-
1
-
-
46449110634
-
One hundred years after "carcinoid": Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
-
Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008; 26: 3063-3072.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3063-3072
-
-
Yao, J.C.1
Hassan, M.2
Phan, A.3
-
2
-
-
52449104598
-
Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors
-
Modlin IM, Moss SF, Chung DC, et al. Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors. J Natl Cancer Inst 2008; 100: 1282-1289.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1282-1289
-
-
Modlin, I.M.1
Moss, S.F.2
Chung, D.C.3
-
3
-
-
53849134827
-
Somatostatin analogues in the control of neuroendocrine tumors: Efficacy and mechanisms
-
Grozinsky-Glasberg S, Shimon I, Korbonits M, et al. Somatostatin analogues in the control of neuroendocrine tumors: efficacy and mechanisms. Endocr Relat Cancer 2008; 15: 701-720.
-
(2008)
Endocr Relat Cancer
, vol.15
, pp. 701-720
-
-
Grozinsky-Glasberg, S.1
Shimon, I.2
Korbonits, M.3
-
4
-
-
66549116148
-
Neuroendocrine gastroenteropancreatic tumors: ESMO Clinical Recommendation for diagnosis, treatment and follow-up
-
on behalf of the ESMO Guidelines Working Group
-
Ö berg K, Jelic S, on behalf of the ESMO Guidelines Working Group. Neuroendocrine gastroenteropancreatic tumors: ESMO Clinical Recommendation for diagnosis, treatment and follow-up. Ann Oncol 2009; 20 Suppl. 4: iv150-153.
-
(2009)
Ann Oncol
, vol.20
, Issue.SUPPL. 4
-
-
Öberg, K.1
Jelic, S.2
-
5
-
-
38449109564
-
Molecular mechanisms of the antiproliferative activity of somatostatin receptors (sstrs) in neuroendocrine tumors
-
Florio T. Molecular mechanisms of the antiproliferative activity of somatostatin receptors (sstrs) in neuroendocrine tumors. Front Biosci 2008; 13: 822-840.
-
(2008)
Front Biosci
, vol.13
, pp. 822-840
-
-
Florio, T.1
-
6
-
-
0034662634
-
Insulin-like growth factor-I is an autocrine regulator of chromogranin a secretion and growth in human neuroendocrine tumor cells
-
von Wichert G, Jehle PM, Hoeflich A, et al. Insulin-like growth factor-I is an autocrine regulator of chromagranin A secretion and growth in human neuroendocrine tumor cells. Cancer Res 2000; 60: 4573-4581. (Pubitemid 32103642)
-
(2000)
Cancer Research
, vol.60
, Issue.16
, pp. 4573-4581
-
-
Von Wichert, G.1
Jehle, P.M.2
Hoeflich, A.3
Koschnick, S.4
Dralle, H.5
Wolf, E.6
Wiedenmann, B.7
Boehm, B.O.8
Adler, G.9
Seufferlein, T.10
-
8
-
-
0026526078
-
Presence of IGF-I in human midgut carcinoid tumours: An autocrine regulator of carcinoid tumour growth?
-
Nilsson O, Wä ngberg B, Theodorsson E, et al. Presence of IGF-I in human midgut carcinoid tumours: an autocrine regulator of carcinoid tumour growth? Int J Cancer 1992; 51: 195-203.
