Expression of the H-subunit and L-subunit of ferritin in bone marrow macrophages and cells of the erythron during cellular immune activation

Blood Cells, Molecules, and Diseases

Volumn 47, Issue 1, 2011, Pages 50-55

  Koorts, A M ^a   Levay, P F ^b   Hall, A N ^c   van der Merwe, C F ^c   Becker, P J ^a,d   Viljoen, M ^a  

^a University of Pretoria   (South Africa)

^b UNIVERSITY OF PRETORIA   (South Africa)

^c UNIVERSITY OF PRETORIA   (South Africa)

^d SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

Cellular immune activation; Ferritin; H subunit; Iron; Isoferritins; L subunit

Indexed keywords

FERRITIN; FERRITIN H; FERRITIN L; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; NEOPTERIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CELL; BONE MARROW CELL; CELLULAR IMMUNE ACTIVATION; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHRON CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOLOCALIZATION; IMMUNOREGULATION; MACROPHAGE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TH1 CELL; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

APOFERRITINS; BONE MARROW; CYTOKINES; ERYTHROID PRECURSOR CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, CELLULAR; MACROPHAGES; NEOPTERIN; UP-REGULATION;

EID: 79956323849     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.04.006     Document Type: Article

References (44)

1. Chasteen N.D. Ferritin. Uptake, storage, and release of iron. Met. Ions Biol. Syst. 1998, 35:479-514.
2. Arosio P., Levi S., Santambrogio P., Cozzi A., Luzzago A., Cesareni G., Albertini A. Structural and functional studies of human ferritin H and L chains. Curr. Stud. Hematol. Blood Transfus. 1991, 58:127-131.
3. Chiancone E., Stefanini S. Heterogeneity of ferritin. I. Structural and functional aspects. Ferritins and Isoferritins as Biochemical Markers 1984, 23-32. Elsevier Science Publishers, Amsterdam. A. Albertini, P. Arosio, E. Chiancone, J. Drysdale (Eds.).
4. Meyron-Holtz E.G., Fibach E., Gelvan D., Konijn A.M. Binding and uptake of exogenous isoferritins by cultured human erythroid precursor cells. Br. J. Haematol. 1994, 86:635-641.
5. Broxmeyer H.E., Gentile P., Listowsky I., Cavanna F., Feickert H.J., Dorner M.H., Ruggeri G., Cazzola M., Cooper S. Acidic isoferritins in the regulation of hematopoiesis in vitro and in vivo. Ferritins and Isoferritins as Biochemical Markers 1984, 97-111. Elsevier Science Publishers, Amsterdam. A. Albertini, P. Arosio, E. Chiancone, J. Drysdale (Eds.).
6. Torti S.V., Torti F.M. Iron and ferritin in inflammation and cancer. Adv. Inorg. Biochem. 1994, 10:119-137.
7. Rogers J., Lacroix L., Durmowitz G., Kasschau K., Andriotakis J., Bridges K.R. The role of cytokines in the regulation of ferritin expression. Adv. Exp. Med. Biol. 1994, 356:127-132.
8. Tsuji Y., Ayaki H., Whitman S.P., Morrow C.S., Torti S.V., Torti F.M. Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress. Mol. Cell. Biol. 2000, 20(16):5818-5827.
9. Kakhlon O., Gruenbaum Y., Cabantchik Z.I. Repression of ferritin expression increase the labile iron pool, oxidative stress, and short-term growth of human erythroleukemia cells. Blood 2001, 97(9):2853-2871.
10. Bevilacqua M.A., Costanzo F., Buonaguro L., Cimino F. Ferritin H and L mRNAs in human neoplastic tissues. Ital. J. Biochem. 1988, 37(1):1-7.
11. Connor J.R., Snyder B.S., Arosio P., Loeffler D.A., LeWitt P. A quantitative analysis of isoferritins in select regions of aged, Parkinsonian, and Alzheimer's diseased brains. J. Neurochem. 1995, 65:717-724.
12. Higgy N.A., Salicioni A.M., Russo I.H., Zhang P.L., Russo J. Differential expression of human ferritin H chain gene in immortal human breast epithelial MCF-10F cells. Mol. Carcinogenesis 1997, 20(4):332-339.
13. Jones B.M., Worwood M., Jacobs A. Serum ferritin in patients with cancer: determination with antibodies to HeLa cell and spleen ferritin. Clin. Chim. Acta 1980, 106:203-214.
14. Lin F., Girotti A.W. Elevated ferritin production, iron containment, and oxidant resistance in hemin-treated leukaemia cells. Arch. Biochem. Biophys. 1997, 346(1):131-141.
15. Miller L.L., Miller S.C., Torti S.V., Tsuji Y., Torti F.M. Iron-independent induction of ferritin H chain by tumor necrosis factor. Proc. Natl. Acad. Sci. USA 1991, 88(11):4946-4950.
16. Tripathi P.K., Chatterjee S.K. Elevated expression of ferritin H-chain mRNA in metastatic ovarian tumor. Cancer Invest. 1996, 14(6):518-526.
17. Vernet M., Renversez J.C., Lasne Y., Revenant M.C., Charlier-de-Bressing C., Guillemin C., Pressac M., Rymer J.C. Comparison of six serum ferritin immunoassays and isoferritin spectrotypes in malignancies. Ann. Biol. Clin. 1995, 53:419-427.
