Physiological importance and control of non-shivering facultative thermogenesis

Frontiers in Bioscience - Scholar

Volumn 3 S, Issue 1, 2011, Pages 352-371

  Silva, J Enrique ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Body Temperature Control; Energy Balance; Review; Sympathetic Nervous System; Thermogenesis; Thyroid Hormones

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GLYCEROL; LIOTHYRONINE; LIPOPROTEIN LIPASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THYROID HORMONE; THYROID HORMONE RECEPTOR ALPHA; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

5' UNTRANSLATED REGION; ADRENERGIC STIMULATION; ADRENERGIC SYSTEM; BASAL METABOLIC RATE; BEHAVIOR CHANGE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; COLD ACCLIMATIZATION; CORE TEMPERATURE; CYTOSOL; DIET RESTRICTION; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; ENDOPLASMIC RETICULUM; ENERGY COST; ENERGY EXPENDITURE; ENVIRONMENTAL TEMPERATURE; FACULTATIVE THERMOGENESIS; FOOD AVAILABILITY; GENE EXPRESSION; GENE OVEREXPRESSION; HORMONAL REGULATION; HUMAN; HYPERTHYROIDISM; LUNG GAS EXCHANGE; MALIGNANT HYPERTHERMIA; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR CLONING; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PHOSPHORYLATION; PROTON MOTIVE FORCE; REFLEX; REVIEW; SARCOPLASMIC RETICULUM; SKIN TEMPERATURE; STARVATION; SYMPATHETIC TONE; THERMODYNAMICS; THERMOGENESIS; THERMOREGULATION; THYROID HORMONE RELEASE; THYROTOXICOSIS; UBIQUITINATION; VASOCONSTRICTION; WARMING; WHITE ADIPOSE TISSUE; ADAPTATION; ANIMAL; EVOLUTION; METABOLISM; MOUSE; PHYSIOLOGY; SHIVERING;

MAMMALIA; MUS MUSCULUS;

ADAPTATION, BIOLOGICAL; ADIPOSE TISSUE, BROWN; ANIMALS; BASAL METABOLISM; BIOLOGICAL EVOLUTION; ION CHANNELS; MICE; MITOCHONDRIAL PROTEINS; SHIVERING; SYMPATHETIC NERVOUS SYSTEM; THERMOGENESIS; THYROID HORMONES;

EID: 79955977007     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s156     Document Type: Review

References (138)

1. P. Koteja The evolution of concepts on the evolution of endothermy in birds and mammals. Physiol Biochem Zool 77:1043-1050 (2004) (Pubitemid 40241046)
2. F. Geiser Ontogeny and phylogeny of endothermy and torpor in mammals and birds. Comp Biochem Physiol A Mol Integr Physiol 150:176-180 (2008)
3. A. F. Bennett Thermal dependence of locomotor capacity. Am J Physiol 259:R253-R258 (1990) (Pubitemid 20259456)
4. M. J. Angilletta Jr.; P. H. Niewiarowski and C. A. Navas The evolution of thermal physiology in ectotherms. J Therm Biol 27:249-268 (2002) (Pubitemid 34548670)
5. W. J. Hillenius, J. A. Ruben The evolution of endothermy in terrestrial vertebrates: Who? When? Why? Physiol Biochem Zool 77:1019-1042 (2004) (Pubitemid 40241045)
6. J. R. Speakman Body size, energy metabolism and lifespan. J Exp Biol 208:1717-1730 (2005) (Pubitemid 40697620)
7. P. L. Else, A. J. Hulbert Comparison of the "mammal machine" and the "reptile machine" : energy production. Am J Physiol 240:R3-R9 (1981)
8. A. J. Hulbert, P. L. Else Membranes and the setting of energy demand. J Exp Biol 208:1593-1599 (2005) (Pubitemid 40697607)
9. A. J. Hulbert, P. L. Else Basal metabolic rate: history, composition, regulation, and usefulness. Physiol Biochem Zool 77:869-876 (2004) (Pubitemid 40241034)
10. J. E. Silva Thermogenic Mechanisms and Their Hormonal Regulation. Physiol Rev 86:435-464 (2006)
11. J. Diamond. Guns, Germs and Steel. 1st ed. New York City: W. W, Norton (1997)
12. J. E. Silva Thyroid Hormone and the Energetic Cost of Keeping Body Temperature. Biosci Rep 25:129-148 (2005) (Pubitemid 41609280)
