Genetic determinants of severe respiratory syncytial virus infection and post-bronchiolitis wheeze: A systematic review

Current Respiratory Medicine Reviews

Volumn 7, Issue 3, 2011, Pages 149-159

  Schuurhof, Annemieke ^a,b   Kok, Marthe ^b,c   Kimpen, Jan L L ^b,c   Bont, Louis ^b   Janssen, Riny ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Genetic association; Haplotype; Post bronchiolitis wheeze; Respiratory syncytial virus; Single nucleotide polymorphism

Indexed keywords

ADAM PROTEIN; ADAM33 PROTEIN; ALPHA INTERFERON; CD14 ANTIGEN; CD28 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON ALPHA 13; INTERFERON ALPHA 5; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 8; INTERLEUKIN 9 RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 2; NCF2 PROTEIN; NITRIC OXIDE SYNTHASE 2A; PROTEIN; PROTEIN C JUN; STAT1 PROTEIN; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VITAMIN D RECEPTOR;

ADAPTIVE IMMUNITY; ALLERGIC ASTHMA; CHEMOTAXIS; CHILDHOOD DISEASE; DISEASE SEVERITY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INFECTION SENSITIVITY; INNATE IMMUNITY; LOWER RESPIRATORY TRACT INFECTION; POST BRONCHIOLITIS WHEEZE; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RESPIRATORY TRACT MUCOSA; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; VIRAL BRONCHIOLITIS; WHEEZING;

EID: 79956289727     PISSN: 1573398X     EISSN: 18756387     Source Type: Journal    
DOI: 10.2174/157339811795589450     Document Type: Review

References (65)

