Zinc inhibition of bacterial cytochrome bc1 reveals the role of cytochrome b E295 in proton release at the Qo site

Biochemistry

Volumn 50, Issue 20, 2011, Pages 4263-4272

  Lee, Dong Woo ^a,e   El Khoury, Youssef ^b   Francia, Francesco ^c   Zambelli, Barbara ^c,d   Ciurli, Stefano ^c,d   Venturoli, Giovanni ^c   Hellwig, Petra ^b   Daldal, Fevzi ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

^e Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; APPARENT K; BINDING AFFINITIES; BINDING MECHANISMS; COFACTORS; CYTOCHROME B; DIFFERENCE SPECTROSCOPY; EFFLUX PATHWAYS; ELECTRON TRANSFER; ELECTRON TRANSFERRING; EXTENDED X-RAY ABSORPTION FINE STRUCTURES; FOURIER TRANSFORM INFRARED; FTIR; HIGH-AFFINITY SITES; INHIBITORY EFFECT; ISOTHERMAL TITRATION CALORIMETRY; KINETIC ANALYSIS; KINETIC STUDY; MOLECULAR BASIS; PROTON RELEASE; PROTON-COUPLED ELECTRON TRANSFER; PROTON-MOTIVE FORCES; PROTONATED; REDOX POTENTIALS; RHODOBACTER CAPSULATUS; WILD TYPES;

ABSORPTION SPECTROSCOPY; AMINO ACIDS; BINDING ENERGY; CALORIMETRY; ELECTRON TRANSITIONS; ENZYME INHIBITION; ENZYME KINETICS; FOURIER TRANSFORMS; KINETICS; REDOX REACTIONS; ZINC;

PROTONS;

BACTERIAL ENZYME; CYTOCHROME; CYTOCHROME BE295; PROTON; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; VALINE; ZINC;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BINDING AFFINITY; CATALYSIS; ELECTROCHEMISTRY; ELECTRON TRANSPORT; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; INFRARED SPECTROSCOPY; ISOTHERMAL TITRATION CALORIMETRY; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTON TRANSPORT; RHODOBACTER CAPSULATUS; X RAY ABSORPTION SPECTROSCOPY;

CALORIMETRY; CATALYTIC DOMAIN; ELECTRON TRANSPORT COMPLEX III; ENZYME INHIBITORS; GLUTAMIC ACID; HEME; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTONS; RHODOBACTER CAPSULATUS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; ZINC;

BACTERIA (MICROORGANISMS); RHODOBACTER CAPSULATUS;

EID: 79956208939     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200230e     Document Type: Article

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