Simple and objective method for routine detection of the macular pigment xanthophyll

Journal of Biomedical Optics

Volumn 15, Issue 6, 2010, Pages

  Schweitzer, Dietrich ^a   Jentsch, Susanne ^a   Dawczynski, Jens ^a   Hammer, Martin ^a   Wolf Schnurrbusch, Ute E K ^b   Wolf, Sebastian ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

age related macular degeneration; blue light; macular pigment xanthophyll; objective detection; pseudophakic eye; reflection; stray light

Indexed keywords

AGE-RELATED MACULAR DEGENERATION; BLUE LIGHT; MACULAR PIGMENT XANTHOPHYLL; OBJECTIVE DETECTION; PSEUDOPHAKIC EYE;

CRYSTALLINE MATERIALS; LIGHT REFLECTION; OPHTHALMOLOGY; OPTICAL INSTRUMENTS; STRAY LIGHT;

MAMMALS;

XANTHOPHYLL;

AGED; ARTICLE; FEMALE; HUMAN; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; REFRACTOMETRY; REPRODUCIBILITY; RETINA MACULA DEGENERATION; RETINOSCOPY; SENSITIVITY AND SPECIFICITY;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; REFRACTOMETRY; REPRODUCIBILITY OF RESULTS; RETINOSCOPY; SENSITIVITY AND SPECIFICITY; XANTHOPHYLLS;

EID: 79955959666     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3526358     Document Type: Conference Paper

References (49)

