The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl- LIGRL-NH2and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 19076-19088

  Flynn, Andrea N ^a   Tillu, Dipti V ^a   Asiedu, Marina N ^a   Hoffman, Justin ^a   Vagner, Josef ^a   Price, Theodore J ^a   Boitano, Scott ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR RESPONSE; G PROTEIN COUPLED RECEPTORS; HIGH POTENCY; HYPERALGESIA; IN-VITRO; IN-VIVO; INTRACELLULAR CA; MAPK SIGNALING; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPLE CELL TYPES; NOCICEPTION; PEPTIDOMIMETICS; PHYSIOLOGICAL RESPONSE; PROTEOLYTIC CLEAVAGE; RANK ORDER; SIGNALING PATHWAYS; TETHERED LIGAND;

CALCIUM; ENZYME ACTIVITY; LIGANDS; PEPTIDES; PHYSIOLOGICAL MODELS; PHYSIOLOGY; RATING;

SIGNALING;

CALCIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; PENTAPEPTIDE; PEPTIDOMIMETIC AGENT; PROTEASE ACTIVATED RECEPTOR 2 AGONIST; PROTEINASE ACTIVATED RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRIGEMINUS GANGLION;

CALCIUM; CALCIUM SIGNALING; CELL LINE, TRANSFORMED; HUMANS; HYPERALGESIA; LIGANDS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PEPTIDOMIMETICS; RECEPTOR, PAR-2;

EID: 79956291844     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.185264     Document Type: Article

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