Oral baclofen reduces visceral pain-related pseudo-affective responses to colorectal distension in rats: Relation between plasma exposure and efficacy

Scandinavian Journal of Gastroenterology

Volumn 46, Issue 6, 2011, Pages 652-662

  Lindström, Erik ^a,d   Brusberg, Mikael ^a   Ravnefjord, Anna ^a   Kakol Palm, Dorota ^a   Påhlman, Ingrid ^a,c   Novéén, Anna ^a   Larsson, Håkan ^a   Martinez, Vicente ^a,b,e  

^a ASTRAZENECA R AND D   (Sweden)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Albireo AB   (Sweden)

^d MEDIVIR AB   (Sweden)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Baclofen; colorectal distension; GABAB receptors; irritable bowel syndrome; visceral hypersensitivity; visceral pain

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN;

ANIMAL EXPERIMENT; ARTICLE; COLORECTAL DISTENSION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; FEMALE; HEART RATE; INTESTINE DISTENSION; MEAN ARTERIAL PRESSURE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; VISCERAL PAIN;

ABDOMINAL PAIN; ADMINISTRATION, ORAL; ANIMALS; BACLOFEN; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; COLON; DILATATION, PATHOLOGIC; FEMALE; GABA-B RECEPTOR AGONISTS; HEART RATE; IRRITABLE BOWEL SYNDROME; NERVE FIBERS; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; TREATMENT OUTCOME; VISCERA;

EID: 79955980815     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2011.560677     Document Type: Article

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