Design, synthesis and pharmacological evaluation of spirocyclic σ1 receptor ligands with exocyclic amino moiety (increased distance 1)

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 10, 2011, Pages 3141-3151

  Rack, Elisabeth ^a   Fröhlich, Roland ^a   Schepmann, Dirk ^a   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

1 Pharmacophore models; 1 Receptor ligands; Conformational analysis; Diastereoselectivity; Spirocyclic 1 ligands; Structure 1 affinity relationships; X ray

Indexed keywords

2 [2 (1 HYDROXY 4 OXOCYCLOHEXYL)PHENYL]ACETALDEHYDEDIMETHYL ACETAL; 3 METHOXY 3,4 DIHYDROSPIRO[2]BENZOPYRAN 1,1' CYCLOHEXAN 4' ONE; 3 METHOXY N,N DIMETHYL 3,4 DIHYDROSPIRO [[2]BENZOPYRAN 1,1' CYCLOHEXAN] 4'AMINE; N (4 METHOXYBENZYL) 3 METHOXY 3,4 DIHYDROSPIRO [[2]BENZOPYRAN 1,1' CYCLOHEXAN] 4'AMINE; N BENZYL 3 METHOXY 3,4 DIHYDROSPIRO[[20]BENZOPYRAN 1,1' CYCLOHEXAN] 4' AMINE; N,N DIBENZYL 3 METHOXY 3,4 DIHYDROSPIRO [[20]BENZOPYRAN 1,1' CYCLOHEXAN] 4' AMINE; SIGMA RECEPTOR LIGAND; SPIROCYCLIC SIGMA1 RECEPTOR LIGAND; UNCLASSIFIED DRUG;

AMINATION; ANIMAL TISSUE; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PHARMACOPHORE; PROTON TRANSPORT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMINES; ANIMALS; CELL MEMBRANE; GUINEA PIGS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; RATS; RECEPTORS, SIGMA; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79956193000     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.002     Document Type: Article

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