Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis

International Journal of Experimental Pathology

Volumn 92, Issue 3, 2011, Pages 211-217

  Reynolds, John ^a,b  

^a UNIVERSITY OF BEDFORDSHIRE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Anti GBM disease; Experimental autoimmune glomerulonephritis; Glomerular basement membrane; Non collagenous domain of the alpha 3 chain of type IV collagen; Strain differences

Indexed keywords

COLLAGEN TYPE 4;

ALLERGIC GLOMERULONEPHRITIS; AUTOIMMUNE DISEASE; CELLULAR IMMUNITY; GENE IDENTIFICATION; GENETIC SUSCEPTIBILITY; GLOMERULONEPHRITIS; GOODPASTURE SYNDROME; HUMORAL IMMUNITY; IMMUNOPATHOGENESIS; INFLAMMATION; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT STRAIN; REVIEW; STRAIN DIFFERENCE;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MICE; MICE, INBRED AKR; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED DBA; RATS; RATS, INBRED BN; RATS, INBRED F344; RATS, INBRED LEW; RATS, INBRED WKY;

EID: 79955944822     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2011.00763.x     Document Type: Review

References (46)

1. Aitman T.J., Dong R., Vyse T.J. et al. (2006) Copy number polymorphism in fcgr3 predisposes to glomerulonephritis in rats and humans. Nature 439, 851-855.
2. Behmoaras J., Bhangal G., Smith J. et al. (2008) Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat. Genet. 40, 553-559.
3. Bolton W.K., May W.J., Sturgill B.C. (1993) Proliferative autoimmune glomerulonephritis in rats: a model for autoimmune glomerulonephritis in humans. Kidney Int. 44, 294-306.
4. Bolton W.K., Chen L., Hellmark T., Wieslander J., Fox J. (2005) Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen. J. Am. Soc. Nephrol. 16, 2657-2666.
5. Cook P.R., Evans D.J., Reynolds J., Aitman T.J., Pusey C.D. (2004) Genetic analysis of experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol. 15, 664A. (Abstract).
6. Dean E.G., Wilson G.R.A., Li M. et al. (2005) Experimental autoimmune Goodpasture's disease: a pathogenic role for both effector cells and antibody in injury. Kidney Int. 67, 566-575.
7. Fisher M., Pusey C.D., Vaughan R.W., Rees A.J. (1997) Susceptibility to Goodpasture's disease is strongly associated with HLA-DRB1 genes. Kidney Int. 51, 222-229.
8. Goodpasture E.W. (1919) The significance of certain pulmonary lesions to the etiology of influenza. Am. J. Med. Sci. 158, 863-870.
9. Hopfer H., Maron R., Butzmann U., Helmchen U., Weiner H.L., Kalluri R. (2003) The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J. 17, 860-868.
10. Kalluri R., Danoff T.M., Okada H., Neilson E.G. (1997) Susceptibility to anti-glomerular basement membrane disease and Goodpasture's syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J. Clin. Invest. 100, 2263-2275.
11. Kohda T., Okada S., Hayashi A. et al. (2004) High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBM nephritis. Kidney Int. 66, 177-186.
12. Lloyd C.M., Minto A.W., Dorf M.E. et al. (1997) RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med. 185, 1371-1380.
13. Luo A.M., Fox J.W., Chen L., Bolton W.K. (2002) Synthetic peptides of Goodpasture's antigen in anti-glomerular basement membrane nephritis in rats. J. Lab. Clin. Med. 139, 303-310.
14. Ooi J.D., Phoon R.K., Holdsworth S.R., Kitching A.R. (2009) IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J. Am. Soc. Nephrol. 20, 980-989.
15. Phelps R.G. & Rees A.J. (1999) The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity. Kidney Int. 56, 1638-1653.
16. Pusey C.D. (2003) Anti-glomerular basement membrane disease. Kidney Int, 64, 1535-1550.
17. Pusey C.D., Holland M.J., Cashman S.J. et al. (1991) Experimental autoimmune glomerulonephritis induced by homologous and isologous glomerular basement membrane in Brown-Norway rats. Nephrol. Dial. Transplant. 6, 457-465.
18. Reynolds J. & Pusey C.D. (1994) In vivo treatment with a monoclonal antibody to T helper cells in experimental autoimmune glomerulonephritis. Clin. Exp. Immunol. 95, 122-127.
19. Reynolds J. & Pusey C.D. (2001) Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol. 12, 61-70.
20. Reynolds J., Mavromatidis K., Cashman S.J., Evans D.J., Pusey C.D. (1998) Experimental autoimmune glomerulonephritis (EAG) induced by homologous and heterologous glomerular basement membrane in two sub-strains of Wistar Kyoto rat. Nephrol. Dial. Transplant. 13, 44-52.
21. Reynolds J., Tam F.W.K., Chandraker A. et al. (2000) CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. J. Clin. Invest. 105, 643-651.
22. Reynolds J., Norgan V.A., Bhambra U., Smith J., Cook H.T., Pusey C.D. (2002a) Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol. 13, 359-369.
