-
1
-
-
33751216840
-
The molecular pathogenesis of pancreatic cancer: Clarifying a complex circuitry
-
DOI 10.1101/gad.1501106
-
AK Rustgi 2006 The molecular pathogenesis of pancreatic cancer: clarifying a complex circuitry Genes Dev 20 3049 3053 17114578 10.1101/gad.1501106 1:CAS:528:DC%2BD28Xht1Gnt77I (Pubitemid 44790620)
-
(2006)
Genes and Development
, vol.20
, Issue.22
, pp. 3049-3053
-
-
Rustgi, A.K.1
-
2
-
-
18844431062
-
Pancreatic cancer: Basic and clinical aspects
-
DOI 10.1053/j.gastro.2005.04.001, PII S0016508505006323
-
G Schneider JT Siveke F Eckel RM Schmid 2005 Pancreatic cancer: basic and clinical aspects Gastroenterology 128 1606 1625 15887154 10.1053/j.gastro.2005. 04.001 1:CAS:528:DC%2BD2MXltlOgtbw%3D (Pubitemid 40692555)
-
(2005)
Gastroenterology
, vol.128
, Issue.6
, pp. 1606-1625
-
-
Schneider, G.1
Siveke, J.T.2
Eckel, F.3
Schmid, R.M.4
-
3
-
-
33646577163
-
Genetics and biology of pancreatic ductal adenocarcinoma
-
DOI 10.1101/gad.1415606
-
AF Hezel AC Kimmelman BZ Stanger N Bardeesy RA Depinho 2006 Genetics and biology of pancreatic ductal adenocarcinoma Genes Dev 20 1218 1249 16702400 10.1101/gad.1415606 1:CAS:528:DC%2BD28XltVyrtb4%3D (Pubitemid 43727584)
-
(2006)
Genes and Development
, vol.20
, Issue.10
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
Bardeesy, N.4
DePinho, R.A.5
-
5
-
-
1642312315
-
Genetic alterations in pancreatic carcinoma
-
DOI 10.1186/1476-4598-2-15
-
G Schneider RM Schmid 2003 Genetic alterations in pancreatic carcinoma Mol Cancer 2 15 12605716 10.1186/1476-4598-2-15 (Pubitemid 38751482)
-
(2003)
Molecular Cancer
, vol.2
, pp. 15
-
-
Schneider, G.1
Schmid, R.M.2
-
6
-
-
33749337828
-
The use of targeted mouse models for preclinical testing of novel cancer therapeutics
-
DOI 10.1158/1078-0432.CCR-06-0436
-
KP Olive DA Tuveson 2006 The use of targeted mouse models for preclinical testing of novel cancer therapeutics Clin Cancer Res 12 5277 5287 17000660 10.1158/1078-0432.CCR-06-0436 1:CAS:528:DC%2BD28XpvFShs7w%3D (Pubitemid 44497240)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.18
, pp. 5277-5287
-
-
Olive, K.P.1
Tuveson, D.A.2
-
7
-
-
67149143399
-
Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
19460966 10.1126/science.1171362 1:CAS:528:DC%2BD1MXntVSiu7Y%3D
-
KP Olive MA Jacobetz CJ Davidson A Gopinathan D McIntyre D Honess, et al. 2009 Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer Science 324 1457 1461 19460966 10.1126/science.1171362 1:CAS:528:DC%2BD1MXntVSiu7Y%3D
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
8
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
18772397 10.1126/science.1164368 1:CAS:528:DC%2BD1cXhtFCrtLrL
-
S Jones X Zhang DW Parsons JC Lin RJ Leary P Angenendt, et al. 2008 Core signaling pathways in human pancreatic cancers revealed by global genomic analyses Science 321 1801 1806 18772397 10.1126/science.1164368 1:CAS:528:DC%2BD1cXhtFCrtLrL
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
9
-
-
33744792310
-
Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
-
DOI 10.1101/gad.1424806
-
MG Rosenfeld VV Lunyak CK Glass 2006 Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response Genes Dev 20 1405 1428 16751179 10.1101/gad.1424806 1:CAS:528:DC%2BD28XlsF2ktLw%3D (Pubitemid 43830648)
-
(2006)
Genes and Development
, vol.20
, Issue.11
, pp. 1405-1428
-
-
Rosenfeld, M.G.1
Lunyak, V.V.2
Glass, C.K.3
-
10
-
-
0035839136
-
