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Volumn 20, Issue 12, 2011, Pages 2344-2355

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; HUNTINGTIN; MUTANT PROTEIN; NERVE CELL ADHESION MOLECULE;

EID: 79957440957     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr127     Document Type: Article
Times cited : (30)

References (59)
  • 2
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group. (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 72, 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 4
    • 67349247037 scopus 로고    scopus 로고
    • Mitochondrial structural and functional dynamics in Huntington's disease
    • Reddy, P.H., Mao, P. and Manczak, M. (2009) Mitochondrial structural and functional dynamics in Huntington's disease. Brain Res. Rev., 61, 33-48.
    • (2009) Brain Res. Rev. , vol.61 , pp. 33-48
    • Reddy, P.H.1    Mao, P.2    Manczak, M.3
  • 5
    • 33947360340 scopus 로고    scopus 로고
    • Hypothesis: huntingtin may function in membrane association and vesicular trafficking
    • Truant, R., Atwal, R. and Burtnik, A. (2006) Hypothesis: huntingtin may function in membrane association and vesicular trafficking. Biochem. Cell Biol., 84, 912-917.
    • (2006) Biochem. Cell Biol. , vol.84 , pp. 912-917
    • Truant, R.1    Atwal, R.2    Burtnik, A.3
  • 6
    • 44049091740 scopus 로고    scopus 로고
    • Using participant observation in pediatric health care settings: ethical challenges and solutions
    • Carnevale, F.A., Macdonald, M.E., Bluebond-Langner, M. and McKeever, P. (2008) Using participant observation in pediatric health care settings: ethical challenges and solutions. J. Child Health Care, 12, 18-32.
    • (2008) J. Child Health Care , vol.12 , pp. 18-32
    • Carnevale, F.A.1    Macdonald, M.E.2    Bluebond-Langner, M.3    McKeever, P.4
  • 9
    • 34548399406 scopus 로고    scopus 로고
    • Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism
    • Lee, J.M., Ivanova, E.V., Seong, I.S., Cashorali, T., Kohane, I., Gusella, J.F. and MacDonald, M.E. (2007) Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism. PLoS Genet., 3., e135.
    • (2007) PLoS Genet. , vol.3
    • Lee, J.M.1    Ivanova, E.V.2    Seong, I.S.3    Cashorali, T.4    Kohane, I.5    Gusella, J.F.6    MacDonald, M.E.7
  • 12
    • 33845727992 scopus 로고    scopus 로고
    • The cadherin superfamily in neuronal connections and interactions
    • Takeichi, M. (2007) The cadherin superfamily in neuronal connections and interactions. Nat. Rev. Neurosci., 8, 11-20.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 11-20
    • Takeichi, M.1
  • 13
    • 0028581961 scopus 로고
    • ATP depletion: a novel method to study junctional properties in epithelial tissues. II. Internalization of Na+,K(+)-ATPase and E-cadherin
    • Mandel, L.J., Doctor, R.B. and Bacallao, R. (1994) ATP depletion: a novel method to study junctional properties in epithelial tissues. II. Internalization of Na+,K(+)-ATPase and E-cadherin. J. Cell Sci., 107, 3315-3324.
    • (1994) J. Cell Sci. , vol.107 , pp. 3315-3324
    • Mandel, L.J.1    Doctor, R.B.2    Bacallao, R.3
  • 14
    • 0034116268 scopus 로고    scopus 로고
    • Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia
    • Bush, K.T., Tsukamoto, T. and Nigam, S.K. (2000) Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Am. J. Physiol. Renal Physiol., 278, F847-852.
    • (2000) Am. J. Physiol. Renal Physiol. , vol.278
    • Bush, K.T.1    Tsukamoto, T.2    Nigam, S.K.3
  • 16
  • 17
    • 0023838733 scopus 로고
    • Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family
    • Hatta, K., Nose, A., Nagafuchi, A. and Takeichi, M. (1988) Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family. J. Cell Biol., 106, 873-881.
    • (1988) J. Cell Biol. , vol.106 , pp. 873-881
    • Hatta, K.1    Nose, A.2    Nagafuchi, A.3    Takeichi, M.4
  • 18
    • 0025325167 scopus 로고
    • Cadherins: a molecular family important in selective cell-cell adhesion
    • Takeichi, M. (1990) Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem., 59, 237-252.