23. Reynolds J., Cook P.R., Ryan J.J. et al. (2002b) Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene. Exp. Nephrol. 10, 402-407.
24. Reynolds J., Moss J., Duda M.A. et al. (2003) The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease. J. Pathol. 200, 118-129.
25. Reynolds J., Khan S.B., Allen A.R., Benjamin C.D., Pusey C.D. (2004) Blockade of the CD154-CD40 T cell costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis. Kidney Int. 66, 1444-1452.
26. Reynolds J., Prodromidi E.I., Juggapah J.K. et al. (2005) Nasal administration of recombinant rat α3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol. 16, 1350-1359.
27. Reynolds J., Albouainain A., Duda M.A., Evans D.J., Pusey C.D. (2006) Strain susceptibility to active induction and passive transfer of experimental autoimmune glomerulonephritis in the rat. Nephrol. Dial. Transplant. 21, 3398-3408.
28. Reynolds J., Haxby J., Juggapah J.K., Evans D.J., Pusey C.D. (2008a) Identification of a nephritogenic immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis. Clin. Exp. Immunol. 155, 311-319.
29. Reynolds J., Marshall D., Shaw S., Gelinas R.E., Cook H.T., Pusey C.D. (2008b) Effect of anti-IL6 monoclonal antibody therapy in experimental autoimmune glomerulonephritis in the CD1 mouse. J. Am. Soc. Nephrol. 19, 414A. (Abstract).
30. Reynolds J., Tadros S., Smith J. et al. (2008c) Genetic susceptibility to experimental autoimmune glomerulonephritis in congenic rats. J. Am. Soc. Nephrol. 19, 414-415A. (Abstract).
31. Reynolds J., Abbott D.S., Karegli J., Evans D.J., Pusey C.D. (2009a) Mucosal tolerance induced by an immunodominant peptide from rat α3(IV)NC1 in established experimental autoimmune glomerulonephritis. Am. J. Pathol. 174, 2202-2210.
32. Reynolds J., Tee J., Smith J. et al. (2009b) Macrophage activation and function in experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol. 20, 62A. (Abstract).
33. Ryan J.J., Reynolds J., Norgan V.A., Pusey C.D. (2001) Expression and characterisation of recombinant rat α3(IV)NC1 and its use in the induction of experimental autoimmune glomerulonephritis. Nephrol. Dial. Transplant. 16, 253-261.
34. Sado Y., Okigaki T., Takamiya H., Seno S. (1984) Experimental autoimmune glomerulonephritis with pulmonary haemorrhage in rats. The dose-effect relationship of the nephritogenic antigen from bovine glomerular basement membrane. J. Clin. Lab. Immunol. 15, 199-204.
35. Sado Y., Naito I., Akita M., Okigaki T. (1986) Strain specific responses of inbred rats on the severity of experimental autoimmune glomerulonephritis. J. Clin. Lab. Immunol. 19, 193-199.
36. Sado Y., Naito I., Okigaki T. (1989) Transfer of anti-glomerular basement membrane antibody-induced glomerulonephritis in inbred rats with isologous antibodies from urine of nephritic rats. J. Pathol. 158, 325-332.
37. Sado Y., Boutaud A.A., Kagawa M., Naito I., Ninomiya Y., Hudson B.G. (1998) Induction of anti-GBM nephritis in rats by recombinant α3(IV) NC1 and α4(IV) NC1 of type IV collagen. Kidney Int. 53, 664-671.
38. Salama A.D. & Pusey C.D. (2002) Immunology of anti-glomerular basement membrane disease. Curr. Opin. Nephrol. Hypertens. 1, 279-286.
39. Saus J., Wieslander J., Langeveld J.P.M., Quinones S., Hudson B.G. (1998) Identification of the Goodpasture antigen as the α3 chain of collagen IV. J. Biol. Chem. 263, 13374-13380.
40. Steblay R.W. (1962) Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund's complete adjuvant. J. Exp. Med. 116, 253-272.
41. Turner N., Mason P.J., Brown R. et al. (1992) Molecular cloning of the human Goodpasture antigen demonstrates it to be the α3 chain of type IV collagen. J. Clin. Invest. 89, 592-601.
42. Walters G., Habib A.-M., Reynolds J., Wu H., Knight J.F., Pusey C.D. (2004) Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vβ T cell receptor families in experimental autoimmune glomerulonephritis. Nephron. Exp. Nephrol. 98, 71-81.
43. Wilson C.B. & Dixon F.J. (1973) Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int. 3, 74-89.
44. Wu J., Hicks J., Ou C., Singleton D., Borillo J., Lou Y.-H. (2001) Glomerulonephritis induced by recombinant collagen IV alpha 3 chain noncollagen domain 1 is not associated with glomerular basement membrane antibody: a potential T cell-mediated mechanism. J. Immunol. 167, 2388-2395.
45. Wu J., Hicks J., Borillo J., Glass W.F., Lou Y.-H. (2002) CD4+ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis. J. Clin. Invest. 109, 517-525.
46. Wu J., Borillo J., Glass W.F., Hicks J., Ou C.-N., Lou Y.-H. (2003) T-cell epitope of α3 chain of type IV collagen induces severe glomerulonephritis. Kidney Int. 64, 1292-1301.