-
(1992)
Int J Cancer
, vol.51
, pp. 195-203
-
-
Nilsson, O.1
Wängberg, B.2
Theodorsson, E.3
-
9
-
-
77956229765
-
Expression and activation of mTOR in neuroendocrine tumors: Effects of mTOR inhibition by RAD001 upon growth, cell cycle regulation, and signaling in neuroendocrine cell lines [abstract no. 10570]
-
Hö rsch D, Tielke S, Schrader J. Expression and activation of mTOR in neuroendocrine tumors: effects of mTOR inhibition by RAD001 upon growth, cell cycle regulation, and signaling in neuroendocrine cell lines [abstract no. 10570]. J Clin Oncol 2007; 25 (18S): 582s.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Hörsch, D.1
Tielke, S.2
Schrader, J.3
-
10
-
-
42449118823
-
Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell line
-
DOI 10.1159/000111501
-
Grozinsky-Glasberg S, Franchi G, TengM, et al. Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell line. Neuroendocrinology 2008; 87: 168-181. (Pubitemid 351563811)
-
(2008)
Neuroendocrinology
, vol.87
, Issue.3
, pp. 168-181
-
-
Grozinsky-Glasberg, S.1
Franchi, G.2
Teng, M.3
Leontiou, C.A.4
Ribeiro De Oliveira Jr., A.5
Dalino, P.6
Salahuddin, N.7
Korbonits, M.8
Grossman, A.B.9
-
11
-
-
0037323565
-
The pathophysiological consequences of somatostatin receptor internalization and resistance
-
DOI 10.1210/er.2000-0001
-
Hofland LJ, Lamberts SWJ. The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocr Rev 2003; 24: 28-47. (Pubitemid 36223278)
-
(2003)
Endocrine Reviews
, vol.24
, Issue.1
, pp. 28-47
-
-
Hofland, L.J.1
Lamberts, S.W.J.2
-
12
-
-
0030054029
-
Octreotide
-
DOI 10.1056/NEJM199601253340408
-
Lamberts SW, van der Lely AJ, de Herder WW, et al. Octreotide. N Engl J Med 1996; 334: 246-254. (Pubitemid 26030676)
-
(1996)
New England Journal of Medicine
, vol.334
, Issue.4
, pp. 246-254
-
-
Lamberts, S.W.J.1
Van Der Lely, A.-J.2
De Herder, W.W.3
Hofland, L.J.4
-
13
-
-
3442884868
-
Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system
-
DOI 10.1093/annonc/mdh216
-
Ö berg K, Kvols L, Caplin M, et al. Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. Ann Oncol 2004; 15: 966-973. (Pubitemid 39004355)
-
(2004)
Annals of Oncology
, vol.15
, Issue.6
, pp. 966-973
-
-
Oberg, K.1
Kvols, L.2
Caplin, M.3
Dell Fave, G.4
De Herder, W.5
Rindi, G.6
Ruszniewski, P.7
Woltering, E.A.8
Wiedenmann, B.9
-
14
-
-
72949085528
-
Review articles: Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours
-
Modlin IM, Pavel M, Kidd M, et al. Review articles: somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine (carcinoid) tumours. Aliment Pharmacol Ther 2010; 31: 169-188.
-
(2010)
Aliment Pharmacol Ther
, vol.31
, pp. 169-188
-
-
Modlin, I.M.1
Pavel, M.2
Kidd, M.3
-
15
-
-
47549085629
-
Expression of vascular endothelial growth factor in growth hormone-secreting pituitary adenomas: Special reference to the octreotide treatment
-
DOI 10.1179/174313208X289499
-
KurosakiM, Saeger W, Abe T, et al. Expression of vascular endothelial growth factor in growth hormone-secreting pituitary adenomas: special reference to the octreotide treatment. Neurol Res 2008; 30: 518-522. (Pubitemid 352008712)
-
(2008)
Neurological Research
, vol.30
, Issue.5
, pp. 518-522
-
-
Kurosaki, M.1
Saeger, W.2
Abe, T.3
Ludecke, D.K.4
-
16
-
-
0029899285
-
Somatostatin receptor imaging: Predictive and prognostic considerations
-
Anthony LB, Martin W, Delbeke D, et al. Somatostatin receptor imaging: predictive and prognostic considerations. Digestion 1996; 57: 50-53. (Pubitemid 26183922)
-
(1996)
Digestion
, vol.57
, Issue.SUPPL. 1
, pp. 50-53
-
-
Anthony, L.B.1
Martin, W.2
Delbeke, D.3
Sandler, M.4
-
17
-
-
77649334249
-
Metastatic carcinoid tumor: Changing patterns of care over two decades
-
Townsend A, Price T, Yeend S, et al. Metastatic carcinoid tumor: changing patterns of care over two decades. J Clin Gastroenterol 2010; 44: 195-199.
