Molecular docking studies and in vitro screening of new dihydropyridine derivatives as human MRP1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 10, 2011, Pages 3249-3254

  Sirisha, Kalam ^a   Shekhar, Maddela Chandra ^b   Umasankar, Kulandaivelu ^c   Mahendar, Porika ^a   Sadanandam, Abbagani ^a   Achaiah, Garlapati ^a   Reddy, Vanga Malla ^d  

^a KAKATIYA UNIVERSITY   (India)

^b National Institute of Pharmaceutical Education and Research (NIPER)   (India)

^c Vaagdevi College of Pharmacy   (India)

^d Divis Laboratories Limited   (India)

Author keywords

1,4 Dihydropyridines; ATPase; Docking; MRP1; Multidrug resistance

Indexed keywords

4 (2 FURYL) 2,6 DIMETHYL 3,5 BIS N (PHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 FURYL) 2,6 DIMETHYL 3,5 BIS N (PYRIDIN 2 YL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 IMIDAZOLYL) 2,6 DIMETHYL 3,5 BIS N (4 METHYLPHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 IMIDAZOLYL) 2,6 DIMETHYL 3,5 BIS N (PHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 IMIDAZOLYL) 2,6 DIMETHYL 3,5 BIS N (PYRIDIN 2 YL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 PYRIDYL) 2,6 DIMETHYL 3,5 BIS N (PHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 PYRROLYL) 2,6 DIMETHYL 3,5 BIS N (PHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 PYRROLYL) 2,6 DIMETHYL 3,5 BIS N (PYRIDIN 2 YL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (2 THIENYL) 2,6 DIMETHYL 3,5 BIS N (PHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; 4 (4 CHLOROPHENYL) 2,6 DIMETHYL 3,5 BIS N (PHENYL)CARBAMOYL 1,4 DIHYDROPYRIDINE; ADENOSINE TRIPHOSPHATASE; AMLODIPINE; BENZBROMARONE; DIHYDROPYRIDINE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 1 INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ASSAY; IC 50; IN VITRO STUDY; INSECT CELL; MOLECULAR DOCKING; NONHUMAN; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL LINE; DIHYDROPYRIDINES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; INSECTS; P-GLYCOPROTEIN; PROTEIN BINDING;

HEXAPODA;

EID: 79956219259     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.051     Document Type: Article

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