Physiological and biochemical effects of 17β estradiol in aging female rat brain

Experimental Gerontology

Volumn 46, Issue 7, 2011, Pages 597-605

  Kumar, Pardeep ^a   Taha, Asia ^a   Kale, R K ^a   Cowsik, S M ^a   Baquer, Najma Zaheer ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Brain aging; Endocrine; Estrogen; Glucose transporter; Membrane fluidity; Neurodegenerative diseases

Indexed keywords

4 HYDROXYNONENAL; AMINE OXIDASE (FLAVIN CONTAINING); ESTRADIOL; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; LIPOFUSCIN; MESSENGER RNA;

AGING; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; BRAIN REGION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; MEMBRANE FLUIDITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

AGING; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; BRAIN; ESTRADIOL; ESTROGENS; FEMALE; GLUCOSE TRANSPORTER TYPE 4; IMMUNOHISTOCHEMISTRY; INSULIN; LIPID PEROXIDATION; LIPOFUSCIN; MEMBRANE FLUIDITY; MEMBRANE LIPIDS; MONOAMINE OXIDASE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RNA, MESSENGER;

RATTUS;

EID: 79956302996     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.02.008     Document Type: Article

References (68)

1. Alonso A., Moreno M., Ordoñez P., Fernández R., Pérez C., Fernando D., Navarro A., Tolivia J., Gonzalez C. Chronic estradiol treatment improves brain homeostasis during aging in female rats. Endocrinology 2008, 149:57-72.
2. Apelt J., Mehlhorn G., Schliebs R. Insulin-sensitive GLUT4 glucose transporters are colocalized with GLUT3-expressing cells and demonstrate a chemically distinct neurone-specific localization in rat brain. J. Neurosci. Res. 1999, 57:693-705.
3. Bala K., Tripathy B.C., Sharma D. Neuroprotective and anti-ageing effect of curcumin in aged rat brain regions. Biogerontology 2006, 7:81-89.
4. Baquer N.Z., Taha A., Kumar P., McLean P., Cowsik S.M., Kale R.K., Singh R., Sharma D. A metabolic and functional overview of brain aging linked to neurological disorders. Biogerontology 2009, 10:377-413.
5. Behl C. Estrogen as a neuroprotective hormone. Nat. Rev. Neurosci. 2002, 3:433-442.
6. Benedetti M.D., Maraganore D.M., Bower J.H., McDonnell S.K., Peterson B.J., Ahlskog J.E., Schaid D.J., Rocca W.A. Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case-control study. Mov. Disord. 2001, 16:830-837.
7. Biessels G.J., van der Heide L.P., Kamal A., Bleys R.L., Gispen W.H. Ageing and diabetes: implications for brain function. Eur. J. Pharmacol. 2002, 441:1-14.
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
9. Brann D.W., Krishnan D., Chandramohan W., Virendra B.M., Mohammad M.K. Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Steroids 2007, 72:381-405.
10. Butterfield D.A., Gnjec A., Poon H.F., Castegna A., Pierce W.M., Klein J.B., Martins R.N. Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: an initial assessment. J. Alzheimers Dis. 2006, 10:391-397.
11. Calabrese V., Cornelius C., Mancuso C., Pennisi G., Calafato S., Bellia F., Bates T.E., Giuffrida Stella A.M., Schapira T., Dinkova Kostova A.T., Rizzarelli E. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem. Res. 2008, 33:2444-2471.
12. Catravas G.N., Takenaga J., McHale C.G. Effect of chronic administration of morphine on monoamine oxidase activity in discrete regions of the brain of rats. Biochem. Pharmacol. 1977, 26:211-214.
13. Chautan M., Dell'Amico M., Bourdeaux M., Leonardi J., Charbonnier M., Lafont H. Lipid diet and enterocytes microsomal membrane fluidity in rats. Chem. Phys. Lipids 1990, 54:25-32.
14. Choi J.H., Yu B.P. Brain synaptosomal aging: free radicals and membrane fluidity. Free Radic. Biol. Med. 1995, 18:133-139.
15. Compton J., Therese van A., Declan M. HRT and its effect on normal ageing of the brain and dementia. J. Clin. Pharmacol. 2003, 52:647-653.
16. Craig M.C., Murphy D.G. Estrogen: effects on normal brain function and neuropsychiatric disorders. Climacteric 2007, 10:97-104.
17. El Messari S., Leloup C., Quignon M., Brisorgueil M.J., Pénicaud L., Arluison M. Immunocytochemical localization of the insulin-responsive glucose transporter 4 (Glut 4) in the rat central nervous system. J. Comp. Neurol. 1998, 399:492-512.
