A novel specific application of pyruvate protects the mouse retina against white light damage: Differential stabilization of HIF-1α and HIF-2α

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 6, 2011, Pages 3112-3118

  Ren, Hao ^a,b   Liu, Ning Yu ^a   Song, Xiao Feng ^a,c   Ma, Yun Sheng ^a,c   Zhai, Xiao Yue ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE 2; PYRUVIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EXPLANT; EYE PROTECTION; HYPOXIA; LIGHT DAMAGE; LIGHT EXPOSURE; MORPHOLOGY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; RETINA; WESTERN BLOTTING; WHITE LIGHT;

ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOTTING, WESTERN; ERYTHROPOIETIN; HEME OXYGENASE-1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGHT; MICE; MICE, INBRED BALB C; PHOTORECEPTOR CELLS, VERTEBRATE; PROCOLLAGEN-PROLINE DIOXYGENASE; PYRUVIC ACID; RADIATION INJURIES, EXPERIMENTAL; RETINAL DEGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79955974125     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5605     Document Type: Article

References (24)

1. Samardzija M, Wenzel A, Thiersch M, Frigg R, Remé C, Grimm C. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2006;47(12):5181-5190.
2. Wenzel A, Reme CE, Williams TP, Hafezi F, Grimm C. The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration. J Neurosci. 2001;21(1):53-58.
3. Grimm C, Wenzel A, Groszer M, et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med. 2002;8(7):718-724.
4. Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem. 1996;271(30):17771-17778.
5. Marzo F, Lavorgna A, Coluzzi G, et al. Erythropoietin in heart and vessels: focus on transcription and signalling pathways. J Thromb Thrombolysis. 2008;26(3):183-187.
6. Arai-Gaun S, Katai N, Kikuchi T, Kurokawa T, Ohta K, Yoshimura N. Heme oxygenase-1 induced in Müller cells plays a protective role in retinal ischemia-reperfusion injury in rats. Invest Ophthalmol Vis Sci. 2004;45(11):4226-4232.
7. Nakayama K. Cellular signal transduction of the hypoxia response. J Biochem. 2009;146(6):757-765.
8. Wenger RH, Camenisch G, Stiehl DP, Katschinski DM. HIF prolyl- 4-hydroxylase interacting proteins: consequences for drug targeting. Curr Pharm Des. 2009;15(33):3886-3894.
9. Tanaka T, Nangaku M. Drug discovery for overcoming chronic kidney disease (CKD): prolyl-hydroxylase inhibitors to activate hypoxia-inducible factor (HIF) as a novel therapeutic approach in CKD. J Pharmacol Sci. 2009;109(1):24-31.
10. Carroll VA, Ashcroft M. Role of hypoxia-inducible factor (HIF)- 1alpha versus Hif-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Cancer Res. 2006;66(12):6264-6270.
11. Hirsilä M, Koivunen P, Xu L, Seeley T, Kivirikko KI, Myllyharju J. Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J. 2005;19(10):1308-1310.
12. Lisy K, Peet J. Turn me on: regulating HIF transcriptional activity. Cell Death Differentiation 2008;15:642-649.
13. Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol. 2009;92(3):329-333.
14. Semenza GL. HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev. 2010;20(1):51-56.
15. Ren H, Leib SL, Ferriero DM, Täuber MG, Christen S. Induction of haem oxygenase-1 causes cortical non-haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up-regulation prevents iron-induced oxidative damage. J Neurochem. 2007;100(2):532-544.
16. Webb JD, Coleman ML, Pugh CW. Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci. 2009;66(22):3539-3554.
17. Metzen E. Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps. Biochem J. 2007;408(2):e5-6.
18. Dalgard CL, Lu H, Mohyeldin A, Verma A. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem J. 2004;380(pt 2):419-424.
19. Xue J, Li X, Jiao S, Wei Y, Wu G, Fang J. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. Gastroenterology. 2010; 138(2):606-615.
20. Willam C, Maxwell PH, Nichols L, et al. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. J Mol Cell Cardiol. 2006; 41(1):68-77.
21. Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxiainducible factors Hif-1alpha and Hif-2alpha. Mol Biol Cell. 2007; 18(11):4528-4542.
22. Katschinski DM. In vivo functions of the prolyl-4-hydroxylase domain oxygen sensors: direct route to the treatment of anaemia and the protection of ischaemic tissues. Acta Physiol (Oxf). 2009; 195(4):407-414.
23. Gorres KL, Raines RT. Prolyl 4-hydroxylase. Crit Rev Biochem Mol Biol. 2010;45(2):106-124.
24. Rankin EB, Biju MP, Liu Q, et al. Hypoxia-inducible factor-2 (Hif-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007; 117(4):1068-1077.