Cam interaction and ser181 phosphorylation as new k-ras signaling modulators

Small GTPases

Volumn 2, Issue 2, 2011, Pages 99-103

  Alvarez Moya, Blanca ^a   Barceló, Carles ^a   Tebar, Francesc ^a   Jaumot, Montserrat ^a   Agell, Neus ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

2; Calmodulin; Erk1; GTPase activating protein; K Ras; Oncogenesis; Phosphorylation; PI3 kinase; Protein kinase c; Raf

Indexed keywords

CALMODULIN; K RAS PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MEMBRANE; ENZYME ACTIVITY; ENZYME REGULATION; NONHUMAN; ONCOGENE K RAS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 79956007102     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.2.2.15555     Document Type: Article

References (37)

1. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989; 49:4682-9.
2. Malumbres M, Barbacid M. RAS on cogenes: the first 30 years. Nature Rev Cancer 2003; 3:459-65.
3. Downward J. Control of ras activation. Cancer Surv 1996; 27:87-100.
4. Marshall CJ. Ras effectors. Curr Opin Cell Biol 1996; 8:197-204.
5. Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, et al. The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins. Cell 2010; 141:458-71.
6. Rocks O, Peyker A, Kahms M, Verveer PJ, Koerner C, Lumbierres M, et al. An acylation cycle regulates localization and activity of palmitoylated Ras iso-forms. Science 2005; 307:1746-52.
7. Ballester R, Furth ME, Rosen OM. Phorbol ester-and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product. J Biol Chem 1987; 262:2688-95.
8. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995; 80:179-85.
9. Agell N, Bachs O, Rocamora N, Villalonga P. Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+) and calmodulin. Cell Signal 2002; 14:649-54.
10. Alvarez-Moya B, Lopez-Alcala C, Drosten M, Bachs O, Agell N. K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function. Oncogene 2010; 29:5911-22.
11. Plowman SJ, Ariotti N, Goodall A, Parton RG, Hancock JF. Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Mol Cell Biol 2008; 28:4377-85.
12. Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, et al. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-X- on mitochondria and induces Lapoptosis. Mol Cell 2006; 21:481-93.
13. INK4a. Cell 1997; 88:593-602.
14. 2+/calmodulin. J Cell Biol 2005; 170:429-41.
15. Lopez-Alcala C, Alvarez-Moya B, Villalonga P, Calvo M, Bachs O, Agell N. Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization. J Biol Chem 2008; 283:10621-31.
16. Jackson JH, Li JW, Buss JE, Der CJ, Cochrane CG. Polylysine domain of K-ras 4B protein is crucial for malignant transformation. Proc Natl Acad Sci USA 1994; 91:12730-4.
17. Welman A, Burger MM, Hagmann J. Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation. Oncogene 2000; 19:4582-91.
18. Yeung T, Terebiznik M, Yu L, Silvius J, Abidi WM, Philips M, et al. Receptor activation alters inner surface potential during phagocytosis. Science 2006; 313:347-51.
19. Lu A, Tebar F, Alvarez-Moya B, Lopez-Alcala C, Calvo M, Enrich C, et al. A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol 2009; 184:863-79.
20. Heit B, Yeung T, Grinstein S. Changes in Mitochondrial Surface Charge Mediate Recruitment of Signalling Molecules During Apoptosis. Am J Physiol Cell Physiol 2010; 300:33-41.
21. Prior IA, Muncke C, Parton RG, Hancock JF. Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol 2003; 160:165-70.
22. Inder K, Harding A, Plowman SJ, Philips MR, Parton RG, Hancock JF. Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs. Mol Biol Cell 2008; 19:4776-84.
23. McLaughlin S, Hangyas-Mihalyne G, Zaitseva I, Golebiewska U. Reversible-through calmodulin- electrostatic interactions between basic residues on proteins and acidic lipids in the plasma membrane. Biochem Soc Symp 2005; 189-98.
24. 2+-calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains. Trends Neurosci 1999; 22:12-6.
25. Shalom-Feuerstein R, Plowman SJ, Rotblat B, Ariotti N, Tian T, Hancock JF, et al. K-ras nanoclustering is subverted by over expression of the scaffold protein galectin-3. Cancer Res 2008; 68:6608-16.
26. Inder KL, Lau C, Loo D, Chaudhary N, Goodall A, Martin S, et al. Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. J Biol Chem 2009; 284:28410-9.
27. Lu KP, Means AR. Regulation of the cell cycle by calcium and calmodulin. Endocrime Rev 14:40-58.
28. 2+/calmodulin-dependent protein kinases. Curr Opin Cell Biol 1993; 5:247-53.
29. Moreto J, Llado A, Vidal-Quadras M, Calvo M, Pol A, Enrich C, et al. Calmodulin modulates H-Ras mediated Raf-1 activation. Cell Signal 2008; 20:1092-103.
30. Tebar F, Villalonga P, Sorkina T, Agell N, Sorkin A, Enrich C. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Mol Biol Cell 2002; 13:2057-68.
31. Tebar F, Llado A, Enrich C. Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC. FEBS Lett 2002; 517:206-10.
32. Bhagatji P, Leventis R, Rich R, Lin CJ, Silvius JR. Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane. Biophys J 2010; 99:3327-35.
33. Li H, Ruano MJ, Villalobo A. Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells. FEBS Lett 2004; 559:175-80.
34. Villalonga P, López-Alcalá C, Bosch M, Chiloeches A, Rocamora N, Gil J, et al. Calmodulin binds to K-RAs but H- or N-Ras, and Modulates Its Downstream Signaling. Mol Cell Biol 2001; 21:7345-54.
35. Rodriguez-Vilarrupla A, Jaumot M, Abella N, Canela N, Brun S, Diaz C, et al. Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase C-mediated phosphorylation of Ser153. Mol Cell Biol 2005; 25:7364-74.
36. Agell N, Jaumot M, Rodriguez-Vilarrupla A, Brun S, Abella N, Canela N, et al. The diverging roles of calmodulin and PKC in the regulation of p21 intracellular localization. Cell Cycle 2006; 5:3-6.
37. Villalonga P, Lopez-Alcala C, Chiloeches A, Gil J, Marais R, Bachs O, et al. Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts. J Biol Chem 2002; 277:37929-35.