Newly synthesized dihydropyridine derivatives as modulators of P-glycoprotein-mediated multidrug resistance

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 11, 1998, Pages 2219-2227

  Tanabe, Hirokazu ^a   Tasaka, Shigeyuki ^a   Ohmori, Hiromasa ^a   Gomi, Noriaki ^a   Sasaki, Yoshiyuki ^a   MacHida, Toshiki ^a   Iino, Mayumi ^a   Kiue, Akira ^a   Naito, Seiji ^b   Kuwano, Michihiko ^b  

^a Nikken Chemicals Co Ltd   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

1,4 Dihydropyridine derivatives; Calcium antagonistic activity; Multidrug resistance; P glycoprotein; P388 leukemia bearing mice

Indexed keywords

DIHYDROPYRIDINE DERIVATIVE; DOXORUBICIN; GLYCOPROTEIN P; VERAPAMIL; VINCRISTINE SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM ANTAGONISM; CANCER RESISTANCE; CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA P 388; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; DOXORUBICIN; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; HUMANS; KB CELLS; LEUKEMIA P388; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0031738659     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00170-9     Document Type: Article

References (26)

1. Davis, H. L.; Davis, T. E. Cancer Treat. Rep. 1979, 63, 809.
2. Pastan, I.; Gottesman, M. M. N. Engl. J. Med. 1987, 316, 1388.
3. Endicott, J. A.; Ling, V. Ann. Rev. Biochem. 1989, 58, 137.
4. Kartner, N.; Riordan, J. R.; Ling, V. Science 1983, 221, 1285.
5. Ueda, K.; Cornwell, M. M.; Gottesman, M. M.; Pastan, I.; Roninson, I. B.; Ling, V.; Riordan, J. R. Biochem. Biophys. Res. Commun. 1986, 141, 956.
6. Gottesman, M. M.; Pastan, I. Ann. Rev. Biochem. 1993, 62, 385.
7. Akiyama, S.; Shiraishi, N.; Kuratomi, Y.; Nakagawa, M.; Kuwano, M. J. Natl. Cancer Inst. 1986, 76, 839.
8. Tsuruo, T.; Iida, H.; Tsukagoshi, S.; Sakurai, Y. Cancer Res. 1981, 41, 1967.
9. Rogan, A. M.; Hamilton, T. C.; Young, R. C. Science 1984, 224, 994.
10. Ince, P.; Appleton, D. R.; Finney, K. J.; Sunter, J. P.; Watson, A. J. Br. J. Cancer 1986, 53, 137.
11. Shinoda, H.; Inaba, M.; Tsuruo, T. Cancer Res. 1989, 49, 1722.
12. Tsuruo, T.; Iida, H.; Nojiri, M.; Tsukagoshi, S.; Sakurai, Y. Cancer Res. 1983, 43, 2905.
13. Dodic, N.; Dumaitre, B.; Daugan, A.; Pianetti, P. J. Med. Chem. 1995, 38, 2418.
14. Fisher, G. A.; Sikic, B. I. Drug Resistance in Clinical Oncology and Hemalology 1995, 9, 363.
15. Pommerenke, E. W.; Mattern, J.; Traugott, U.; Volm, M. Arzneim-Forsch. Drug. Res. 1991, 41, 855.
16. Hofmann, J.; Gekeler. V.; Ise, W.; Noller, A.; Mitterdorfer, J.; Hofer, S.; Utz, I.; Gotwald. M.; Boer, R.; Glossmann, H.; Grunicke, H. H. Biochem. Phann. 1994, 49. 603.
17. Kiue, A.; Sano, T.; Naito, A.; Inada, H.; Suzuki, K.; Okumura, M.; Kikuchi, J.; Sato, S.; Takano, H.; Kohno, K.; Kuwano, M. Jpn. J. Cancer Res. 1990, 81, 1057.
18. Watanabe, Y.; Takano, H.; Kiue, A.; Kohno, K.; Kuwano, M. Anti-Cancer Drug Design 1991, 6, 47.
19. Kiue, A.; Sano, T.; Suzuki, K.; Inada, H.; Okumura, M.; Kikuchi, J.; Sato, S.; Kohono, K.; Kuwano, M. Cancer Res. 1990, 50, 310.
20. Kiue, A.; Sano, T.; Naito, A.; Okumura, M.; Kohono, K.; Kuawno, M. Br. J. Cancer 1991, 64, 221.
21. Nogae, I.; Kohno, K.; Kikuchi, J.; Kuwano, M.; Akiyama, S.; Kiue, A.; Suzuki, K.; Yoshida, Y.; Cornwell, M. M.; Pastan, I.; Gottesman, M. M. Biochem. Pharm. 1989, 38, 519.
22. Tasaka, S.; Tanabe, H.; Sasaki, Y.; Machida, T.; Iino, M.; Kiue, A.; Naito, S.; Kuwano, M. J. Heterocyclic Chem. 1997, 34, 1763.
23. Meguro, K.; Aizawa, M.; Sohda, T.; Kawamatu, Y.; Nagaoka, A. Chem. Pharm. Bull. 1985, 33, 3787.
24. Cozzi, P.; Carganico, G.; Fusar, D.; Grossoni, M.; Menichincheri, M.; Pinciroli V.; Tonani, R.; Vaghi, F.; Salvati, P. J. Med. Chem. 1993, 36, 2964.
25. Loev, B.; Goodman, M. M.; Snader, K. M.; Tedeschi, R.; Macko, E. J. Med. Chem. 1974, 17, 956.
26. Kohno, K.; Kikuchi, J.; Sato, S. Jpn. J. Cancer Res. 1988, 79, 1238.