메뉴 건너뛰기




Volumn 35, Issue 10, 2010, Pages 815-822

Veliparib hydrochloride: Poly(ADP-ribose)polymerase inhibitor oncolytic

Author keywords

[No Author keywords available]

Indexed keywords

A 861695; BRCA1 PROTEIN; BRCA2 PROTEIN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; GEMCITABINE; IRINOTECAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NSC 737664; TEMOZOLOMIDE; TOPOTECAN; UNCLASSIFIED DRUG; VELIPARIB;

EID: 79956199846     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2010.035.010.1526315     Document Type: Review
Times cited : (1)

References (40)
  • 1
    • 84882775895 scopus 로고    scopus 로고
    • 1H-Benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors
    • Abbott Laboratories, Inc.. EP 1869011, JP 2008535926, US 2006229289, WO 2006110816
    • Zhu, G.-D., Gong, J., Gandhi, V.B., Penning, T.D., Giranda, V.L. (Abbott Laboratories, Inc.). 1H-Benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors. EP 1869011, JP 2008535926, US 2006229289, WO 2006110816.
    • Zhu, G.-D.1    Gong, J.2    Gandhi, V.B.3    Penning, T.D.4    Giranda, V.L.5
  • 2
    • 60549117554 scopus 로고    scopus 로고
    • Discovery of the poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer
    • Penning, T.D., Zhu, G.D., Gandhi, V.B. et al. Discovery of the poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H- benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem 2009, 52(2): 514-23.
    • (2009) J Med Chem , vol.52 , Issue.2 , pp. 514-523
    • Penning, T.D.1    Zhu, G.D.2    Gandhi, V.B.3
  • 3
    • 0034733928 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model?
    • Shall, S., de Murcia, G. Poly(ADP-ribose) polymerase-1: What have we learned from the deficient mouse model? Mutat Res 2000, 460(1): 1-15.
    • (2000) Mutat Res , vol.460 , Issue.1 , pp. 1-15
    • Shall, S.1    De Murcia, G.2
  • 5
    • 0033580856 scopus 로고    scopus 로고
    • PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
    • Ame, J.C., Rolli, V., Schreiber, V. et al. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 1999, 274(25): 17860-8.
    • (1999) J Biol Chem , vol.274 , Issue.25 , pp. 17860-17868
    • Ame, J.C.1    Rolli, V.2    Schreiber, V.3
  • 7
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
    • Virag, L., Szabo, C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 2002, 54(3): 375-429.
    • (2002) Pharmacol Rev , vol.54 , Issue.3 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 8
    • 0017331465 scopus 로고
    • Poly(ADP-ribose) and ADP-ribosylation of proteins
    • Hayaishi, O., Ueda, K. Poly(ADP-ribose) and ADP-ribosylation of proteins. Annu Rev Biochem 1977, 46: 95-116.
    • (1977) Annu Rev Biochem , vol.46 , pp. 95-116
    • Hayaishi, O.1    Ueda, K.2
  • 9
  • 11
    • 0019788529 scopus 로고
    • Poly(ADP-ribose) synthesis in human cervical cancer cell - Diagnostic cytological usefulness
    • Fukushima, M., Kuzuya, K., Ota, K., Ikai, K. Poly(ADP-ribose) synthesis in human cervical cancer cell-diagnostic cytological usefulness. Cancer Lett 1981, 14(3): 227-36. (Pubitemid 12223479)
    • (1981) Cancer Letters , vol.14 , Issue.3 , pp. 227-236
    • Fukushima, M.1    Kuzuya, K.2    Ota, K.3    Ikai, K.4
  • 12
    • 68449096428 scopus 로고    scopus 로고
    • Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial
    • 45th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009 Abst 3
    • O'Shaughnessy, J., Osborne, C., Pippen, J. et al. Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial. J Clin Oncol [45th Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Orlando) 2009] 2009, 27(15, Suppl.): Abst 3.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 15
    • 67650476607 scopus 로고    scopus 로고
    • Synthetic lethality - A new direction in cancerdrug development
    • Iglehart, J.D., Silver, D.P. Synthetic lethality - A new direction in cancerdrug development. N Engl J Med 2009, 361(2): 189-91.
    • (2009) N Engl J Med , vol.361 , Issue.2 , pp. 189-191
    • Iglehart, J.D.1    Silver, D.P.2
  • 16