1. C. C. Klaver, R. C. Wolfs, J. R. Vingerling, A. Hofmann, and P. T. de Jong, Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam study., Arch. Ophthalmol. 116 (5), 653-658 (1998). (Pubitemid 28414581)
2. P. Bhosale, B. Serban, and P. S. Bernstein, Retinal carotenoids can attenuate formation of A2E in retinal pigment epithelium., Arch. Biochem. Biophys. 483, 175-181 (2009). 10.1016/j.abb.2008.09.012
3. C. A. Parish, M. Hashimoto, K. Nakanishi, J. Dillon, and J. R. Sparrow, Isolation and one step preparation of A2E and iso-A2E, fluorophoresfrom human retinal pigment epithelium., Proc. Natl. Acad. Sci. U S A 95, 14609-14613 (1998). 10.1073/pnas.95.25.14609 (Pubitemid 29003678)
4. G. E. Eldred, Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration., Gerontology 41 (Suppl. 2), 15-28 (1995). 10.1159/000213722 (Pubitemid 26019903)
5. S. P. Sundelin and S. E. G. Nilsson, Lipofuscin-formation in retinal pigment epithelial cells is reduced by antioxidants., Free Radic. Biol. Med. 31 (2), 217-225 (2001). 10.1016/S0891-5849(01)00573-1 (Pubitemid 32607588)
6. M. A. Zarbin, Current concepts in pathogenesis of age-related macular degeneration., Arch. Ophthalmol. 122, 598-614 (2004). 10.1001/archopht.122.4.598 (Pubitemid 38456297)
7. M. Rozanovska, J. Jarvis-Evans, W. Korytkowski, M. E. Boulton, J. M. Burke, and T. Sarna, Blue light-induced reactivity of retinal age pigment: in vivo generation of oxygen reactive species., J. Biol. Chem. 270, 18825-18830 (1995). 10.1074/jbc.270.32.18825
8. M. Rozanovska, J. Wessel, M. E. Boulton, J. M. Burke, M. A. Rodgers, T. G. Truscott, and T. Sarna, Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media., Free Radic. Biol. Med. 24, 1107-1112 (1998). 10.1016/S0891-5849(97)00395-X (Pubitemid 28246724)
9. U. Wihlmark, A. Wrigstad, K. Roberg, S. E. G. Nilsson, and U. T. Brunk, Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation., Free Radic. Biol. Med. 22, 1229-1234 (1997). 10.1016/S0891-5849(96)00555-2 (Pubitemid 27171965)
10. C. S. Foote, C. Y. Chang, and R. W. Denny, Chemistry of singlet oxygen. X. carotenoid quenching parallels biological protection., J. Am. Chem. Soc. 92, 5216-5218 (1970). 10.1021/ja00720a036
11. K. Kirchfeld, Carotenoid pigments: their role in protecting against photooxidation in eyes and photoreceptor cells., Proc. R. Soc. Lond. 216, 71-85 (1982). 10.1098/rspb.1982.0061
12. D. M. Snodderly, Evidence for protection against age related macular degeneration by carotenoids and antioxidant vitamins., Am. J. Clin. Nutr. 62 (Suppl.), 1448-1460 (1995).
13. B. R. Wooten and B. R. Hammond, Spectral absorbance and special distribution of macular pigment using hererochromic flicker photometry., Optom. Vis. Sci. 82, 378-386 (2005). 10.1097/01.OPX.0000162654.32112.A1 (Pubitemid 40664334)
14. E. L. Loane, J. M. Nolan, O. ODonovan, P. Bhosale, P. S. Bernstein, and S. Beatty, Transport and retinal rapture of lutein and zaxanthin with reference to age-related macular degeneration., Surv. Ophthalmol. 53 (1), 68-81 (2008). 10.1016/j.survophthal.2007.10.008
15. R. A. Bone, J. T. Landrum, and S. L. Tarsis, Preliminary identification of the human macular pigment., Vis. Res. 25, 1531-1539 (1985). 10.1016/0042-6989(85)90123-3 (Pubitemid 16207358)
16. J. T. Landrum and R. A. Bone, Minireview lutein, zeaxanthin, and the macular pigment., Arch. Biochem. Biophys. 385 (1), 28-40 (2001). 10.1006/abbi.2000.2171 (Pubitemid 32988979)
17. M. D. Snodderly, J. D. Auran, and F. C. Delori, The macular pigment. II: Spatial distribution in primate retinas., Invest. Ophthalmol. Vis. Sci. 25, 674-685 (1984). (Pubitemid 14082977)
18. E. W. Chong, T. Y. Wong, A. J. Kreis, J. A. Simpson, and R. H. Guymer, Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis., British Medical Journal 335 (7623), 755-759 (2007). 10.1136/bmj.39350.500428.47 (Pubitemid 47612631)
19. J. P. SanGiovanni, E. Y. Chew, T. E. Clemons, F. L. Ferris 3rd, G. Gensler, A. S. Lindblad, R. C. Milton, J. M. Seddon, R. D. Sperduto, and Age-Related Eye Disease Study Research Group, The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22., Arch. Ophthalmol. 125 (9), 1225-1232 (2007). 10.1001/archopht.125.9.1225 (Pubitemid 47403030)
20. S. Richer, W. Stiles, L. Statkute, J. Pulido, J. Frankowski, D. Rudy, K. Pei, M. Tsipursky, and J. Nyland, Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (lutein antioxidant supplementation trial.), Optometry 75 (4), 216-230 (2004). (Pubitemid 39208022)
21. V. M. Flood, W. Smith, E. Rochtchina, J. J. Wang, and P. Mitchell, Assembling a nutrient database for a large cohort study: the Blue Mountains Eye Study., Food Austral. 60 (1-2) 37-41 (2008).
22. E. Cho, J. M. Seddon, B. Rosner, W. C. Willett, and S. E. Hankinson, Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy., Arch Ophthalmol. 122 (6), 883-892 (2004). 10.1001/archopht.122.6.883 (Pubitemid 38736248)
23. G. M. Van Den Langenberg, J. A. Mares-Perlman, R. Klein, B. E. K. Klein, W. E. Brady, and M. Palata, Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study., Am. J. Epidemiol. 148, 204-214 (1998). (Pubitemid 28334898)
24. E. W. Chong, A. J. Sinclair, and R. H. Guymer, Facts on fats., Clin. Exp. Ophthalmol. 34 (5), 464-471 (2006). 10.1111/j.1442-9071.2006.01250.x (Pubitemid 44027236)
25. R. van Leeuwen, S. Boekhoorn, J. R. Vingerling, J. C. Witteman, C. C. Klaver, A. Hofman, and P. T. de Jong, Dietary intake of antioxidants and risk of age-related macular degeneration., J. Am. Med. Assn. 294 (24), 3101-3107 (2005). 10.1001/jama.294.24.3101 (Pubitemid 43016801)
