Neurostimulatory and antioxidative effects of L-deprenyl in aged rat brain regions

Biogerontology

Volumn 4, Issue 2, 2003, Pages 105-111

  Kaur, Jaspreet ^a,b   Singh, Sangeeta ^a,c   Sharma, Deepak ^a   Singh, Rameshwar ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b SETON HALL UNIVERSITY   (United States)

^c BAREILLY COLLEGE   (India)

Author keywords

Anti ageing effects; Antioxidant enzymes; K+ ATPase; L deprenyl; Lipid peroxidation; Lipofuscin; Multiple unit action potentials; Na+

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPOFUSCIN; SELEGILINE;

ACTION POTENTIAL; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN REGION; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; ENZYME ACTIVITY; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; NERVE CONDUCTION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS;

ACTION POTENTIALS; AGING; ANIMALS; ANTIOXIDANTS; BRAIN; ELECTROPHYSIOLOGY; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; LIPOFUSCIN; MALE; NA(+)-K(+)-EXCHANGING ATPASE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SELEGILINE;

EID: 0037648874     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023351904840     Document Type: Article

References (42)

1. Amenta F, Bongrani S, Cadel S, Ferrante F, Valsecchi B and Zeng YC (1994) Influence of treatment With L-deprenyl on the structure of the cerebellar cortex of aged rats. Mech Ageing Dev 75: 157-167
2. Amenta F, Mignini F, Ricci A, Sabbatini M Tomassoni D and Tayebati SK (2001) Age-related changes of dopamine receptors in the rat hippocampus: a light microscopic autoradiographic study. Mech Ageing Dev 122: 2071-2083
3. Apartis E, Poindessous-Jazat F, Epelbaum J and Bassant MH (2000) Age-related changes in rhythmically bursting activity in the middle septum of rats. Brain Res 876: 37-47
4. Bickford PC, Adams CE, Boyson SJ, Curella P, Gerhardt GA, Heron C, Ivy GO, Lin AMLY, Murphy MP, Poth K, Wallace DR, Young DA, Zahniser NR and Rose GM (1997) Long term treatment of male F344 rats with deprenyl: assessment of effects on longevity, behavior, and brain function. Neurobiol Aging 18: 309-318
5. Cardozo-Pelaez F, Brooks PJ, Stedeford T, Song S and Sanchez-Ramos J (2000) DNA damage, repair and antioxidant systems in brain regions: a correlative study. Free Radic Biol Med 28: 779-785
6. Carrillo MC, Kanai S, Nokubo M and Kitani K (1991) (-)Deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats. Life Sci 48: 517-521
7. Carrillo MC, Kanai S, Nokubo M, Ivy GO, Sato Y and Kitani K (1992a) (-)Deprenyl increases activities of superoxide dismutase and catalase in striatum but not in the hippocampus of rat. Exp Neurol 116: 284-294
8. Carrillo MC, Kitani K, Kanai S , Sato Y and Ivy GO (1992b) The ability of (-)-deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective. Life Sci 50: 1985-1992
9. Carrillo MC, Kitani K, Kanai S, Sato Y, Miyasaka K and Ivy GO (1994) The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats. Biochem Pharmacol 47: 1333-1338
10. De Haan JB, Newmann JD and Kola I ( 1992) Cu/Zn superoxide dismutase m RNA and enzyme activity, and susceptibility to lipid peroxidation, increases with ageing in murine brains. Mol Brain Res 13: 179-187
11. Dringen R and Hamprecht B (1997) Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydroperoxide by cultured astroglial cells. Brain Res 759: 67-75
12. Esterbauer H, Schaur RJ and Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic Biol Med 11: 81-128
13. Fletcher BL, Dillard CJ and Tappel AL (1973) Measurement of fluorescent peroxidation products in biological system and tissues. Anal Biochem 52: 1-9
14. Flohe L and Gunzler WA (1984) Assays of glutathione peroxidase. In: Methods of Enzymology, pp 114-121. Academic Press, New York
15. Gopal PV, Sriram AV, Sharma D and Singh R (2000) Glutathione-s-transferase in the ageing rat brain cerebrum and the effect of chlorpromazine. Gerontology 46: 7-11
16. Gupta M and Kulkarni SK (2000) Studies on anticonvulsant action of L-deprenyl. Indian J Exp Biol 38: 332-337
17. Habig WH, Pabst MJ and Jakoby WB (1974) Glutathione-s-transferases. J Biol Chem 249: 7130-7138
18. Huang C-C, Tsai J-J and Hsu K-S (1997) L-deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism. Brain Res 753: 27-35
