Evaluating the Effect of 3 Glucocorticoid Receptor Gene Polymorphisms on Risk of Relapse in 100 Iranian Children With Acute Lymphoblastic Leukemia: A Case-Control Study

Clinical Therapeutics

Volumn 33, Issue 3, 2011, Pages 280-290

  Namazi, Soha ^a   Zareifar, Soheila ^b   Monabati, Ahmad ^b   Ansari, Shahla ^c   Karimzadeh, Iman ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute lymphoblastic leukemia; Childhood; Glucocorticoid receptor gene; Iranian population; Polymorphism; Relapse

Indexed keywords

ASPARAGINASE; DAUNORUBICIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; PREDNISOLONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CANADA; CANCER RELAPSE; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HOMOZYGOSITY; HUMAN; INCIDENCE; IRAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RECURRENCE RISK; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DNA; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INFANT; IRAN; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTORS, GLUCOCORTICOID; RECURRENCE;

EID: 79955999315     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2011.03.004     Document Type: Article

References (46)

1. Margolin J.F., Steuber S.C., Poplack D.G. Acute lymphoblastic leukemia. Principles and Practice of Pediatric Oncology 2005, 538-590. Lippincott Williams & Wilkins, Philadelphia, Pa. P.A. Pizzo, D.G. Poplack (Eds.).
2. Pui C.H., Evans W.E. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006, 354:166-178.
3. Mahoney D.H. Acute lymphoblastic leukemia. Oski's Pediatrics 2006, 1750-1758. Lippincott Williams & Wilkins, Philadelphia, Pa. U.A. McMillan, C.D. DeAngelis, R.D. Feigin, J.B. Warshaw (Eds.).
4. Mousavi S.M., Pourfeizi A., Dastgiri S. Childhood cancer in Iran. J Pediatr Hematol Oncol 2010, 32:376-382.
5. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249.
6. Chessells J.M. Relapsed lymphoblastic leukaemia in children: a continuing challenge. Br J Haematol 1998, 102:423-438.
7. Gaynon P.S. Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol 2005, 131:579-587.
8. Verrills N.M., Liem N.L., Liaw T.Y., et al. Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia-an in vivo study. Proteomics 2006, 6:1681-1694.
9. Tissing W.J., Meijerink J.P., den Boer M.L., Pieters R. Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia. Leukemia 2003, 17:17-25.
10. Schrappe M., Reiter A., Zimmermann M., et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster. Leukemia 2000, 14:2205-2222.
11. Lauten M., Stanulla M., Zimmermann M., et al. Clinical outcome of patients with childhood acute lymphoblastic leukaemia and an initial leukaemic blood blast count of less than 1000 per microliter. Klin Padiatr 2001, 213:169-174.
12. Pieters R., Huismans D.R., Loonen A.H., et al. Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia. Lancet 1991, 338:399-403.
13. Hongo T., Yajima S., Sakurai M., et al. In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia. Blood 1997, 89:2959-2965.
14. Kaspers G.J., Pieters R., Van Zantwijk C.H., et al. Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. Blood 1998, 92:259-266.
15. Kofler R., Schmidt S., Kofler A., Ausserlechner M.J. Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia. J Endocrinol 2003, 178:19-27.
16. Hurley D.M., Accili D., Stratakis C.A., et al. Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest 1991, 87:680-686.
17. Ruiz M., Lind U., Gåfvels M., et al. Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance. Clin Endocrinol 2001, 55:363-371.
18. van Rossum E.F., Koper J.W., van den Beld A.W., et al. Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clinl Endocrinol 2003, 59:585-592.
19. Weaver J.U., Hitman G.A., Kopelman P.G. An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. J Mol Endocrinol 1992, 9:295-300.
20. Bueman B., Vohl M.C., Chagnon M., et al. Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus. Obes Res 1997, 5:186-192.
