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Volumn 32, Issue 7, 2008, Pages 1101-1111

Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia

Author keywords

Acute myeloid leukemia; Hematopoiesis; p15Ink4b; p16Ink4a; RUNX1 ETO

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; HYBRID PROTEIN; PROTEIN ETO; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; PRIMER DNA; RUNX1 PROTEIN, MOUSE;

EID: 41949094721     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2007.10.012     Document Type: Article
Times cited : (4)

References (40)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 1 (2000) 57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0015694741 scopus 로고
    • Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia
    • Rowley J.D. Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia. Ann de Genetique 16 2 (1973) 109-112
    • (1973) Ann de Genetique , vol.16 , Issue.2 , pp. 109-112
    • Rowley, J.D.1
  • 3
    • 0029019659 scopus 로고
    • AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia
    • Nucifora G., and Rowley J.D. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86 1 (1995) 1-14
    • (1995) Blood , vol.86 , Issue.1 , pp. 1-14
    • Nucifora, G.1    Rowley, J.D.2
  • 4
    • 0032822953 scopus 로고    scopus 로고
    • The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance
    • Downing J.R. The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance. Br J Haematol 106 2 (1999) 296-308
    • (1999) Br J Haematol , vol.106 , Issue.2 , pp. 296-308
    • Downing, J.R.1
  • 5
    • 0026757174 scopus 로고
    • Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • Erickson P., Gao J., Chang K.S., Look T., Whisenant E., Raimondi S., et al. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80 7 (1992) 1825-1831
    • (1992) Blood , vol.80 , Issue.7 , pp. 1825-1831
    • Erickson, P.1    Gao, J.2    Chang, K.S.3    Look, T.4    Whisenant, E.5    Raimondi, S.6
  • 6
    • 0027180828 scopus 로고
    • An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation
    • Downing J.R., Head D.R., Curcio-Brint A.M., Hulshof M.G., Motroni T.A., Raimondi S.C., et al. An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood 81 11 (1993) 2860-2865
    • (1993) Blood , vol.81 , Issue.11 , pp. 2860-2865
    • Downing, J.R.1    Head, D.R.2    Curcio-Brint, A.M.3    Hulshof, M.G.4    Motroni, T.A.5    Raimondi, S.C.6
  • 7
    • 0027218725 scopus 로고
    • The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
    • Miyoshi H., Kozu T., Shimizu K., Enomoto K., Maseki N., Kaneko Y., et al. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO J 12 7 (1993) 2715-2721
    • (1993) EMBO J , vol.12 , Issue.7 , pp. 2715-2721
    • Miyoshi, H.1    Kozu, T.2    Shimizu, K.3    Enomoto, K.4    Maseki, N.5    Kaneko, Y.6
  • 8
    • 0031724804 scopus 로고    scopus 로고
    • ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
    • Lutterbach B., Westendorf J.J., Linggi B., Patten A., Moniwa M., Davie J.R., et al. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol 18 12 (1998) 7176-7184
    • (1998) Mol Cell Biol , vol.18 , Issue.12 , pp. 7176-7184
    • Lutterbach, B.1    Westendorf, J.J.2    Linggi, B.3    Patten, A.4    Moniwa, M.5    Davie, J.R.6
  • 9
    • 0031723957 scopus 로고    scopus 로고
    • Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
    • Gelmetti V., Zhang J., Fanelli M., Minucci S., Pelicci P.G., and Lazar M.A. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 18 12 (1998) 7185-7191
    • (1998) Mol Cell Biol , vol.18 , Issue.12 , pp. 7185-7191
    • Gelmetti, V.1    Zhang, J.2    Fanelli, M.3    Minucci, S.4    Pelicci, P.G.5    Lazar, M.A.6
  • 10
    • 0036463950 scopus 로고    scopus 로고
    • Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
    • Higuchi M., O'Brien D., Kumaravelu P., Lenny N., Yeoh E.J., and Downing J.R. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1 1 (2002) 63-74
    • (2002) Cancer Cell , vol.1 , Issue.1 , pp. 63-74
    • Higuchi, M.1    O'Brien, D.2    Kumaravelu, P.3    Lenny, N.4    Yeoh, E.J.5    Downing, J.R.6
