A new class of bradykinin 1 receptor antagonists containing the piperidine acetic acid tetralin core

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2071-2075

  Fotsch, Christopher ^a   Biddlecome, Gloria ^a   Biswas, Kaustav ^a   Chen, Jian Jeff ^a   D'Amico, Derin C ^a   Groneberg, Robert D ^b   Han, Nianhe Bruce ^a   Hsieh, Feng Yin ^a   Kamassah, Augustus ^a   Kumar, Gondi ^a   Lester Zeiner, Dianna ^a   Liu, Qingyian ^a   Mareska, David A ^b   Riahi, Babak Bobby ^a   Wang, Yueh Ju Judy ^a   Yang, Kevin ^a   Zhan, James ^b   Zhu, Joe ^a   Johnson, Eileen ^a   Ng, Gordon ^a   Askew, Benny C ^a   more..

^a AMGEN INC   (United States)

^b ARRAY BIOPHARMA INC   (United States)

Author keywords

Antagonists; Bradykinin 1; Tetralin

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; TETRALIN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETIC ACID; ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; INHIBITORY CONCENTRATION 50; PIPERIDINES; RATS; RECEPTOR, BRADYKININ B1; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

ANIMALIA;

EID: 33644799005     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.069     Document Type: Article

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20. Compounds containing a chroman ring system were prepared by procedures that are analogous to those found in Scheme 1.
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