메뉴 건너뛰기




Volumn 43, Issue 2, 2011, Pages 103-115

What's new in non-small cell lung cancer forpathologists: The importance of accurate subtyping, EGFR mutations and ALK rearrangements

Author keywords

Adenocarcinoma; ALK; Diagnosis; Epidermal growth factor receptor; FISH; Immunohistochemistry; Non small cell lung cancer; NSCLC subtype; Protein tyrosine kinases; Small biopsy; Squamous cell carcinoma

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; PROTEIN TYROSINE KINASE; TUMOR MARKER;

EID: 79955974560     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e328342629d     Document Type: Review
Times cited : (58)

References (127)
  • 1
    • 13944270480 scopus 로고    scopus 로고
    • Australian Institute of Health and Welfare (AIHW) and Australasian Association of Cancer Registries (AACR) Canberra: AIHW
    • Australian Institute of Health and Welfare (AIHW) and Australasian Association of Cancer Registries (AACR). Cancer in Australia 2001. Canberra: AIHW; 2004.
    • (2004) Cancer in Australia 2001
  • 2
    • 77950999338 scopus 로고    scopus 로고
    • Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology
    • Travis WD, Rekhtman N, Riley GJ, et al.Pathologic diagnosis of advanced lung cancer based on small biopsies and cytology. J Thorac Oncol 2010; 5: 411-4.
    • (2010) J Thorac Oncol , vol.5 , pp. 411-414
    • Travis, W.D.1    Rekhtman, N.2    Riley, G.J.3
  • 4
    • 33645052711 scopus 로고    scopus 로고
    • Distinct epidermal growth factor receptor and KRAS mutationpatterns in non small cell lung cancerpatients with different tobacco exposure and clinicoPathologic features
    • Tam IYS, Chung LP, Suen WS, et al. Distinct epidermal growth factor receptor and KRAS mutationpatterns in non small cell lung cancerpatients with different tobacco exposure and clinicoPathologic features. Clin Cancer Res 2006; 12: 1647-53.
    • (2006) Clin Cancer Res , vol.12 , pp. 1647-1653
    • Iys, T.1    Chung, L.P.2    Suen, W.S.3
  • 6
    • 33645804773 scopus 로고    scopus 로고
    • Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors
    • DOI 10.1200/JCO.2005.03.8224
    • Takeuchi T, Tomida S, Yatabe Y, et al. Expressionprofile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicoPathologic behaviors. J Clin Oncol 2006; 24: 1679-88. (Pubitemid 46622139)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.11 , pp. 1679-1688
    • Takeuchi, T.1    Tomida, S.2    Yatabe, Y.3    Kosaka, T.4    Osada, H.5    Yanagisawa, K.6    Mitsudomi, T.7    Takahashi, T.8
  • 7
    • 70350225538 scopus 로고    scopus 로고
    • Maintenancepemetrexedplus best supportive care versusplaceboplus best supportive care for nonsmall- cell lung cancer: A randomised, double-blind,phase 3 study
    • Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenancepemetrexedplus best supportive care versusplaceboplus best supportive care for nonsmall- cell lung cancer: a randomised, double-blind,phase 3 study. Lancet 2009; 374: 1432-40.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 8
    • 64049115311 scopus 로고    scopus 로고
    • The differential efficacy ofpemetrexed according to NSCLC histology: A review of twophase III studies
    • Scagliotti G, Hanna N, Fossella F, et al. The differential efficacy ofpemetrexed according to NSCLC histology: a review of twophase III studies. Oncologist 2009; 14: 253-63.
    • (2009) Oncologist , vol.14 , pp. 253-263
    • Scagliotti, G.1    Hanna, N.2    Fossella, F.3
  • 9
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatinplus gemcitabine with cisplatinpluspemetrexed in chemotherapy- naivepatients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV,Parikh P, vonpawel J, et al.Phase III study comparing cisplatinplus gemcitabine with cisplatinpluspemetrexed in chemotherapy- naivepatients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008; 26: 3543-51.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Vonpawel, J.3
  • 11
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel inpulmonary adenocarcinoma
    • Mok TS, Wu Y, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel inpulmonary adenocarcinoma. N Engl J Med 2009; 361: 947-57.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.2    Thongprasert, S.3
  • 12
    • 70349342712 scopus 로고    scopus 로고
    • EML4-ALK: Honing in on a new target in non-small-cell lung cancer
    • Horn L,pao W. EML4-ALK: honing in on a new target in non-small-cell lung cancer. J Clin Oncol 2009; 27: 4232-5.
    • (2009) J Clin Oncol , vol.27 , pp. 4232-4425
    • Horn, L.1    Pao, W.2
  • 13
    • 0026494947 scopus 로고
    • A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7Hpyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
    • Taylor EC, Kuhnt D, Shih C, et al. A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7Hpyrrolo[2, 3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J Med Chem 1992; 35: 4450-4.
    • (1992) J Med Chem , vol.35 , pp. 4450-4454
    • Taylor, E.C.1    Kuhnt, D.2    Shih, C.3
  • 15
    • 42549116071 scopus 로고    scopus 로고
    • Ispemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of aphase III trial ofpemetrexed vs docetaxel inpreviously treatedpatients with advanced non-small cell lung cancer (NSCLC):p2-328
    • Petersonp,Park K, Fossella F, Gatzemeier U, John W, Scagliotti G. Ispemetrexed more effective in adenocarcinoma and large cell lung cancer than in squamous cell carcinoma? A retrospective analysis of aphase III trial ofpemetrexed vs docetaxel inpreviously treatedpatients with advanced non-small cell lung cancer (NSCLC):p2-328. J Thorac Oncol 2007; 2: S851.