-
(2010)
J Clin Gastroenterol
, vol.44
, pp. 195-199
-
-
Townsend, A.1
Price, T.2
Yeend, S.3
-
18
-
-
0035040838
-
Antitumour activity of somatostatin analogues in progressive metastatic neuroendocrine tumours
-
DOI 10.1016/S0959-8049(01)00073-9, PII S0959804901000739
-
Aparicio T, Ducreux M, Baudin E, et al. Antitumor activity of somatostatin analogues in progressive metastatic neuroendocrine tumors. Eur J Cancer 2001; 37: 1014-1019. (Pubitemid 32397687)
-
(2001)
European Journal of Cancer
, vol.37
, Issue.8
, pp. 1014-1019
-
-
Aparicio, T.1
Ducreux, M.2
Baudin, E.3
Sabourin, J.-C.4
De Baere, T.5
Mitry, E.6
Schlumberger, M.7
Rougier, P.8
-
19
-
-
33644692000
-
Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated entero-pancreatic endocrine carcinoma
-
DOI 10.1093/annonc/mdj113
-
Panzuto F, Di Fonzo M, Iannicelli E, et al. Long-term clinical outcome of somatostatin analogues for treatment of progressive, metastatic, well-differentiated enteropancreatic endocrine carcinoma. Ann Oncol 2006; 17: 461-466. (Pubitemid 43329584)
-
(2006)
Annals of Oncology
, vol.17
, Issue.3
, pp. 461-466
-
-
Panzuto, F.1
Di Fonzo, M.2
Iannicelli, E.3
Sciuto, R.4
Maini, C.L.5
Capurso, G.6
Milione, M.7
Cattaruzza, M.S.8
Falconi, M.9
David, V.10
Ziparo, V.11
Pederzoli, P.12
Bordi, C.13
Delle Fave, G.14
-
20
-
-
70350442637
-
Placebo controlled double-blind prospective randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: A report from the PROMID Study Group
-
Rinke A, Mü ller HH, Schade-Brittinger C, et al. Placebo controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 2009; 27: 4656-4663.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4656-4663
-
-
Rinke, A.1
Müller, H.H.2
Schade-Brittinger, C.3
-
21
-
-
79956154070
-
Efficacy and safety results from a phase II study of pasireotide (SOM230) in the treatment of patients with metastatic NET refractory or resistant to octreotide LAR [poster presentation C57]
-
Mar 11-12; Berlin
-
Kvols L, Wiedenmann B, Ö berg K, et al. Efficacy and safety results from a phase II study of pasireotide (SOM230) in the treatment of patients with metastatic NET refractory or resistant to octreotide LAR [poster presentation C57]. Conference of the European Neuroendocrine Tumour Society; 2010 Mar 11-12; Berlin.
-
(2010)
Conference of the European Neuroendocrine Tumour Society
-
-
Kvols, L.1
Wiedenmann, B.2
Öberg, K.3
-
24
-
-
33847221165
-
Mechanisms of disease: Metabolic effects of growth hormone and insulin-like growth factor 1
-
LeRoith D, Yakar S. Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab 2007; 3: 302-310.
-
(2007)
Nat Clin Pract Endocrinol Metab
, vol.3
, pp. 302-310
-
-
Leroith, D.1
Yakar, S.2
-
25
-
-
0024443313
-
Somatostatin analogue SMS 201-995 reduces serum IGF-I levels in patients with neoplasms potentially dependent on IGF-I
-
Pollak MN, Polychronakos C, Guyda H. Somatostatin analogue SMS 201-995 reduces serum IGF-I levels in patients with neoplasms potentially dependent on IGF-I. Anticancer Res 1989; 9: 889-892. (Pubitemid 19266323)
-
(1989)
Anticancer Research
, vol.9
, Issue.4
, pp. 889-892
-
-
Pollak, M.N.1
Polychronakos, C.2
Guyda, H.3
-
26
-
-
79956125109
-
Inhibitory effect of pasireotide in a rat pancreatic tumor model (CA20948) alone and in combination with everolimus (RAD001) [poster]
-
Apr 18-22; Denver (CO)
-
Schmid HA, Stumm M, McSheehy P, et al. Inhibitory effect of pasireotide in a rat pancreatic tumor model (CA20948) alone and in combination with everolimus (RAD001) [poster]. Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver (CO).