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong, P.C., Boss, D.S., Yap, T.A. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009, 361(2): 123-34.
    • (2009) N Engl J Med , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 17
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt, A., Robson, M., Garber, J.E. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial. Lancet 2010, 376(9737): 235-44.
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 18
    • 77955039099 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial
    • Audeh, M.W., Carmichael, J., Penson, R.T. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial. Lancet 2010, 376(9737): 245-51.
    • (2010) Lancet , vol.376 , Issue.9737 , pp. 245-251
    • Audeh, M.W.1    Carmichael, J.2    Penson, R.T.3
  • 21
    • 73149110553 scopus 로고    scopus 로고
    • ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors
    • Palma, J.P., Wang, Y.C., Rodriguez, L.E. et al. ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. Clin Cancer Res 2009, 15(23): 7277-90.
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7277-7290
    • Palma, J.P.1    Wang, Y.C.2    Rodriguez, L.E.3
  • 23
    • 0028133013 scopus 로고
    • NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
    • Denny, B.J., Wheelhouse, R.T., Stevens, M.F., Tsang, L.L., Slack, J.A. NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry 1994, 33(31): 9045-51. (Pubitemid 24272851)
    • (1994) Biochemistry , vol.33 , Issue.31 , pp. 9045-9051
    • Denny, B.J.1    Wheelhouse, R.T.2    Stevens, M.F.G.3    Tsang, L.L.H.4    Slack, J.A.5
  • 24
    • 19444375973 scopus 로고    scopus 로고
    • Chemopotentiation by PARP inhibitors in cancer therapy
    • DOI 10.1016/j.phrs.2005.02.010, PII S1043661805000423
    • Tentori, L., Graziani, G. Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacol Res 2005, 52(1): 25-33. (Pubitemid 40725597)
    • (2005) Pharmacological Research , vol.52 , Issue.1 SPEC. ISS , pp. 25-33
    • Tentori, L.1    Graziani, G.2
  • 25
    • 0030611436 scopus 로고    scopus 로고
    • 6-Alkylguanine DNA-Alkyltransferase or poly(ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide
    • Tentori, L., Orlando, L., Lacal, P.M. et al. Inhibition of O6-alkylguanine DNA-alkyl transferase or poly (ADP-ribose) polymerase increases susceptibility of leukemic cells to apoptosis induced by temozolomide. Mol Pharmacol 1997, 52(2): 249-58. (Pubitemid 27349616)
    • (1997) Molecular Pharmacology , vol.52 , Issue.2 , pp. 249-258
    • Tentori, L.1    Orlando, L.2    Lacal, P.M.3    Benincasa, E.4    Faraoni, I.5    Bonmassar, E.6    D'Atri, S.7    Graziani, G.8
  • 26
    • 0029662166 scopus 로고    scopus 로고
    • 6-alkylguanine-DNA alkyltransferase activity
    • Wedge, S.R., Porteous, J.K., Newlands, E.S. 3-Aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity. Br J Cancer 1996, 74(7): 1030-6. (Pubitemid 26333902)
    • (1996) British Journal of Cancer , vol.74 , Issue.7 , pp. 1030-1036
    • Wedge, S.R.1    Porteous, J.K.2    Newlands, E.S.3
  • 27
    • 68849128273 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: Influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity
    • Horton, T.M., Jenkins, G., Pati, D. et al. Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: Influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. Mol Cancer Ther 2009, 8(8): 2232-42.
    • (2009) Mol Cancer Ther , vol.8 , Issue.8 , pp. 2232-2242
    • Horton, T.M.1    Jenkins, G.2    Pati, D.3
  • 28
    • 75549087966 scopus 로고    scopus 로고
    • Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates
    • Muscal, J.A., Thompson, P.A., Giranda, V.L. et al. Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates. Cancer Chemother Pharmacol 2010, 65(3): 419-25.
    • (2010) Cancer Chemother Pharmacol , vol.65 , Issue.3 , pp. 419-425
    • Muscal, J.A.1    Thompson, P.A.2    Giranda, V.L.3
  • 29
    • 77955877185 scopus 로고    scopus 로고
    • A phase II trial of the PARP inihibitor veliparib (ABT-888) and temozolomide for metastatic breast cancer
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010 Abst 1019