    • (1990) Annu. Rev. Biochem. , vol.59 , pp. 237-252
    • Takeichi, M.1
  • 19
    • 0028578064 scopus 로고
    • Assembly of the cadherin-catenin complex in vitro with recombinant proteins
    • Aberle, H., Butz, S., Stappert, J., Weissig, H., Kemler, R. and Hoschuetzky, H. (1994) Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J. Cell Sci., 107, 3655-3663.
    • (1994) J. Cell Sci. , vol.107 , pp. 3655-3663
    • Aberle, H.1    Butz, S.2    Stappert, J.3    Weissig, H.4    Kemler, R.5    Hoschuetzky, H.6
  • 20
    • 0028979956 scopus 로고
    • Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin
    • Knudsen, K.A., Soler, A.P., Johnson, K.R. and Wheelock, M.J. (1995) Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. J. Cell Biol., 130, 67-77.
    • (1995) J. Cell Biol. , vol.130 , pp. 67-77
    • Knudsen, K.A.1    Soler, A.P.2    Johnson, K.R.3    Wheelock, M.J.4
  • 21
    • 0035956921 scopus 로고    scopus 로고
    • Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
    • Baki, L., Marambaud, P., Efthimiopoulos, S., Georgakopoulos, A., Wen, P., Cui, W., Shioi, J., Koo, E., Ozawa, M., Friedrich, V.L. Jr et al. (2001) Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex. Proc. Natl Acad. Sci. USA, 98, 2381-2386.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2381-2386
    • Baki, L.1    Marambaud, P.2    Efthimiopoulos, S.3    Georgakopoulos, A.4    Wen, P.5    Cui, W.6    Shioi, J.7    Koo, E.8    Ozawa, M.9    Friedrich Jr., V.L.10
  • 22
    • 0034614941 scopus 로고    scopus 로고
    • Regulation of cadherin adhesive activity
    • Gumbiner, B.M. (2000) Regulation of cadherin adhesive activity. J. Cell Biol., 148, 399-404.
    • (2000) J. Cell Biol. , vol.148 , pp. 399-404
    • Gumbiner, B.M.1
  • 24
    • 0042190049 scopus 로고    scopus 로고
    • Huntingtin is degraded to small fragments by calpain after ischemic injury
    • Kim, M., Roh, J.K., Yoon, B.W., Kang, L., Kim, Y.J., Aronin, N. and DiFiglia, M. (2003) Huntingtin is degraded to small fragments by calpain after ischemic injury. Exp. Neurol., 183, 109-115.
    • (2003) Exp. Neurol. , vol.183 , pp. 109-115
    • Kim, M.1    Roh, J.K.2    Yoon, B.W.3    Kang, L.4    Kim, Y.J.5    Aronin, N.6    DiFiglia, M.7
  • 26
    • 0020073581 scopus 로고
    • Teratocarcinoma cell adhesion: identification of a cell-surface protein involved in calcium-dependent cell aggregation
    • Yoshida, C. and Takeichi, M. (1982) Teratocarcinoma cell adhesion: identification of a cell-surface protein involved in calcium-dependent cell aggregation. Cell, 28, 217-224.
    • (1982) Cell , vol.28 , pp. 217-224
    • Yoshida, C.1    Takeichi, M.2
  • 27
    • 0025215306 scopus 로고
    • Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth
    • Bixby, J.L. and Zhang, R. (1990) Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J. Cell Biol., 110, 1253-1260.
    • (1990) J. Cell Biol. , vol.110 , pp. 1253-1260
    • Bixby, J.L.1    Zhang, R.2
  • 28
    • 16644371434 scopus 로고    scopus 로고
    • Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton
    • Goodwin, M. and Yap, A.S. (2004) Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J. Mol. Histol., 35, 839-844.
    • (2004) J. Mol. Histol. , vol.35 , pp. 839-844
    • Goodwin, M.1    Yap, A.S.2
  • 29
    • 22544450745 scopus 로고    scopus 로고
    • Cadherins: actin with the cytoskeleton to form synapses
    • Bamji, S.X. (2005) Cadherins: actin with the cytoskeleton to form synapses. Neuron, 47, 175-178.