13. K. J. Collins, J. S. Weiner Endocrinological aspects of exposure to high environmental temperatures. Physiol Rev 48:785-839 (1968)
14. P. H. Konits; B. P. Hamilton; E. S. Pruce; M. Whitacre and D. H. Van Echo Serum thyroid hormone changes during whole body hyperthermia. Cancer 54:2432-2435 (1984) (Pubitemid 15223384)
15. B. Rousset, M. Cure Variations of rat thyroid activity during exposure to high environmental temperature (34 degrees C). Relation between hypothalamic pituitary and thyroid hormone levels. Pfluge rs Arch 354:101-115 (1975)
16. J. B. Young; E. Saville; N. J. Rothwell; M. J. Stock and L. Landsberg Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. J Clin Invest 69:1061-1071 (1982) (Pubitemid 12115670)
17. C. J. Gordon. Temperature regulation in laboratory rodents. New York: Cambridge University Press (1993)
18. D. H. MacLennan, M. S. Phillips Malignant hyperthermia. Science 256:789-794 (1992)
19. F. Haman; F. Peronnet; G. P. Kenny; D. Massicotte; C. Lavoie; C. Scott and J. M. Webe r Effect of cold exposure on fuel utilization in humans: plasma glucose, muscle glycogen, and lipids. J Appl Physiol 93:77-84 (2002) (Pubitemid 34686196)
20. B. Cannon, J. Nedergaard Brown adipose tissue: function and physiological significance. Physiol Rev 84:277-359 (2004)
21. DO Foster. Quantitative role of brown adipose tissue in thermogenesis. In: Trayhurn P, Nicholls DG, eds. Brown Adipose Tissue. London: Edward Arnold; 31-51 (1986)
22. D. O. Foster Quantitative contribution of brown adipose tissue thermogenesis to overall metabolism. Can J Biochem Cell Biol 62:618-622 (1984) (Pubitemid 14025640)
23. D. A. Hughes; M. Jastroch; M. Stoneking and M. Klingenspor Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis. BMC Evol Biol 9:4.:4 (2009)
24. C. Fleury; M. Neverova; S. Collins; S. Raimbault; O. Champigny; C. Levi-Meyruis; F. Bouillaud; M. F. Seldin; R. S. Surwit; D. Ricquier and C. H. Warden Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics 15:269-272 (1997) (Pubitemid 27098720)
25. D. W. Gong; Y. F. He; M. Karas and M. Reitman Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, b3-adrenergic agonists, and leptin. J Biol Chem 272:24129-24132 (1997) (Pubitemid 27418606)
26. A. Vidal-Puig; G. Solanes; D. Grujic; J. S. Flier and B. B. Lowell UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Comm 235:79-82 (1997) (Pubitemid 27302688)
27. J. C. Clapham; J. R. Arch; H. Chapman; A. Haynes; C. Lister; G. B. Moore; V. Piercy; S. A. Carter; I. Lehner; S. A. Smith; L. J. Beeley; R. J. Godden; N. Herrity; M. Skehel; K. K. Changani; P. D. Hockings; D. G. Reid; S. M. Squires; J. Hatcher; B. Trail; J. Latcham; S. Rastan; A. J. Harper; S. Cadenas; J. A. Buckingham; M. D. Brand and A. Abuin Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406:415-418 (2000) (Pubitemid 30625561)
28. J. Mozo; Y. Emre; F. Bouillaud; D. Ricquier and F. Criscuolo Thermoregulation: what role for UCPs in mammals and birds? Biosci Rep 25:227-249 (2005) (Pubitemid 41609284)
29. M. D. Brand; C. Affourtit; T. C. Esteves; K. Green; A. J. Lambert; S. Miwa; J. L. Pakay and N. Parker Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37:755-767 (2004) (Pubitemid 39078548)
30. S. Rousset; M. C. Alves-Guerra; J. Mozo; B. Miroux; A. M. Cassard-Doulcier; F. Bouillaud and D. Ricquier The biology of mitochondrial uncoupling proteins. Diabetes 53 Suppl 1:S130-5.:S130-S135 (2004)