-
(2009)
Annual Meeting of the American Association for Cancer Research
-
-
Schmid, H.A.1
Stumm, M.2
McSheehy, P.3
-
27
-
-
79956090359
-
Effect of the somatostatin analog octreotide acetate on circulating IGF-1 and on PSA in patients with castration-resistant prostate cancer (CRPC): Results of a phase II study [abstract no. 99 plus poster]
-
Mar 5-7; San Francisco (CA)
-
Friedlander T, Weinberg V, Sharib J, et al. Effect of the somatostatin analog octreotide acetate on circulating IGF-1 and on PSA in patients with castration-resistant prostate cancer (CRPC): results of a phase II study [abstract no. 99 plus poster]. Genitourinary Cancers Symposium; 2010 Mar 5-7; San Francisco (CA).
-
(2010)
Genitourinary Cancers Symposium
-
-
Friedlander, T.1
Weinberg, V.2
Sharib, J.3
-
28
-
-
64549086809
-
Pituitaryindependent effect of octreotide on IGF1 generation
-
Pokrajac A, Frystyk J, Flyvbjerg A, et al. Pituitaryindependent effect of octreotide on IGF1 generation. Eur J Endocrinol 2009; 160: 543-548.
-
(2009)
Eur J Endocrinol
, vol.160
, pp. 543-548
-
-
Pokrajac, A.1
Frystyk, J.2
Flyvbjerg, A.3
-
29
-
-
79951812671
-
A phase II clinical trial ofMK-0646 an insulin-like growth factor-1 receptor inhibitor (IGF-1R) in patients with metastatic well-differentiated neuroendocrine tumors (NETs) [abstract no. 4163]
-
ReidyDL, Hollywood E, Segal M, et al.A phase II clinical trial ofMK-0646, an insulin-like growth factor-1 receptor inhibitor (IGF-1R), in patients with metastatic well-differentiated neuroendocrine tumors (NETs) [abstract no. 4163]. J Clin Oncol 2010; 28 Suppl.: 15s.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Reidy, D.L.1
Hollywood, E.2
Segal, M.3
-
30
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
DOI 10.1038/nrd2062, PII NRD2062
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006; 5 (8): 671-688. (Pubitemid 44151605)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.8
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
31
-
-
65549167833
-
Targeting the mTOR signaling network for cancer therapy
-
Meric-Bernstam F, Gonzalez-Angulo AM. Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 2009; 27 (13): 2278-2287.
-
(2009)
J Clin Oncol
, vol.27
, Issue.13
, pp. 2278-2287
-
-
Meric-Bernstam, F.1
Gonzalez-Angulo, A.M.2
-
32
-
-
77649190362
-
Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
-
Shida T, Kishimoto T, Furuya M, et al. Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors. Cancer Chemother Pharmacol 2010; 65: 889-893.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 889-893
-
-
Shida, T.1
Kishimoto, T.2
Furuya, M.3
-
33
-
-
36549057831
-
Emerging drugs for the treatment of metastatic renal cancer
-
DOI 10.1517/14728214.12.4.605
-
Samlowski WE, Vogelzang NJ. Emerging drugs for the treatment of metastatic renal cancer. Expert Opin Emerg Drugs 2007; 12: 605-618. (Pubitemid 350189126)
-
(2007)
Expert Opinion on Emerging Drugs
, vol.12
, Issue.4
, pp. 605-618
-
-
Samlowski, W.E.1
Vogelzang, N.J.2
-
34
-
-
74949122343
-
Pancreatic endocrine tumors: Expression profiling evidences a role for AktmTOR pathway
-
Missiaglia E, Dalai I, Barbi S, et al. Pancreatic endocrine tumors: expression profiling evidences a role for AktmTOR pathway. J Clin Oncol 2010; 28: 245-255.
-
(2010)
J Clin Oncol
, vol.28
, pp. 245-255
-
-
Missiaglia, E.1
Dalai, I.2
Barbi, S.3
-
36
-
-
41349119602
-
Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
-
DOI 10.1677/ERC-07-0202
-
Moreno A, Akcakanat A, Munsell MF, et al. Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors. Endocr Relat Cancer 2008; 15: 257-266. (Pubitemid 351449744)
-
(2008)
Endocrine-Related Cancer
, vol.15
, Issue.1
, pp. 257-266
-
-
Moreno, A.1
Akcakanat, A.2
Munsell, M.F.3
Soni, A.4
Yao, J.C.5
Meric-Bernstam, F.6
-
37
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
DOI 10.1073/pnas.171076798
-
Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98: 10314-0319. (Pubitemid 32803017)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.18
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
38
-
-
84877744162
-
PI3K suppression by the mTOR inhibitor ridaforolimus and the AKT inhibitor MK-2206 is associated with enhanced anti-tumor activity and hyperglycemia in preclinicalmodels [abstract no. 3478]
-
Apr 17-21;Washington (DC)
-
Artime MC, Blackman S, Ebbinghaus S, et al. PI3K suppression by the mTOR inhibitor ridaforolimus and the AKT inhibitor MK-2206 is associated with enhanced anti-tumor activity and hyperglycemia in preclinicalmodels [abstract no. 3478]. Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21;Washington (DC).