19. Ingram DK, Wiener HL, Chachich ME, Long JM, Hengemihle J and Gupta M (1993) Chronic treatment of aged mice with L-deprenyl produces marked striatal MAO-B inhibition but no beneficial effects on survival, motor performance, or nigral lipofuscin accumulation. Neurobiol Aging 14: 431-440
20. Kaur J, Sharma D and Singh R (1998) Regional effects of ageing on Na+,K+-ATPase activity in rat brain and correlation with multiple unit action potentials and lipid peroxidation. Indian J Biochem Biophys 35: 364-371
21. Kaur J, Sharma D and Singh R (2001) Acetyl-L-carnitine enhances Na+,K+-ATPase, glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions. Neurosci Lett 301: 1-4
22. Kitani K, Kanai S, Ivy GO and Carrillo MC (1999) Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. Mech Ageing Dev 111: 211-221
23. Kontkanen O and Castren E (1999) Trophic effects of selegiline on cultured dopaminergic neurons. Brain Res 829: 190-192
24. Kotake Y, Tasaki Y, Hiroba M and Ohta S (1998) Deprenyl decreases an endogenous Parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice: in vivo and in vitro studies. Brain Res 787: 341-343
25. Mattson MP (1998) Modification of ion homeostasis by lipid peroxidation: role in neuronal degeneration and adaptive plasticity. Trends Neurosci 21: 53-57
26. Paxinos G and Watson C (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York
27. Pellmar T (1986) Eectrophysiological correlates of peroxide damage in guinea pig hippocampus in vitro. Brain Res 364: 377-381
28. Puurunen K, Jolkkonen J, Sirvio J, Haapalinna A and Sivenius J (2001) Selegiline combined with enriched environment housing attenuates spatial learning deficits following focal cerebral ischemia in rats. Exp Neurol 167: 348-355
29. Rehncrona S, Smith DS and Akesson B (1980) Peroxidative changes in brain cortical fatty acids and phospholipids, as characterized during Fe+ and ascorbic acid stimulated peroxidation in vitro. J Neurochem 34: 1630-1638
30. Roy D and Singh R (1988) Age-related changes in multiple unit activity of the rat brain parietal cortex and the effect of centrophenoxine. Exp Gerontol 23: 161-174
31. Roy D, Pathak DN and Singh R (1983) Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain. Exp Gerontol 18: 185-197
32. Roy D, Pathak DN and Singh R (1984) Effect of chlorpromazine on the activities of antioxidant enzymes and lipid peroxidation in the various regions of ageing rat brain. J Neurochem 42: 628-633
33. Sano M, Ernesto C, Thomas RG, Klauber MR, Schafer K, Grundman M, Woodbury P, Growdon J, Cotman CW, Pfeiffer E, Schneider LS and Thal LJ (1997) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. New Engl J Med 336: 1216-1222
34. Sharma D and Singh R (1996) Age-related decline in multiple unit action potentials of cerebral cortex correlates with the number of lipofuscin containing neurons. Indian J Exp Biol 34: 776-781
35. Sharma D, Maurya AK and Singh R (1993) Age-related decline in multiple unit action potentials of CA3 regions of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. Neurobiol Aging 14: 319-330
36. Singh R and Pathak DN (1990) Lipid peroxidation and glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase and glucose-6-phosphate dehydrogenase activities in FeCl3-induced epileptogenic foci in the rat brain. Epilepsia 31: 15-26
37. Tanaka Y and Ando S (1990) Synaptic aging as revealed by changes in membrane potential and decreased activity of Na+,K+-ATPase. Brain Res 506: 46-52
38. Tatton WG and Chalmers-Redman RME (1996) Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl related compounds in controlling neurodegeneration. Neurology 47 (Suppl 3): S171-S183
39. Thiffault C, Aumont N, Quirion R and Poirier J (1995) Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain. J Neurochem 65: 2725-2733
40. Wu R-M, Murphy DL and Chiueh CC (1996) Suppression of hydroxyl radical formation and protection of nigral neurons by L-deprenyl (selegiline). Annals N Y Acad Sci 786: 379-390
41. Viani P, Cerrato G, Fiorilli A and Cestaro B (1991) Age-related differences in synaptosomal peroxidative damage and membrane properties. J Neurochem 56: 253-258
42. Xie C, Lovel MA and Markesbury WR (1998) Glutathione transferase protects neuronal cultures against 4-hydroxynonenal toxicity. Free Radic Biol Med 25: 979-988