-
1
-
-
77954762633
-
Annotating non-coding regions of the genome
-
Alexander, R.P., Fang, G., Rozowsky, J., Snyder, M. & Gerstein, M.B. (2010) Annotating non-coding regions of the genome. Nat. Rev. Genet. 11, 559-571.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 559-571
-
-
Alexander, R.P.1
Fang, G.2
Rozowsky, J.3
Snyder, M.4
Gerstein, M.B.5
-
2
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S. & Wright, W.E. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
3
-
-
0016692602
-
Mutation selection and the natural history of cancer
-
Cairns, J. (1975) Mutation selection and the natural history of cancer. Nature 255, 197-200.
-
(1975)
Nature
, vol.255
, pp. 197-200
-
-
Cairns, J.1
-
4
-
-
2942538551
-
Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice
-
Canela, A., Martín-Caballero, J., Flores, J.M. & Blasco, M.A. (2004) Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice. Mol. Cell. Biol. 24, 4275-4293.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 4275-4293
-
-
Canela, A.1
Martín-Caballero, J.2
Flores, J.M.3
Blasco, M.A.4
-
5
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
D'adda di Fagagna, F., Reaper, P.M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N.P. & Jackson, S.P. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
D'adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
6
-
-
0033120871
-
Elimination of replication block protein Fob1 extends the life span of yeast mother cells
-
Defossez, P.A., Prusty, R., Kaeberlein, M., Lin, S.J., Ferrigno, P., Silver, P.A., Keil, R.L. & Guarente, L. (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 3, 447-455.
-
(1999)
Mol. Cell
, vol.3
, pp. 447-455
-
-
Defossez, P.A.1
Prusty, R.2
Kaeberlein, M.3
Lin, S.J.4
Ferrigno, P.5
Silver, P.A.6
Keil, R.L.7
Guarente, L.8
-
7
-
-
0028785586
-
The Bloom's syndrome gene product is homologous to RecQ helicases
-
Ellis, N.A., Groden, J., Ye, T.Z., Straughen, J., Lennon, D.J., Ciocci, S., Proytcheva, M. & German, J. (1995) The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83, 655-666.
-
(1995)
Cell
, vol.83
, pp. 655-666
-
-
Ellis, N.A.1
Groden, J.2
Ye, T.Z.3
Straughen, J.4
Lennon, D.J.5
Ciocci, S.6
Proytcheva, M.7
German, J.8
-
8
-
-
33646505742
-
Telomerase regulation and stem cell behaviour
-
Flores, I., Benetti, R. & Blasco, M.A. (2006) Telomerase regulation and stem cell behaviour. Curr. Opin. Cell Biol. 18, 254-260.
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 254-260
-
-
Flores, I.1
Benetti, R.2
Blasco, M.A.3
-
9
-
-
40349085766
-
The longest telomeres: a general signature of adult stem cell compartments
-
Flores, I., Canela, A., Vera, E., Tejera, A., Cotsarelis, G. & Blasco, M.A. (2008) The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 22, 654-667.
-
(2008)
Genes Dev.
, vol.22
, pp. 654-667
-
-
Flores, I.1
Canela, A.2
Vera, E.3
Tejera, A.4
Cotsarelis, G.5
Blasco, M.A.6
-
10
-
-
0037370054
-
In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes
-
French, S.L., Osheim, Y.N., Cioci, F., Nomura, M. & Beyer, A.L. (2003) In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes. Mol. Cell. Biol. 23, 1558-1568.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1558-1568
-
-
French, S.L.1
Osheim, Y.N.2
Cioci, F.3
Nomura, M.4
Beyer, A.L.5
-
11
-
-
23844492486
-
Identifying gene-independent noncoding functional elements in the yeast ribosomal DNA by phylogenetic footprinting
-
Ganley, A.R., Hayashi, K., Horiuchi, T. & Kobayashi, T. (2005) Identifying gene-independent noncoding functional elements in the yeast ribosomal DNA by phylogenetic footprinting. Proc. Natl Acad. Sci. USA 102, 11787-11792.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 11787-11792
-
-
Ganley, A.R.1
Hayashi, K.2
Horiuchi, T.3
Kobayashi, T.4
-
12
-
-
69749092718
-
The effect of replication initiation on gene amplification in the rDNA and its relationship to aging
-
Ganley, A.R.G., Ide, S., Saka, K. & Kobayashi, T. (2009) The effect of replication initiation on gene amplification in the rDNA and its relationship to aging. Mol. Cell 35, 683-693.
-
(2009)
Mol. Cell
, vol.35
, pp. 683-693
-
-
Ganley, A.R.G.1
Ide, S.2
Saka, K.3
Kobayashi, T.4
-
13
-
-
0036787840
-
Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
-
González-Suárez, E., Flores, J.M. & Blasco, M.A. (2002) Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol. Cell. Biol. 22, 7291-7301.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7291-7301
-
-
González-Suárez, E.1
Flores, J.M.2
Blasco, M.A.3
-
14
-
-
0024536650
-
A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
-
Gottlieb, S. & Esposito, R.E. (1989) A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56, 771-776.