31. D. Ricquier; G. Mory; F. Bouillaud; J. Thibault and J. Weissenbach Rapid increase of mitochondrial uncoupling protein and its mRNA in stimulated brown adipose tissue. FEBS Lett 178:240-244 (1984) (Pubitemid 15199582)
32. S. Rehnmark; A. C. Bianco; J. D. Kieffer and J. E. Silva Transcriptional and post-transcriptional mechanisms in the uncoupling protein mRNA response to cold. Am J Physiol 262:E58-E67 (1992)
33. C. Duchamp, H. Barré Skeletal muscle as the major site of nonshivering thermogenesis in cold-adapted ducklings. Am J Physiol Reg Integ Comp Physiol 265:R1076-R1083 (1993)
34. E. Dumonteil; H. Barre and G. Meissner Expression of sarcoplasmic reticulum Ca2+ transport proteins in coldacclimating ducklings. Am J Physiol 269:C955-C960 (1995)
35. J. E. Bicudo; A. C. Bianco and C. R. Vianna Adaptive thermogenesis in hummingbirds. J Exp Biol 205:2267-2273 (2002)
36. N. V. Mezentseva; J. S. Kumaratilake and S. A. Newman The brown adipocyte differentiation pathway in b irds: an evolutionary road not taken. BMC Biol 6:17.:17 (2008)
37. D. Arsenijevic; H. Onuma; C. Pecqueur; S. Raimbault; B. S. Manning; B. Miroux; E. Couplan; M. C. Alves-Guerra; M. Goubern; R. Surwit; F. Bouillaud; D. Richard; S. Collins and D. Ricquier Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26:435-4 39 (2000)
38. D. F. S. Rolfe, G. C. Brown Cellular Energy Utilization and Molecular Origin of Standard Metabolic Rate in Mammals. Physiol Rev 77:731-758 (1997) (Pubitemid 27328739)
39. T. Clausen; C. van Hardeveld and M. E. Everts Significance of cation transport in control of energy metabolism and thermogenesis. Physiol Rev 71:733-774 (1991)
40. A. L. Lehninger, D. L. Nelson and M. M. Cox. Principles of Biochemistry. Second Edition ed. New York: Worth Publishers (1993)
41. L. D. Meis Energy interconversion by the sarcoplasmic reticulum Ca2+-ATPase: ATP hydrolysis, Ca2+ transport, ATP synthesis and heat production. An Acad Bras Cienc 72:365-379 (2000)
42. A. Magnus-Levy Ueber den respiratorischen Gaswechsel unter Einfluss de Thyroidea sowie unter verschiedenen pathologische Zustand. Berlin Klin Wochschr 32:650-652 (1895)
43. V. van Ginneken; B. Ballieux; E. Antonissen; L. R. van der; A. Gluvers and T. G. van den Direct calorimetry of free-moving eels with manipulated thyroid status. Naturwisse nschaften 94:128-133 (2007) (Pubitemid 46122168)
44. B. B. Gupta, P. Chakrabarty Effects of thyroidal, gonadal and adrenal hormones on tissue respiration of streaked frog, Rana limnocharis, at low temperature. Indian J Exp Biol 28:23-26 (1990) (Pubitemid 20101505)
45. R. T. Weirich; H. L. Schwartz and J. H. Oppenheimer An Analysis of the Interrelationship of Nuclear and Plasma Triiodothyronine in the Sea Lamprey, Lake Trout,and Rat: Evolutionary Considerations. Endocrinology 120:664-677 (1987) (Pubitemid 17020422)
46. J. E. Silva, S. D. Bianco Thyroid-adrenergic interactions: physiological and clinical implications. Thyroid 18:157-165 (2008) (Pubitemid 351271529)
47. JE Silva. Thermogenesis and the Sympathoadrenal System in Thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid, A Fundamental and Clinical Text. Ninth ed. Philadelphia: Lippincott-Williams & Wilkins; 607-620 (2005)
48. JE Silva. Intermediary Metabolism and the Sympathoadrenal System in Hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The Thyroid, A Fundamental and Clinical Text. Ninth ed. Philadelphia: Lippincott-Williams & Wilkins; 817-823 (2005)
49. M. Klingenberg, S. G. Huang Structure and function of the uncoupling protein from brown adipose tissue. Biochim Biophys Acta 1415:271-296 (1999) (Pubitemid 29065294)