    • (2007) J Thorac Oncol , vol.2
    • Peterson, P.1    Park, K.2    Fossella, F.3    Gatzemeier, U.4    John, W.5    Scagliotti, G.6
  • 16
    • 37349035474 scopus 로고    scopus 로고
    • Phase III study ofpemetrexedplus cisplatin versus gemcitabineplus cisplatin in chemonaivepatients with locally advanced or metastatic non-small cell lung cancer (NSCLC):pRS-03
    • Scagliotti G,purvishp, vonpawel J, et al.Phase III study ofpemetrexedplus cisplatin versus gemcitabineplus cisplatin in chemonaivepatients with locally advanced or metastatic non-small cell lung cancer (NSCLC):pRS-03. J Thorac Oncol 2007; 2: S306.
    • (2007) J Thorac Oncol , vol.2
    • Scagliotti, G.1    Purvish, P.2    Vonpawel, J.3
  • 18
    • 22344449812 scopus 로고    scopus 로고
    • Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells
    • DOI 10.1124/mol.104.009373
    • Giovannetti E, Mey V, Nannizzi S, et al. Cellular andpharmacogenetics foundation of synergistic interaction ofpemetrexed and gemcitabine in human non-small-cell lung cancer cells. Molpharmacol 2005; 68: 110-8. (Pubitemid 41002949)
    • (2005) Molecular Pharmacology , vol.68 , Issue.1 , pp. 110-118
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3    Pasqualetti, G.4    Marini, L.5    Del Tacca, M.6    Danesi, R.7
  • 19
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • DOI 10.1038/nm0603-669
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-76. (Pubitemid 36749215)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.-P.2    LeCouter, J.3
  • 20
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatinplus gemcitabine with eitherplacebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL
    • Reck M, vonpawel J, Zatloukalp, et al.Phase III trial of cisplatinplus gemcitabine with eitherplacebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL. J Clin Oncol 2009; 27: 1227-34.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    Vonpawel, J.2    Zatloukal, P.3
  • 22
    • 70349149267 scopus 로고    scopus 로고
    • Diagnostic reproducibility of squamous cell carcinoma (SC) in the era of histology-directed nonsmall cell lung cancer (NSCLC) chemotherapy: A largeprospective study
    • abstr
    • Grilley-Olson JE, Hayes DN, Qaqish BF, et al. Diagnostic reproducibility of squamous cell carcinoma (SC) in the era of histology-directed nonsmall cell lung cancer (NSCLC) chemotherapy: A largeprospective study. J Clin Oncol 2009; 27: S409; (abstr).
    • (2009) J Clin Oncol , vol.27
    • Grilley-Olson, J.E.1    Hayes, D.N.2    Qaqish, B.F.3
  • 24
    • 33644759126 scopus 로고    scopus 로고
    • Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study
    • DOI 10.1016/j.lungcan.2005.11.012, PII S0169500206000237
    • Stang A,pohlabeln H, Muller KM, Jahn I, Giersiepen K, Jockel KH. Diagnostic agreement in the histoPathological evaluation of lung cancer tissue in apopulation-based case-control study. Lung Cancer 2006; 52: 29-36. (Pubitemid 43340196)
    • (2006) Lung Cancer , vol.52 , Issue.1 , pp. 29-36
    • Stang, A.1    Pohlabeln, H.2    Muller, K.M.3    Jahn, I.4    Giersiepen, K.5    Jockel, K.-H.6
  • 26
    • 0033934570 scopus 로고    scopus 로고
    • Preoperative histological classification of primary lung cancer: Accuracy of diagnosis and use of the non-small cell category
    • DOI 10.1136/jcp.53.7.537
    • Edwards SL, Roberts C, McKean ME, et al.preoperative histological classification ofprimary lung cancer: accuracy of diagnosis and use of the non-small cell category. J Clinpathol 2000; 53: 537-40. (Pubitemid 30432112)
    • (2000) Journal of Clinical Pathology , vol.53 , Issue.7 , pp. 537-540
    • Edwards, S.L.1    Roberts, C.2    McKean, M.E.3    Cockburn, J.S.4    Jeffrey, R.R.5    Kerr, K.M.6
  • 27
    • 77951019161 scopus 로고    scopus 로고
    • Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytological material, using apanel of mucin staining, TTF-1, cytokeratin 5/6, andp63, and EGFR mutation analysis
    • Nicholson AG, Gonzales D, Shahp, et al. Refining the diagnosis and EGFR status of non-small cell lung carcinoma in biopsy and cytological material, using apanel of mucin staining, TTF-1, cytokeratin 5/6, andp63, and EGFR mutation analysis. J Thorac Oncol 2010; 5: 436-41.