  • 11
    • 0034665765 scopus 로고    scopus 로고
    • Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model
    • Rhoades K.L., Hetherington C.J., Harakawa N., Yergeau D.A., Zhou L., Liu L.Q., et al. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model. Blood 96 6 (2000) 2108-2115
    • (2000) Blood , vol.96 , Issue.6 , pp. 2108-2115
    • Rhoades, K.L.1    Hetherington, C.J.2    Harakawa, N.3    Yergeau, D.A.4    Zhou, L.5    Liu, L.Q.6
  • 12
    • 17944376561 scopus 로고    scopus 로고
    • AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
    • Yuan Y., Zhou L., Miyamoto T., Iwasaki H., Harakawa N., Hetherington C.J., et al. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Proc Natl Acad Sci USA 98 18 (2001) 10398-10403
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.18 , pp. 10398-10403
    • Yuan, Y.1    Zhou, L.2    Miyamoto, T.3    Iwasaki, H.4    Harakawa, N.5    Hetherington, C.J.6
  • 13
    • 0036317908 scopus 로고    scopus 로고
    • Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation
    • de Guzman C.G., Warren A.J., Zhang Z., Gartland L., Erickson P., Drabkin H., et al. Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol Cell Biol 22 15 (2002) 5506-5517
    • (2002) Mol Cell Biol , vol.22 , Issue.15 , pp. 5506-5517
    • de Guzman, C.G.1    Warren, A.J.2    Zhang, Z.3    Gartland, L.4    Erickson, P.5    Drabkin, H.6
  • 14
    • 0037020837 scopus 로고    scopus 로고
    • AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency
    • Schwieger M., Lohler J., Friel J., Scheller M., Horak I., and Stocking C. AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med 196 9 (2002) 1227-1240
    • (2002) J Exp Med , vol.196 , Issue.9 , pp. 1227-1240
    • Schwieger, M.1    Lohler, J.2    Friel, J.3    Scheller, M.4    Horak, I.5    Stocking, C.6
  • 15
    • 0031972701 scopus 로고    scopus 로고
    • The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation
    • Westendorf J.J., Yamamoto C.M., Lenny N., Downing J.R., Selsted M.E., and Hiebert S.W. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation. Mol Cell Biol 18 1 (1998) 322-333
    • (1998) Mol Cell Biol , vol.18 , Issue.1 , pp. 322-333
    • Westendorf, J.J.1    Yamamoto, C.M.2    Lenny, N.3    Downing, J.R.4    Selsted, M.E.5    Hiebert, S.W.6
  • 16
    • 0035047652 scopus 로고    scopus 로고
    • AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia
    • Pabst T., Mueller B.U., Harakawa N., Schoch C., Haferlach T., Behre G., et al. AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med 7 4 (2001) 444-451
    • (2001) Nat Med , vol.7 , Issue.4 , pp. 444-451
    • Pabst, T.1    Mueller, B.U.2    Harakawa, N.3    Schoch, C.4    Haferlach, T.5    Behre, G.6
  • 17
    • 0034941566 scopus 로고    scopus 로고
    • Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation
    • Burel S.A., Harakawa N., Zhou L., Pabst T., Tenen D.G., and Zhang D.E. Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation. Mol Cell Biol 21 16 (2001) 5577-5590
    • (2001) Mol Cell Biol , vol.21 , Issue.16 , pp. 5577-5590
    • Burel, S.A.1    Harakawa, N.2    Zhou, L.3    Pabst, T.4    Tenen, D.G.5    Zhang, D.E.6
  • 18
    • 0036889143 scopus 로고    scopus 로고
    • Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein
    • Kummalue T., Lou J., and Friedman A.D. Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein. Mol Cell Biol 22 23 (2002) 8278-8291
    • (2002) Mol Cell Biol , vol.22 , Issue.23 , pp. 8278-8291
    • Kummalue, T.1    Lou, J.2    Friedman, A.D.3
  • 19
    • 33746494493 scopus 로고    scopus 로고
    • Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells
    • Li X., Xu Y.B., Wang Q., Lu Y., Zheng Y., Wang Y.C., et al. Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells. J Cell Physiol 208 3 (2006) 594-601
    • (2006) J Cell Physiol , vol.208 , Issue.3 , pp. 594-601
    • Li, X.1    Xu, Y.B.2    Wang, Q.3    Lu, Y.4    Zheng, Y.5    Wang, Y.C.6
  • 20
    • 0034682252 scopus 로고    scopus 로고
    • Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF-a model for overcoming inhibition of proliferation by CBF oncoproteins