1. Henrickson KJ, Hoover S, Kehl KS, Hua W. National disease burden of respiratory viruses detected in children by polymerase chain reaction. Pediatr Infect Dis J 2004; 23: S11-S18.
2. Meissner HC. Selected populations at increased risk from respiratory syncytial virus infection. Pediatr Infect Dis J 2003; 22: S40-S44.
3. McNamara PS, Smyth RL. The pathogenesis of respiratory syncytial virus disease in childhood. Br Med Bull 2002; 61: 13-28.
4. Boyce TG, Mellen BG, Mitchel EF, Jr., Wright PF, Griffin MR. Rates of hospitalization for respiratory syncytial virus infection among children in medicaid. J Pediatr 2000; 137: 865-70.
5. Shay DK, Holman RC, Newman RD, et al. Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA 1999; 282: 1440-6.
6. Openshaw PJ, Tregoning JS. Immune responses and disease enhancement during respiratory syncytial virus infection. Clin Microbiol Rev 2005; 18: 541-55.
7. Bloemers BL, van Furth AM, Weijerman ME, et al. Down syndrome: a novel risk factor for respiratory syncytial virus bronchiolitis--a prospective birth-cohort study. Pediatrics 2007; 120: e1076-e1081.
8. Simoes EA, Carbonell-Estrany X. Impact of severe disease caused by respiratory syncytial virus in children living in developed countries. Pediatr Infect Dis J 2003; 22: S13-S18.
9. Thomsen SF, Stensballe LG, Skytthe A, et al. Increased concordance of severe respiratory syncytial virus infection in identical twins. Pediatrics 2008; 121: 493-6.
10. Bont L, Aalderen WM, Kimpen JL. Long-term consequences of respiratory syncytial virus (RSV) bronchiolitis. Paediatr Respir Rev 2000; 1: 221-7.
11. Ermers MJ, Rovers MM, Van Woensel JB, Kimpen JL, Bont LJ. The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial. BMJ 2009; 338: b897.
12. Henry RL, Hodges IG, Milner AD, Stokes GM. Respiratory problems 2 years after acute bronchiolitis in infancy. Arch Dis Child 1983; 58: 713-6.
13. Pullan CR, Hey EN. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J (Clin Res Ed) 1982; 284: 1665-9.
14. Bont L, Steijn M, Van Aalderen WM, Kimpen JL. Impact of wheezing after respiratory syncytial virus infection on healthrelated quality of life. Pediatr Infect Dis J 2004; 23: 414-7.
15. Stevens CA, Turner D, Kuehni CE, Couriel JM, Silverman M. The economic impact of preschool asthma and wheeze. Eur Respir J 2003; 21: 1000-6.
16. Thomsen SF, Sluis SV, Stensballe LG, et al. Exploring The association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am J Respir Crit Care Med 2009; 179: 1091-7.
17. Wu P, Dupont WD, Griffin MR, et al. Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am J Respir Crit Care Med 2008; 178: 1123-9.
18. Bont L, Van Aalderen WM, Versteegh J, et al. Airflow limitation during respiratory syncytial virus lower respiratory tract infection predicts recurrent wheezing. Pediatr Infect Dis J 2001; 20: 277-82.
19. Stensballe LG, Ravn H, Kristensen K, et al. Respiratory syncytial virus neutralizing antibodies in cord blood, respiratory syncytial virus hospitalization, and recurrent wheeze. J Allergy Clin Immunol 2009; 123: 398-403.
20. Collins PL, Graham BS. Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol 2008; 82: 2040-55.
21. Hall CB, Douglas RG, Jr., Geiman JM. Quantitative shedding patterns of respiratory syncytial virus in infants. J Infect Dis 1975; 132: 151-6.
22. Buckingham SC, Bush AJ, DeVincenzo JP. Nasal quantity of respiratory syncytical virus correlates with disease severity in hospitalized infants. Pediatr Infect Dis J 2000; 19: 113-7.
23. Wright PF, Gruber WC, Peters M, et al. Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J Infect Dis 2002; 185: 1011-8.
24. Graham BS, Henderson GS, Tang YW, et al. Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus. J Immunol 1993; 151: 2032-40.
25. Waris ME, Tsou C, Erdman DD, Zaki SR, Anderson LJ. Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. J Virol 1996; 70: 2852-60.
26. Janssen R, Bont L, Siezen CL, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 2007; 196: 826-34.
27. Forton JT, Rowlands K, Rockett K, et al. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 2009; 64: 345-52.
28. Hoebee B, Rietveld E, Bont L, et al. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J Infect Dis 2003; 187: 2-11.
29. Hoebee B, Bont L, Rietveld E, et al. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J Infect Dis 2004; 189: 239-47.
30. Puthothu B, Krueger M, Forster J, Heinzmann A. Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes. J Infect Dis 2006; 193: 438-41.
31. Inoue Y, Shimojo N, Suzuki Y, et al. CD14 -550 C/T, which is related to the serum level of soluble CD14, is associated with the development of respiratory syncytial virus bronchiolitis in the Japanese population. J Infect Dis 2007; 195: 1618-24.
32. Tal G, Mandelberg A, Dalal I, et al. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis 2004; 189: 2057-63.
33. Lahti M, Lofgren J, Marttila R, et al. Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res 2002; 51: 696-9.
34. Puthothu B, Krueger M, Forster J, et al. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Pediatr Infect Dis J 2007; 26: 1094-8.
35. Mailaparambil B, Krueger M, Heinze J, Forster J, Heinzmann A. Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. Dis Markers 2008; 25: 59-65.
36. Lu A, Wang L, Zhang X. Haplotype of IL-8 -251T and 781C is associated with the susceptibility to respiratory syncytial virus. J Trop Pediatr 2009.
37. Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax 2000; 55: 1023-7.
38. Amanatidou V, Sourvinos G, Apostolakis S, Tsilimigaki A, Spandidos DA. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J 2006; 25: 410-4.
39. Janssen R, Pennings J, Hodemaekers H, et al. Host transcription profiles upon primary respiratory syncytial virus infection. J Virol 2007; 81: 5958-67.
40. McNamara PS, Flanagan BF, Hart CA, Smyth RL. Production ofb chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis 2005; 191: 1225-32.
41. Siezen CL, Bont L, Hodemaekers HM, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pediatr Infect Dis J 2009; 28: 333-5.
42. Awomoyi AA, Rallabhandi P, Pollin TI, et al. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J Immunol 2007; 179: 3171-7.
43. Hoffjan S, Ostrovnaja I, Nicolae D, et al. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol 2004; 113: 511-8.
44. Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A. Haplotypes of surfactant protein C are associated with common paediatric lung diseases. Pediatr Allergy Immunol 2006; 17: 572-7.
45. Puthothu B, Forster J, Heinzmann A, Krueger M. TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease. Dis Markers 2006; 22: 303-8.
46. Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A. Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. Clin Mol Allergy 2006; 4: 2.
47. Puthothu B, Forster J, Heinze J, Heinzmann A, Krueger M. Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. BMC Pulm Med 2007; 7: 6.
48. Puthothu B, Bierbaum S, Kopp MV, et al. Association of TNFalpha with severe respiratory syncytial virus infection and bronchial asthma. Pediatr Allergy Immunol 2009; 20: 157-63.
49. Lofgren J, Ramet M, Renko M, Marttila R, Hallman M. Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J Infect Dis 2002; 185: 283-9.
50. El Saleeby CM, Li R, Somes GW, et al. Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population. J Pediatr 2010; 156: 409-14.
51. Thomas NJ, DiAngelo S, Hess JC, et al. Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatr Res 2009; 66: 70-3.
52. Choi EH, Lee HJ, Yoo T, Chanock SJ. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 2002; 186: 1207-11.
53. Amanatidou V, Sourvinos G, Apostolakis S, et al. RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis. Pediatr Infect Dis J 2008; 27: 38-42.
54. Hull J, Rowlands K, Lockhart E, et al. Haplotype mapping of the bronchiolitis susceptibility locus near IL8. Hum Genet 2004; 114: 272-9.
55. Hull J, Ackerman H, Isles K, et al. Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. Am J Hum Genet 2001; 69: 413-9.
56. Kerr MH, Paton JY. Surfactant protein levels in severe respiratory syncytial virus infection. Am J Respir Crit Care Med 1999; 159: 1115-8.
57. LeVine AM, Gwozdz J, Stark J, et al. Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. J Clin Invest 1999; 103: 1015-21.
58. Griese M. Respiratory syncytial virus and pulmonary surfactant. Viral Immunol 2002; 15: 357-63.
59. Dargaville PA, South M, McDougall PN. Surfactant abnormalities in infants with severe viral bronchiolitis. Arch Dis Child 1996; 75: 133-6.
60. Palmer LJ, Cardon LR. Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 2005; 366: 1223-34.
61. Ermers MJ, Hoebee B, Hodemaekers HM, et al. IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection. J Allergy Clin Immunol 2007; 119: 1086-91.
62. Tian M, Liu F, Wen GY, et al. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Eur J Pediatr 2009; 168: 963-7.
63. Goetghebuer T, Isles K, Moore C, et al. Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. Clin Exp Allergy 2004; 34: 801-3.
64. Kuehni CE, Spycher BD, Silverman M. Causal links between RSV infection and asthma: no clear answers to an old question. Am J Respir Crit Care Med 2009; 179: 1079-80.
65. Wu P, Dupont WD, Griffin MR, Hartert TV. A role for genes and environment in the causal relationship between infant RSV infection and childhood asthma. Am J Respir Crit Care Med 2010; 181: 194-5.