Na+-Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory

Journal of Neuroscience

Volumn 31, Issue 20, 2011, Pages 7312-7321

  Molinaro, Pasquale ^a   Viggiano, Davide ^a   Nisticò, Robert ^b,c   Sirabella, Rossana ^d   Secondo, Agnese ^a,f   Boscia, Francesca ^d   Pannaccione, Anna ^a,f   Scorziello, Antonella ^a,f   Mehdawy, Bisan ^b,h   Sokolow, Sophie ^e,g   Herchuelz, André ^e   di Renzo, Gianfranco F ^a,f   Annunziato, Lucio ^a,d,f  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF CALABRIA   (Italy)

^d IRCCS SDN   (Italy)

^e UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^f National Institute of Neuroscience   (Italy)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; SODIUM CALCIUM EXCHANGE PROTEIN; SLC8A3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; CONDITIONING; CONTROLLED STUDY; GENE; GENE DELETION; HIPPOCAMPAL CA1 REGION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NCX3 GENE; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION; TASK PERFORMANCE; ANIMAL; BEHAVIOR; C57BL MOUSE; CELL CULTURE; COMPARATIVE STUDY; GENE SILENCING; GENETICS; HIPPOCAMPUS; MEMORY; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; GENE SILENCING; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SODIUM-CALCIUM EXCHANGER; SPATIAL BEHAVIOR; SYNAPTIC TRANSMISSION;

EID: 79956327464     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6296-10.2011     Document Type: Article

References (37)

1. 2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol Rev 56:633-654.
2. Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81:905-915.
3. Bangasser DA, Waxler DE, Santollo J, Shors TJ (2006) Trace conditioning and the hippocampus: the importance of contiguity. J Neurosci 26:8702-8706.
4. Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93:74-104.
5. Barnes CA (1988) Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat. Trends Neurosci 11:163-169.
6. 2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. J Cereb Blood Flow Metab 26:502-517.
7. Burke RE, Cadet JL, Kent JD, Karanas AL, Jackson-Lewis V (1990) An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats. J Neurosci Methods 35:63-73.
8. Capowski JJ (1989) Computer techniques in neuroanatomy. New York: Plenum.
9. Carlucci A, Adornetto A, Scorziello A, Viggiano D, Foca M, Cuomo O, Annunziato L, Gottesman M, Feliciello A (2008) Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. EMBO J 27:1073-1084.
10. D'Adamo P, Welzl H, Papadimitriou S, Raffaele di Barletta M, Tiveron C, Tatangelo L, Pozzi L, Chapman PF, Knevett SG, Ramsay MF, Valtorta F, Leoni C, Menegon A, Wolfer DP, Lipp HP, Toniolo D (2002) Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Hum Mol Genet 11:2567-2580.
11. Dere E, Huston JP, De Souza Silva MA (2007) The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci Biobehav Rev 31:673-704.
12. Desmedt A, Marighetto A, Garcia R, Jaffard R (2003) The effects of ibotenic hippocampal lesions on discriminative fear conditioning to context in mice: impairment or facilitation depending on the associative value of a phasic explicit cue. Eur J Neurosci 17:1953-1963.
13. Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res 31:47-59.
14. Fontán-Lozano A, Romero-Granados R, del-Pozo-Martín Y, Suárez-Pereira I, Delgado-García JM, Penninger JM, Carrión AM (2009) Lack of DREAM protein enhances learning and memory and slows brain aging. Curr Biol 19:54-60.
15. 2+ homeostasis and viability in cerebellar neurons. J Neurosci 25:10822-10830.
16. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
17. Huerta PT, Sun LD, Wilson MA, Tonegawa S (2000) Formation of temporal memory requires NMD Areceptors within CA1 pyramidal neurons. Neuron 25:473-480.
18. 2+ exchanger 2. Neuron 38:965-976.
19. Kassed CA, Herkenham M (2004) NF-kappa B p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety. Behav Brain Res 154:577-584.
20. Kazlauckas V, Schuh J, Dall'Igna OP, Pereira GS, Bonan CD, Lara DR (2005) Behavioral and cognitive profile of mice with high and low exploratory phenotypes. Behav Brain Res 162:272-278.
21. 2+ levels affect plasticity differently: the LTP zone, the LTD zone and no man's land. J Physiol 532:285.
22. Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17:5196-5205.
23. McEchron MD, Bouwmeester H, Tseng W, Weiss C, Disterhoft JF (1998) Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat. Hippocampus 8:638-646.
24. 2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J Neurosci 28:1179-1184.
25. 2+ exchanger transcripts and proteins in rat brain regions. J Comp Neurol 461:31-48.
26. Pignataro G, Gala R, Cuomo O, Tortiglione A, Giaccio L, Castaldo P, Sirabella R, Matrone C, Canitano A, Amoroso S, Di Renzo G, Annunziato L (2004) Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35:2566-2570.
27. 2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat. Am J Physiol 272:C1250-C1261.
28. 2+ exchanger in presynaptic boutons of hippocampal cells in culture. Neuron 15:1077-1084.
29. Secondo A, Staiano RI, Scorziello A, Sirabella R, Boscia F, Adornetto A, Valsecchi V, Molinaro P, Canzoniero LM, Di Renzo G, Annunziato L (2007) BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCX1 and NCX2: possible relationship with mitochondrial membrane potential. Cell Calcium 42:521-535.
30. Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J, Basile AS, Alzheimer C, Wess J (2004) M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci 24:10117-10127.
31. Silva AJ, Stevens CF, Tonegawa S, Wang Y (1992a) Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science 257:201-206.
32. Silva AJ, Paylor R, Wehner JM, Tonegawa S (1992b) Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257:206-211.
33. Skeberdis VA, Chevaleyre V, Lau CG, Goldberg JH, Pettit DL, Suadicani SO, Lin Y, Bennett MV, Yuste R, Castillo PE, Zukin RS (2006) Protein kinase A regulates calcium permeability of NMDA receptors. Nat Neurosci 9:501-510.
34. Sokolow S, Manto M, Gailly P, Molgó J, Vandebrouck C, Vanderwinden JM, Herchuelz A, Schurmans S (2004) Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. J Clin Invest 113:265-273.
35. Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, et al. (2006) Molecular anatomy of a trafficking organelle. Cell 127:831-846.
36. Wu LJ, Mellström B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M (2010) DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. Mol Brain 3:3.
37. Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu Rev Physiol 64:355-405.