18. El Messari S., Aït-Ikhlef A., Ambroise D.H., Penicaud L., Arluison M. Expression of insulin-responsive glucose transporter GLUT4 mRNA in the rat brain and spinal cord: an in situ hybridization study J. Chem. Neuroanat. 2002, 24:225-242.
19. Escrivá F., Gavete M.L., Fermín Y., Pérez C., Gallardo N., Alvarez C., Andrés A., Ros M., Carrascosa J.M. Effect of age and moderate food restriction on insulin sensitivity in Wistar rats: role of adiposity. J. Endocrinol. 2007, 194:131-141.
20. Esterbauer H., Schaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic. Biol. Med. 1991, 11:81-128.
21. Fukaya T., Gondaira T., Kashiyae Y., Kotani S., Ishikura Y., Fujikawa S., Kiso Y., Sakakibara M. Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats. Neurobiol. Aging 2007, 28:1179-1186.
22. Garcia-Segura L.M., Azcoitia I., DonCarlos L.L. Neuroprotection by estradiol. Prog. Neurobiol. 2001, 63:29-60.
23. Genet S., Kale R.K., Baquer N.Z. Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (TSP foenum-graecum). Mol. Cell. Biochem. 2002, 236:7-12.
24. Gomez C.R., Plackett T.P., Kovacs E.J. Aging and estrogen: modulation of inflammatory responses after injury. Exp. Gerontol. 2007, 42:451-456.
25. Gutteridge J.M.C., Cutler R.G., Packer L., Bertram J., Mori A. Oxidative Stress and Aging 1995, 287-302. Birkhauser Verlag, Basel, Switzerland.
26. Harman D. Free radical theory of aging. Mutat. Res. 1992, 275:257-266.
27. Hauptmann N., Grimsby J., Shih J.C., Cadenas E. The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA. Arch. Biochem. Biophys. 1996, 335:295-304.
28. Henderson V.W. Action of estrogens in the aging brain: dementia and cognitive aging. Biochim. Biophys. Acta 2010, 1800:1077-1083.
29. Holschneider D.P., Kumazawa T., Chen K., Shih J.C. Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. Life Sci. 1998, 63:155-160.
30. Ibberson M., Uldry M., Thorens B. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J. Biol. Chem. 2000, 275:4607-4612.
31. Jung T., Bader N., Grune T. Lipofuscin: formation, distribution, and metabolic consequences. Ann. NY Acad. Sci. 2007, 1119:97-111.
32. Karjalainen A., Paassilta M., Heikkinen J., Bäckström A.C., Savolainen M., Kesäniemi Y.A. Effects of peroral and transdermal oestrogen replacement therapy on glucose and insulin metabolism. Clin. Endocrinol. 2001, 54:165-173.
33. Kaur J., Sharma D., Singh R. Acetyl-l-carnitine enhances Na (+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions. Neurosci. Lett. 2001, 23:1-4.
34. Kaur J., Singh S., Sharma D., Singh R. Neurostimulatory and antioxidative effects of l-deprenyl in aged rat brain regions. Biogerontology 2003, 4:105-111.
35. Kumagai S., Holmäng A., Björntorp P. The effects of oestrogen and progesterone on insulin sensitivity in female rats. Acta Physiol. Scand. 1993, 149:91-97.
36. Kumar P., Taha A., Sharma D., Kale R.K., Baquer N.Z. Effect of dehydroepiandrosterone (DHEA) on monoamine oxidase activity, lipid peroxidation and lipofuscin accumulation in aging rat brain regions. Biogerontology 2008, 9,235-9,246. Erratum: 9,283-284.
37. Leloup C., Arluison M., Kassis N., Lepetit N., Cartier N., Ferre P., Penicaud L. Discrete brain areas express the insulin-responsive glucose transporter GLUT4. Mol. Brain Res. 1996, 38:45-53.
38. Leutner S., Eckert A., Müller W.E. ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain. J. Neural Transm. 2001, 108:955-967.
39. Mantha A.K., Moorthy K., Cowsik S.M., Baquer N.Z. Membrane associated functions of neurokinin B (NKB) on amyloid-beta (25-35) induced toxicity in aging rat brain synaptosomes. Biogerontology 2006, 7:19-33.
40. Mayanil C.S., Kazmi S.M., Baquer N.Z. Changes in monoamine oxidase activity in rat brain during alloxan diabetes. J. Neurochem. 1982, 38:179-183.
41. Meyers B., D'Agostino A., Walker J., Kritzer M.F. Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats. Neuroscience 2010, 165:850-862.
42. Min J.N., Whaley R.A., Sharpless N.E., Lockyer P., Portbury A.L., Patterson C. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Mol. Cell. Biol. 2008, 28:4018-4025.
43. Moorthy K., Yadav U.C.S., Siddiqui M.R., Basir S.F., Sharma D., Baquer N.Z. Effect of estradiol and progesterone treatment on carbohydrate metabolizing enzymes in tissues of aging female rats. Biogerontology 2004, 5:249-259.