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 1019.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Isakoff, S.J.1    Overmoyer, B.2    Tung, N.M.3
  • 31
    • 70649085081 scopus 로고    scopus 로고
    • A phase I combination study of ABT-888 and topotecan hydrochloride in adults with refractory solid tumors and lymphomas
    • Kummar, S., Ji, J., Zhang, Y. et al. A phase I combination study of ABT-888 and topotecan hydrochloride in adults with refractory solid tumors and lymphomas. Ann Oncol 2009, 20(Suppl. 3): G03.
    • (2009) Ann Oncol , vol.20 , Issue.SUPPL. 3
    • Kummar, S.1    Ji, J.2    Zhang, Y.3
  • 32
    • 61349172882 scopus 로고    scopus 로고
    • Phase 0 pharmacodynamic study of poly (ADP -ribose) polymerase inhibitor ABT-888 in patients with refractory solid tumors and lymphomas: Immunohistochemistry results
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008 Abst 3580
    • th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(15, Suppl.): Abst 3580.
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Yang, S.X.1    Kummar, S.2    Rubinstein, L.3
  • 33
    • 66849106010 scopus 로고    scopus 로고
    • Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies
    • Kummar, S., Kinders, R., Gutierrez, M.E. et al. Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies. J Clin Oncol 2009, 27(16): 2705-11.
    • (2009) J Clin Oncol , vol.27 , Issue.16 , pp. 2705-2711
    • Kummar, S.1    Kinders, R.2    Gutierrez, M.E.3
  • 34
    • 0024560495 scopus 로고
    • Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity
    • Jaxel, C., Kohn, K., Wani, M., Wall, M., Pommier, Y. Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: Evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 1989, 49(6): 1465-9. (Pubitemid 19088683)
    • (1989) Cancer Research , vol.49 , Issue.6 , pp. 1465-1469
    • Jaxel, C.1    Kohn, K.W.2    Wani, M.C.3    Wall, M.E.4    Pommier, Y.5
  • 35
    • 77956336578 scopus 로고    scopus 로고
    • Pharmacodynamic response in phase I combination study of ABT-888 and topotecan in adults with refractory solid tumors and lymphomas
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010 Abst 2514
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 2514.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Ji, J.J.1    Kummar, S.2    Chen, A.P.3
  • 36
    • 79956213176 scopus 로고    scopus 로고
    • Veliparib (ABT-888) reaches the critical tumor compartment and target cells in patients with leukemia
    • th Annu Meet Am Soc Clin Pharmacol Ther (ASCPT) (March 17-20, Atlanta) 2010 Abst PIII-30
    • th Annu Meet Am Soc Clin Pharmacol Ther (ASCPT) (March 17-20, Atlanta) 2010] 2010, 87(Suppl. 1): Abst PIII-30.
    • (2010) Clin Pharmacol Ther , vol.87 , Issue.SUPPL. 1
    • Zhao, M.1    Mnatsakanyan, A.2    Xu, L.3
  • 37
    • 77956300908 scopus 로고    scopus 로고
    • Preliminary results of a phase I trial of ABT-888, a poly(ADP-ribose) polymerase (PARP) inhibitor, in combination with cyclophosphamide
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010 Abst 3000
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 3000.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Tan, A.R.1    Gibbon, D.2    Stein, M.N.3
  • 38
    • 79956209286 scopus 로고    scopus 로고
    • A phase I study of ABT-888(A) in combination with metronomic cyclophosphamide(C) in adults with refractory solid tumors and lymphomas
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010 Abst 2605
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst 2605.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Kummar, S.1    Chen, A.P.2    Ji, J.J.3
  • 39
    • 79956187588 scopus 로고    scopus 로고
    • Targeting fanconi anemia (FA) repair pathway deficiency for treatment with PARP inhibitors
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010 Abst TPS168
    • th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28(15, Suppl.): Abst TPS168.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Zhao, W.1    Duan, W.2    Leon, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.