Translating the histone code
-
DOI 10.1126/science.1063127
-
T Jenuwein CD Allis 2001 Translating the histone code Science 293 1074 1080 11498575 10.1126/science.1063127 1:CAS:528:DC%2BD3MXmtVWltro%3D (Pubitemid 32758077)
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
11
-
-
77955150176
-
Targeting histone deacetylases in pancreatic ductal adenocarcinoma
-
19929947 10.1111/j.1582-4934.2009.00974.x 1:CAS:528:DC%2BC3cXhtVGksLvM
-
G Schneider OH Krämer P Fritsche S Schüler RM Schmid D Saur 2010 Targeting histone deacetylases in pancreatic ductal adenocarcinoma J Cell Mol Med 14 1255 1263 19929947 10.1111/j.1582-4934.2009.00974.x 1:CAS:528:DC%2BC3cXhtVGksLvM
-
(2010)
J Cell Mol Med
, vol.14
, pp. 1255-1263
-
-
Schneider, G.1
Krämer, O.H.2
Fritsche, P.3
Schüler, S.4
Schmid, R.M.5
Saur, D.6
-
12
-
-
39749127166
-
The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men
-
DOI 10.1038/nrm2346, PII NRM2346
-
XJ Yang E Seto 2008 The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men Nat Rev Mol Cell Biol 9 206 218 18292778 10.1038/nrm2346 1:CAS:528:DC%2BD1cXitlGnurk%3D (Pubitemid 351301825)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.3
, pp. 206-218
-
-
Yang, X.-J.1
Seto, E.2
-
13
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
19065135 10.1038/nrg2485 1:CAS:528:DC%2BD1cXhsFWis7bI
-
M Haberland RL Montgomery EN Olson 2009 The many roles of histone deacetylases in development and physiology: implications for disease and therapy Nat Rev Genet 10 32 42 19065135 10.1038/nrg2485 1:CAS:528:DC%2BD1cXhsFWis7bI
-
(2009)
Nat Rev Genet
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
14
-
-
56049090769
-
Acetylation of non-histone proteins modulates cellular signalling at multiple levels
-
18804549 10.1016/j.biocel.2008.08.027 1:CAS:528:DC%2BD1cXhsVWnu7zP
-
S Spange T Wagner T Heinzel OH Krämer 2009 Acetylation of non-histone proteins modulates cellular signalling at multiple levels Int J Biochem Cell Biol 41 185 198 18804549 10.1016/j.biocel.2008.08.027 1:CAS:528:DC%2BD1cXhsVWnu7zP
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 185-198
-
-
Spange, S.1
Wagner, T.2
Heinzel, T.3
Krämer, O.H.4
-
15
-
-
67349202438
-
HDACi-targets beyond chromatin
-
19342155 10.1016/j.canlet.2009.02.028 1:CAS:528:DC%2BD1MXmsF2jt7w%3D
-
M Buchwald OH Krämer T Heinzel 2009 HDACi-targets beyond chromatin Cancer Lett 280 160 167 19342155 10.1016/j.canlet.2009.02.028 1:CAS:528:DC%2BD1MXmsF2jt7w%3D
-
(2009)
Cancer Lett
, vol.280
, pp. 160-167
-
-
Buchwald, M.1
Krämer, O.H.2
Heinzel, T.3
-
16
-
-
34547897023
-
Histone deacetylases and cancer
-
DOI 10.1038/sj.onc.1210610, PII 1210610
-
MA Glozak E Seto 2007 Histone deacetylases and cancer Oncogene 26 5420 5432 17694083 10.1038/sj.onc.1210610 1:CAS:528:DC%2BD2sXovFeku7Y%3D (Pubitemid 47255924)
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
17
-
-
67650090545
-
Histone deacetylase inhibitors: Potential in cancer therapy
-
19459166 10.1002/jcb.22185 1:CAS:528:DC%2BD1MXosFOiurg%3D
-
PA Marks WS Xu 2009 Histone deacetylase inhibitors: potential in cancer therapy J Cell Biochem 107 600 608 19459166 10.1002/jcb.22185 1:CAS:528:DC%2BD1MXosFOiurg%3D
-
(2009)
J Cell Biochem
, vol.107
, pp. 600-608
-
-
Marks, P.A.1
Xu, W.S.2
-
18
-
-
41149162821
-
Expression of hypoxia-inducible factor-1α, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: Correlation with poor prognosis with possible regulation
-
