Clostridium difficile transcriptome analysis using pig ligated loop model reveals modulation of pathways not modulated in vitro

Journal of Infectious Diseases

Volumn 203, Issue 11, 2011, Pages 1613-1620

  Scaria, Joy ^a   Janvilisri, Tavan ^a,b   Fubini, Susan ^a   Gleed, Robin D ^a   McDonough, Sean P ^a   Chang, Yung Fu ^a  

^a Department of Obstetrics Gynecology   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL SPORE; BACTERIAL VIRULENCE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; MODEL; NONHUMAN; PIG LIGATED LOOP MODEL; PRIORITY JOURNAL; RNA ANALYSIS; SPOROGENESIS; SWINE; TRANSCRIPTOME ANALYSIS; UPREGULATION;

ABDOMINAL CAVITY; ANIMALS; BACTERIAL PROTEINS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; METABOLIC NETWORKS AND PATHWAYS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SWINE;

EID: 79956197132     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir112     Document Type: Article

References (34)

1. Gerding DN, Johnson S, Peterson LR, Mulligan ME, Silva J Jr. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 1995; 16:459-77.
2. Songer JG, Anderson MA. Clostridium difficile: an important pathogen of food animals. Anaerobe 2006; 12:1-4. (Pubitemid 41774737)
3. O'Brien JA, Lahue BJ, Caro JJ, Davidson DM. The emerging infectious challenge of Clostridium difficile-associated disease in Massachusetts hospitals: clinical and economic consequences. Infect Control Hosp Epidemiol 2007; 28:1219-7.
4. Warny M, Pepin J, Fang A, et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet 2005; 366:1079-84. (Pubitemid 41338761)
5. McDonald LC, Killgore GE, Thompson A, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl JMed 2005; 353:2433-41. (Pubitemid 41770164)
6. Akerlund T, Persson I, Unemo M, et al. Increased sporulation rate of epidemic Clostridium difficile Type 027/NAP1. J Clin Microbiol 2008;46:1530-3. (Pubitemid 351563610)
7. Sebaihia M, Wren BW, Mullany P, et al. The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet 2006; 38:779-86. (Pubitemid 43980598)
8. Janvilisri T, Scaria J, Thompson AD, et al. Microarray identification of Clostridium difficile core components and divergent regions associated with host origin. J Bacteriol 2009; 191:3881-91.
9. Stabler RA, He M, Dawson L, et al. Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol 2009; 10:R102.
10. Scaria J, Ponna L, Janvilisri T, Yan W, Mueller LA, Chang YF. Analysis of ultra low genome conservation in Clostridium difficile. PloS One 2010; 5:e15147.
11. Emerson JE, Stabler RA, Wren BW, Fairweather NF. Microarray analysis of the transcriptional responses of Clostridium difficile to environmental and antibiotic stress. J Med Microbiol 2008; 57:757-64. (Pubitemid 351842069)
12. Janvilisri T, Scaria J, Chang YF. Transcriptional profiling of Clostridium difficile and Caco-2 cells during infection. J Infect Dis 2010; 202:282-90.
13. Karp PD, Paley S, Romero P. The Pathway Tools software. Bioinformatics 2002; 18(Suppl 1):S225-32.
14. Lawley TD, Croucher NJ, Yu L, et al. Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores. J Bacteriol 2009; 191:5377-86.
15. Wright A, Wait R, Begum S, et al. Proteomic analysis of cell surface proteins from Clostridium difficile. Proteomics 2005; 5:2443-52. (Pubitemid 40835415)
16. Paley SM, Karp PD. The Pathway Tools cellular overview diagram and Omics Viewer. Nucleic Acids Res 2006; 34:3771-8. (Pubitemid 44400426)
17. O'Connor JR, Johnson S, Gerding DN. Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology 2009; 136:1913-24.
18. Razaq N, Sambol S, Nagaro K, et al. Infection of hamsters with historical and epidemic BI types of Clostridium difficile. J Infect Dis 2007; 196:1813-9. (Pubitemid 351411942)
19. Akerlund T, Svenungsson B, Lagergren A, Burman LG. Correlation of disease severity with fecal toxin levels in patients with Clostridium dif- ficile-associated diarrhea and distribution of PCR ribotypes and toxin yields in vitro of corresponding isolates. J Clin Microbiol 2006; 44:353-8. (Pubitemid 43222222)
20. Karlsson S, Burman LG, Akerlund T. Induction of toxins in Clostridium difficile is associated with dramatic changes of its metabolism. Microbiology 2008; 154:3430-6.
21. Williams DL, Slayden RA, Amin A, et al. Implications of high level pseudogene transcription in Mycobacterium leprae. BMC Genomics 2009; 10:397.
22. Guell M, van Noort V, Yus E, et al. Transcriptome complexity in a genome-reduced bacterium. Science 2009; 326:1268-71.
23. Henderson GB, Huennekens FM. Membrane-associated folate transport proteins. Methods Enzymol 1986; 122:260-9. (Pubitemid 16017516)
24. Bermingham A, Derrick JP. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays 2002; 24:637-48. (Pubitemid 34780351)
25. de Vries YP, Atmadja RD, Hornstra LM, de Vos WM, Abee T. Influence of glutamate on growth, sporulation, and spore properties of Bacillus cereus ATCC 14579 in defined medium. Appl Environ Microbiol 2005; 71:3248-54. (Pubitemid 40807236)
26. Gorke B, Stulke J. Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol 2008; 6:613-24. (Pubitemid 352006104)
27. Dupuy B, Sonenshein AL. Regulated transcription of Clostridium difficile toxin genes. Mol Microbiol 1998; 27:107-20. (Pubitemid 28022581)
28. Varga J, Stirewalt VL, Melville SB. The CcpA protein is necessary for efficient sporulation and enterotoxin gene (cpe) regulation in Clostridium perfringens. J Bacteriol 2004; 186:5221-9. (Pubitemid 39038125)
29. Mahe S, Corthier G, Dubos F. Effect of various diets on toxin production by two strains of Clostridium difficile in gnotobiotic mice. Infect Immun 1987; 55:1801-5.
30. Schulz S, Dickschat JS. Bacterial volatiles: the smell of small organisms. Nat Prod Rep 2007; 24:814-42. (Pubitemid 47106912)
31. Chen H, Fink GR. Feedback control of morphogenesis in fungi by aromatic alcohols. Genes Dev 2006; 20:1150-61.
32. Potrykus K, Cashel M. (p)ppGpp: still magical? Annu Rev Microbiol 2008; 62:35-51.
33. Shen Y, Liu J, Estiu G, et al. Blueprint for antimicrobial hit discovery targeting metabolic networks. Proc Natl Acad Sci U S A 2010; 107:1082-7.
34. Karp PD. Pathway Tools software and its role in antimicrobial drug discovery. In: Dougherty T, Projan S eds. Microbial genomics and drug discovery. New York: Marcel Dekker Inc., 2003; 43.