-
(2010)
Annual Meeting of the American Association for Cancer Research
-
-
Artime, M.C.1
Blackman, S.2
Ebbinghaus, S.3
-
39
-
-
34047255081
-
The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells
-
DOI 10.1159/000100057
-
Zitzmann K, De Toni EN, Brand S, et al. The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. Neuroendocrinology 2007; 85: 54-60. (Pubitemid 46550026)
-
(2007)
Neuroendocrinology
, vol.85
, Issue.1
, pp. 54-60
-
-
Zitzmann, K.1
De Toni, E.N.2
Brand, S.3
Goke, B.4
Meinecke, J.5
Spottl, G.6
Meyer, H.H.D.7
Auernhammer, C.J.8
-
40
-
-
33750510023
-
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
-
DOI 10.1038/sj.bjc.6603419, PII 6603419
-
Duran I, Kortmansky J, Singh D, et al. A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer 2006; 95: 1148-1154. (Pubitemid 44660065)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.9
, pp. 1148-1154
-
-
Duran, I.1
Kortmansky, J.2
Singh, D.3
Hirte, H.4
Kocha, W.5
Goss, G.6
Le, L.7
Oza, A.8
Nicklee, T.9
Ho, J.10
Birle, D.11
Pond, G.R.12
Arboine, D.13
Dancey, J.14
Aviel-Ronen, S.15
Tsao, M.-S.16
Hedley, D.17
Siu, L.L.18
-
41
-
-
73949088959
-
Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II trial
-
Yao JC, Lombard-Bohas C, Baudin E, et al. Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial. J Clin Oncol 2010; 28: 69-76.
-
(2010)
J Clin Oncol
, vol.28
, pp. 69-76
-
-
Yao, J.C.1
Lombard-Bohas, C.2
Baudin, E.3
-
42
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 2011; 364: 514-523.
-
N Engl J Med
, vol.2011
, Issue.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
-
44
-
-
0033588842
-
New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
-
DOI 10.1038/sj.onc.1203035
-
Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietin and VEGF. Oncogene 1999; 18: 5356-5362. (Pubitemid 29462372)
-
(1999)
Oncogene
, vol.18
, Issue.38
, pp. 5356-5362
-
-
Holash, J.1
Wiegand, S.J.2
Yancopoulos, G.D.3
-
45
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
-
Casanovas O, Hicklin DJ, Bergers G, et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005; 8: 299-309. (Pubitemid 41443415)
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
46
-
-
0036491615
-
VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis
-
DOI 10.1016/S1535-6108(02)00031-4
-
Inoue M, Hager JH, FerraraN, et al. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 2002; 1: 193-202. (Pubitemid 41039165)
-
(2002)
Cancer Cell
, vol.1
, Issue.2
, pp. 193-202
-
-
Inoue, M.1
Hager, J.H.2
Ferrara, N.3
Gerber, H.-P.4
Hanahan, D.5
-
47
-
-
0037258782
-
Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: Correlation with microvessel density and clinicopathologic
-
DOI 10.1053/hupa.2003.56
-
La Rosa S, Uccella S, Finzi G, et al. Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum Pathol 2003; 34: 18-27. (Pubitemid 36160017)
-
(2003)
Human Pathology
, vol.34
, Issue.1
, pp. 18-27
-
-
La Rosa, S.1
Uccella, S.2
Finzi, G.3
Albarello, L.4
Sessa, F.5
Capella, C.6
-
48
-
-
34247162696
-
Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
-
DOI 10.1002/cncr.22554
-
Zhang J, Jia Z, Li Q, et al. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer 2007; 109: 1478-1486. (Pubitemid 46595681)
-
(2007)
Cancer
, vol.109
, Issue.8
, pp. 1478-1486
-
-
Zhang, J.1
Jia, Z.2
Li, Q.3
Wang, L.4
Rashid, A.5
Zhu, Z.6
Evans, D.B.7
Vauthey, J.-N.8
Xie, K.9
Yao, J.C.10
-
49
-
-
0037770033
-
Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression
-
DOI 10.1097/01.MP.0000077416.68489.50
-
Hansel DE, Rahman A, Hermans J, et al. Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression. Mod Pathol 2003; 16: 652-659. (Pubitemid 36871497)
-
(2003)
Modern Pathology
, vol.16
, Issue.7
, pp. 652-659
-
-
Hansel, D.E.1
Rahman, A.2
Hermans, J.3
De Krijger, R.R.4
Ashfaq, R.5
Yeo, C.J.6
Cameron, J.L.7
Maitra, A.8
-
50
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
-
DOI 10.1200/JCO.2005.07.093
-
Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005; 23: 939-952. (Pubitemid 46202314)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.5