-
(1989)
Cell
, vol.56
, pp. 771-776
-
-
Gottlieb, S.1
Esposito, R.E.2
-
15
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider, C.W. & Blackburn, E.H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413.
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
16
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley, C.B., Futcher, A.B. & Greider, C.W. (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
17
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
-
Herbig, U., Jobling, W.A., Chen, B.P., Chen, D.J. & Sedivy, J.M. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14, 501-513.
-
(2004)
Mol. Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.3
Chen, D.J.4
Sedivy, J.M.5
-
18
-
-
76249101086
-
Abundance of ribosomal RNA gene copies maintains genome integrity
-
Ide, S., Miyazaki, T., Maki, H. & Kobayashi, T. (2010) Abundance of ribosomal RNA gene copies maintains genome integrity. Science 327, 693-696.
-
(2010)
Science
, vol.327
, pp. 693-696
-
-
Ide, S.1
Miyazaki, T.2
Maki, H.3
Kobayashi, T.4
-
19
-
-
33846147338
-
Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast
-
Ide, S., Watanabe, K., Watanabe, H., Shirahige, K., Kobayashi, T. & Maki, H. (2007) Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast. Mol. Cell. Biol. 27, 568-578.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 568-578
-
-
Ide, S.1
Watanabe, K.2
Watanabe, H.3
Shirahige, K.4
Kobayashi, T.5
Maki, H.6
-
20
-
-
0026709385
-
Sister chromatid are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
-
Kadyk, L.C. & Hartwell, L.H. (1992) Sister chromatid are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 132, 387-402.
-
(1992)
Genetics
, vol.132
, pp. 387-402
-
-
Kadyk, L.C.1
Hartwell, L.H.2
-
21
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein, M., McVey, M. & Guarente, L. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580.
-
(1999)
Genes Dev.
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
22
-
-
0344629438
-
The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork
-
Kobayashi, T. (2003) The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork. Mol. Cell. Biol. 23, 9178-9188.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9178-9188
-
-
Kobayashi, T.1
-
23
-
-
33747156656
-
Strategies to maintain the stability of the ribosomal RNA gene repeats
-
Kobayashi, T. (2006) Strategies to maintain the stability of the ribosomal RNA gene repeats. Genes Genet. Syst. 81, 155-161.
-
(2006)
Genes Genet. Syst.
, vol.81
, pp. 155-161
-
-
Kobayashi, T.1
-
24
-
-
40349106009
-
A new role of the rDNA and nucleolus in the nucleus- rDNA instability maintains genome integrity
-
Kobayashi, T. (2008) A new role of the rDNA and nucleolus in the nucleus- rDNA instability maintains genome integrity. Bioessays 30, 267-272.
-
(2008)
Bioessays
, vol.30
, pp. 267-272
-
-
Kobayashi, T.1
-
25
-
-
79953707188
-
Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast
-
Kobayashi, T. (2011) Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast. Cell. Mol. Life Sci. 68, 1395-1403.
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, pp. 1395-1403
-
-
Kobayashi, T.1
-
26
-
-
0032535478
-
Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I
-
Kobayashi, T., Heck, D.J., Nomura, M. & Horiuchi, T. (1998) Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes Dev. 12, 3821-3830.
-
(1998)
Genes Dev.
, vol.12
, pp. 3821-3830
-
-
Kobayashi, T.1
Heck, D.J.2
Nomura, M.3
Horiuchi, T.4
-
27
-
-
0030133624
-
A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities
-
Kobayashi, T. & Horiuchi, T. (1996) A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities. Genes Cells 1, 465-474.
-
(1996)
Genes Cells
, vol.1
, pp. 465-474
-
-
Kobayashi, T.1
Horiuchi, T.2
-
28
-
-
2342666131
-
SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast
-
Kobayashi, T., Horiuchi, T., Tongaonkar, P., Vu, L. & Nomura, M. (2004) SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast. Cell 117, 441-453.
-
(2004)
Cell
, vol.117
, pp. 441-453
-
-
Kobayashi, T.1
Horiuchi, T.2
Tongaonkar, P.3
Vu, L.4
Nomura, M.5
-
29
-
-
34250728609
-
Immortal strands? Give me a break
-
Lansdorp, P.M. (2007) Immortal strands? Give me a break. Cell 129, 1244-1247.
-
(2007)
Cell
, vol.129
, pp. 1244-1247
-
-
Lansdorp, P.M.1
-
30
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S.J., Defossez, P.A. & Guarente, L. (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
31
-
-
22744445281
-
Overview of caloric restriction and ageing
-
Masoro, E.J. (2005) Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913-922.
