., Nakajima T., Higuchi T., Sano M., Machida M., Sarker R.I., Maloney P.C. Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction. J. Bacteriol. 2002, 184:2906-2913.
2. Abe K., Hayashi H., Maloney P.C. Exchange of aspartate and alanine. Mechanism for development of a proton-motive force in bacteria. J. Biol. Chem. 1996, 271:3079-3084.
3. Ambudkar S., Maloney P.C. Bacterial anion exchange. Use of osmolytes during solubilization and reconstitution of phosphate-linked antiport from Streptcoccus lactis. J. Biol. Chem. 1986, 261:10079-10086.
4. Anantharaman V., Koonin E.V., Aravind L. Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. J. Mol. Biol. 2001, 307:1271-1292.
5. Asai Y., Inui M., Vertès A., Kobayashi M., Yukawa H. Cloning and sequence determination of the aspartase-encoding gene from Brevibacterium flavum MJ233. Gene 1995, 158:87-90.
6. Barabote R.D., Tamang D.G., Abeywardena S.N., Fallah N.S., Fu J.Y., Lio J.K., Mirhosseini P., Pezeshk R., Podell S., Salampessy M.L., Thever M.D., Saier M.H. Extra domains in secondary transport carriers and channel proteins. Biochim. Biophys. Acta 2006, 1758:1557-1579.
7. Bröer S., Krämer R. Lysine secretion by Corynebacterium glutamicum. 1. Identification of a specific secretion carrier system. Eur. J. Biochem. 1991, 202:131-135.
8. 2 emission. J. Biosci. Bioeng. 2007, 103:262-269.
9. Clark D.P. The fermentation pathways of Escherichia coli. EEMS. Microbiol. Lett. 1989, 63:223-234.
10. Dominguez H., Rollin C., Guyonvarch A., Guerquin-Kern J., Cocaign-Bousquet M., Lindley N.D. Carbon-flux distribution in the central metabolic pathways of Corynebacterium glutamicum during growth of fructose. Eur. J. Biochem. 1998, 254:96-102.
11. Donnelly, M.I., Millard, C.S., Stols, L., June 1998. Mutant E. coli strain with increased succinic acid production. U.S. Patent 5,770,435.
12. Engel P., Krämer R., Unden G. Anaerobic fumarate transport in Escherichia coli by an FNR-dependent dicarboxylate uptake system which is different from the aerobic dicarboxylate uptake system. J. Bacteriol. 1992, 174:5533-5539.
13. Engel P., Krämer R., Unden G. Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux. Eur. J. Biochem. 1994, 222:605-614.
14. Engels V., Linder S., Wendisch V.F. The global repressor SugR controls expression of genes of glycolysis and of the l-lactate dehydrogenase LdhAA in Corynebacterium glutamicum. J. Bacteriol. 2008, 190:8033-8044.
15. Flieger M., Kantorova M., Prell A., Rezanka T., Votruba J. Biodegradable plastics from renewable sources. Folia Microbiol. 2003, 48:27-44.
16. Guettler, M.V., Jain, M.K., 1996. Method for making succinic acid, Anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants. U.S. Patent 5,521,075.
17. Guettler M.V., Rumler D., Jain M.K. Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen. Int. J. Syst. Evol. Microbiol. 1999, 49:207-216.
18. Gutmann M., Hoischen C., Krämer R. Carrier-mediated glutamate secretion by Corynebacterium glutamicum under biotin limitation. Biochim. Biophys. Acta 1992, 1112:115-123.
19. +-coupled dicarboxylate carrier protein from Staphylococcus aureus. J. Bacteriol. 2005, 187:5189-5194.
20. Inui M., Murakami S., Okino S., Kawaguchi H., Vertès A.A., Yukawa H. Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J. Mol. Microbiol. Biotechnol. 2004, 7:182-196.
21. 4-dicarboxylic acids by Escherichia coli. Eur. J. Biochem. 1971, 18:274-281.
22. Kinoshita S., Udaka S., Shimono M. Studies on the amino acid fermentation. Part1. Production of l-glutamic acid by various microorganisms. J. Gen. Appl. Microbiol. 1957, 3:193-205.
23. Kurusu Y., Kainuma M., Inui M., Satoh Y., Yukawa H. Electroporation-transformation system for coryneform bacteria by auxotrophic complementation. Agric. Biol. Chem. 1990, 54:443-447.
24. Lee P.C., Lee S.Y., Hong S.H., Chang H.N. Isolation and characterization of a new succinic acid-producing bacterium, Mannheimia succiniciproducens MBEL55E, from bovine rumen. Appl. Microbiol. Biotechnol. 2002, 58:663-668.
25. Lee P.C., Lee W.G., Kwon S., Lee S.Y., Chang H.N. Batch and continuous cultivation of Anaerobiospirillum succiniciproducens for the production of succinic acid from whey. Appl. Microbiol. Biotechnol. 2000, 54:23-27.
26. Miller J.H. Experiments in Molecular Genetics 1972, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
27. Miwa K., Matsui K., Terabe M., Ito K., Ishida M., Takagi H., Nakamori S., Sano K. Construction of novel shuttle vectors and a cosmid vector for the glutamic acid-producing bacteria Brevibacterium lactofermentum and Corynebacterium glutamicum. Gene 1985, 39:281-286.