DOI 10.1097/MPA.0b013e31815f2c2a, PII 0000667620080400000022
-
K Miyake T Yoshizumi S Imura K Sugimoto E Batmunkh H Kanemura, et al. 2008 Expression of hypoxia-inducible factor-1alpha, histone deacetylase 1, and metastasis-associated protein 1 in pancreatic carcinoma: correlation with poor prognosis with possible regulation Pancreas 36 e1 e9 18362831 10.1097/MPA.0b013e31815f2c2a 1:CAS:528:DC%2BD1cXkvVenur0%3D (Pubitemid 351440946)
-
(2008)
Pancreas
, vol.36
, Issue.3
-
-
Miyake, K.1
Yoshizumi, T.2
Imura, S.3
Sugimoto, K.4
Batmunkh, E.5
Kanemura, H.6
Morine, Y.7
Shimada, M.8
-
19
-
-
67649965963
-
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer
-
19424621 1:CAS:528:DC%2BD1MXmsVaqtrw%3D
-
W Wang J Gao XH Man ZS Li YF Gong 2009 Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer Oncol Rep 21 1439 1447 19424621 1:CAS:528:DC%2BD1MXmsVaqtrw%3D
-
(2009)
Oncol Rep
, vol.21
, pp. 1439-1447
-
-
Wang, W.1
Gao, J.2
Man, X.H.3
Li, Z.S.4
Gong, Y.F.5
-
20
-
-
70349309923
-
HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA
-
19528037 10.1136/gut.2009.180711 1:CAS:528:DC%2BD1MXhtlSks7bN
-
P Fritsche B Seidler S Schüler A Schnieke M Göttlicher RM Schmid, et al. 2009 HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA Gut 58 1399 1409 19528037 10.1136/gut.2009.180711 1:CAS:528:DC%2BD1MXhtlSks7bN
-
(2009)
Gut
, vol.58
, pp. 1399-1409
-
-
Fritsche, P.1
Seidler, B.2
Schüler, S.3
Schnieke, A.4
Göttlicher, M.5
Schmid, R.M.6
-
21
-
-
71049115609
-
High class i HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo
-
19912635 10.1186/1471-2407-9-395
-
A Lehmann C Denkert J Budczies AC Buckendahl S Darb-Esfahani A Noske BM Muller M Bahra P Neuhaus M Dietel G Kristiansen W Weichert 2009 High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo BMC Cancer 9 395 19912635 10.1186/1471-2407-9-395
-
(2009)
BMC Cancer
, vol.9
, pp. 395
-
-
Lehmann, A.1
Denkert, C.2
Budczies, J.3
Buckendahl, A.C.4
Darb-Esfahani, S.5
Noske, A.6
Muller, B.M.7
Bahra, M.8
Neuhaus, P.9
Dietel, M.10
Kristiansen, G.11
Weichert, W.12
-
22
-
-
48149115853
-
High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas
-
18506539 10.1245/s10434-008-9940-z
-
M Ouaissi I Sielezneff R Silvestre B Sastre JP Bernard JS Lafontaine, et al. 2008 High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas Ann Surg Oncol 15 2318 2328 18506539 10.1245/s10434-008-9940-z
-
(2008)
Ann Surg Oncol
, vol.15
, pp. 2318-2328
-
-
Ouaissi, M.1
Sielezneff, I.2
Silvestre, R.3
Sastre, B.4
Bernard, J.P.5
Lafontaine, J.S.6
-
23
-
-
49749105155
-
Apoptotic pathways in pancreatic ductal adenocarcinoma
-
18652674 10.1186/1476-4598-7-64
-
R Hamacher RM Schmid D Saur G Schneider 2008 Apoptotic pathways in pancreatic ductal adenocarcinoma Mol Cancer 7 64 18652674 10.1186/1476-4598-7-64
-
(2008)
Mol Cancer
, vol.7
, pp. 64
-
-
Hamacher, R.1
Schmid, R.M.2
Saur, D.3
Schneider, G.4
-
24
-
-
34748924281
-
Bcl-2-regulated apoptosis: Mechanism and therapeutic potential
-
DOI 10.1016/j.coi.2007.05.004, PII S0952791507000994, Hematopoietic cell death/Immunogenetics/Transplantation
-
JM Adams S Cory 2007 Bcl-2-regulated apoptosis: mechanism and therapeutic potential Curr Opin Immunol 19 488 496 17629468 10.1016/j.coi.2007.05.004 1:CAS:528:DC%2BD2sXhtFSmu7vN (Pubitemid 47487452)
-
(2007)
Current Opinion in Immunology
, vol.19
, Issue.5
, pp. 488-496
-
-
Adams, J.M.1
Cory, S.2
-
25
-
-
34249819032
-
BH3-only proteins trigger cytochrome c release, but how?