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 913-922
-
-
Masoro, E.J.1
-
32
-
-
0141819143
-
An age-induced switch to a hyper-recombinational state
-
McMurray, M.A. & Gottschling, D.E. (2003) An age-induced switch to a hyper-recombinational state. Science 301, 1908-1911.
-
(2003)
Science
, vol.301
, pp. 1908-1911
-
-
McMurray, M.A.1
Gottschling, D.E.2
-
33
-
-
0032911048
-
Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae
-
Park, P.U., Defossez, P.A. & Guarente, L. (1999) Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 3848-3856.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3848-3856
-
-
Park, P.U.1
Defossez, P.A.2
Guarente, L.3
-
34
-
-
34250740943
-
The immortal strand hypothesis: segregation and reconstruction
-
Rando, T.A. (2007) The immortal strand hypothesis: segregation and reconstruction. Cell 129, 1239-1243.
-
(2007)
Cell
, vol.129
, pp. 1239-1243
-
-
Rando, T.A.1
-
35
-
-
0026054961
-
A role for regulation of human cellular senescence
-
Shay, J.W., Pereira-Smith, O.M. & Wright, W.E. (1991) A role for regulation of human cellular senescence. Exp. Cell Res. 196, 33-39.
-
(1991)
Exp. Cell Res.
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
36
-
-
0031459980
-
Extrachromosomal rDNA circles-a cause of aging in yeast
-
Sinclair, D.A. & Guarente, L. (1997) Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91, 1033-1042.
-
(1997)
Cell
, vol.91
, pp. 1033-1042
-
-
Sinclair, D.A.1
Guarente, L.2
-
37
-
-
41949089130
-
Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4
-
Steffen, K.K., MacKay, V.L., Kerr, E.O., Tsuchiya, M., Hu, D., Fox, L.A., Dang, N., Johnston, E.D., Oakes, J.A., Tchao, B.N., Pak, D.N., Fields, S., Kennedy, B.K. & Kaeberlein, M. (2008) Yeast life span extension by depletion of 60S ribosomal subunits is mediated by Gcn4. Cell 133, 292-302.
-
(2008)
Cell
, vol.133
, pp. 292-302
-
-
Steffen, K.K.1
MacKay, V.L.2
Kerr, E.O.3
Tsuchiya, M.4
Hu, D.5
Fox, L.A.6
Dang, N.7
Johnston, E.D.8
Oakes, J.A.9
Tchao, B.N.10
Pak, D.N.11
Fields, S.12
Kennedy, B.K.13
Kaeberlein, M.14
-
38
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai, H., Smogorzewska, A. & de Lange, T. (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
de Lange, T.3
-
39
-
-
0038046165
-
Transcription-dependent recombination and the role of fork collision in yeast rDNA
-
Takeuchi, Y., Horiuchi, T. & Kobayashi, T. (2003) Transcription-dependent recombination and the role of fork collision in yeast rDNA. Genes Dev. 17, 1497-1506.
-
(2003)
Genes Dev.
, vol.17
, pp. 1497-1506
-
-
Takeuchi, Y.1
Horiuchi, T.2
Kobayashi, T.3
-
40
-
-
55449122193
-
Telomerase reverse transcriptase delays aging in cancer-resistant mice
-
Tomas-Loba, A., Flores, I., Fernandez-Marcos, P.J., Cayuela, M.L., Maraver, A., Tejera, A., Borras, C., Matheu, A., Klatt, P., Flores, J.M., Vina, J., Serrano, M. & Blasco, M.A. (2008) Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135, 609-622.
-
(2008)
Cell
, vol.135
, pp. 609-622
-
-
Tomas-Loba, A.1
Flores, I.2
Fernandez-Marcos, P.J.3
Cayuela, M.L.4
Maraver, A.5
Tejera, A.6
Borras, C.7
Matheu, A.8
Klatt, P.9
Flores, J.M.10
Vina, J.11
Serrano, M.12
Blasco, M.A.13
-
41
-
-
0033229970
-
The economics of ribosome biosynthesis in yeast
-
Warner, J.R. (1999) The economics of ribosome biosynthesis in yeast. Trends Biochem. Sci. 24, 437-440.
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 437-440
-
-
Warner, J.R.1
-
42
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
Yu, C.E., Oshima, J., Fu, Y.H., Wijsman, E.M., Hisama, F., Alisch, R., Matthews, S., Nakura, J., Miki, T., Ouais, S., Martin, G.M., Mulligan, J., & Schellenberg, G.D. (1996) Positional cloning of the Werner's syndrome gene. Science 272, 258-262.
-
(1996)
Science
, vol.272
, pp. 258-262
-
-
Yu, C.E.1
Oshima, J.2
Fu, Y.H.3
Wijsman, E.M.4
Hisama, F.5
Alisch, R.6
Matthews, S.7
Nakura, J.8
Miki, T.9
Ouais, S.10
Martin, G.M.11
Mulligan, J.12
Schellenberg, G.D.13
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