Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome

In Vivo

Volumn 25, Issue 3, 2011, Pages 315-323

  Goff, Julie P ^a   Epperly, Michael W ^a   Dixon, Tracy ^a   Wang, Hong ^a   Franicola, Darcy ^a   Shields, Donna ^a   Wipf, Peter ^b   Li, Song ^b   Gao, Xiang ^b   Greenberger, Joel S ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

GS nitroxide; Hematopoietic syndrome; Radiation mitigation; Total body irradiation

Indexed keywords

JP 4 039; NITROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD DISEASE; BONE MARROW; COLONY FORMING CELL; COLONY FORMING UNIT GEMM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; ELECTROLYTE BLOOD LEVEL; FEMALE; HEMATOPOIETIC CELL; HEMATOPOIETIC SYNDROME; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; LYMPHOCYTE COUNT; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PERIPHERAL LYMPHOCYTE; RADIATION DOSE; SURVIVAL RATE; WHOLE BODY RADIATION;

EID: 79956369369     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Vriesendorp HM and van Bekkum DW: Susceptibility to total-body irradiation. In: Response to Total-Body Irradiation in Different Species. Broerse JJ, MacVittie T (eds.). Amsterdam: Martinus Nijhoff. 1984.
2. Epperly M, Brand R, Stottlemyer J, Dixon TM, Gao X, Li S, Huq S, Wipf P, Falo LD and Greenberger JS: Topical application of GS-nitroxide JP4-039 emulsion mitigation ionizing irradiation induced skin burns. American Society for Therapeutic Radiology and Oncology, Abstract, San Diego, CA, 2010c.
3. Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA and McBride WH: High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res 15(23):7238-7245, 2009.
4. Stone HB, Coleman CN, Moulder JE, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, MacVittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins MEC, Schiestl RH, Seed TM, Tomaszewski J, Travis EL, Wallner PE, Wolpert M and Zaharevitz D: Models for evaluating agents intended for the prophylaxis, mitigation, and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res 162: 711-718, 2004.
5. Vriesendorp HM, Chu H, Ochran TG, Besa PC and Champlin RE: Radiobiology of total body radiation. Bone Marrow Transplantation 14(Suppl): S4-S8, 1994.
6. Thomas ED: Observations on supralethal whole-body irradiation and marrow transplantation in man and dog. Ann NY Acad Sci 114: 393-402, 1964.
7. Haralambie E and Schmidt-Weinmar A: Infections after experimental cadaver bone marrow transplantation in beagle dogs. Transplantations with and without selective gastrointestinal decontamination. Infection 16: 36-41, 1988.
8. Vriesendorp HM, Heidt PJ and Zurcher C: Gastrointestinal decontamination of dogs treated with total body irradiation and bone marrow transplantation. Exp Hematol 9: 904-916, 1981. (Pubitemid 13175969)
9. Puzova H, Szabova K, Cerman SJ, Puza A, Kunstadt E and Zaduban M: The problem of autoinfection after total-body lethal irradiation of dogs with 60Co. Folia Biol 8: 298-308, 1962.
10. Hemplemann LH, Lisco H and Hoffman JD: The acute radiation syndrome: a study of nine cases and a review of the problem. Anna Intern Med 36: 279-510, 1952.
11. Thomas ED, Storb R and Buckner CD: Total-body irradiation in preparation for marrow engraftment. Transplant Proc 8: 591-593, 1976. (Pubitemid 8006528)
12. Travis EL, Peters LJ, McNeill J, Thames HD Jr. and Karolis C: Effect of dose-rate on total-body irradiation: lethality and pathologic findings. Radiother Onc 4: 341-351, 1985. (Pubitemid 16210084)
13. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S and Sharkis SJ: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105: 369-377, 2001. (Pubitemid 32455343)
14. Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C and Kolesnick R: Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293: 293-297, 2001. (Pubitemid 32694744)
15. Qiu W, Carson-Walter EB, Liu H, Epperly M, Greenberger JS, Zambetti GP, Zhang L and Yu J: PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell 2: 576-583, 2008. (Pubitemid 351729214)
16. Epperly M, Jin SQ, Nie S, Cao S, Zhang X, Franicola D, Fink M and Greenberger JS: Ethyl pyruvate, a potentially effective total body irradiation damage mitigator. Radiat Res 168: 552-559, 2007. (Pubitemid 351295118)
17. Rajagopalan MS, Gupta K, Epperly MW, Franicola D, Zhang X, Wang H, Zhao H, Tyurin VA, Pierce JG, Kagan VE, Kanai AJ and Greenberger JS: The mitochondrial targeted JP4-039 augments potentially lethal irradiation damage. In Vivo 23: 717-726, 2009.
18. Weisdorf D, Chao N, Waselenko JK, Dainiak N, Armitage JO, McNiece I and Confer D: Acute radiation injury: contingency planning for triage, supportive care, and transplantation. Biol Blood Marrow Transplant 12: 672-682, 2006.
19. Chao N: Hematopoietic stem cell transplantation. Curr Opin Hem 11: 373-374, 2004.
20. Epperly MW, Franicola D, Shields D, Rwigema J-C, Stone B, Zhang X, McBride W, Georges G, Wipf P and Greenberger JS: Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. In Vivo 24: 9-20, 2010a.