    • (2010) J Thorac Oncol , vol.5 , pp. 436-441
    • Nicholson, A.G.1    Shahp, G.D.2
  • 28
    • 0021832916 scopus 로고
    • Lung cancer heterogeneity: A blinded and randomized study of 100 consecutive cases
    • DOI 10.1016/S0046-8177(85)80106-4
    • Roggli VL, Vollmer RT, Greenberg SD, et al. Lung cancer heterogeneity: a blinded and randomized study of 100 consecutive cases. Hum Pathol 1985; 16: 569-79. (Pubitemid 15049631)
    • (1985) Human Pathology , vol.16 , Issue.6 , pp. 569-579
    • Roggli, V.L.1    Vollmer, R.T.2    Greenberg, S.D.3
  • 30
    • 24944524154 scopus 로고    scopus 로고
    • Positive thyroid transcription factor I staining strongly correlates with survival of patients with adenocarcinoma of the lung
    • DOI 10.1038/sj.bjc.6602717, PII 6602717
    • Barlesi F,pinot D, Legoffic A, et al.positive thyroid transcription factor 1 staining strongly correlates with survival ofpatients with adenocarcinoma of the lung. Br J Cancer 2005; 93: 450-2. (Pubitemid 43080019)
    • (2005) British Journal of Cancer , vol.93 , Issue.4 , pp. 450-452
    • Barlesi, F.1    Pinot, D.2    LeGoffic, A.3    Doddoli, C.4    Chetaille, B.5    Torre, J.-P.6    Astoul, P.7
  • 31
    • 5644291814 scopus 로고    scopus 로고
    • Histopathologic classification of lung cancer: Relevance of cytokeratin and TTF-1 immunophenotyping
    • DOI 10.1016/j.anndiagpath.2004.07.001, PII S1092913404000632
    • Johansson L. HistoPathological classification of lung cancer: relevance of cytokeratin and TTF-1 immunophenotyping. Ann Diagnpathol 2004; 8: 259-67. (Pubitemid 39370567)
    • (2004) Annals of Diagnostic Pathology , vol.8 , Issue.5 , pp. 259-267
    • Johansson, L.1
  • 32
    • 33746271856 scopus 로고    scopus 로고
    • TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in previously pap-stained cytologic material
    • DOI 10.1038/modpathol.3800629, PII 3800629
    • Kalhor N, Zander DS, Liu J. TTF-1 andp63 for distinguishingpulmonary small cell carcinoma frompoorly differentiated squamous cell carcinoma inpreviouslypAP stained cytological material. Mod pathol 2006; 19: 1117-23. (Pubitemid 44106727)
    • (2006) Modern Pathology , vol.19 , Issue.8 , pp. 1117-1123
    • Kalhor, N.1    Zander, D.S.2    Liu, J.3
  • 33
    • 0034817033 scopus 로고    scopus 로고
    • Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34βe12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung
    • DOI 10.1053/hupa.2001.27110
    • Sturm N, Lantuujoul S, Laverriere MH, et al. Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14(34bE12) expression in basaloid and largecell neuroendocrine carcinomas of the lung. Hum Pathol 2001; 32: 918-25. (Pubitemid 32911313)
    • (2001) Human Pathology , vol.32 , Issue.9 , pp. 918-925
    • Sturm, N.1    Lantuejoul, S.2    Laverriere, M.-H.3    Papotti, M.4    Brichon, P.-Y.5    Brambilla, C.6    Brambilla, E.7
  • 34
    • 0037531707 scopus 로고    scopus 로고
    • Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: A high-throughput tissue microarray and immunohistochemistry study
    • DOI 10.1016/S0046-8177(03)00180-1
    • Tan D, Li O, Deeb G, et al. Thyroid transcription factor-1 expressionprevalence and its clinical implications in non-small cell lung cancer: a high throughput tissue microarray and immunohistochemical study. Hum Pathol 2003; 34: 597-604. (Pubitemid 36750372)
    • (2003) Human Pathology , vol.34 , Issue.6 , pp. 597-604
    • Tan, D.1    Li, Q.2    Deeb, G.3    Ramnath, N.4    Slocum, H.K.5    Brooks, J.6    Cheney, R.7    Wiseman, S.8    Anderson, T.9    Loewen, G.10
  • 35
    • 16544368541 scopus 로고    scopus 로고
    • P63 expression in lung carcinoma: A tissue microarray study of 408 cases
    • Au NH, Gown AM, Cheang M, et al.p63 expression in lung carcinoma: a tissue microarray study of 408 cases. Appl Immunohistochem Mol Morphol 2004; 12: 240-7.
    • (2004) Appl Immunohistochem Mol Morphol , vol.12 , pp. 240-247
    • Au, N.H.1    Gown, A.M.2    Cheang, M.3
  • 36
    • 33646122426 scopus 로고    scopus 로고
    • Expression ofp63, keratin 5/6, keratin 7 and surfactant-A in non-small cell carcinoma
    • Camilo R, Capelozzi VL, Siqueira SAC, Bernardi FDC. Expression ofp63, keratin 5/6, keratin 7 and surfactant-A in non-small cell carcinoma. Hum Pathol 2006; 37: 542-6.
    • (2006) Hum Pathol , vol.37 , pp. 542-546
    • Camilo, R.1    Capelozzi, V.L.2    Sac, S.3    Fdc, B.4
  • 37
    • 0033971623 scopus 로고    scopus 로고
    • Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B
    • DOI 10.1046/j.1365-2559.2000.00801.x
    • Kaufmann O, Dietel M. Thyroid transcription factor-1 is the superior immunohistochemical marker forpulmonary adenocarcinomas and large cell carcinomas compared to surfactantproteins A and B. Histopathology 2000; 36: 8-16. (Pubitemid 30055417)
    • (2000) Histopathology , vol.36 , Issue.1 , pp. 8-16
    • Kaufmann, O.1    Dietel, M.2
  • 40
    • 0036100810 scopus 로고    scopus 로고
    • TTF-1 expression inpulmonary adenocarcinomas
    • Yatabe Y, Mitsudomi T, Takahashi T, et al. TTF-1 expression inpulmonary adenocarcinomas. Am J Surgpathol 2002; 26: 767-72.
    • (2002) Am J Surgpathol , vol.26 , pp. 767-772
    • Yatabe, Y.1    Mitsudomi, T.2    Takahashi, T.3
  • 41
    • 77950974826 scopus 로고    scopus 로고
    • Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimens
    • LoopSL, Thomas SC, Nicolson MC, Fyfe MN, Kerr KM. Subtyping of undifferentiated non-small cell carcinomas in bronchial biopsy specimens. J Thorac Oncol 2010; 5: 442-7.