50. M. Klingenberg Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem Sci 15:108-112 (1990)
51. O. Boss; P. Muzzin and J. P. Giacobino The uncoupling proteins, a review. Eur J Endocrinol 139:1-9 (1998) (Pubitemid 28351225)
52. D. G. Nicholls A history of UCP1. Biochem Soc Trans 29:751-755 (2001)
53. D. G. Nicholls The non-Ohmic proton leak - 25 years on. Biosci Rep 17:251-257 (1997) (Pubitemid 27466749)
54. D. Ricquier, J. C. Kader Mitochondrial protein alteration in active brown fat: a soidum dodecyl sulfatepolyacrylamide gel electrophoretic study. Biochem Biophys Res Commun 73:577-583 (1976)
55. A. C. Bianco, J. E. Silva Intracellular conversion of thyroxine to triiodothyronine is required for the op timal thermogenic function of brown adipose tissue. J Clin Invest 79:295-300 (1987) (Pubitemid 17232532)
56. K. D. Garlid; M. Jaburek and P. Jezek The mechanism of proton transport mediated by mitochondrial uncoupling proteins. FEBS Lett 438:10-14 (1998) (Pubitemid 28517826)
57. M. M. Gonzalez-Barroso; C. Fleury; F. Bouillaud; D. G. Nicholls and E. Rial The uncoupling protein UCP1 does not increase the proton conductance of the inner mi tochondrial membrane by functioning as a fatty acid anion transporter. J Biol Chem 273:15528-15532 (1998) (Pubitemid 28298163)
58. DG Nicholls, SA Cunningham, and E Rial. The bioenergetic mechanisms of brown adipose tissue thermogenesis. In: Trayhurn P, Nicholls DG, eds. Brown Adipose Tissue. London: Edward Arnold; 52-85 (1986)
59. L Girardier, J Seydoux. Neural Control of Brown Adipose Tissue. In: Trayhurn P, Nicholls DG, eds. B rown Adipose Tissue. First ed. London, UK: Arnold; 122-151 (1986)
60. A. C. Bianco; X. Sheng and J. E. Silva Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem 263:18168-18175 (1988) (Pubitemid 19005093)
61. A. Rubio; A. Raasmaja; A. L. Maia; K.-R. Kim and J. E. Silva Effects of Thyroid Hormone on Norepinephrine Signalling in Brown Adipose Tissue. I: b1- and b2- Adrenergic Receptors and Cyclic Adenosine Monophosphate Generation. Endocrinology 136:3267-3276 (1995)
62. P. Muzzin; J. P. Revelli; F. Kuhne; J. D. Gocayne; W. R. McCombie; J. C. Venter; J.-P. Giacobino and C. M. Fraser An adipose tissue-specific b-adrenergic receptor. Molecular cloning and down-regulation in obesity. J Biol Chem 266:24053-24058 (1991) (Pubitemid 21908904)
63. V. S. Susulic; R. C. Frederich; J. Lawitts; E. Tozzo; B. B. Kahn; M. E. Harper; J. Himms-Hagen; J. S. Flier and B. B. Lowell Targeted disruption of the beta(3)-adrenergic receptor gene. J Biol Chem 270:29483-29492 (1995)
64. E. S. Bachman; H. Dhillon; C. Y. Zhang; S. Cinti; A. C. Bianco; B. K. Kobilka and B. B. Lowell betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297:843-845 (2002) (Pubitemid 34839635)
65. G. Mory; D. Ricquier; P. Pesquies and P. Hemon Effects of hypothyroidism on the brown adipose tissue of adult rats: Comparison with the effects of adaptation to the cold. J Endocrinol 91:515-524 (1981) (Pubitemid 12203827)
66. J. Triandafillou; C. Gwilliam and J. Himms-Hagen Role of thyroid hormone in cold-induced changes in rat brown adipose tissue mitochondria. Can J Biochem 60:530-537 (1982) (Pubitemid 12067607)
67. J. Seydoux; J.-P. Giacobino and L. Girardier Impaired metabolic response to nerve stimulation i n brown adipose tissue of hypothyroid rats. Mol Cell Endocrinol 25:213-226 (1982) (Pubitemid 12124533)
68. U. Sundin GDP binding to rat brown fat mitochondria: Effects of thyroxine at different ambient temperature. Am J Physiol 241:C134-C139 (1981)
