Mechanistic studies of the radical S-adenosyl-l-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-d-quinovose

Journal of the American Chemical Society

Volumn 133, Issue 19, 2011, Pages 7292-7295

  Ruszczycky, Mark W ^a   Choi, Sei Hyun ^a   Mansoorabadi, Steven O ^a   Liu, Hung Wen ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHETIC PATHWAY; C-H BOND; DESOSAMINE; EPR SPECTROSCOPY; G-VALUES; HYPERFINE COUPLING; MECHANISTIC STUDIES; RADICAL MECHANISM; S ADENOSYL L METHIONINES; SPIN 1/2; SPLITTING CONSTANT; STREPTOMYCES VENEZUELAE; UNPAIRED ELECTRONS;

AMINO ACIDS; CATALYSIS; DEHYDROGENATION; ENZYMES; GLUCOSE; REACTION INTERMEDIATES;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

3 KETO 4,6 DIDEOXY DEXTRO GLUCOSE; 4 AMINO 4,6 DIDEOXY DEXTRO GLUCOSE; ALPHA HYDROXYALKYL; AMINE; DES2 ENZYME; DESOSAMINE; DEXTRO QUINOVOSE; GLUCOSE DERIVATIVE; RADICAL; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; DEHYDROGENATION; ELECTRON SPIN RESONANCE; HYDROGEN BOND; MOLECULAR MECHANICS; STREPTOMYCES VENEZUELAE;

BIOCATALYSIS; CARBOHYDRATE SEQUENCE; DEOXYGLUCOSE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICALS; HYDROGENATION; MOLECULAR SEQUENCE DATA; S-ADENOSYLMETHIONINE; STREPTOMYCES;

EID: 79955924346     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja201212f     Document Type: Article

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