    • (2010) J Thorac Oncol , vol.5 , pp. 442-447
    • Loop, S.L.1    Thomas, S.C.2    Nicolson, M.C.3    Fyfe, M.N.4    Kerr, K.M.5
  • 42
    • 1842853121 scopus 로고    scopus 로고
    • Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumours
    • Liu J, Farhood A. Immunostaining for thyroid transcription factor-1 on fine-needle aspiration specimens of lung tumours. Cancer Cytopathol 2004; 102: 109-14.
    • (2004) Cancer Cytopathol , vol.102 , pp. 109-114
    • Liu, J.1    Farhood, A.2
  • 43
    • 58449083554 scopus 로고    scopus 로고
    • Pulmonary adenocarcinomas: Classification and reporting
    • Kerr KM.pulmonary adenocarcinomas: classification and reporting. Histopathology 2009; 54: 12-27.
    • (2009) Histopathology , vol.54 , pp. 12-27
    • Kerr, K.M.1
  • 44
    • 49649087950 scopus 로고    scopus 로고
    • If it's not CK5/6positive TTF-1 negative it's not a squamous cell carcinoma of lung
    • Downeyp, Cummins R, Moran M, Gulmann C. If it's not CK5/6positive, TTF-1 negative it's not a squamous cell carcinoma of lung. APMIS 2008; 116: 526-9.
    • (2008) APMIS , vol.116 , pp. 526-529
    • Downey, P.1    Cummins, R.2    Moran, M.3    Gulmann, C.4
  • 45
    • 37349100847 scopus 로고    scopus 로고
    • The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas
    • DOI 10.1097/PAI.0b013e31802fab75, PII 0012903920071200000009
    • Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK5/6 andp63 immunostaining in classification of lung carcinomas. Mol Morphol 2007; 15: 415-20. (Pubitemid 350307847)
    • (2007) Applied Immunohistochemistry and Molecular Morphology , vol.15 , Issue.4 , pp. 415-420
    • Kargi, A.1    Gurel, D.2    Tuna, B.3
  • 46
    • 0035184548 scopus 로고    scopus 로고
    • Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas
    • DOI 10.1309/21TW-2NDG-JRK4-PFJX
    • Kaufmann O, Fietze E, Mengs J, et al. Value ofp63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis ofpoorly differentiated and undifferentiated carcinomas. Am J Clinpathol 2001; 116: 823-30. (Pubitemid 33108152)
    • (2001) American Journal of Clinical Pathology , vol.116 , Issue.6 , pp. 823-830
    • Kaufmann, O.1    Fietze, E.2    Mengs, J.3    Dietel, M.4
  • 47
    • 65349083842 scopus 로고    scopus 로고
    • P63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples: Implications in treatment selection
    • Jorda M, Gomez-Fernandez C, Garcia M, et al.p63 differentiates subtypes of nonsmall cell carcinomas of lung in cytologic samples: implications in treatment selection. Cancer Cytopathol 2009; 117: 46-50.
    • (2009) Cancer Cytopathol , vol.117 , pp. 46-50
    • Jorda, M.1    Gomez-Fernandez, C.2    Garcia, M.3
  • 49
    • 46249096082 scopus 로고    scopus 로고
    • Lung adenocarcinoma: Modification of the 2004 WHO mixed subtype to include the major histology subtype suggests correlations betweenpapillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
    • Motoi N, Szoke H, Riely GJ, et al. Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histology subtype suggests correlations betweenpapillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surgpathol 2008; 32: 810-27.
    • Am J Surgpathol , vol.2008 , Issue.32 , pp. 810-827
    • Motoi, N.1    Szoke, H.2    Riely, G.J.3
  • 50
    • 53549134344 scopus 로고    scopus 로고
    • Influence of tumourpatterns in mixed-type adenocarcinoma onpost-operative survival
    • Kerr KM, Fyfe MN, Nicolson MC, et al. Influence of tumourpatterns in mixed-type adenocarcinoma onpost-operative survival. J Thorac Oncol 2007; 2: S801-2.
    • (2007) J Thorac Oncol , vol.2
    • Kerr, K.M.1    Fyfe, M.N.2    Nicolson, M.C.3
  • 51
    • 33646853678 scopus 로고    scopus 로고
    • Prognostic value of histology in resected lung cancer with emphasis on the relevance of the adenocarcinoma subtyping
    • DOI 10.1016/j.athoracsur.2006.01.021, PII S0003497506000282
    • Riquet M, Foucault C, Bernap, et al.prognostic value of histology in resected lung cancer with emphasis on the relevance of the adenocarcinoma subtyping. Ann Thorac Surg 2006; 81: 1988-95. (Pubitemid 43775587)
    • (2006) Annals of Thoracic Surgery , vol.81 , Issue.6 , pp. 1988-1995
    • Riquet, M.1    Foucault, C.2    Berna, P.3    Assouad, J.4    Dujon, A.5    Danel, C.6
  • 52
    • 8744288852 scopus 로고    scopus 로고
    • Prognostic analysis of pulmonary adenocarcinoma subclassification with special consideration of papillary and bronchioloalveolar types
    • DOI 10.1111/j.1365-2559.2004.01946.x
    • Aida S, Shimazaki H, Sato K, et al.prognostic analysis ofpulmonary adenocarcinomas subclassification with special consideration ofpapillary and bronchioloalveolar types. Histopathology 2004; 45: 468-76. (Pubitemid 39524321)
    • (2004) Histopathology , vol.45 , Issue.5 , pp. 468-476
    • Aida, S.1    Shimazaki, H.2    Sato, K.3    Sato, M.4    Deguchi, H.5    Ozeki, Y.6    Tamai, S.7
  • 53
    • 0034283155 scopus 로고    scopus 로고
    • Favourable and unfavourable morphologicalprognostic factors inperipheral lung adenocarcinoma of the lung 3 cm or less in diameter
    • Yokose T, Suzuki K, Nagai K, et al. Favourable and unfavourable morphologicalprognostic factors inperipheral lung adenocarcinoma of the lung 3 cm or less in diameter. Lung Cancer 2000; 29: 179-88.