-
DOI 10.1016/j.abb.2006.12.022, PII S0003986106005030, Highlight Issue: Pro- and antiapoptotic Signalling
-
G Häcker A Weber 2007 BH3-only proteins trigger cytochrome c release, but how? Arch Biochem Biophys 462 150 155 17306210 10.1016/j.abb.2006. 12.022 (Pubitemid 46856314)
-
(2007)
Archives of Biochemistry and Biophysics
, vol.462
, Issue.2
, pp. 150-155
-
-
Hacker, G.1
Weber, A.2
-
27
-
-
70449675089
-
HDAC2: A critical factor in health and disease
-
19892411 10.1016/j.tips.2009.09.007
-
OH Krämer 2009 HDAC2: a critical factor in health and disease Trends Pharmacol Sci 30 647 655 19892411 10.1016/j.tips.2009.09.007
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 647-655
-
-
Krämer, O.H.1
-
28
-
-
0037925520
-
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
-
DOI 10.1093/emboj/cdg315
-
OH Krämer P Zhu HP Ostendorff M Golebiewski J Tiefenbach MA Peters, et al. 2003 The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2 EMBO J 22 3411 3420 12840003 10.1093/emboj/cdg315 (Pubitemid 36834871)
-
(2003)
EMBO Journal
, vol.22
, Issue.13
, pp. 3411-3420
-
-
Kramer, O.H.1
Zhu, P.2
Ostendorff, H.P.3
Golebiewski, M.4
Tiefenbach, J.5
Peters, M.A.6
Brill, B.7
Groner, B.8
Bach, I.9
Heinzel, T.10
Gottlicher, M.11
-
29
-
-
29144484694
-
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia
-
DOI 10.1002/cncr.21589
-
G Bug M Ritter B Wassmann C Schoch T Heinzel K Schwarz, et al. 2005 Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia Cancer 104 2717 2725 16294345 10.1002/cncr.21589 1:CAS:528:DC%2BD28XptlSktg%3D%3D (Pubitemid 41798282)
-
(2005)
Cancer
, vol.104
, Issue.12
, pp. 2717-2725
-
-
Bug, G.1
Ritter, M.2
Wassmann, B.3
Schoch, C.4
Heinzel, T.5
Schwarz, K.6
Romanski, A.7
Kramer, O.H.8
Kampfmann, M.9
Hoelzer, D.10
Neubauer, A.11
Ruthardt, M.12
Ottmann, O.G.13
-
30
-
-
38449110353
-
NF-kappaB as a molecular target in the therapy of pancreatic carcinoma
-
18084957 10.1007/978-3-540-71279-4-17 1:CAS:528:DC%2BD1cXhslSjtr8%3D
-
S Sebens A Arlt H Schäfer 2008 NF-kappaB as a molecular target in the therapy of pancreatic carcinoma Recent Results Cancer Res 177 151 164 18084957 10.1007/978-3-540-71279-4-17 1:CAS:528:DC%2BD1cXhslSjtr8%3D
-
(2008)
Recent Results Cancer Res
, vol.177
, pp. 151-164
-
-
Sebens, S.1
Arlt, A.2
Schäfer, H.3
-
31
-
-
33748052706
-
IKKα controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression
-
DOI 10.1038/sj.emboj.7601259, PII 7601259
-
G Schneider D Saur JT Siveke R Fritsch FR Greten RM Schmid 2006 IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression EMBO J 25 3801 3812 16902410 10.1038/sj.emboj.7601259 1:CAS:528:DC%2BD28XovVSqu7o%3D (Pubitemid 44300266)
-
(2006)
EMBO Journal
, vol.25
, Issue.16
, pp. 3801-3812
-
-
Schneider, G.1
Saur, D.2
Siveke, J.T.3
Fritsch, R.4
Greten, F.R.5
Schmid, R.M.6
-
33
-
-
33646345376
-
Ubiquitin ligases: Cell-cycle control and cancer
-
16633365 10.1038/nrc1881 1:CAS:528:DC%2BD28XjslGitb4%3D
-
KI Nakayama K Nakayama 2006 Ubiquitin ligases: cell-cycle control and cancer Nat Rev Cancer 6 369 381 16633365 10.1038/nrc1881 1:CAS:528: DC%2BD28XjslGitb4%3D
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 369-381
-
-
Nakayama, K.I.1
Nakayama, K.2
-
34
-
-
33646843794
-
High-level Skp2 expression in pancreatic ductal adenocarcinoma: Correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome
-
DOI 10.1097/01.mpa.0000220862.78248.c4, PII 0000667620060500000007
-
T Einama Y Kagata H Tsuda D Morita S Ogata S Ueda, et al. 2006 High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome Pancreas 32 376 381 16670630 10.1097/01.mpa.0000220862.78248.c4 1:CAS:528:DC%2BD28XlsFCqs7w%3D (Pubitemid 43772193)
-
(2006)
Pancreas
, vol.32
, Issue.4
, pp. 376-381
-
-
Einama, T.1
Kagata, Y.2
Tsuda, H.3