69. D. Ricquier; F. Bouillaud; P. Toumelin; G. Mory; R. Bazin; J. Arch and L. Penicaud Expression of Uncoupling Protein mRNA in Thermogenic or Weakly Thermogenic Brown Adipose Tissue. J Biol Chem 261:13905-13910 (1986)
70. T. J. Visser; M. M. Kaplan; J. L. Leonard and P. R. Larsen Evidence for two pathways of iodothyronine 5'- deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest 71:992-1002 (1983) (Pubitemid 13163272)
71. J. E. Silva; J. L. Leonard; F. R. Crantz and P. R. Larsen Evidence for two tissue- specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest 69:1176-1184 (1982) (Pubitemid 12115682)
72. P. R. Larsen Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone. Biochem Soc Trans 25:588-592 (1997) (Pubitemid 27260877)
73. J. E. Silva, P. R. Larsen Pituitary nuclear 3,5,3'- triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science 198:617-619 (1977)
74. F. R. Crantz; J. E. Silva and P. R. Larsen An analysis of the sources and quantity of 3,5,3'- triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 110:367-375 (1982) (Pubitemid 12162924)
75. J. E. Silva, P. R. Larsen Comparison of iodothyronine 5'-deiodinase and other thyroid- hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. J Clin Invest 70:1110-1123 (1982) (Pubitemid 13254935)
76. J. L. Leonard; S. A. Mellen and P. R. Larsen Thyroxine 5'-deiodinase activity in brown adipose tissue. Endocrinology 112:1153-1155 (1983)
77. J. E. Silva, P. R. Larsen Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305:712-713 (1983) (Pubitemid 13021520)
78. J. E. Silva, P. R. Larsen Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine and nuclear triiodothyronine receptor saturation in pituitary, liver and kidney of hypothyroid rats. Further evidence relating saturation of pituitary nuclear triiodothyronine receptors and the acute inhibition of thyroid- stimulating hormone release. J Clin Invest 61:1247-1259 (1978) (Pubitemid 8338407)
79. J. E. Silva; T. E. Dick and P. R. Larsen The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver and kidney of euthyroid rats. Endocrinology 103:1196-1207 (1978) (Pubitemid 9048006)
80. P. R. Larsen, R. D. Frumess Comparison of the biological effects of thyroxine and triiodothyronine in the rat. Endocrinology 100:980-988 (1977) (Pubitemid 8080363)
81. A. C. Bianco; D. Salvatore; B. Gereben; M. J. Berry and P. R. Larsen Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38-89 (2002) (Pubitemid 34185306)
82. J. E. Silva, P. R. Larsen Hormonal regulation of iodothyronine 5'-deiodinase in rat brown adipose tissue. Am J Physiol 251:E639-E643 (1986)
83. J. E. Silva, P. R. Larsen Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5'-iodothyronine deiodinase in rat brown adipose tissue. J Clin Invest 77:1214-1223 (1986) (Pubitemid 16047143)
84. J. E. Silva, P. Matthews Thyroid hormone metabolism and the source of plasma triiodothyronine in 2-week old rats: Effects of thyroid status. Endocrinology 114:2394-2405 (1984) (Pubitemid 14120303)
85. J. E. Silva; M. B. Gordon; F. R. Crantz; J. L. Leonard and P. R. Larsen Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest 73:898-907 (1984) (Pubitemid 14132817)
86. A. C. Bianco, J. E. Silva Optimal response of key enzymes and uncoupling protein to cold in brown adipose tissue depends on local T3 generation. Am J Physiol 253:E255-E263 (1987)
87. A. C. Bianco, J. E. Silva Cold exposure rapidly produces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol 255:E496-E508 (1988)