    • (2000) Lung Cancer , vol.29 , pp. 179-188
    • Yokose, T.1    Suzuki, K.2    Nagai, K.3
  • 55
    • 77952251380 scopus 로고    scopus 로고
    • The new IASLC/ATS/ERS international multidisciplinary lung adenocarcinoma classification
    • abstr
    • Travis WD, Brambilla E, Noguchi M, et al. The new IASLC/ATS/ERS international multidisciplinary lung adenocarcinoma classification. J Thorac Oncol 2009; 4: S86-9; (abstr).
    • (2009) J Thorac Oncol , vol.4
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 59
    • 33846187218 scopus 로고    scopus 로고
    • Update on epidermal growth factor receptor mutations in non-small cell lung cancer
    • DOI 10.1158/1078-0432.CCR-06-0658
    • Riely GJ,politi KA, Miller VA,paoW. Update on epidermal growth factor receptor mutations in non small cell lung cancer. Clin Cancer Res 2006; 12: 7232-41. (Pubitemid 46095394)
    • (2006) Clinical Cancer Research , vol.12 , Issue.24 , pp. 7232-7241
    • Riely, G.J.1    Politi, K.A.2    Miller, V.A.3    Pao, W.4
  • 60
    • 41149097557 scopus 로고    scopus 로고
    • Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype,predict response to erlotinib
    • Miller VA, Riely GJ, Zakowski MF, et al. Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype,predict response to erlotinib. J Clin Oncol 2008; 26: 1472-8.
    • (2008) J Clin Oncol , vol.26 , pp. 1472-1478
    • Miller, V.A.1    Riely, G.J.2    Zakowski, M.F.3
  • 63
    • 33846483745 scopus 로고    scopus 로고
    • EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: Retro- and prospective observations in non-small-cell lung cancer
    • DOI 10.1093/annonc/mdl323
    • van Zandwijk N, Mathy A, Boerrigter L, et al. EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: retro- andprospective observations in non-small-cell lung cancer. Ann Oncol 2007; 18: 99-103. (Pubitemid 46152507)
    • (2007) Annals of Oncology , vol.18 , Issue.1 , pp. 99-103
    • Van Zandwijk, N.1    Mathy, A.2    Boerrigter, L.3    Ruijter, H.4    Tielen, I.5    De Jong, D.6    Baas, P.7    Burgers, S.8    Nederlof, P.9
  • 64
    • 33745683527 scopus 로고    scopus 로고
    • Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy
    • DOI 10.1158/1078-0432.CCR-06-0261
    • BunnpA, Dziadziuszko R, Varella-Garcia M, et al. Biological markers for non-small cell lung cancerpatient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy. Clin Cancer Res 2006; 12: 3652-6. (Pubitemid 44000246)
    • (2006) Clinical Cancer Research , vol.12 , Issue.12 , pp. 3652-3656
    • Bunn Jr., P.A.1    Dziadziuszko, R.2    Varella-Garcia, M.3    Franklin, W.A.4    Witta, S.E.5    Kelly, K.6    Hirsch, F.R.7
  • 65
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010; 362: 2380-8.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 66
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatinplus docetaxel inpatients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomisedphase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatinplus docetaxel inpatients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomisedphase 3 trial. Lancet Oncol 2010; 11: 121-8.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 67
    • 0141599428 scopus 로고    scopus 로고
    • Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4- anilinoquinazoline inhibitor
    • Stamos J, Sliwkowski MX, Eigenbrot C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4- anilinoquinazoline inhibitor. J Biol Chem 2002; 277: 46265-72.
    • (2002) J Biol Chem , vol.277 , pp. 46265-44672
    • Stamos, J.1    Sliwkowski, M.X.2    Eigenbrot, C.3
  • 68
    • 63149108552 scopus 로고    scopus 로고
    • Mutations and response to epidermal growth factor receptor inhibitors
    • Laurent-Puig P, Lievre A, Blons H. Mutations and response to epidermal growth factor receptor inhibitors. Clin Cancer Res 2009; 15: 1133-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 1133-1139
    • Laurent-Puig, P.1    Lievre, A.2    Blons, H.3
  • 70
    • 33847406095 scopus 로고    scopus 로고
    • Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity
    • DOI 10.1016/j.ccr.2006.12.017, PII S1535610807000281
    • Yun CH, Boggon TJ, Li Y, et al. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell 2007; 11: 217-27. (Pubitemid 46349842)
    • (2007) Cancer Cell , vol.11 , Issue.3 , pp. 217-227
    • Yun, C.-H.1    Boggon, T.J.2    Li, Y.3    Woo, M.S.4    Greulich, H.5    Meyerson, M.6    Eck, M.J.7
  • 73
    • 22044454824 scopus 로고    scopus 로고
    • EGFR mutation conferring primary resistance to gefitinib in non-small-cell lung cancer [2] (multiple letters)
    • DOI 10.1056/NEJM200507143530217
    • Shih J-Y, Gow C-H, Yangp-C. EGFR mutation conferringprimary resistance to gefitinib in non-small-cell lung cancer. N Engl J Med 2005; 353: 207-8. (Pubitemid 41058355)
    • (2005) New England Journal of Medicine , vol.353 , Issue.2 , pp. 207-208
    • Shih, J.-Y.1    Gow, C.-H.2    Yang, P.-C.3
  • 76
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • Turke AB, Zejnullahu K,Wu Y, et al.preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 2010; 17: 77-88.
