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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3384-3389

3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation

(25) Chen, Jian Jeffrey a Nguyen, Thomas a D'Amico, Derin C a Qian, Wenyuan a Human, Jason a Aya, Toshihiro a Biswas, Kaustav a Fotsch, Christopher a Han, Nianhe a Liu, Qingyian a Nishimura, Nobuko a Peterkin, Tanya A N a Yang, Kevin a Zhu, Jiawang a Riahi, Babak Bobby a Hungate, Randall W a Andersen, Neil G a Colyer, John T a Faul, Margaret M a Kamassah, Augustus a more..

a AMGEN INC (United States)

b Serono Research Institute (United States)

Author keywords

Antagonist; Bradykinin B1; GPCR; Inflammation; Oxopiperazine; Pain; Tetralin

Indexed keywords

2 [1 [(4 METHYLPHENYL)SULFONYL] 3 OXO 2 PIPERAZINYL] N [6 (1 PIPERIDINYLMETHYL) 1,2,3,4 TETRAHYDRO 1 NAPHTHALENYL]ACETAMIDE; 3 OXO 2 PIPERAZINYL ACETAMIDE DERIVATIVE; BRADYKININ B1 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; CHIRALITY; CONTROLLED STUDY; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; INFLAMMATION; NONHUMAN; PAIN; RABBIT; RAT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; DOGS; INFLAMMATION; INHIBITORY CONCENTRATION 50; MICE; MODELS, ANIMAL; MOLECULAR STRUCTURE; PAIN; PIPERAZINES; RABBITS; RATS; RECEPTOR, BRADYKININ B1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 79956069370 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.03.115 Document Type: Article

Times cited : (8)

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