88. L. A. de Jesus; S. D. Carvalho; M. O. Ribeiro; M. Schneider; S. W. Kim; J. W. Harney; P. R. Larsen and A. C. Bianco The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest 108:1379-1385 (2001) (Pubitemid 33107766)
89. J. E. Silva Full expression of uncoupling protein gene requires the concurrence of norepinephrine and triiodothyronine. Mol Endocrinol 2:706-713 (1988)
90. A. M. Cassard-Doulcier; C. Gelly; F. Bouillaud and D. Ricquier A 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue. Bi ochem J 333:243-246 (1998) (Pubitemid 28379522)
91. U. C. Kozak; J. Kopecky; J. Teisinger; S. Enerbäck; B. B. Boyer and L. P. Kozak An upstream enhancer regulating brown-fat specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 14:59-67 (1994)
92. R. Rabelo; A. Schifman; A. Rubio; X. Sheng and J. E. Silva Delineation of Thyroid Hormone Responsive Sequences within a Critical Enhancer in the Rat Uncoupling Protein Gene. Endocrinology 136:1003-1013 (1995)
93. R. Rabelo; C. Reyes; A. Schifman and J. E. Silva A Complex Retinoic Acid Response Element in the Uncoupling Protein Gene Defines a Novel Role for Retinoids in Thermogenesis. Endocrinology 137:3488-3496 (1996) (Pubitemid 26250203)
94. F. Villarroya; M. Giralt and R. Iglesias Retinoids and adipose tissues: metabolism, cell differentiation and gene expression. Int J Obes Relat Metab Disord 23:1-6 (1999) (Pubitemid 29008392)
95. U. C. Kozak; W. Held; D. Kreutter and L. P. Kozak Adrenergic regulation of the mitochondrial uncoupling protein gene in brown fat tumor cells. Mol Endocrinol 6:763-772 (1992)
96. J. E. Silva, R. Rabelo Regulation of the Uncoupling Protein Gene Expression. Eur J Endocrinol 136:251-264 (1997) (Pubitemid 27130045)
97. U. Sundin; I. Mills and J. N. Fain Thyroidcatecholamine interactions in isolated brown adipocytes. Metabolism:Clin &Expt 33:1028-1033 (1984) (Pubitemid 15210838)
98. L. T. Williams; R. J. Lefkowitz; A. M. Watanabe; D. R. Hathaway and H. R. Besch, Jr. Thyroid hormone regulation of beta-adrenergic receptor number. J Biol Chem 252:2787-2789 (1977) (Pubitemid 8094132)
99. A. Rubio; A. Raasmaja and J. E. Silva Effects of Thyroid Hormone on Norepinephrine Signalling in Brown Adipose Tissue. II: Differential Effects of Thyroid Hormone on b3-Adrenergic Recepto rs in Brown and White Adipose Tissue. Endocrinology 136:3277-3284 (1995)
100. M. O. Ribeiro; S. D. Carvalho; J. J. Schultz; G. Chiellini; T. S. Scanlan; A. C. Bianco and G. A. Brent Thyroid Hormone-Sympathetic Interaction and Adaptive Thermogenesis Are Thyroid Hormone Receptor Isoform-Specific. J Clin Invest 108:97-105 (2001) (Pubitemid 32634926)
101. S. D. Carvalho; A. C. Bianco and J. E. Silva Effects o f Hypothyroidism on Brown Adipose Tissue Adenylyl Cyclase Activity. Endocrinology 137:5519-5529 (1996) (Pubitemid 26423119)
102. M. Noronha; A. Raasmaja; N. Moolten and P. R. Larsen Triiodothyronine causes a rapid reversal of a1/cAMP synergism on brown adipose tissue respiration and Type II deiodinase activity. Metabolism:Clin &Expt 40:1327-1332 (1991)
103. J. P. B ilezikian, J. N. Loeb The influence of hyperthyroidism and hyperthyroidism on a- and badrenergic receptor systems and adrenergic responsiveness. Endocr Rev 4:378-388 (1983)
104. G. Canettieri; F. S. Celi; G. Baccheschi; L. Salvatori; M. Andreoli and M. Centanni Isolation of human type 2 deiodinase gene promoter and characterization of a functional cyclic adenosine monophosphate response element. Endocrinology 141:1804-1813 (2000) (Pubitemid 32274411)
