Short term effects of exercise training on exercise capacity and quality of life in patients with pulmonary arterial hypertension: Protocol for a randomised controlled trial

BMC Pulmonary Medicine

Volumn 11, Issue , 2011, Pages

  Ganderton, Louise ^a,b,c   Jenkins, Sue ^a,c,d   Gain, Kevin ^a,b,e   Fowler, Robin ^a,b,c   Winship, Peta ^b   Lunt, Dianne ^b   Gabbay, Eli ^a,b,c,e,f  

^a CURTIN UNIVERSITY   (Australia)

^b ROYAL PERTH HOSPITAL   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f UNIVERSITY OF NOTRE DAME   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE;

ANAEROBIC THRESHOLD; ARTICLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE COURSE; END TIDAL CARBON DIOXIDE TENSION; ENDURANCE; FUNCTIONAL STATUS; HOME CARE; HUMAN; KINESIOTHERAPY; OUTPATIENT CARE; OXYGEN CONSUMPTION; PULMONARY HYPERTENSION; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; SINGLE BLIND PROCEDURE; AUSTRALIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EXERCISE TOLERANCE; METHODOLOGY; OUTPATIENT; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; TREATMENT OUTCOME;

AUSTRALIA; EXERCISE THERAPY; EXERCISE TOLERANCE; HUMANS; HYPERTENSION, PULMONARY; OUTPATIENTS; PROSPECTIVE STUDIES; QUALITY OF LIFE; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 79956221609     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-11-25     Document Type: Article

References (42)

