The GABAB receptor agonist, baclofen, and the positive allosteric modulator, CGP7930, inhibit visceral pain-related responses to colorectal distension in rats

Neuropharmacology

Volumn 56, Issue 2, 2009, Pages 362-367

  Brusberg, Mikael ^a   Ravnefjord, Anna ^a   Martinsson, Rakel ^a   Larsson, Håkan ^a   Martinez, Vicente ^a   Lindström, Erik ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Baclofen; CGP7930; Colorectal distension; Visceral pain; Visceromotor response

Indexed keywords

2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL; BACLOFEN;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CARDIOVASCULAR RESPONSE; COLON DILATATION; COLORECTAL DISTENSION; CONSCIOUSNESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; FEMALE; HEART RATE; INHIBITION KINETICS; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; TELEMETRY; VISCERAL PAIN;

ABDOMINAL PAIN; ANIMALS; BACLOFEN; BLOOD PRESSURE; COLON; COMPLIANCE; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA AGONISTS; HEART RATE; PAIN MEASUREMENT; PHENOLS; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 58549112362     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.09.006     Document Type: Article

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