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
51
-
-
79851499956
-
Combined anti- VEGFR and anti-PDGFR actions of sunitinib on blood vessels in preclinical tumor models [abstract]
-
Yao VJ, Sennino B, Davis RB, et al. Combined anti- VEGFR and anti-PDGFR actions of sunitinib on blood vessels in preclinical tumor models [abstract]. Eur J Cancer 2006; 4 Suppl.: 27-28.
-
(2006)
Eur J Cancer
, vol.4
, Issue.SUPPL.
, pp. 27-28
-
-
Yao, V.J.1
Sennino, B.2
Davis, R.B.3
-
52
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
DOI 10.1200/JCO.2005.02.2194
-
Faivre S, Delbaldo C, Vera K, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006; 24: 25-35. (Pubitemid 46630490)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.1
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
Robert, C.4
Lozahic, S.5
Lassau, N.6
Bello, C.7
Deprimo, S.8
Brega, N.9
Massimini, G.10
Armand, J.-P.11
Scigalla, P.12
Raymond, E.13
-
53
-
-
49149114782
-
Activity of sunitinib in patients with advanced neuroendocrine tumors
-
Kulke MH, Lenz HJ,Meropol NJ, et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 2008; 26: 3403-3410.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3403-3410
-
-
Kulke, M.H.1
Lenz Hjmeropol, N.J.2
-
54
-
-
79851482955
-
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
-
Raymond E, Dahan L, Raoul J-L, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 2011; 364: 501-513.
-
N Engl J Med
, vol.2011
, Issue.364
, pp. 501-513
-
-
Raymond, E.1
Dahan, L.2
Raoul, J.-L.3
-
55
-
-
41649114168
-
Targeting vascular endothelial growth factor in advanced carcinoid tumor: A
-
random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alfa-2b
-
Yao JC, Phan A, Hoff PM, et al. Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alfa-2b. J Clin Oncol 2008; 26: 1316-1323.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1316-1323
-
-
Yao, J.C.1
Phan, A.2
Hoff, P.M.3
-
56
-
-
77954789459
-
Randomized run-in study of bevacizumab (B) and everolimus (E) in low- to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker [abstract no. 4002]
-
Yao JC, Phan AT, Fogelman D, et al. Randomized run-in study of bevacizumab (B) and everolimus (E) in low- to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker [abstract no. 4002]. J Clin Oncol 2010; 28 Suppl.: 15s.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Yao, J.C.1
Phan, A.T.2
Fogelman, D.3
-
57
-
-
34848871080
-
Targeted agents: The rules of combination
-
DOI 10.1158/1078-0432.CCR-07-1385
-
Kwak EL, Clark JW, Chabner B. Targeted agents: the rules of combination. Clin Cancer Res 2007; 13: 5232-5237. (Pubitemid 47510344)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.18
, pp. 5232-5237
-
-
Kwak, E.L.1
Clark, J.W.2
Chabner, B.3
-
58
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
DOI 10.1158/0008-5472.CAN-05-2925
-
O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006; 66: 1500-1508. (Pubitemid 43259931)
-
(2006)
Cancer Research
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.-B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
59
-
-
10644257697
-
Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cells
-
DOI 10.1016/j.surg.2004.06.061, PII S0039606004005537
-
Van Gompel JJ, Chen H. Insulin-like growth factor 1 signaling in human gastrointestinal carcinoid tumor cells. Surgery 2004; 136: 1297-1302. (Pubitemid 39647548)
-
(2004)
Surgery
, vol.136
, Issue.6
, pp. 1297-1302
-
-
Van Gompel, J.J.1
Chen, H.2
-
60
-
-
0035111692
-
Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells
-
DOI 10.1210/en.142.1.121
-
Charland S, Boucher M-J, Houde M, et al. Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells. Endocrinology 2001; 142: 121-128. (Pubitemid 32183673)
-
(2001)
Endocrinology
, vol.142
, Issue.1
, pp. 121-128
-
-
Charland, S.1
Boucher, M.-J.2
Houde, M.3
Rivard, N.4
-
61
-
-
76549120195
-
The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells
-
Cerovac V, Monteserin-Garcia J, Rubinfeld H, et al. The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells. Cancer Res 2010; 70: 666-674.
