The selective 5-hydroxytryptamine 1A antagonist, AZD7371 [3(R)-(N,N-dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5- carboxamide (R,R)-tartrate monohydrate] (robalzotan tartrate monohydrate), inhibits visceral pain-related visceromotor, but not autonomic cardiovascular, responses to colorectal distension in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 3, 2009, Pages 1048-1055

  Lindstrom E ^a   Ravnefjord, A ^a   Brusberg, M ^a   Hjorth, S ^a   Larsson, H ^a   Martinez, Vicente ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AZD 7371; ROBALZOTAN; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR RESPONSE; COLON DILATATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; FEMALE; HYPERTENSION; IRRITABLE COLON; MICTURITION; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; TACHYCARDIA; TELEMETRY; VISCERAL PAIN;

ABDOMINAL MUSCLES; ABDOMINAL PAIN; ANIMALS; BENZOPYRANS; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; COLONIC DISEASES; DILATATION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN ANTAGONISTS; URINATION;

EID: 66749157266     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.152330     Document Type: Article

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