Morita, D.4
Ogata, S.5
Ueda, S.6
Takigawa, T.7
Kawarabayashi, N.8
Fukatsu, K.9
Sugiura, Y.10
Matsubara, O.11
Hatsuse, K.12
-
35
-
-
65549128635
-
New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
-
19383165 10.1186/1747-1028-4-7
-
KJ Stanya HY Kao 2009 New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR Cell Div 4 7 19383165 10.1186/1747-1028-4-7
-
(2009)
Cell Div
, vol.4
, pp. 7
-
-
Stanya, K.J.1
Kao, H.Y.2
-
36
-
-
34447307175
-
HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2
-
DOI 10.1111/j.1365-2184.2007.00454.x
-
G Schneider M Reichert D Saur R Hamacher R Fritsch RM Schmid 2007 HDAC3 is linked to cell cycle machinery in MiaPaCa2 cells by regulating transcription of skp2 Cell Prolif 40 522 531 17635519 10.1111/j.1365-2184.2007.00454.x 1:CAS:528:DC%2BD2sXhtVSksLbP (Pubitemid 47063293)
-
(2007)
Cell Proliferation
, vol.40
, Issue.4
, pp. 522-531
-
-
Schneider, G.1
Reichert, M.2
Saur, D.3
Hamacher, R.4
Fritsch, R.5
Schmid, R.M.6
-
37
-
-
33751252276
-
Cancer Metastasis: Building a Framework
-
DOI 10.1016/j.cell.2006.11.001, PII S0092867406014140
-
GP Gupta J Massague 2006 Cancer metastasis: building a framework Cell 127 679 695 17110329 10.1016/j.cell.2006.11.001 1:CAS:528:DC%2BD28Xht1yqs7rL (Pubitemid 44781029)
-
(2006)
Cell
, vol.127
, Issue.4
, pp. 679-695
-
-
Gupta, G.P.1
Massague, J.2
-
38
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
19945376 10.1016/j.cell.2009.11.007 1:CAS:528:DC%2BC3cXksFWltA%3D%3D
-
JP Thiery H Acloque RY Huang MA Nieto 2009 Epithelial-mesenchymal transitions in development and disease Cell 139 871 890 19945376 10.1016/j.cell.2009.11.007 1:CAS:528:DC%2BC3cXksFWltA%3D%3D
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
39
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
19487818 10.1172/JCI39104 1:CAS:528:DC%2BD1MXntVCjtr0%3D
-
R Kalluri RA Weinberg 2009 The basics of epithelial-mesenchymal transition J Clin Invest 119 1420 1428 19487818 10.1172/JCI39104 1:CAS:528:DC%2BD1MXntVCjtr0%3D
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
40
-
-
1042267263
-
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
-
U Cavallaro G Christofori 2004 Cell adhesion and signalling by cadherins and Ig-CAMs in cancer Nat Rev Cancer 4 118 132 14964308 10.1038/nrc1276 1:CAS:528:DC%2BD2cXhtlaquro%3D (Pubitemid 38198740)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.2
, pp. 118-132
-
-
Cavallaro, U.1
Christofori, G.2
-
41
-
-
67649200336
-
E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex
-
10.1053/j.gastro.2009.04.004 371 e361-365
-
J von Burstin S Eser MC Paul B Seidler M Brandl M Messer, et al. 2009 E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex Gastroenterology 137 361 371 10.1053/j.gastro.2009.04.004 371 e361-365
-
(2009)
Gastroenterology
, vol.137
, pp. 361-371
-
-
Von Burstin, J.1
Eser, S.2
Paul, M.C.3
Seidler, B.4
Brandl, M.5
Messer, M.6
-
42
-
-
34548078651
-
Epithelial to mesenchymal transition: Expression of the regulators snail, slug, and twist in pancreatic cancer
-
DOI 10.1158/1078-0432.CCR-06-2926
-
B Hotz M Arndt S Dullat S Bhargava HJ Buhr HG Hotz 2007 Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer Clin Cancer Res 13 4769 4776 17699854 10.1158/1078-0432.CCR- 06-2926 1:CAS:528:DC%2BD2sXptVGmtrY%3D (Pubitemid 47294783)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4769-4776
-
-
Hotz, B.1
Arndt, M.2
Dullat, S.3
Bhargava, S.4
Buhr, H.-J.5
Hotz, H.G.6
-
43
-
-
65249180911
-
Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling
-
19088080 10.1074/jbc.M807791200 1:CAS:528:DC%2BD1MXisVSkur4%3D
-
MJ Truty G Lomberk ME Fernandez-Zapico R Urrutia 2009 Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling J Biol Chem 284 6291 6300 19088080 10.1074/jbc.M807791200 1:CAS:528: DC%2BD1MXisVSkur4%3D