    • (2010) Cancer Cell , vol.17 , pp. 77-88
    • Turke, A.B.1    Zejnullahu, K.2    Wu, Y.3
  • 78
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS arepredictive andprognostic indicators inpatients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS arepredictive andprognostic indicators inpatients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005; 23: 5900-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 80
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R, Moran T, Queralt C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009; 361: 958-67.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3
  • 83
    • 22244436599 scopus 로고    scopus 로고
    • Female sex and bronchioloalveolar pathologic subtype predict EGFR mutations in non-small cell lung cancer
    • DOI 10.1378/chest.128.1.317
    • Hsieh R-K, Lim K-H, Kuo H-T, Tzen C-Y, Huang M-J. Female sex and bronchioloalveolarPathologic subtypepredict EGFR mutations in nonsmall cell lung cancer. Chest 2005; 128: 317-21. (Pubitemid 40994490)
    • (2005) Chest , vol.128 , Issue.1 , pp. 317-321
    • Hsieh, R.-K.1    Lim, K.-H.2    Kuo, H.-T.3    Tzen, C.-Y.4    Huang, M.-J.5
  • 85
    • 28844449401 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations and gene amplification IDEAL INTACT gefitinib trials
    • Bell DW, Lynch TJ, Haserlat SM, et al. Epidermal growth factor receptor mutations and gene amplification IDEAL INTACT gefitinib trials. J Clin Oncol 2005; 23: 8081-92.
    • (2005) J Clin Oncol , vol.23 , pp. 8081-8092
    • Bell, D.W.1    Lynch, T.J.2    Haserlat, S.M.3
  • 86
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect keypathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect keypathways in lung adenocarcinoma. Nature 2008; 455: 1069-75.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 87
    • 33746877875 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation testing in the care of lung cancerpatients
    • Sequist LV, Joshi V, JannepA, et al. Epidermal growth factor receptor mutation testing in the care of lung cancerpatients. Clin Cancer Res 2006; 12: S4403-8.
    • (2006) Clin Cancer Res , vol.12
    • Sequist, L.V.1    Jannepa, J.V.2
  • 88
    • 17744371335 scopus 로고    scopus 로고
    • EGFR mutation is specific for terminal respiratory unit type adenocarcinoma
    • DOI 10.1097/01.pas.0000157935.28066.35
    • Yatabe Y, Kosaka T, Takahashi T, Mitsudomi T. EGFR mutation is specific for terminal respiratory unit type adenocarcinoma. Am J Surgpathol 2005; 29: 633-9. (Pubitemid 40577873)
    • (2005) American Journal of Surgical Pathology , vol.29 , Issue.5 , pp. 633-639
    • Yatabe, Y.1    Kosaka, T.2    Takahashi, T.3    Mitsudomi, T.4
  • 89
    • 48049116431 scopus 로고    scopus 로고
    • EGFR assays in lung cancer
    • Dacic S. EGFR assays in lung cancer. Adv Anatpathol 2008; 15: 241-7.
    • (2008) Adv Anatpathol , vol.15 , pp. 241-247
    • Dacic, S.1
  • 90
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib inpatients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
    • Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib inpatients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008; 26: 2442-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 91
    • 33645163460 scopus 로고    scopus 로고
    • A correlation between EGFR gene mutation status and bronchioloalveolar carcinoma features in Japanesepatients with adenocarcinoma
    • Haneda H, Sasaki H, Lindeman N, et al. A correlation between EGFR gene mutation status and bronchioloalveolar carcinoma features in Japanesepatients with adenocarcinoma. Japan J Clin Oncol 2006; 36: 69-75.
    • (2006) Japan J Clin Oncol , vol.36 , pp. 69-75
    • Haneda, H.1    Sasaki, H.2    Lindeman, N.3
  • 92
    • 65349167234 scopus 로고    scopus 로고
    • EGFR and K-ras mutations along the spectrum ofpulmonary epithelial tumors of the lung and elaboration of a combined clinicoPathologic and molecular scoring system topredict clinical responsiveness to EGFR inhibitors
    • Sartori G, Cavazza A, Sgambato A, et al. EGFR and K-ras mutations along the spectrum ofpulmonary epithelial tumors of the lung and elaboration of a combined clinicoPathologic and molecular scoring system topredict clinical responsiveness to EGFR inhibitors. Am J Clinpathol 2009; 131: 478-89.
    • (2009) Am J Clinpathol , vol.131 , pp. 478-489
    • Sartori, G.1    Cavazza, A.2    Sgambato, A.3
  • 93
    • 57349141411 scopus 로고    scopus 로고
    • EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance
    • Jiang SX, Yamashita K, Yamamoto M, et al. EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance. Int J Cancer 2008; 123: 2480-6.
    • (2008) Int J Cancer , vol.123 , pp. 2480-2486
    • Jiang, S.X.1    Yamashita, K.2    Yamamoto, M.3
  • 95
    • 58049205542 scopus 로고    scopus 로고
    • Correlation between morphology and EGFR mutations in lung adenocarcinomas significance of the micropapillarypattern and the hobnail cell type
    • Ninomiya H, Hiramatsu M, Inamura K, et al. Correlation between morphology and EGFR mutations in lung adenocarcinomas significance of the micropapillarypattern and the hobnail cell type. Lung Cancer 2009; 63: 235-40.