105. S. B. Barker, H. M. Klitgaard Metabolism of Tissues Excised from Thyroxine-Injected Rats. J Physiol (Lond) 170:81-86 (1952)
106. J. Bernal, J. Nunez Thyroid hormones and brain development. Eur J Endocrinol 133:390-398 (1995)
107. J. Steinsapir; A. C. Bianco; C. Buettner; J. Harney and P. R. Larsen Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology 141:1127-1135 (2000) (Pubitemid 32260455)
108. S. D. Carvalho; E. T. Kimura; A. C. Bianco and J. E. Silva Central role of brown adipose tissue thyroxine 5'deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology 128:2149-2159 (1991)
109. Z. Glick; S. Y. Wu; J. Lupien; R. Reggio; G. A. Bray and D. A. Fisher Meal-induced brown fat thermogenesis and thyroid hormone metabolism in rats. Am J Physiol 249:E519-E524 (1985) (Pubitemid 16235832)
110. P. Trayhurn, G. Jennings Evidence that fasting can induce a selective loss of uncoupling protein from brown adipose tissue mitochondria of mice. Biosci Rep 6:805-810 (1986) (Pubitemid 17222886)
111. N. J. Rothwell; M. E. Saville and M. J. Stock Brown fa t activity in fasted and refed rats. Biosci Rep 4:351-357 (1984) (Pubitemid 14118174)
112. J. B. Young, L. Landsberg Effect of concomitant fasting and cold exposure on sympathoadrenal activity in rats. Am J Physiol 240:E314-E319 (1981) (Pubitemid 11137946)
113. P. J. Burstein; B. Draznin; C. J. Johnson and D. S. Schalch The effect of hypothyroidism on growth, serum growth hormone, the growth hormone-dependent somatomedin, insulin-like growth factor, and its carrier protein in rats. Endocrinology 104:1107-1111 (1979) (Pubitemid 9179162)
114. D. F. Wood; J. A. Franklyn; K. Docherty; D. B. Ramsden and M. C. Sheppard The effect of thyroid hormones on growth hormone gene expression in vivo in rats. J Endocrinol 112:459-463 (1987) (Pubitemid 17020884)
115. P. Trayhurn, D. Richard Brown adipose tissue thermogenesis and the energetics of pregnancy and lactation in rodents. Biochem Soc Transac 13:826-828 (1985) (Pubitemid 15248548)
116. F. Villarroya; A. Felipe and T. Mampel Sequential changes in brown adipose tissue composition, cytochrome oxidase activity and GDP bindin g throughout pregnancy and lactation in the rat. Biochim Biophys Acta 882:187-191 (1986) (Pubitemid 16100018)
117. R. Rabelo; C. Reyes; A. Schifman and J. E. Silva Interactions among receptors, thyroid hormone response elements and ligands in the regulation of the rat uncoupling protein gene by thyroid hormone. Endocrinology 137:3478-3487 (1996) (Pubitemid 26250202)
118. N. J. Rothwell, M. J. Stock Similarities between cold- and diet-induced thermogenesis in the rat. Can J Physiol Pharmacol 58:842-848 (1980) (Pubitemid 11205088)
119. B. B. Lowell; V. D. Susulic; A. Hamann; J. A. Lawitts; J. Himms-Hagen; L. P. Kozak and J. S. Flier Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740-742 (1993) (Pubitemid 24038513)
120. S. Enerbäck; A. Jacobsson; E. M. Simpson; C. Guerra; H. Yamashita; M. E. Harper and L. P. Kozak Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-94 (1997) (Pubitemid 27202655)
121. X. Liu; M. Rossmeisl; J. McClaine and L. P. Kozak Paradoxical resistance to diet-induced obesity in UCP1- deficient mice. J Clin Invest 111:399-407 (2003) (Pubitemid 36182217)
122. K. Gauthier; M. Plateroti; C. B. Harvey; G. R. Williams; R. E. Weiss; S. Refetoff; J. F. Willott; V. Sundin; J. P. Roux; L. Malaval; M. Hara; J. Samarut and O. Chassande Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus. Mol Cell Biol 21:4748-4760 (2001) (Pubitemid 32588255)