-
(2009)
J Biol Chem
, vol.284
, pp. 6291-6300
-
-
Truty, M.J.1
Lomberk, G.2
Fernandez-Zapico, M.E.3
Urrutia, R.4
-
44
-
-
69449089064
-
Sin3: Master scaffold and transcriptional corepressor
-
19505602 1:CAS:528:DC%2BD1MXhtV2ksrrK
-
A Grzenda G Lomberk JS Zhang R Urrutia 2009 Sin3: master scaffold and transcriptional corepressor Biochim Biophys Acta 1789 443 450 19505602 1:CAS:528:DC%2BD1MXhtV2ksrrK
-
(2009)
Biochim Biophys Acta
, vol.1789
, pp. 443-450
-
-
Grzenda, A.1
Lomberk, G.2
Zhang, J.S.3
Urrutia, R.4
-
45
-
-
47549090432
-
TGFβ in Cancer
-
DOI 10.1016/j.cell.2008.07.001, PII S0092867408008787
-
J Massague 2008 TGFbeta in cancer Cell 134 215 230 18662538 10.1016/j.cell.2008.07.001 1:CAS:528:DC%2BD1cXptlaltbk%3D (Pubitemid 352010335)
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 215-230
-
-
Massague, J.1
-
46
-
-
45949086682
-
TGFβ-regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer
-
V Ellenrieder 2008 TGFbeta regulated gene expression by Smads and Sp1/KLF-like transcription factors in cancer Anticancer Res 28 1531 1539 18630508 1:CAS:528:DC%2BD1cXos1WktLg%3D (Pubitemid 351892926)
-
(2008)
Anticancer Research
, vol.28
, Issue.3 A
, pp. 1531-1539
-
-
Ellenrieder, V.1
-
47
-
-
0034067359
-
Differential expression of transforming growth factor β receptors in human pancreatic adenocarcinoma
-
K Venkatasubbarao MM Ahmed M Mohiuddin C Swiderski E Lee WR Gower Jr, et al. 2000 Differential expression of transforming growth factor beta receptors in human pancreatic adenocarcinoma Anticancer Res 20 43 51 10769633 1:CAS:528:DC%2BD3cXisl2nsrk%3D (Pubitemid 30189732)
-
(2000)
Anticancer Research
, vol.20
, Issue.1 A
, pp. 43-51
-
-
Venkatasubbarao, K.1
Ahmed, M.M.2
Mohiuddin, M.3
Swiderski, C.4
Lee, E.5
Gower Jr., W.R.6
Salhab, K.F.7
McGrath, P.8
Strodel, W.9
Freeman, J.W.10
-
48
-
-
33751247898
-
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-β signaling in cooperation with active Kras expression
-
DOI 10.1101/gad.1475506
-
H Ijichi A Chytil AE Gorska ME Aakre Y Fujitani S Fujitani, et al. 2006 Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression Genes Dev 20 3147 3160 17114585 10.1101/gad.1475506 1:CAS:528:DC%2BD28Xht1Gnt7%2FP (Pubitemid 44790629)
-
(2006)
Genes and Development
, vol.20
, Issue.22
, pp. 3147-3160
-
-
Ijichi, H.1
Chytil, A.2
Gorska, A.E.3
Aakre, M.E.4
Fujitani, Y.5
Fujitani, S.6
Wright, C.V.E.7
Moses, H.L.8
-
49
-
-
0032404111
-
Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
-
M Goggins M Shekher K Turnacioglu CJ Yeo RH Hruban SE Kern 1998 Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas Cancer Res 58 5329 5332 9850059 1:CAS:528: DyaK1cXotVSkt7g%3D (Pubitemid 28551110)
-
(1998)
Cancer Research
, vol.58
, Issue.23
, pp. 5329-5332
-
-
Goggins, M.1
Shekher, M.2
Turnacioglu, K.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
50
-
-
0038519756
-
Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor β type II receptor expression in human pancreatic cancer cells
-
S Zhao K Venkatasubbarao S Li JW Freeman 2003 Requirement of a specific Sp1 site for histone deacetylase-mediated repression of transforming growth factor beta Type II receptor expression in human pancreatic cancer cells Cancer Res 63 2624 2630 12750289 1:CAS:528:DC%2BD3sXjsleht7o%3D (Pubitemid 36605205)
-
(2003)
Cancer Research
, vol.63
, Issue.10
, pp. 2624-2630
-
-
Zhao, S.1
Venkatasubbarao, K.2
Li, S.3
Freeman, J.W.4
-
51
-
-
15444362640
-
Trichostatin A induces transforming growth factor β type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1NF-Y complex
-
DOI 10.1074/jbc.M408680200
-