    • (2009) Lung Cancer , vol.63 , pp. 235-240
    • Ninomiya, H.1    Hiramatsu, M.2    Inamura, K.3
  • 99
    • 77954157136 scopus 로고    scopus 로고
    • Use of erlotinib or gefitinib as initial therapy in advanced NSCLC
    • Oxnard GR, Miller VA. Use of erlotinib or gefitinib as initial therapy in advanced NSCLC. Oncology 2010; 24: 392-9.
    • (2010) Oncology , vol.24 , pp. 392-399
    • Oxnard, G.R.1    Miller, V.A.2
  • 100
    • 77958185649 scopus 로고    scopus 로고
    • Consensus for EGFR mutation testing in non-small cell lung cancer. Results from a European Workshop
    • Pirker R, Herth JF, Kerr KM, et al. Consensus for EGFR mutation testing in non-small cell lung cancer. Results from a European Workshop. J Thorac Oncol 2010; 5: 1706-13.
    • (2010) J Thorac Oncol , vol.5 , pp. 1706-1713
    • Pirker, R.1    Herth, J.F.2    Kerr, K.M.3
  • 101
    • 76149086520 scopus 로고    scopus 로고
    • Endobronchial ultrasoundguided transbronchial needle aspiration for identifying EGFR mutations
    • Garcia-Olive I, Monso E, Andreo F, et al. Endobronchial ultrasoundguided transbronchial needle aspiration for identifying EGFR mutations. Eur Resp J 2010; 35: 391-5.
    • (2010) Eur Resp J , vol.35 , pp. 391-395
    • Garcia-Olive, I.1    Monso, E.2    Andreo, F.3
  • 102
    • 38049008135 scopus 로고    scopus 로고
    • Comprehensive epidermal growth factor gene analysis from cytological specimens of non-small-cell lung cancers
    • Savic S, Tapia C, Grilli B, et al. Comprehensive epidermal growth factor gene analysis from cytological specimens of non-small-cell lung cancers. Br J Cancer 2008; 98: 154-60.
    • (2008) Br J Cancer , vol.98 , pp. 154-160
    • Savic, S.1    Tapia, C.2    Grilli, B.3
  • 103
    • 77958175650 scopus 로고    scopus 로고
    • A brief retrospective report on the feasibility of epidermal growth factor receptor and KRAS mutation analysis in transesophageal ultrasound- and endobronchial ultrasound-guided fine needle cytological aspirates
    • Schuurbiers OCJ, Looijen-Salamon MG, Ligtenberg MJL, van der Heijden HFM. A brief retrospective report on the feasibility of epidermal growth factor receptor and KRAS mutation analysis in transesophageal ultrasound- and endobronchial ultrasound-guided fine needle cytological aspirates. J Thorac Oncol 2010; 5: 1664-7.
    • (2010) J Thorac Oncol , vol.5 , pp. 1664-1667
    • Schuurbiers, O.C.J.1    Looijen-Salamon, M.G.2    Ligtenberg, M.J.L.3    Van Der Heijden, H.F.M.4
  • 104
    • 77953000554 scopus 로고    scopus 로고
    • EGFR mutation is a betterpredictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry
    • Sholl LM, Xiao Y, Joshi V, et al. EGFR mutation is a betterpredictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry. Am J Clinpathol 2010; 133: 922-34.
    • (2010) Am J Clinpathol , vol.133 , pp. 922-934
    • Sholl, L.M.1    Xiao, Y.2    Joshi, V.3
  • 105
    • 77958198161 scopus 로고    scopus 로고
    • Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: Immunohistochemistry as apossible screening method for epidermal growth factor receptor mutations
    • Kato Y,Peled N, Wynes M, et al. Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: immunohistochemistry as apossible screening method for epidermal growth factor receptor mutations. J Thorac Oncol 2010; 5: 1551-8.
    • (2010) J Thorac Oncol , vol.5 , pp. 1551-1558
    • Kato, Y.1    Peled, N.2    Wynes, M.3
  • 106
    • 65649128973 scopus 로고    scopus 로고
    • Mutation-specific antibodies for the detection of EGFR mutations in non-small cell lung cancer
    • Yu J, Kane S,Wu J, et al. Mutation-specific antibodies for the detection of EGFR mutations in non-small cell lung cancer. Clin Cancer Res 2009; 15: 3023-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 3023-3028
    • Yu, J.1    Kane Swu, J.2
  • 107
    • 77954224784 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFR mutation using mutation-specific antibodies in lung cancer
    • Kitamura A, Hosoda W, Sasaki E, Mitsudomi T, Yatabe Y. Immunohistochemical detection of EGFR mutation using mutation-specific antibodies in lung cancer. Clin Cancer Res 2010; 16: 3349-55.
    • (2010) Clin Cancer Res , vol.16 , pp. 3349-3355
    • Kitamura, A.1    Hosoda, W.2    Sasaki, E.3    Mitsudomi, T.4    Yatabe, Y.5
  • 109
    • 43649099401 scopus 로고    scopus 로고
    • Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
    • DOI 10.1111/j.1349-7006.2008.00782.x
    • Taniguchi K, Okami J, Kodama K, Higashiyama M, Kato K. Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib. Cancer Sci 2008; 99: 929-35. (Pubitemid 351997594)
    • (2008) Cancer Science , vol.99 , Issue.5 , pp. 929-935
    • Taniguchi, K.1    Okami, J.2    Kodama, K.3    Higashiyama, M.4    Kato, K.5
  • 110
    • 68549111225 scopus 로고    scopus 로고
    • Discordance of molecular biomarkers associated with epidermal growth factor receptorpathway betweenprimary tumors and lymph node metastasis in non-small cell lung cancer
    • Park S, Holmes-Tisch AJ, Cho EY, et al. Discordance of molecular biomarkers associated with epidermal growth factor receptorpathway betweenprimary tumors and lymph node metastasis in non-small cell lung cancer. J Thorac Oncol 2009; 4: 809-15.