123. H. Marrif; A. Schifman; Z. Stepanyan; M. A. Gillis; A. Calderone; R. E. Weiss; J. Samarut and J. E. Silva Temperature Homeostasis in transgenic mice lacking thyroid hormone receptor alpha gene products. Endocrinology 146:2872-2884 (2005) (Pubitemid 41002794)
124. P. Pelletier; K. Gauthier; O. Sideleva; J. Samarut and J. E. Silva Mice lacking the th yroid hormone receptor-alpha gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity. Endocrinology 149:6471-6486 (2008)
125. J. Nedergaard; V. Golozoub ova; A. Matthias; I. Shabalina; K. Ohba; K. Ohlson; A. Jacobsson and B. Cannon Life without UCP1: mitochondrial, cellular and organismal characteristics of the UCP1-ablated mice. Biochem Soc Trans 29:756-763 ( 2001) (Pubitemid 33131776)
126. J. Ukropec; R. V. Anunciado; Y. Ravussin and L. P. Kozak Leptin is required for uncoupling protein-1- independent thermogenesis during cold stress. Endocrinology 147:2468-2480 (2006)
127. J. Ukropec; R. P. Anunciado; Y. Ravussin; M. W. Hulver and L. P. Kozak UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice. J Biol Chem 281:31894-31908 (2006) (Pubitemid 46041452)
128. W. Ramadan; S. Huang; A. Marsili; P. R. Larsen and J. E. Silva, Mouse Skeletal Muscle Microsomes have Type- 2 Iodothyronine Deiodinase (D2) mRNA and Activity. Possible Role in the Hypermetabolism of TRa-Deficient Mice. p 177 2009 (Abstract)
129. W. S. Simonides, C. van Hardeveld Effects of the thyroid status on the sarcoplasmic reticulum in slow skeletal muscle of the rat. Cell Calcium 7:147-160 (1986)
130. W. S. Simonides; M. H. Thelen; C. G. van der Linden; A. Muller and C. van Hardeveld Mechanism of thyroidhormone regulated expression of the SERCA genes in skeletal muscle: implications for thermogenesis. Biosci R ep 21:139-154 (2001) (Pubitemid 33070945)
131. J. F. Surmely; M. J. Voirol; N. Stefanoni; F. ssimacopoulos-Jeannet; J. P. Giacobino; E. Jequier; R. C. Gaillard and L. Tappy Stimulation by leptin of 3H GDP binding to brown adip ose tissue of fasted but not fed rats. Int J Obes Relat Metab Disord 22:923-926 (1998) (Pubitemid 28395961)
132. C. S. Asensio; D. Arsenijevic; L. Lehr; J. P. Giacobino; P. Muzzin and F. Rohner-Jeanrenaud Effects of leptin on energy metabolism in beta-less mice. Int J Obes (Lond) 32:936-942 (2008) (Pubitemid 351986218)
133. R. S. Ahima; D. Prabakaran; C. Mantzoros; D. Qu; B. Lowell; E. Maratos-Flier and J. S. Flie r Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252 (1996) (Pubitemid 26251358)
134. M. Hayashi, T. Nagasaka Suppression of norepinephrine-induced thermogenesis in brown adipose tissue by fasting. Am J Physiol 245:E582-E586 (1983) (Pubitemid 14216802)
135. C. J. Gordon Behavioral and autonomic thermoregulation in the rat following propylthiouracilinduced hypothyroidism. Pharmacol Biochem Behav 58:231-236 (1997) (Pubitemid 27334376)
136. A. Alfadda; R. A. DosSantos; Z. Stepanyan; H. Marrif and J. E. Silva Mice with Deletion of the Mitochondrial Glycerol-3-Phosphate Dehydrogenase Gene Exhibit a Thrifty Phenotype. Effect of Gender. Am J Physiol Regul Integr Comp Physiol 287:R147-R156 (2004) (Pubitemid 38856321)
137. R. A. DosSantos; A. Alfadda; K. Eto; T. Kadowaki and J. E. Silva Evidence for a compensated thermogenic defect in transgenic mice lacking the mitochondrial glycerol 3-phosphate dehydrogenase gene. Endocrinology 144:5469-5479 (2003) (Pubitemid 37476076)
138. Y. P. Lee, H. A. Lardy Influence of thyroid hormones on l-a-glycerophosphate dehydrogenases and other de hydrogenases in various organs of the rat. J Biol Chem 240:1427-1436 (1965)