W Huang S Zhao S Ammanamanchi M Brattain K Venkatasubbarao JW Freeman 2005 Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex J Biol Chem 280 10047 1054 15647279 10.1074/jbc.M408680200 1:CAS:528:DC%2BD2MXit1ektLc%3D (Pubitemid 40395856)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.11
, pp. 10047-10054
-
-
Huang, W.1
Zhao, S.2
Ammanamanchi, S.3
Brattain, M.4
Venkatasubbarao, K.5
Freeman, J.W.6
-
52
-
-
0034912742
-
Histone acetyltransferases
-
DOI 10.1146/annurev.biochem.70.1.81
-
SY Roth JM Denu CD Allis 2001 Histone acetyltransferases Annu Rev Biochem 70 81 120 11395403 10.1146/annurev.biochem.70.1.81 1:CAS:528: DC%2BD3MXlsVehtrc%3D (Pubitemid 32662206)
-
(2001)
Annual Review of Biochemistry
, vol.70
, pp. 81-120
-
-
Roth, S.Y.1
Denu, J.M.2
Allis, C.D.3
-
53
-
-
59449087016
-
Histone modifying enzymes: Structures, mechanisms, and specificities
-
18722564 1:CAS:528:DC%2BD1cXhsVOis7bJ
-
R Marmorstein RC Trievel 2009 Histone modifying enzymes: structures, mechanisms, and specificities Biochim Biophys Acta 1789 58 68 18722564 1:CAS:528:DC%2BD1cXhsVOis7bJ
-
(2009)
Biochim Biophys Acta
, vol.1789
, pp. 58-68
-
-
Marmorstein, R.1
Trievel, R.C.2
-
54
-
-
56249097914
-
Chromatin-modifying enzymes as therapeutic targets-part 2
-
18851700 10.1517/14728222.12.11.1457
-
BR Keppler TK Archer 2008 Chromatin-modifying enzymes as therapeutic targets-part 2 Expert Opin Ther Targets 12 1457 1467 18851700 10.1517/14728222.12.11.1457
-
(2008)
Expert Opin Ther Targets
, vol.12
, pp. 1457-1467
-
-
Keppler, B.R.1
Archer, T.K.2
-
55
-
-
73449085536
-
EP300-a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas
-
19569050 10.1002/ijc.24695 1:CAS:528:DC%2BD1MXhsVamtL7L
-
ST Mees WA Mardin C Wendel N Baeumer E Willscher N Senninger, et al. 2010 EP300-a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas Int J Cancer 126 114 124 19569050 10.1002/ijc.24695 1:CAS:528:DC%2BD1MXhsVamtL7L
-
(2010)
Int J Cancer
, vol.126
, pp. 114-124
-
-
Mees, S.T.1
Mardin, W.A.2
Wendel, C.3
Baeumer, N.4
Willscher, E.5
Senninger, N.6
-
56
-
-
33645294070
-
Oncomirs-microRNAs with a role in cancer
-
16557279 10.1038/nrc1840 1:CAS:528:DC%2BD28XivVyqtrs%3D
-
A Esquela-Kerscher FJ Slack 2006 Oncomirs-microRNAs with a role in cancer Nat Rev Cancer 6 259 269 16557279 10.1038/nrc1840 1:CAS:528: DC%2BD28XivVyqtrs%3D
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
57
-
-
0034104047
-
Mutations truncating the EP300 acetylase in human cancers
-
DOI 10.1038/73536
-
SA Gayther SJ Batley L Linger A Bannister K Thorpe SF Chin, et al. 2000 Mutations truncating the EP300 acetylase in human cancers Nat Genet 24 300 303 10700188 10.1038/73536 1:CAS:528:DC%2BD3cXhvFaqtL4%3D (Pubitemid 30132203)
-
(2000)
Nature Genetics
, vol.24
, Issue.3
, pp. 300-303
-
-
Gayther, S.A.1
Batley, S.J.2
Linger, L.3
Bannister, A.4
Thorpe, K.5
Chin, S.-F.6
Daigo, Y.7
Russell, P.8
Wilson, A.9
Sowter, H.M.10
Delhanty, J.D.A.11
Ponder, B.A.J.12
Kouzarides, T.13
Caldas, C.14
-
58
-
-
77249176619
-
NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells
-
A König T Linhart K Schlengemann K Reutlinger J Wegele G Adler, et al. 2009 NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells Gastroenterology 138 1189-99 e1 e2
-
(2009)
Gastroenterology
, vol.138
, Issue.118
-
-
König, A.1
Linhart, T.2
Schlengemann, K.3
Reutlinger, K.4
Wegele, J.5
Adler, G.6
-
59
-
-
54349087788
-
Myc's broad reach
-
18923074 10.1101/gad.1712408 1:CAS:528:DC%2BD1cXht12ht7zE
-
M Eilers RN Eisenman 2008 Myc's broad reach Genes Dev 22 2755 2766 18923074 10.1101/gad.1712408 1:CAS:528:DC%2BD1cXht12ht7zE
-
(2008)
Genes Dev
, vol.22
, pp. 2755-2766
-
-
Eilers, M.1
Eisenman, R.N.2
-
60
-
-
0036229486
-
c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: Incidence, mechanisms, and clinical significance
-
DOI 10.1038/modpathol.3880547
-