    • (2009) J Thorac Oncol , vol.4 , pp. 809-815
    • Park, S.1    Holmes-Tisch, A.J.2    Cho, E.Y.3
  • 111
    • 51449101924 scopus 로고    scopus 로고
    • Comparison of EGFR and K-RAS gene status betweenprimary tumours and corresponding metastases in NSCLC
    • Kalikaki A, Koutsopoulos A, Trypaki M, et al. Comparison of EGFR and K-RAS gene status betweenprimary tumours and corresponding metastases in NSCLC. Br J Cancer 2008; 99: 923-9.
    • (2008) Br J Cancer , vol.99 , pp. 923-939
    • Kalikaki, A.1    Koutsopoulos, A.2    Trypaki, M.3
  • 112
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U, Iafrate AJ, Gray NS, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res 2008; 68: 3389-95.
    • (2008) Cancer Res , vol.68 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3
  • 113
    • 66949152073 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase: Signalling in development and disease
    • Palmer RH, Vernersson E, Grabbe C, Hallberg B. Anaplastic lymphoma kinase: signalling in development and disease. Biochem J 2009; 420: 345-61.
    • (2009) Biochem J , vol.420 , pp. 345-361
    • Palmer, R.H.1    Vernersson, E.2    Grabbe, C.3    Hallberg, B.4
  • 115
    • 48249114422 scopus 로고    scopus 로고
    • EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
    • Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008; 14: 4275-83.
    • (2008) Clin Cancer Res , vol.14 , pp. 4275-4283
    • Koivunen, J.P.1    Mermel, C.2    Zejnullahu, K.3
  • 116
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALKpositive lung cancer
    • Soda M, Takada S, Takeuchi K, et al. A mouse model for EML4-ALKpositive lung cancer.Proc Natl Acad Sci 2008; 105: 19893-7.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 117
    • 74249123333 scopus 로고    scopus 로고
    • ALK gene rearrangements. A new therapeutic target in a molecularly defined subset of non-small cell lung cancer
    • Solomon B, Varella-garcia M, Camidge DR. ALK gene rearrangements. A new therapeutic target in a molecularly defined subset of non-small cell lung cancer. J Thorac Oncol 2009; 4: 1450-4.
    • (2009) J Thorac Oncol , vol.4 , pp. 1450-1454
    • Solomon, B.1    Varella-Garcia, M.2    Camidge, D.R.3
  • 118
    • 77649091118 scopus 로고    scopus 로고
    • A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    • Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010; 16: 1561-71.
    • (2010) Clin Cancer Res , vol.16 , pp. 1561-1571
    • Mino-Kenudson, M.1    Chirieac, L.R.2    Law, K.3
  • 119
    • 67650441507 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas
    • Boland JM, Erdogan S, Vasmatzis G, et al. Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas. Hum Pathol 2009; 40: 1152-8.
    • (2009) Hum Pathol , vol.40 , pp. 1152-1158
    • Boland, J.M.1    Erdogan, S.2    Vasmatzis, G.3
  • 120
    • 37549060017 scopus 로고    scopus 로고
    • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
    • Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 2008; 3: 13-7.
    • (2008) J Thorac Oncol , vol.3 , pp. 13-17
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 121
    • 59649127007 scopus 로고    scopus 로고
    • EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues
    • Martelli MP, Sozzi G, Hernandez L, et al. EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol 2009; 174: 661-70.
    • (2009) Am J Pathol , vol.174 , pp. 661-670
    • Martelli, M.P.1    Sozzi, G.2    Hernandez, L.3
  • 122
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicoPathologic features characterize ALK-rearranged lung adenocarcinoma in the Westernpopulation
    • Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicoPathologic features characterize ALK-rearranged lung adenocarcinoma in the Westernpopulation. Clin Cancer Res 2009; 15: 5216-23.
    • (2009) Clin Cancer Res , vol.15 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 123
    • 77958072736 scopus 로고    scopus 로고
    • EML4-ALK fusion gene assessment using metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration
    • Sakairi Y, Nakajima T, Yasufuku K, et al. EML4-ALK fusion gene assessment using metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration. Clin Cancer Res 2010; 16: 4938-45.
    • (2010) Clin Cancer Res , vol.16 , pp. 4938-4945
    • Sakairi, Y.1    Nakajima, T.2    Yasufuku, K.3
  • 124
    • 63949086127 scopus 로고    scopus 로고
    • KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
    • Takeuchi K, Choi YL, Togashi Y, et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res 2009; 15: 3143-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 3143-3149
    • Takeuchi, K.1    Choi, Y.L.2    Togashi, Y.3
  • 125
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome ofpatients with non-small cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome ofpatients with non-small cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009; 27: 4247-53.
    • (2009) J Clin Oncol , vol.27 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 126
    • 77149130499 scopus 로고    scopus 로고
    • ClinicoPathologic features of non-small cell lung cancer with EML4-ALK fusion gene
    • Takahashi T, Sonobe M, Kobayashi M, et al. ClinicoPathologic features of non-small cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol 2010; 17: 889-97.
    • (2010) Ann Surg Oncol , vol.17 , pp. 889-897
    • Takahashi, T.1    Sonobe, M.2    Kobayashi, M.3
  • 127
    • 65249095599 scopus 로고    scopus 로고
    • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • Wong DW, Leung EL, So KK-T, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer 2009; 115: 1723-33.
    • (2009) Cancer , vol.115 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    Kk-T, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.