26. S. M. Moeller, N. Parekh, L. Tinker, C. Ritenbaugh, B. Blodi, R. B. Wallace, J. A. Mares, and CAREDS Research Study Group, Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Womens Health Initiative., Arch. Ophthalmol. 124 (8), 1151-1162 (2006). 10.1001/archopht.124.8.1151 (Pubitemid 44232345)
27. R. A. Bone, J. T. Landrum, and A. Cains, Optical density spectra of the macular pigment in vivo and in vitro., Vis. Res. 32 (1), 105-110 (1992). 10.1016/0042-6989(92)90118-3
28. J. T. Landrum, R. A. Bone, H. Joa, M. D. Kilburn, L. L. Moore, and K. E. Sprague, A one year study of the macular pigment: the effect of the 140 days of lutein supplementation., Exp. Eye Res. 65, 57-62 (1997). 10.1006/exer.1997.0309 (Pubitemid 27322038)
29. B. R. Hammond, E. J. Johnson, R. M. Russell, N. Krinsky, K. J. Yeum, R. B. Edwards, and M. D. Snodderly, Dietary modification of human macular pigment density., Invest. Ophthalmol. Vis. Sci. 38, 1795-1801 (1997). (Pubitemid 27382345)
30. A. E. Elsner, S. A. Burns, F. C. Delori, and R. H. Webb, Quantitative reflectometry with the SLO., Chapter 10 in Laser Scanning Ophthalmoscopy and Tomography, J. E. Nasemann, and, R. O. W. Burk, Eds., pp. 109-121, Quintessenz, Muenchen (1990).
31. D. van Norren and L. F. Tiemeijer, Spectral reflectance of the human eye., Vis. Res. 26 (2), 313-320 (1986). 10.1016/0042-6989(86)90028-3 (Pubitemid 16154347)
32. T. T. Berendschot, R. A. Goldbohm, W. A. Klopping, J. van de Kraats, J. van Norel, and D. van Norren, Influence of lutein supplementation on macular pigment, assessed with two objective techniques., Invest. Ophthalmol. Vis. Sci. 41 (11), 3322-3326 (2000).
33. J. van de Kraats, M. J. Kanis, S. W. Genders, and D. van Norren, Lutein and zeaxanthin measured separately in the living human retina with fundus reflectometry., Invest. Ophthalmol. Vis. Sci. 49 (12), 5568-5573. (2008). 10.1167/iovs.08-1939
34. N. P. A. Zagers and D. van Norren, Absorption of the eye lens and macular pigment derived from the reflectance of cone photoreceptors., J. Opt. Soc. Am. A 21 (12), 2257-2268 (2004). 10.1364/JOSAA.21.002257 (Pubitemid 40009321)
35. D. Schweitzer, M. Hammer, and M. Scibor, Imaging spectrometry in ophthalmology-principle and applications in microcirculation and in investigation of pigments., Ophthalmic. Res. 28 (Suppl 2), 37-44 (1996). 10.1159/000267955
36. F. C. Delori, D. G. Goger, B. R. Hammond, M. D. Snodderly, and S. A. Burns, Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry., J. Opt. Soc. Am. A 18 (6), 1212-1230 (2001). 10.1364/JOSAA.18.001212
37. P. S. Bernstein, M. D. Yoshida, N. B. Katz, R. W. Mc Clane, and W. Gellermann, Raman detection of macular carotenoid pigments in intact human retina., Invest. Ophthalmol. Vis. Sci. 39 (11), 2003-2011 (1998). (Pubitemid 28455069)
38. D. Schweitzer, In Vivo-Detection of macular pigment and its effect by lutein supplementation.. Chapter 12 in Focus on Macular Degeneration Research, O. R. Ioseliani, Ed., pp. 253-257, Nova Science, New York (2003).
39. S. Beatty, F. J. G. M. van Kuijk, and U. Chakravarthy, Macular pigment and age-related macular degeneration: longitudinal data and better techniques of measurement are needed., Invest. Ophthalmol. Vis. Sci. 49 (3), 843-845 (2008). 10.1167/iovs.07-1276
40. G. Wyszecki and W. S. Stiles, Colour Science: Concepts and Methods, Quantitative Data and Formulae, 2nd ed. Wiley, Hoboken, NJ (1982).
41. R. T. Smith, T. Nagasaki, J. R. Sparrow, I. Barbazetto, C. C. W. Klaver, and J. K. Chan, A method of drusen measurement based on the geometry of fundus reflectance., Biomed. Eng. Online 2 10 April 18 (2003). 10.1186/1475-925X-2-10 (Pubitemid 38824764)
42. L. Leistritz and D. Schweitzer, Automated detection and quantification of exudates in retinal images., Proc. SPIE 2298, 690-696 (1994).
43. H. Wustemeyer, C. Jahn, A. Nestler, T. Barth, and S. Wolf, A new instrument for the quantification of macular pigment density: first results in patients with AMD and healthy subjects., Graefes. Arch. Clin Exp. Ophthalmol. 240, 666-671 (2002). 10.1007/s00417-002-0515-6 (Pubitemid 36075628)
44. M. Jarc-Vidmar, A. Kraut, and M. Hawlina, Fundus autofluorescence imaging in Bests vitelliform dystrophy., Klin, Monbl. Augenheilkd. 220 (12), 861-867 (2003). 10.1055/s-2003-812555 (Pubitemid 38084170)
45. M. Trieschmann, B. Heimes, H. W. Hense, and D. Pauleikhoff, Macular pigment optical density measurement in autofluorescence imaging: comparison of one- and two-wavelength methods., Graefes. Arch. Clin Exp. Ophthalmol. 244 (12), 1565-1574 (2006). 10.1007/s00417-006-0289-3 (Pubitemid 44830814)
46. T. J. T. P. van den Berg, L. J. van Rijn, R. Michael, C. Heine, T. Coeckelbergh, C. Nischler, H. Wilhelm, G. Grabner, M. Emesz, R. I. Barraquer, J. E. Coppens, and L. Franssen, Straylight effects with aging and lens extraction., Am. J. Ophthalmol. 144, 358-363 (2007). 10.1016/j.ajo.2007.05.037 (Pubitemid 47331411)
47. T. T. J. M. Berendschot and D. van Norren, On the age dependency of the macular pigment optical density., Exp. Eye Res. 81 (5), 602-609 (2005). 10.1016/j.exer.2005.03.019 (Pubitemid 41532005)
48. J. M. Loan, J. Stack, O. ODonavan, E. Loan, and S. Betty, Risk factors for age-related maculopathy are associated with a lack of macular pigment., Exp. Eye Res. 84, 61-74 (2007). 10.1016/j.exer.2006.08.016 (Pubitemid 44792053)
49. M. J. Kanis, T. T. J. M. Berendschot, and D. van Norren, Interocular agreement in melanin and macular pigment optical density., Exp. Eye Res. 84, 934-938 (2007). 10.1016/j.exer.2007.01.020 (Pubitemid 46590135)