1. Desai S, Channick R. Exercise in patients with pulmonary arterial hypertension. J Cardiopulm Rehabil Prev 2008, 28:12-16.
2. Schannwell C, Steiner S, Strauer B. Diagnostics in pulmonary hypertension. J Physiol Pharmacol 2007, 58(Suppl. 5):591-602.
3. Gabbay E, Reed A, Williams T. Assessment and treatment of pulmonary arterial hypertension: an Australian perspective in 2006. Int Med J 2007, 37:38-48.
4. Rubin L. Primary pulmonary hypertension. N Engl J Med 1997, 336(2):111-119. 10.1056/NEJM199701093360207, 8988890.
5. Arena R, Lavie C, Milani R, Myers J, Guazzi M. Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension: An evidence-based review. J Heart Lung Transplant 2010, 29(2):159-173. 10.1016/j.healun.2009.09.003, 19969471.
6. Sun X, Hansen J, Oudiz R, Wasserman K. Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation 2001, 104:429-435. 10.1161/hc2901.093198, 11468205.
7. Naeije R. Breathing more with weaker respiratory muscles in pulmonary arterial hypertension. Eur Respir J 2005, 25:6-8. 10.1183/09031936.04.00121004, 15640315.
8. Bauer R, Dehnert C, Schoene P, Filusch A, Bärtsch P, Borst M, Katus H, Meyer F. Skeletal muscle dysfunction in patients with idiopathic pulmonary arterial hypertension. Respir Med 2007, 101:2366-2369. 10.1016/j.rmed.2007.06.014, 17689235.
9. Mainguy V, Maltais F, Saey D, Gagnon P, Martel S, Simon M, Provencher S. Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension. Thorax 2010, 65:113-117. 10.1136/thx.2009.117168, 19720606.
10. de Man F, Handoko M, Groepenhoff H, van 't Hul A, Abbink J, Koppers R, Grotjohan H, Twisk J, Bogaard H, Boonstra A, Postmus PE, Westerhof N, van der Laarse WJ, Vonk-Noordegraaf A. Effects of exercise training in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 2009, 34:669-675. 10.1183/09031936.00027909, 19720810.
11. Meyer F, Lossnitzer D, Kristen A, Schoene A, Kübler W, Katus H, Borst M. Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension. Eur Respir J 2005, 25:125-130. 10.1183/09031936.04.00095804, 15640333.
12. Kabitz H, Schwoerer A, Bremer H, Sonntag F, Walterspacher S, Walker D, Schaefer V, Ehlken N, Staehler G, Halank M, Klose H, Ghofrani HA, Hoeper MM, Grünig E, Windisch W. Impairment of respiratory muscle function in pulmonary hypertension. Clin Sci 2008, 114:165-171. 10.1042/CS20070238, 17764445.
13. Velez-Roa S, Ciarka A, Najem B, Vachiery J, Naeije R, van de Borne P. Increased sympathetic nerve activity in pulmonary artery hypertension. Circulation 2004, 110(10):1308-1312. 10.1161/01.CIR.0000140724.90898.D3, 15337703.
14. McLaughlin V, Archer S, Badesch D, Barst R, Farber H, Lindner J, Mathier M, McGoon M, Park M, Rosenson R, Rubin LJ, Tapson VF, Varga J. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on expert consensus documents and the American Heart Association. J Am Coll Cardiol 2009, 53(17):1573-1619. 10.1016/j.jacc.2009.01.004, 19389575.
15. Mereles D, Ehlken N, Kreuscher S, Ghofrani S, Hoeper M, Halank M, Meyer F, Karger G, Buss J, Juenger J, Holzapfel N, Opitz C, Winkler J, Herth F, Wilkens H, Katus HA, Olschewski H, Grünig E. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation 2006, 114:1482-1489. 10.1161/CIRCULATIONAHA.106.618397, 16982941.
16. Belardinelli R, Georgiou D, Cianci G, Purcaro A. Randomised controlled trial of long-term moderate exercise training in chronic heart failure. Circulation 1999, 99:1173-1182.
17. Maiorana A, O'Driscoll G, Cheetham C, Collis J, Goodman C, Rankin S, Taylor R, Green D. Combined aerobic and resistance exercise training improves functional capacity and strength in CHF. J Appl Physiol 2000, 88(5):1565-1570.
18. Piña I, Apstein C, Balady G, Belardinelli R, Chaitman B, Duscha B, Fletcher B, Fleg J, Myers J, Sullivan M. Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation 2003, 107:1210-1225. 10.1161/01.CIR.0000055013.92097.40, 12615804.
19. Rees K, Taylor R, Singh S, Coats A, Ebrahim S. Exercise based rehabilitation for heart failure (review). Cochrane Database Syst Rev 2004, (3). Art. No. CD003331. DOI:10.1002/14651858.CD003331.pub2.
20. Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med 2006, 173(12):1390-1413. 10.1164/rccm.200508-1211ST, 16760357.
21. Troosters T, Casaburi R, Gosselink R, Decramer M. Pulmonary rehabilitation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005, 172:19-38. 10.1164/rccm.200408-1109SO, 15778487.
22. Ries A, Bauldoff G, Carlin B, Casaburi R, Emery C, Mahler D, Make B, Rochester C, ZuWallack R, Herrerias C. Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest 2007, 131(Suppl. 5):4-42.
23. Lacasse Y, Goldstein R, Lasserson T, Martin S. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006, (4). Art. No.CD003793. DOI:10.1002/14651858.CD003793.pub2.
24. Shoemaker M, Wilt J, Dasgupta R, Oudiz R. Exercise training in patients with pulmonary arterial hypertension: a case report. Cardiopulm Phys Ther J 2009, 20(4):12-18. 2845256, 20467524.
25. Uchi M, Saji T, Harada T. Feasibility of cardiopulmonary rehabilitation in patients with idiopathic pulmonary arterial hypertension treated with intravenous prostacyclin infusion therapy. J Cardiol 2005, 46:183-193.
26. Pulmonary rehabilitation toolkit. , http://www.pulmonaryrehab.com.au/welcome.asp
27. Recommended framework for cardiac rehabilitation '04. , http://www.heartfoundation.org.au/SiteCollectionDocuments/Recommended-framework.pdf
28. Moher M, Schultz K, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001, 357:1191-1194. 10.1016/S0140-6736(00)04337-3, 11323066.
29. Beller E, Gebski V, Keech A. Randomisation in clinical trials. Med J Aust 2002, 177:565-567.
30. Wasserman K, Hansen J, Sue D, Stringer W, Whipp B. Clinical exercise testing. Principles of exercise testing and interpretation 2005, 133-160. Philadelphia: Lippincott Williams and Wilkins, 4.
31. Borg G. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 1982, 14:377-381.
32. McKenna S, Doughty N, Meads D, Doward L, Pepke-Zaba J. The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR): A measure of health-related quality of life and quality of life for patients with pulmonary hypertension. Qual Life Res 2006, 15:103-115. 10.1007/s11136-005-3513-4, 16411035.
33. Ganderton L, Gabbay E, Fowler R, Gain K, McKenna S, Jenkins S. Validation of the Cambridge Pulmonary Hypertension Outcome Review for an Australian and New Zealand PAH population [abstract]. Respirology 2009, 14(Suppl. 1):A69.
34. Hawthorne G, Osborne R, Taylor A, Sansoni J. The SF36 Version 2: critical analyses of population weights, scoring algorithms and population norms. Qual Life Res 2007, 16:661-673. 10.1007/s11136-006-9154-4, 17268926.
35. Booth M. Assessment of physical activity: an international perspective. Res Q Exerc Sport 2000, 71(2):s114-120.
36. American Thoracic Society/American College of Chest Physicians ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003, 167:211-277. American Thoracic Society/American College of Chest Physicians.
37. Fox S, Naughton J, Haskell W. Physical activity and the prevention of coronary heart disease. Ann Clin Res 1971, 1(3):404-432.
38. Galiè N, Olschewski H, Oudiz R, Torres F, Frost A, Ghofrani H, Badesch D, McGoon M, McLaughlin V, Roecker E, Gerber MJ, Dufton C, Wiens BL, Rubin LJ. Ambrisentan for the treatment of pulmonary arterial hypertension: Results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 2008, 117:3010-3019. 10.1161/CIRCULATIONAHA.107.742510, 18506008.
39. Ghofrani H, Wilkins M, Rich S. Uncertainties in the diagnosis and treatment of pulmonary arterial hypertension. Circulation 2008, 118:1195-1201. 10.1161/CIRCULATIONAHA.106.674002, 18779455.
40. Myers J. Principles of exercise prescription for patients with chronic heart failure. Heart Fail Rev 2007, 13:61-68.
41. Lachin J. Statistical considerations in the intention-to-treat principle. Control Clin Trials 2000, 21:167-189. 10.1016/S0197-2456(00)00046-5, 10822117.
42. Berger V, Exner D. Detecting selection bias in randomized clinical trials. Control Clin Trials 1999, 20:319-327. 10.1016/S0197-2456(99)00014-8, 10440559.