-
(2010)
Cancer Res
, vol.70
, pp. 666-674
-
-
Cerovac, V.1
Monteserin-Garcia, J.2
Rubinfeld, H.3
-
62
-
-
52049125970
-
Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: Results of a phase II study
-
Yao JC, Phan AT, Chang DZ, et al. Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study. J Clin Oncol 2008; 26: 4311-4318.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4311-4318
-
-
Yao, J.C.1
Phan, A.T.2
Chang, D.Z.3
-
63
-
-
78650443861
-
A randomized, double blind, placebo-controlled, multicenter phase III trial of everolimus 1 octreotide lar vs placebo 1 octreotide in patients with advanced neuroendocrine tumors (NET) (RADIANT-2) [abstract]
-
Pavel M, Hainsworth JD, Baudin E, et al. A randomized, double blind, placebo-controlled, multicenter phase III trial of everolimus 1 octreotide lar vs placebo 1 octreotide in patients with advanced neuroendocrine tumors (NET) (RADIANT-2) [abstract]. Ann Oncol 2010; 21: 4.
-
(2010)
Ann Oncol
, vol.21
, pp. 4
-
-
Pavel, M.1
Hainsworth, J.D.2
Baudin, E.3
-
64
-
-
79956089869
-
Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity [poster]
-
Apr 18-22; Denver (CO)
-
Sathyanarayanan S, Jha S, Klinghoffer R, et al. Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity [poster]. Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver (CO).
-
(2009)
Annual Meeting of the American Association for Cancer Research
-
-
Sathyanarayanan, S.1
Jha, S.2
Klinghoffer, R.3
-
67
-
-
79956102302
-
-
M.D. Anderson Cancer Center US National Institutes of Health, ClinicalTrials. gov [online] [Accessed 2011 Feb 20]
-
M.D. Anderson Cancer Center. Phase I study of anti-IGF- 1R monoclonal antibody, IMC-A12, and mTOR inhibitor, everolimus, in advanced low to intermediate grade neuroendocrine carcinoma [ClinicalTrials.gov identifier NCT01204476]. US National Institutes of Health, ClinicalTrials. gov [online]. Available from URL: http:// www.clinicaltrials.gov [Accessed 2011 Feb 20].
-
Phase i Study of Anti-IGF- 1R Monoclonal Antibody, IMC-A12, and MTOR Inhibitor, Everolimus, in Advanced Low to Intermediate Grade Neuroendocrine Carcinoma [ClinicalTrials.gov Identifier NCT01204476]
-
-
-
68
-
-
68949086867
-
Targeting the RAF-MEK-ERK pathway in cancer therapy
-
Montagut C, Settleman J. Targeting the RAF-MEK-ERK pathway in cancer therapy. Cancer Lett 2009; 283: 125-134.
-
(2009)
Cancer Lett
, vol.283
, pp. 125-134
-
-
Montagut, C.1
Settleman, J.2
-
69
-
-
41349094931
-
MCO44h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A phase II consortium (P2C) study. [abstract no. 4504]
-
Hobday TJ, Rubin J, Holen K, et al. MCO44h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): a phase II consortium (P2C) study. [abstract no. 4504] J Clin Oncol 2007; 25 Suppl. 18: 4504
-
(2007)
J Clin Oncol
, vol.25
, Issue.SUPPL. 18
, pp. 4504
-
-
Hobday, T.J.1
Rubin, J.2
Holen, K.3
|