18. Whittaker D., Torrance J.D., Kew M.C. Isolation of ferritin from human hepatocellular carcinoma. Scand. J. Haematol. 1984, 33(5):432-439.
19. Theil E.C. The ferritin family of iron storage proteins. Adv. Enzymol. Relat. Areas Mol. Biol. 1990, 63:421-449.
20. A.M. Koorts, P.F. Levay, P.J. Becker, M. Viljoen, Pro- and anti-inflammatory cytokines during immune stimulation: modulation of iron status and red blood cell profile, Mediat. Inflamm. (2011) doi:10.1155/2011/716301.
21. Alvarez-Hernández X., Licéaga J., McKay I.C., Brock J.H. Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor. Lab. Invest. 1989, 61(3):319-322.
22. Miyazaki E., Kato J., Kobune M., Okumura K., Sasaki K., Shintani N., Arosio P., Niitsu Y. Denatured H-ferritin subunit is a major constituent of haemosiderin in the liver of patients with iron overload. Gut 2002, 50(3):413-419.
23. Ruggeri G., Santambrogio P., Bonfiglio F., Levi S., Bugari G., Verardi R., Cazzola M., Invernizzi R. Antibodies for denatured human H-ferritin stain only reticuloendothelial cells within the bone marrow. Br. J. Haematol. 1992, 81:118-124.
24. Invernezzi R., Cazzola M., De Fazio P., Rosti V., Ruggeri G., Arosio P. Immunocytochemical detection of ferritin in human bone marrow and peripheral blood cells using monoclonal antibodies specific for the H and L subunit. Br. J. Haematol. 1990, 76(30):427-432.
25. Murr C., Widner B., Wirleitner B., Fuchs D. Neopterin as a marker for immune system activation. Curr. Drug Metabol. 2002, 3:175-187.
26. Mosser D.M. The many faces of macrophage activation. J. Leukoc. Biol. 2003, 73:209-212.
27. Ohmori Y., Hamilton T.A. Regulation of macrophage gene expression by T-cell derived lymphokines. Pharmacol. Therapy 1994, 63:235-264.
28. Montavani A., Sica A., Locati M. New vistas on macrophage differentiation and activation. Eur. J. Immunol. 2007, 37:14-16.
29. Duffield J.S. The inflammatory macrophage: a story of Jekyll and Hyde. Clin. Sci. 2003, 104:27-38.
30. Keshav S., Chung L.-P., Gordon S. Macrophage products in inflammation. Diagn. Microbiol. Infect. Dis. 1990, 13:439-447.
31. Kryworuchko M., Thèze J. Interleukin-2: from T cell growth and homeostasis to immune reconstitution of HIV patients. Vitam. Horm. 2006, 74:531-547.
32. Nunnari G., Nigro L., Palermo D., Leto D., Pomerantz R.J., Cacopardo B. Reduction of serum melatonin levels in HIV-1-infected individuals' parallel disease progression: correlation with serum interleukin-12 levels. Infection 2003, 31(6):379-382.
33. Bazzoni F., Tamassia N., Rossato M., Cassatella M.A. Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: lessons from neutrophils. Eur. J. Immunol. 2010, 40(9):2360-2368.
34. Weiss G., Goodnough L.T. Anemia of chronic disease. New Engl. J. Med. 2005, 352(10):1011-1023.
35. Ludwiczek S., Aigner E., Theurl I., Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 2003, 101(10):4148-4154.
36. Torti F.M., Torti S.V. Regulation of ferritin genes and protein. Blood 2002, 99(10):3505-3516.
37. Koorts A.M., Viljoen M. Ferritin and ferritin isoforms I: structure-function relationships, synthesis, degradation and secretion. Arch. Physiol. Biochem. 2007, 113(1):30-54.
38. Alvarez-Hernández X., Felstein M.V., Brock J.H. The relationship between iron release, ferritin synthesis and intracellular iron distribution in mouse peritoneal macrophages. Evidence for a reduced level of metabolically available iron in elicited macrophages. Biochim. Biophys. Acta 1986, 886:214-222.
39. Savarino A., Pescarmona G.P., Boelaert J.R. Iron metabolism and HIV infection: reciprocal interactions with potentially harmful consequences. Cell Biochem. Funct. 1999, 17:279-287.
40. Rogers J.T., Bridges K.R., Durmowicz G.P., Glass J., Auron P.E., Munro H.N. Translational control during the acute phase response; ferritin synthesis in response to interleukin-1. J. Biol. Chem. 1990, 265(24):14572-14578.
41. Rogers J.T. Ferritin translation by interleukin-1 and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood 1996, 87(6):2525-2537.
42. Pang J.-H.S., Jiang M.-J., Chen Y.-L., Wang F.-W., Wang D.L., Chu S.-H., Chau L.Y. Increased ferritin gene expression in atherosclerotic lesions. J. Clin. Invest. 1996, 97(10):2204-2212.
43. Stites S.W., Plautz M.W., Bailey K., O'Brien-Ladner A.R., Wesselius L.J. Increased concentrations of iron and isoferritins in the lower respiratory tract of patients with stable cystic fibrosis. Am. J. Resp. Crit. Care Med. 1999, 160(3):796-801.
44. Picard V., Renaudie F., Porcher C., Hentze M.W., Grandchamp B., Beaumont C. Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution. Blood 1996, 87(5):2057-2064.