Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen

Annals of Hepatology

Volumn 10, Issue 1, 2011, Pages 63-72

  Kumarappan, Chidambaram ^a,b   Vijayakumar, Madhavan ^c   Thilagam, Ellappan ^d   Balamurugan, Manikam ^e   Thiagarajan, Madheswaran ^f   Senthil, Siddan ^d   Das, Sunil C ^g   Mandal, Subhash C ^a  

^a JADAVPUR UNIVERSITY   (India)

^b INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^c CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

^d RR College of Pharmacy   (India)

^e UNIVERSITY OF NIZWA   (Oman)

^f Yeungnam University   (South Korea)

^g Loyola College (Autonomous)   (India)

Author keywords

Carbon tetrachloride; Hepatoprotection; Ichnocarpus frutescens; Phase I enzymes; Polyphenolic extract; Tamoxifen

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; AMINOPYRINE N DEMETHYLASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; ICHNOCARPUS FRUTESCENSE EXTRACT; LIVER PROTECTIVE AGENT; MALONALDEHYDE; PHENOBARBITAL; PLANT EXTRACT; TAMOXIFEN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOCYNACEAE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; ICHNOCARPUS FRUTESCENSE; LIPID PEROXIDATION; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PLANT LEAF; RAT; SLEEP TIME;

EID: 79955983058     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31589-3     Document Type: Article

References (44)