    • Lou J., Cao W., Bernardin F., Ayyanathan K., Rauscher I.F., and Friedman A.D. Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF-a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 19 22 (2000) 2695-2703
    • (2000) Oncogene , vol.19 , Issue.22 , pp. 2695-2703
    • Lou, J.1    Cao, W.2    Bernardin, F.3    Ayyanathan, K.4    Rauscher, I.F.5    Friedman, A.D.6
  • 21
    • 0034603080 scopus 로고    scopus 로고
    • Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle
    • Strom D.K., Nip J., Westendorf J.J., Linggi B., Lutterbach B., Downing J.R., et al. Expression of the AML-1 oncogene shortens the G(1) phase of the cell cycle. J Biol Chem 275 5 (2000) 3438-3445
    • (2000) J Biol Chem , vol.275 , Issue.5 , pp. 3438-3445
    • Strom, D.K.1    Nip, J.2    Westendorf, J.J.3    Linggi, B.4    Lutterbach, B.5    Downing, J.R.6
  • 22
    • 2442496452 scopus 로고    scopus 로고
    • AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression
    • Bernardin-Fried F., Kummalue T., Leijen S., Collector M.I., Ravid K., and Friedman A.D. AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression. J Biol Chem 279 15 (2004) 15678-15687
    • (2004) J Biol Chem , vol.279 , Issue.15 , pp. 15678-15687
    • Bernardin-Fried, F.1    Kummalue, T.2    Leijen, S.3    Collector, M.I.4    Ravid, K.5    Friedman, A.D.6
  • 23
    • 34248325702 scopus 로고    scopus 로고
    • The p21waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO
    • Peterson L.F., Yan M., and Zhang D.E. The p21waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO. Blood 109 10 (2007) 4392-4398
    • (2007) Blood , vol.109 , Issue.10 , pp. 4392-4398
    • Peterson, L.F.1    Yan, M.2    Zhang, D.E.3
  • 24
    • 33645778328 scopus 로고    scopus 로고
    • The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity
    • Liu Y., Cheney M.D., Gaudet J.J., Chruszcz M., Lukasik S.M., Sugiyama D., et al. The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer Cell 9 4 (2006) 249-260
    • (2006) Cancer Cell , vol.9 , Issue.4 , pp. 249-260
    • Liu, Y.1    Cheney, M.D.2    Gaudet, J.J.3    Chruszcz, M.4    Lukasik, S.M.5    Sugiyama, D.6
  • 25
    • 18444392071 scopus 로고    scopus 로고
    • The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia
    • Linggi B., Muller-Tidow C., van de Locht L., Hu M., Nip J., Serve H., et al. The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nat Med 8 7 (2002) 743-750
    • (2002) Nat Med , vol.8 , Issue.7 , pp. 743-750
    • Linggi, B.1    Muller-Tidow, C.2    van de Locht, L.3    Hu, M.4    Nip, J.5    Serve, H.6
  • 26
    • 21744434372 scopus 로고    scopus 로고
    • Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein
    • Yang G., Khalaf W., van de Locht L., Jansen J.H., Gao M., Thompson M.A., et al. Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein. Mol Cell Biol 25 14 (2005) 5869-5879
    • (2005) Mol Cell Biol , vol.25 , Issue.14 , pp. 5869-5879
    • Yang, G.1    Khalaf, W.2    van de Locht, L.3    Jansen, J.H.4    Gao, M.5    Thompson, M.A.6
  • 27
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
    • Herman J.G., Jen J., Merlo A., and Baylin S.B. Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 56 4 (1996) 722-727
    • (1996) Cancer Res , vol.56 , Issue.4 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3    Baylin, S.B.4
  • 28
    • 0031860559 scopus 로고    scopus 로고
    • Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
    • Drexler H.G. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 12 6 (1998) 845-859
    • (1998) Leukemia , vol.12 , Issue.6 , pp. 845-859
    • Drexler, H.G.1
  • 29
    • 0034654269 scopus 로고    scopus 로고
    • Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications
    • Wong I.H., Ng M.H., Huang D.P., and Lee J.C. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications. Blood 95 6 (2000) 1942-1949
    • (2000) Blood , vol.95 , Issue.6 , pp. 1942-1949
    • Wong, I.H.1    Ng, M.H.2    Huang, D.P.3    Lee, J.C.4
  • 30
    • 0348149013 scopus 로고    scopus 로고
    • Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias
    • Chim C.S., Wong A.S., and Kwong Y.L. Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias. Ann Hematol 82 12 (2003) 738-742
    • (2003) Ann Hematol , vol.82 , Issue.12 , pp. 738-742
    • Chim, C.S.1    Wong, A.S.2    Kwong, Y.L.3
  • 31
    • 0742282005 scopus 로고    scopus 로고
    • Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice
    • Wolff L., Garin M.T., Koller R., Bies J., Liao W., Malumbres M., et al. Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. Oncogene 22 58 (2003) 9265-9274
    • (2003) Oncogene , vol.22 , Issue.58 , pp. 9265-9274
    • Wolff, L.1    Garin, M.T.2    Koller, R.3    Bies, J.4    Liao, W.5    Malumbres, M.6
  • 32
    • 0029119985 scopus 로고
    • Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies
    • Ogawa S., Hangaishi A., Miyawaki S., Hirosawa S., Miura Y., Takeyama K., et al. Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies. Blood 86 4 (1995) 1548-1556
    • (1995) Blood , vol.86 , Issue.4 , pp. 1548-1556
    • Ogawa, S.1    Hangaishi, A.2    Miyawaki, S.3    Hirosawa, S.4    Miura, Y.5    Takeyama, K.6
  • 34
    • 0038819130 scopus 로고    scopus 로고
    • Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development
    • Cotta C.V., Zhang Z., Kim H.G., and Klug C.A. Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development. Blood 101 11 (2003) 4342-4346
    • (2003) Blood , vol.101 , Issue.11 , pp. 4342-4346
    • Cotta, C.V.1    Zhang, Z.2    Kim, H.G.3    Klug, C.A.4
  • 35
    • 28544436371 scopus 로고    scopus 로고
    • Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    • Passegue E., Wagers A.J., Giuriato S., Anderson W.C., and Weissman I.L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 202 11 (2005) 1599-1611
    • (2005) J Exp Med , vol.202 , Issue.11 , pp. 1599-1611
    • Passegue, E.1    Wagers, A.J.2    Giuriato, S.3    Anderson, W.C.4    Weissman, I.L.5
  • 36
    • 0029761781 scopus 로고    scopus 로고
    • Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins
    • Anderson M.T., Tjioe I.M., Lorincz M.C., Parks D.R., Herzenberg L.A., Nolan G.P., et al. Simultaneous fluorescence-activated cell sorter analysis of two distinct transcriptional elements within a single cell using engineered green fluorescent proteins. Proc Natl Acad Sci USA 93 16 (1996) 8508-8511
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.16 , pp. 8508-8511
    • Anderson, M.T.1    Tjioe, I.M.2    Lorincz, M.C.3    Parks, D.R.4    Herzenberg, L.A.5    Nolan, G.P.6
  • 37
    • 0034600841 scopus 로고    scopus 로고
    • Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis
    • Latres E., Malumbres M., Sotillo R., Martin J., Ortega S., Martin-Caballero J., et al. Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J 19 13 (2000) 3496-3506
    • (2000) EMBO J , vol.19 , Issue.13 , pp. 3496-3506
    • Latres, E.1    Malumbres, M.2    Sotillo, R.3    Martin, J.4    Ortega, S.5    Martin-Caballero, J.6
  • 38
    • 33847049430 scopus 로고    scopus 로고
    • Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors
    • Rosu-Myles M., Taylor B.J., and Wolff L. Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors. Exp Hematol 35 3 (2007) 394-406
    • (2007) Exp Hematol , vol.35 , Issue.3 , pp. 394-406
    • Rosu-Myles, M.1    Taylor, B.J.2    Wolff, L.3
  • 39
    • 0027317604 scopus 로고
    • Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission
    • Nucifora G., Larson R.A., and Rowley J.D. Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission. Blood 82 3 (1993) 712-715
    • (1993) Blood , vol.82 , Issue.3 , pp. 712-715
    • Nucifora, G.1    Larson, R.A.2    Rowley, J.D.3
  • 40
    • 0034691092 scopus 로고    scopus 로고
    • AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
    • Miyamoto T., Weissman I.L., and Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci USA 97 13 (2000) 7521-7526
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.13 , pp. 7521-7526
    • Miyamoto, T.1    Weissman, I.L.2    Akashi, K.3


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