    • (2005) Neuron , vol.47 , pp. 175-178
    • Bamji, S.X.1
  • 30
    • 33845414566 scopus 로고    scopus 로고
    • Antagonistic effects of cofilin, beryllium fluoride complex, and phalloidin on subdomain 2 and nucleotide-binding cleft in F-actin
    • Muhlrad, A., Ringel, I., Pavlov, D., Peyser, Y.M. and Reisler, E. (2006) Antagonistic effects of cofilin, beryllium fluoride complex, and phalloidin on subdomain 2 and nucleotide-binding cleft in F-actin. Biophys. J., 91, 4490-4499.
    • (2006) Biophys. J. , vol.91 , pp. 4490-4499
    • Muhlrad, A.1    Ringel, I.2    Pavlov, D.3    Peyser, Y.M.4    Reisler, E.5
  • 34
    • 5344229667 scopus 로고    scopus 로고
    • Temporally distinct demands for classic cadherins in synapse formation and maturation
    • Bozdagi, O., Valcin, M., Poskanzer, K., Tanaka, H. and Benson, D.L. (2004) Temporally distinct demands for classic cadherins in synapse formation and maturation. Mol. Cell Neurosci., 27, 509-521.
    • (2004) Mol. Cell Neurosci. , vol.27 , pp. 509-521
    • Bozdagi, O.1    Valcin, M.2    Poskanzer, K.3    Tanaka, H.4    Benson, D.L.5
  • 35
    • 33748938395 scopus 로고    scopus 로고
    • Synapse development: still looking for the forest, still lost in the trees
    • Garner, C.C., Waites, C.L. and Ziv, N.E. (2006) Synapse development: still looking for the forest, still lost in the trees. Cell Tissue Res., 326, 249-262.
    • (2006) Cell Tissue Res. , vol.326 , pp. 249-262
    • Garner, C.C.1    Waites, C.L.2    Ziv, N.E.3
  • 36
    • 32144455692 scopus 로고    scopus 로고
    • Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro
    • Clabough, E.B. and Zeitlin, S.O. (2006) Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro. Hum. Mol. Genet., 15, 607-623.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 607-623
    • Clabough, E.B.1    Zeitlin, S.O.2
  • 38
    • 0032806558 scopus 로고    scopus 로고
    • Small GTPases and regulation of cadherin dependent cell-cell adhesion
    • Braga, V.M. (1999) Small GTPases and regulation of cadherin dependent cell-cell adhesion. Mol. Pathol., 52, 197-202.
    • (1999) Mol. Pathol. , vol.52 , pp. 197-202
    • Braga, V.M.1
  • 39
    • 77954333340 scopus 로고    scopus 로고
    • Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases
    • Watanabe, T., Sato, K. and Kaibuchi, K. (2009) Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb. Perspect. Biol., 1, a003020.
    • (2009) Cold Spring Harb. Perspect. Biol. , vol.1
    • Watanabe, T.1    Sato, K.2    Kaibuchi, K.3
  • 41
    • 38849091396 scopus 로고    scopus 로고
    • Low plasma total cholesterol in patients with Huntington's disease and first-degree relatives
    • Markianos, M., Panas, M., Kalfakis, N. and Vassilopoulos, D. (2008) Low plasma total cholesterol in patients with Huntington's disease and first-degree relatives. Mol. Genet. Metab., 93, 341-346.
    • (2008) Mol. Genet. Metab. , vol.93 , pp. 341-346
    • Markianos, M.1    Panas, M.2    Kalfakis, N.3    Vassilopoulos, D.4
  • 43
    • 77953846289 scopus 로고    scopus 로고
    • pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking
    • Pardo, R., Molina-Calavita, M., Poizat, G., Keryer, G., Humbert, S. and Saudou, F. (2010) pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking. Mol. Brain, 3, 17.