1. Meyer SA, Kulkarni AP. Introduction to biochemical toxicology, Hepatotoxicity. In: Hodgson E, Smart RC (eds.). 3rd. Ed. A. New York: John Wiley & Sons Inc; 2001, p. 487-490.
2. Tomboloni A, Cingolani M. Fatal accidental ingestion of carbon tetrachloride: a postmortem distribution study. J Forensic Sci 1996; 41(1): 166-168.
3. Tesehke CB, Vierke W, Goldermann L. Carbon tetrachloride levels and serum activities of liver enzymes followingacute carbon tetrachloride intoxication. Toxicol Lett 1983; 17(1-2): 175-180.
4. Jordan VC. Tamoxifen: a most unlikely pioneering medicine. Natl Rev Drug Discov 2003; 2: 205-213.
5. Williams GM, Iatropoulos MJ, Djordjevic MV, Kaltenberg OP. The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis 1993; 14: 315-317.
6. Dehal SS, Kupfer D. CYP2D6 catalyzes tamoxifen 4- hydroxylation in human liver. Cancer Res 1997; 57: 3402-3406.
7. Fowler JS. Carbon tetrachloride metabolism in the rabbit. Br J Pharmacol 1969; 37: 733-737.
8. Emile FN, Dragan YP, Colin RJ, Jordan VC, Pitot, HC. Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver. Cancer Res 1995; 55: 1780-1786.
9. Wong FW, Chan WY, Lee SS. Resistance to carbon tetrachloride induced hepatotoxicity in mice which lack CYP 2E1 expression. Toxicol App Pharmacol 1998; 153: 109-118.
10. Boll M, Weber LW, Becker E, Stampfl A. Mechanism of Carbon Tetrachloride-Induced Hepatotoxicity. Hepatocellular Damage by Reactive Carbon Tetrachloride Metabolites. Z Naturforsch 2001; 56: 649-659.
11. Mitra SK, Venkataranganna MV, Sundaram R, Gopumadhavan S. Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. J Ethnopharmacol 1998; 63(3): 181-186.
12. Sies H. Strategies of antioxidant defence. Europ J Biochem 1993; 215(2): 213-219.
13. Letteron P, Labbe G, Degott C, Berson A, Fromenty B, Delaforge M, Larrey D, Pessayre D. Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem Pharmacol 1990; 39: 2027-2034.
14. Rosen GM, Britigan BE, Halpern HJ, Pou S. Spin trapping free radicals in biological systems; in Free Radicals, Biology and Detection by Spin Trapping. Oxford Press New York: Oxford; 1999, p. 394.
15. Lieber CS. Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv Pharmacol 1997; 38: 601-628.
16. Bass NM. Is there any use for nontraditional or alternative therapies in patients with chronic liver disease? Curr Gastro Rep 1999; 1(1): 50-56.
17. Ross JA, Kasum CM. Dietary flavonoids: bioavailability, metabolic effects, and safety. Ann Rev Nutr 2002; 22: 19-34.
18. Breinholt V, Lauridsen ST, Dragsted LO. Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. Xenobiotica 1999; 29(12): 1227-1240.
19. Hikino H, Kiso Y. Natural products for liver diseases. In: Economical and medicinal plant research. Vol. 2. London: Academic Press; 1988, p. 39-72.
20. Anonymous. Wealth of India. Raw Materials, Council of Scientific and Industrial Research (CSIR). Vol. 5. New Delhi: CSIR; 1976, p. 162-163.
21. Lakshmi DKM, Venkata Rao E, Venkata Rao D. Triterpenoid constituents of Ichnocarpus frutescens. Indian Drugs 1985; 22: 552-523.
22. Singh RP, Singh RP. Flavonoids of the flowers of Ichnocarpus frutescens. J Indian Chem Soc 1987; 14: 715-756.
23. Parinitha M, Harish GU, Vivek NC, Mahesh T, Shivanna MB. Ethno-botanical wealth of Bhadra wild life sanctuary in Karnataka. Indian J Trad Knowl 2004; 3(1): 37-50.
24. Bhandary MJ, Chandrashekar KR, Kaveriappa KM. Medical Ethnobotany of the Siddis of Uttara Kannada District, Karnataka, India. J Ethnopharm 1995; 47(3): 149-158.
25. Kang SY, Sung SH, Park JH, Kim YC. Hepatoprotective activity of scopoletin, a constituent of Solanum lyratum. Arch Pharm Res 1998; 21(6): 718-722.
26. Kumarappan, CT, Chandra R, Mandal SC. Anti-inflammatory activity of Ichnocarpus frutescens. Pharmacologyonline 2006; 3: 201-216.
27. Kumarappan, CT, Mandal SC. Antitumor activity of polyphenolic extract of Ichnocarpus frutescens. Exp Oncol 2007; 29(2): 94-101.
28. Kumarappan, CT, Mandal SC. Polyphenolic extract of Ichnocarpus frutescens attenuates diabetic complications in streptozotocin treated diabetic rats. Renal Failure 2008; 30(3): 307-322.
29. Mukherjee S, Sur A, Maiti BR. Hepatoprotective effect of Swertia chirata on rat. Ind J Exp Biol 1997; 35(4): 384-348.
30. El-Beshbishy H. The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen induced liver injury in rats: DDB use is curative or protective. J Biochem Mol Biol 2005; 38(3): 70-77.
31. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82(1): 70-77.
32. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2): 351-358.
33. Brauer RW, Root MA. The effect of carbon tetrachloride induced liver injury upon the acetylcholine hydrolyzing activity of blood plasma of the rat. J Pharmacol Exp Ther 1946; 88(2): 109-118.
34. Vogel G. New natural products and plants with drugs, pharmacological, biological or therapeutical activity. H. Wagner and P. Wolff (eds.). Heidelberg, Berlin: Springer Verlag: 1977, p. 240-265.
35. Mazel P. Experiments illustrating drug metabolism in vitro. In: La Du, BN, Mandel HG, Way EL (eds.). Fundamentals of drug metabolism and drug disposition. Baltimore: Williams and Wilkins; 1971, p. 546-550.
36. Agarwal AK, Mehendale HM. Chlordecone potentiation of carbon tetrachloride hepatotoxicity in ovariectomized rats. Toxicol 1984; 29(4): 315-223.
37. Pencil SD, Brattin WJ, Glende EA, Recknagel RI. Carbon tetra chloride dependent inhibition of lipid secretion by isolated hepatocytes characterization and requirement for bioactivation. Biochem Pharmacol 1984; 33(15): 2419-2423.
38. Recknagel RO, Glonde EA, Dolak JA, Walter RL. Mechanism of carbon tetrachloride toxicity. Pharmacol Therap 1989; 43(1): 139-154.
39. Farber JL, Gerson RJ. Mechanisms of cell injury with hepatotoxic chemicals. Pharmacol Rev 1984; 36(2): 71S-75S.
40. Azri S, Mata HP, Reid LL, Gandolfi AJ, Brendel K. Further examination of the selective toxicity of CCl4 in rat liver slices. Toxicol Appl Pharmacol 1992; 112(1): 81-86.
41. Desai P, Nallani S, Sane R, Moore L, Goodwin B, Buckley D, Buckley A. Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4- Hydroxytamoxifen. Drug Metab Disp 2002; 30(5): 608-612.
42. Athoupa M, Hirsimaki P, Parssinen R, Mantyla E. Alterations of drug metabolizing and antioxidant enzyme activities during tamoxifen induced hepatocarcinogenesis in rats. Carcinogenesis 1994; 15(5): 863-868.
43. Aguiar M, Masse R, Gibbs BF. Regulation of cytochrome P450 by posttranslational modification. Drug Metab Rev 2005; 37: 379-404.
44. Cooper DY. Discovery of the function of the heme protein P-450: a systematic approach to scientific research. Life Sci 1973; 13: 1151-1161.