44. Moorthy K., Yadav U.C.S., Mantha A.K., Cowsik S.M., Sharma D., Baquer N.Z. Effect of estradiol and progesterone treatment on lipid profile in naturally menopausal rats from different age groups. Biogerontology 2004, 5:1-9.
45. Moorthy K., Sharma D., Basir S.F., Baquer N.Z. Administration of estradiol and progesterone modulate the activities of antioxidant enzyme and aminotransferases in naturally menopausal rats. Exp. Gerontol. 2005, 40:295-302.
46. Moorthy K., Yadav U.C.S., Siddiqui M.R., Mantha A.K., Basir S.F., Sharma D., Cowsik S.M., Baquer N.Z. Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats. Biogerontology 2005, 6:345-356.
47. Moreno M., Ordoñez P., Alonso A., Díaz F., Tolivia J., González C. Chronic 17β-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging. Age Dordr 2010, 32:1-13.
48. Muller W.E., Kirsch C., Eckert G.P. Membrane-disordering effects of beta-amyloid peptides. Biochem. Soc. Trans. 2001, 29:617-623.
49. Naoi M., Maruyama W. Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders. Curr. Pharm. Des. 2010, 16:2799-2817.
50. Nicotra A., Federica Pierucci, Hasan Parvez, Ornella Senatori Monoamine oxidase expression during development and aging. Neurotoxicology 2004, 25:155-165.
51. Oreland L., Gottfries C.G. Brain and brain monoamine oxidase in aging and in dementia of Alzheimer's type. Prog. Neuropsychopharmacol. Biol. Psychiatry 1986, 10:533-540.
52. Poli G., Schaur R.J., Siems W.G., Leonarduzzi G. 4-Hydroxynonenal: a membrane lipid oxidation product of medicinal interest. Med. Res. Rev. 2008, 28:569-631.
53. Poon H.F., Vaishnav R.A., Getchell T.V., Getchell M.L., Butterfield D.A. Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice. Neurobiol. Aging 2006, 27:1010-1019.
54. Pozzi S., Benedusi V., Maggi A., Vegeto E. Estrogen action in neuroprotection and brain inflammation. Ann. NY Acad. Sci. 2006, 1089:302-323.
55. Raz L., Khan M.M., Mahesh V.B., Vadlamudi R.K., Brann D.W. Rapid estrogen signaling in the brain. Neurosignals 2008, 16:140-153.
56. Riga D., Riga S. Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats. Brain Res. 1974, 72:265-275.
57. Riga D., Riga S., Halalau F., Schneider F. Brain lipopigment accumulation in normal and pathological aging. Ann. NY Acad. Sci. 2006, 1067:158-163.
58. Royer C., Lachuer J., Crouzoulon G., Roux J., Peyronnet J., Mamet J., Pequignot J., Dalmaz Y. Effects of gestational hypoxia on mRNA levels of Glut3 and Glut4 transporters, hypoxia inducible factor-1 and thyroid hormone receptors in developing rat brain. Brain Res. 2000, 856:119-128.
59. Saravia F., Beauquis J., Pietraneraa L., De Nicola A.F. Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice. Psychoneuroendocrinology 2007, 32:480-492.
60. Saura J., Richards J.G., Mahy N. Differential age-related changes of MAO-A and MAO-B in mouse brain and peripheral organs. Neurobiol. Aging 1994, 15:399-408.
61. Sherwin B.B., Henry J.F. Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review. Front. Neuroendocrinol. 2008, 29:88-113.
62. Soto-Otero R., Méndez-Alvarez E., Hermida-Ameijeiras A., Sánchez-Sellero I., Cruz-Landeira A., Lamas M.L. Inhibition of brain monoamine oxidase activity by the generation of hydroxyl radicals: potential implications in relation to oxidative stress. Life Sci. 2001, 69:879-889.
63. Spencer J.L., Waters E.M., Romeo R.D., Wood G.E., Milner T.A., McEwen B.S. Uncovering the mechanisms of estrogen effects on hippocampal function. Front. Neuroendocrinol. 2008, 29:219-237.
64. Tappel A.L., Fletcher B., Deamer D. Effects of antioxidants and nutrients on lipid peroxidation fluorescent product and aging parameters in the mouse. J. Gerontol. 1973, 28:415-424.
65. Terman A., Brunk U.T. Oxidative stress, accumulation of biological 'garbage' and aging. Antioxid. Redox Signal. 2006, 8:197-204.
66. Thakur M.K., Sharma P.K. Binding of estrogen receptor alpha promoter to 569 nuclear proteins of mouse cerebral cortex: effect of age, sex, and gonadal 570 steroids. Biogerontology 2008, 9:467-478.
67. Towbin H., Gordon J. Immunoblotting and dot immunobinding current status and outlook. J. Immunol. Meth. 1984, 72:313-340.
68. Veiga S., Melcangi R.C., Doncarlos L.L., Garcia-Segura L.M., Azcoitia I. Sex hormones and brain aging. Exp. Gerontol. 2004, 39:1623-1631.