21. Koper J.W., Stolk R.P., de Lange P., et al. Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. Hum Genet 1997, 99:663-668.
22. Huizenga N.A., Koper J.W., De Lange P., et al. A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 1998, 83:144-151.
23. van Rossum E.F., Koper J.W., Huizenga N.A., et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 2002, 51:3128-3134.
24. Bachmann A.W., Sedgley T.L., Jackson R.V., et al. Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. Psychoneuroendocrinology 2005, 30:297-306.
25. Lin R.C., Wang W.Y., Morris B.J. Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. Hypertension 1999, 34:1186-1192.
26. Dawson B., Trapp R. Basic and Clinical Biostatistics 2004, McGraw-Hill Medical, New York.
27. Fleury I., Primeau M., Doreau A., et al. Polymorphisms in genes involved in the corticosteroid response and the outcome of childhood acute lymphoblastic leukemia. Am J Pharmacogenomics 2004, 4:331-341.
28. Labuda M., Gahier A., Gagné V., et al. Polymorphisms in glucocorticoid receptor gene and the outcome of childhood acute lymphoblastic leukemia (ALL). Leuk Res 2010, 34:492-497.
29. Tissing W.J., Meijerink J.P., den Boer M.L., et al. Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute lymphoblastic leukemia. Clin Cancer Res 2005, 11:6050-6056.
30. Marino S., Verzegnassi F., Tamaro P., et al. Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response. Pediatr Blood Cancer 2009, 53:984-991.
31. Hann I.M., Richards S.M., Eden O.B., Hill F.G. Analysis of the immunophenotype of children treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia Trial XI (MRC UKALLXI). Medical Research Council Childhood Leukaemia Working Party. Leukemia 1998, 12:1249-1255.
32. A randomized trial of the I-BFM-SG for the management of childhood non-B acute lymphoblastic leukemia ALL IC-BFM 2002, Accessed December 17, 2010. http://www.sld.cu/galerias/pdf/sitios/hematologia/all_ic-bfm_2002_-_bp.pdf.
33. Lanzkowsky P. Manual of Pediatric Hematology and Oncology 2000, Academic Press, San Diego, Calif. 3rd ed.
34. Lanzkowsky P. Manual of Pediatric Hematology and Oncology 2005, Elsevier, Burlington, Mass. 4th ed.
35. Aplenc R., Lange B. Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia. Br J Haematol 2004, 125:421-434.
36. Davidsen M.L., Dalhoff K., Schmiegelow K. Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2008, 30:831-849.
37. Haarman E.G., Kaspers G.J., Veerman A.J. Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation. Br J Haematol 2003, 120:19-29.
38. Stevens A., Ray D.W., Zeggini E., et al. Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 2004, 89:892-897.
39. van Rossum E.F., Lamberts S.W. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res 2004, 59:333-357.
40. Panarelli M., Holloway C.D., Fraser R., et al. Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab 1998, 83:1846-1852.
41. Haarman E.G., Kaspers G.J., Pieters R., et al. Glucocorticoid receptor alpha, beta and gamma expression vs in vitro glucocorticod resistance in childhood leukemia. Leukemia 2004, 18:530-537.
42. Lin R.C., Wang W.Y., Morris B.J. High penetrance, overweight, and glucocorticoid receptor variant: case-control study. BMJ 1999, 319:1337-1338.
43. Syed A.A., Irving J.A., Redfern C.P., et al. Low prevalence of the N363S polymorphism of the glucocorticoid receptor in South Asians living in the United Kingdom. J Clin Endocrinol Metab 2004, 89:232-235.
44. van Rossum E.F., Russcher H., Lamberts S.W. Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene. Trends Endocrinol Metab 2005, 16:445-450.
45. van Rossum E.F., Roks P.H., de Jong F.H., et al. Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms. Clin Endocrinol 2004, 61:573-581.
46. Di Blasio A.M., van Rossum E.F., Maestrini S., et al. The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf) 2003, 59:68-74.