    • (2010) Mol. Brain , vol.3 , pp. 17
    • Pardo, R.1    Molina-Calavita, M.2    Poizat, G.3    Keryer, G.4    Humbert, S.5    Saudou, F.6
  • 44
    • 32644434386 scopus 로고    scopus 로고
    • Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease
    • Pal, A., Severin, F., Lommer, B., Shevchenko, A. and Zerial, M. (2006) Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J. Cell Biol., 172, 605-618.
    • (2006) J. Cell Biol. , vol.172 , pp. 605-618
    • Pal, A.1    Severin, F.2    Lommer, B.3    Shevchenko, A.4    Zerial, M.5
  • 46
    • 33847302564 scopus 로고    scopus 로고
    • Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space
    • Strehlow, A.N., Li, J.Z. and Myers, R.M. (2007) Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space. Hum. Mol. Genet., 16, 391-409.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 391-409
    • Strehlow, A.N.1    Li, J.Z.2    Myers, R.M.3
  • 47
    • 33747860195 scopus 로고    scopus 로고
    • N-cadherin signaling in synapse formation and neuronal physiology
    • Bruses, J.L. (2006) N-cadherin signaling in synapse formation and neuronal physiology. Mol. Neurobiol., 33, 237-252.
    • (2006) Mol. Neurobiol. , vol.33 , pp. 237-252
    • Bruses, J.L.1
  • 48
    • 77953106906 scopus 로고    scopus 로고
    • N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth
    • Tan, Z.J., Peng, Y., Song, H.L., Zheng, J.J. and Yu, X. (2010) N-cadherin-dependent neuron-neuron interaction is required for the maintenance of activity-induced dendrite growth. Proc. Natl Acad. Sci. USA, 107, 9873-9878.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 9873-9878
    • Tan, Z.J.1    Peng, Y.2    Song, H.L.3    Zheng, J.J.4    Yu, X.5
  • 50
    • 76049118555 scopus 로고    scopus 로고
    • Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease
    • Molero, A.E., Gokhan, S., Gonzalez, S., Feig, J.L., Alexandre, L.C. and Mehler, M.F. (2009) Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease. Proc. Natl Acad. Sci. USA, 106, 21900-21905.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 21900-21905
    • Molero, A.E.1    Gokhan, S.2    Gonzalez, S.3    Feig, J.L.4    Alexandre, L.C.5    Mehler, M.F.6
  • 52
    • 34247402598 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease
    • Lynch, G., Kramar, E.A., Rex, C.S., Jia, Y., Chappas, D., Gall, C.M. and Simmons, D.A. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J. Neurosci., 27, 4424-4434.
    • (2007) J. Neurosci. , vol.27 , pp. 4424-4434
    • Lynch, G.1    Kramar, E.A.2    Rex, C.S.3    Jia, Y.4    Chappas, D.5    Gall, C.M.6    Simmons, D.A.7
  • 53
    • 63849151219 scopus 로고    scopus 로고
    • Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
    • Simmons, D.A., Rex, C.S., Palmer, L., Pandyarajan, V., Fedulov, V., Gall, C.M. and Lynch, G. (2009) Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc. Natl Acad. Sci. USA, 106, 4906-4911.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 4906-4911
    • Simmons, D.A.1    Rex, C.S.2    Palmer, L.3    Pandyarajan, V.4    Fedulov, V.5    Gall, C.M.6    Lynch, G.7
  • 56
    • 78649262050 scopus 로고    scopus 로고
    • The clinical and genetic features of Huntington disease
    • Sturrock, A. and Leavitt, B.R. (2010) The clinical and genetic features of Huntington disease. J. Geriatr. Psychiatry Neurol., 23, 243-259.
    • (2010) J. Geriatr. Psychiatry Neurol. , vol.23 , pp. 243-259
    • Sturrock, A.1    Leavitt, B.R.2
  • 58
    • 0032555154 scopus 로고    scopus 로고
    • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
    • Endres, M., Laufs, U., Huang, Z., Nakamura, T., Huang, P., Moskowitz, M.A. and Liao, J.K. (1998) Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA, 95, 8880-8885.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 8880-8885
    • Endres, M.1    Laufs, U.2    Huang, Z.3    Nakamura, T.4    Huang, P.5    Moskowitz, M.A.6    Liao, J.K.7
  • 59
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak, K.J. and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


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