28. Nakamura J., Hirano S., Ito H., Wach M. Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce l-glutamic acid production. Appl. Environ. Microbiol. 2007, 73:4491-4498.
29. Nanatani K., Maloney P.C., Abe K. Structural and functional importance of transmembrane domain 3 (TM3) in the aspartate:alanine antiporter AspT: topology and function of the residue of TM3 and oligomerization of AspT. J. Bacteriol. 2009, 191:2122-2132.
30. Nghiem, N.P., Donnelly, M.I., Millard, C.S., Stols, L., 1999. Method for the production of dicarboxylic acids. U.S. Patent 5,869,301.
31. Nishimura T., Vertès A.A., Shinoda Y., Inui M., Yukawa H. Anaerobic growth of Corynebacterium glutamicum using nitrate as a terminal electron acceptor. Appl. Microbiol. Biotechnol. 2007, 75:889-897.
32. Okino S., Inui M., Yukawa H. Production of organic acids by Corynebacterium glutamicum under oxygen deprivation. Appl. Microbiol. Biotechnol. 2005, 68:475-480.
33. Omumasaba C.A., Okai N., Inui M., Yukawa H. Corynebacterium glutamicum glyceraldehyde-3-phosphate dehydrogenase isoforms with opposite, ATP-dependent regulation. J. Mol. Microbiol. Biotechnol. 2004, 8:91-103.
34. Sambrook J., Russell D.W. Molecular Cloning: A Laboratory Manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. third ed.
35. Sánchez A.M., Bennett G.N., San K.Y. Efficient succinic acid production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant. Biotechnol. Prog. 2005, 21:358-365.
36. + in bacterial transport. Mol. Microbiol. 1993, 9:533-543.
37. Shiratsuchi M., Kuronuma H., Kawahara Y., Yoshihara Y., Miwa H., Nakamori S. Simultaneous and high fermentative production of l-lysine and l-glutamic acid using a strain of Brevibacterium lactofermentum. Biosci. Biotechnol. Biochem. 1995, 59:83-86.
38. 4-dicarboxylate membrane transporters (DcuA and DcuB) distinct from the aerobic dicarboxylate transport system (Dct). J. Bacteriol. 1994, 176:6470-6478.
39. Takeno S., Ohnishi J., Komatsu T., Masaki T., Sen K., Ikeda M. Anaerobic growth and potential for amino acid production by nitrate respiration in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 2007, 75:1173-1182.
40. Teramoto H., Shirai T., Inui M., Yukawa H. Identification of a gene encoding a transporter essential for utilization of C4 dicarboxylates in Corynebacterium glutamicum. Appl. Environ. Microbiol. 2008, 74:5290-5296.
41. Trötschel C., Deutenberg D., Bathe B., Burkovski A., Krämer R. Characterization of methionine export in Corynebacterium glutamicum. J. Bacteriol. 2005, 187:3786-3794.
42. Udaka S. Screening method for microorganisms accumulating metabolites and its use in the isolation of Micrococcus glutamicus. J. Bacteriol. 1960, 79:754-755.
43. Unden G., Bongaerts J. Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors. Biochim. Biophys. Acta 1997, 1320:217-234.
44. Vemuri G.N., Eiteman M.A., Altman E. Effect of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli. Appl. Environ. Microbiol. 2002, 68:1715-1727.
45. Vemuri G.N., Eiteman M.A., Altman E. Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions. J. Ind. Microbiol. Biotechnol. 2002, 28:325-332.
46. Vrljic M., Sahm H., Eggeling L. A new type of translocator with a new type of cellular function: l-lysine export from Corynebacterium glutamicum. Mol. Microbiol. 1996, 22:815-826.
47. Youn J.W., Jolkver E., Kramer R., Marin K., Wendisch V.F. Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. J. Bacteriol. 2008, 190:6458-6466.
48. Youn J.W., Jolkver E., Kramer R., Marin K., Wendisch V.F. Characterization of the dicarboxylate transporter DctA in Corynebacterium glutamicum. J. Bacteriol. 2009, 191:5480-5488.
49. Zeikus J.G., Jain M.K., Elankovan P. Biotechnology of succinic acid production and markets for derived industrial products. Appl. Microbiol. Biotechnol. 1999, 51:542-552.
50. Zientz E., Janausch I.G., Six S., Unden G. Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli. J. Bacteriol. 1999, 181:3716-3720.
51. 4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange. J. Bacteriol. 1996, 178:7241-7247.
52. Zittrich S., Krämer R. Quantitative discrimination of carrier-mediated excretion of isoleucine from uptake and diffusion in Corynebacterium glutamicum. J. Bacteriol. 1994, 176:6892-6899.
53. Zwicker N., Theobald U., Zahner H., Fiedler H.P. Optimization of fermentation conditions for the production of ethylene-diamine-disuccinic acid by Amycolatopsis orientalis. J. Ind. Microbiol. Biotechnol. 1997, 19:280-285.