C Schleger C Verbeke R Hildenbrand H Zentgraf U Bleyl 2002 c-MYC activation in primary and metastatic ductal adenocarcinoma of the pancreas: incidence, mechanisms, and clinical significance Mod Pathol 15 462 469 11950922 10.1038/modpathol.3880547 1:STN:280:DC%2BD383hsVGhsQ%3D%3D (Pubitemid 34326956)
-
(2002)
Modern Pathology
, vol.15
, Issue.4
, pp. 462-469
-
-
Schleger, C.1
Verbeke, C.2
Hildenbrand, R.3
Zentgraf, H.4
Bleyl, U.5
-
61
-
-
17444408560
-
Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis
-
15810077 1:CAS:528:DC%2BD2MXktlWrsbc%3D
-
YJ Li ZM Wei YX Meng XR Ji 2005 Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis World J Gastroenterol 11 2117 2123 15810077 1:CAS:528:DC%2BD2MXktlWrsbc%3D
-
(2005)
World J Gastroenterol
, vol.11
, pp. 2117-2123
-
-
Li, Y.J.1
Wei, Z.M.2
Meng, Y.X.3
Ji, X.R.4
-
62
-
-
0036883715
-
Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer
-
DOI 10.1002/gcc.10122
-
EH Mahlamaki M Barlund M Tanner L Gorunova M Hoglund R Karhu, et al. 2002 Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer Genes Chromosom Cancer 35 353 358 12378529 10.1002/gcc.10122 1:CAS:528:DC%2BD38XptVGis70%3D (Pubitemid 35246993)
-
(2002)
Genes Chromosomes and Cancer
, vol.35
, Issue.4
, pp. 353-358
-
-
Mahlamaki, E.H.1
Barlund, M.2
Tanner, M.3
Gorunova, L.4
Hoglund, M.5
Karhu, R.6
Kallioniemi, A.7
-
63
-
-
73349115238
-
PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells
-
19603422 10.1002/mc.20569 1:CAS:528:DC%2BD1MXhsVyls7vL
-
C Schild M Wirth M Reichert RM Schmid D Saur G Schneider 2009 PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells Mol Carcinog 48 1149 1158 19603422 10.1002/mc.20569 1:CAS:528:DC%2BD1MXhsVyls7vL
-
(2009)
Mol Carcinog
, vol.48
, pp. 1149-1158
-
-
Schild, C.1
Wirth, M.2
Reichert, M.3
Schmid, R.M.4
Saur, D.5
Schneider, G.6
-
64
-
-
33747616250
-
2+/calcineurin signaling pathway
-
DOI 10.1038/sj.emboj.7601246, PII 7601246
-
M Buchholz A Schatz M Wagner P Michl T Linhart G Adler, et al. 2006 Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway EMBO J 25 3714 3724 16874304 10.1038/sj.emboj.7601246 1:CAS:528:DC%2BD28XnvVGlsLk%3D (Pubitemid 44264881)
-
(2006)
EMBO Journal
, vol.25
, Issue.15
, pp. 3714-3724
-
-
Buchholz, M.1
Schatz, A.2
Wagner, M.3
Michl, P.4
Linhart, T.5
Adler, G.6
Gress, T.M.7
Ellenrieder, V.8
-
65
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
15765097 10.1038/ng1531 1:CAS:528:DC%2BD2MXislCmurg%3D
-
MF Fraga E Ballestar A Villar-Garea M Boix-Chornet J Espada G Schotta, et al. 2005 Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer Nat Genet 37 391 400 15765097 10.1038/ng1531 1:CAS:528:DC%2BD2MXislCmurg%3D
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
-
66
-
-
21744457108
-
Global histone modification patterns predict risk of prostate cancer recurrence
-
DOI 10.1038/nature03672
-
DB Seligson S Horvath T Shi H Yu S Tze M Grunstein, et al. 2005 Global histone modification patterns predict risk of prostate cancer recurrence Nature 435 1262 1266 15988529 10.1038/nature03672 1:CAS:528:DC%2BD2MXls1Ontbg%3D (Pubitemid 40943093)
-
(2005)
Nature
, vol.435
, Issue.7046
, pp. 1262-1266
-
-
Seligson, D.B.1
Horvath, S.2
Shi, T.3
Yu, H.4
Tze, S.5
Grunstein, M.6
Kurdistani, S.K.7
-
67
-
-
77950510166
-
Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: Results from RTOG 9704
-
20142597 10.1200/JCO.2009.24.5639 1:CAS:528:DC%2BC3cXksFSqur4%3D
-
A Manuyakorn R Paulus J Farrell NA Dawson S Tze G Cheung-Lau, et al. 2010 Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704 J Clin Oncol 28 1358 1365 20142597 10.1200/JCO.2009.24.5639 1:CAS:528:DC%2BC3cXksFSqur4%3D
-
(2010)
J Clin Oncol
, vol.28
, pp. 1358-1365
-
-
Manuyakorn, A.1
Paulus, R.2
Farrell, J.3
Dawson, N.A.4
Tze, S.5
Cheung-Lau, G.6
|