Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells

Bone

Volumn 48, Issue 6, 2011, Pages 1409-1416

  Tada, Hiroyuki ^a   Nemoto, Eiji ^a   Foster, Brian L ^b   Somerman, Martha J ^b   Shimauchi, Hidetoshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

BMP 2; CAMP; Dental pulp cell; ERK1 2; Extracellular phosphate

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 BROMO CYCLIC AMP; BONE MORPHOGENETIC PROTEIN 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOSCARNET; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; PHOSPHATE; PROTEIN KINASE C; PYROPHOSPHATE; SODIUM PHOSPHATE COTRANSPORTER 3;

ADULT; ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; NORMAL HUMAN; ODONTOBLAST; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TOOTH PULP;

BASE SEQUENCE; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DENTAL PULP; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; PHOSPHATES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79955919890     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.03.675     Document Type: Article

References (50)

1. Beck G.R. Inorganic phosphate as a signaling molecule in osteoblast differentiation. J. Cell. Biochem. 2003, 90:234-243.
2. Bellows C.G., Heersche J.N., Aubin J.E. Inorganic phosphate added exogenously or released from beta-glycerophosphate initiates mineralization of osteoid nodules in vitro. Bone Miner. 1992, 17:15-29.
3. Foster B.L., Tompkins K.A., Rutherford R.B., Zhang H., Chu E.Y., Fong H., et al. Phosphate: known and potential roles during development and regeneration of teeth and supporting structures. Birth Defects Res. C Embryo Today 2008, 84:281-314.
4. Beertsen W., VandenBos T., Everts V. Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation. J. Dent. Res. 1999, 78:1221-1229.
5. Beck G.R., Knecht N. Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasome-dependent. J. Biol. Chem. 2003, 278:41921-41929.
6. Julien M., Khoshniat S., Lacreusette A., Gatius M., Bozec A., Wagner E.F., Wittrant Y., Masson M., Weiss P., Beck L., Magne D., Guicheux J. Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1. J. Bone Miner. Res. 2009, 24:1856-1868.
7. Beck G.R., Zerler B., Moran E. Phosphate is a specific signal for induction of osteopontin gene expression. Proc. Natl Acad. Sci. U.S.A. 2000, 97:8352-8357.
8. Julien M., Magne D., Masson M., Rolli-Derkinderen M., Chassande O., Cario-Toumaniantz C., et al. Phosphate stimulates matrix Gla protein expression in chondrocytes through the extracellular signal regulated kinase signaling pathway. Endocrinology 2007, 148:530-537.
9. Fatherazi S., Matsa-Dunn D., Foster B.L., Rutherford R.B., Somerman M.J., Presland R.B. Phosphate regulates osteopontin gene transcription. J. Dent. Res. 2009, 88:39-44.
10. Foster B.L., Nociti F.H., Swanson E.C., Matsa-Dunn D., Berry J.E., Cupp C.J., et al. Regulation of cementoblast gene expression by inorganic phosphate in vitro. Calcif. Tissue Int. 2006, 78:103-112.
11. Rutherford R.B., Foster B.L., Bammler T., Beyer R.P., Sato S., Somerman M.J. Extracellular phosphate alters cementoblast gene expression. J. Dent. Res. 2006, 85:505-509.
12. Berendsen A.D., Smit T.H., Schoenmaker T., Walboomers X.F., Harris S.E., Everts V., et al. Inorganic phosphate stimulates DMP1 expression in human periodontal ligament fibroblasts embedded in three-dimensional collagen gels. Cells Tissues Organs 2010, 192:116-124.
13. Li X., Yang H.Y., Giachelli C.M. Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ. Res. 2006, 98:905-912.
14. Jono S., McKee M.D., Murry C.E., Shioi A., Nishizawa Y., Mori K., et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ. Res. 2000, 87:E10-E17.
15. Loghman-Adham M. Use of phosphonocarboxylic acids as inhibitors of sodium-phosphate cotransport. Gen. Pharmacol. 1996, 27:305-312.
16. Sage A.P., Lu J., Tintut Y., Demer L.L. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int. 2011, 79:414-422.
17. Nadra I., Mason J.C., Philippidis P., Florey O., Smythe C.D., McCarthy G.M., et al. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification?. Circ. Res. 2005, 96:1248-1256.
18. Ewence A.E., Bootman M., Roderick H.L., Skepper J.N., McCarthy G., Epple M., et al. Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization. Circ. Res. 2008, 103:e28-e34.
19. Major M.L., Cheung H.S., Misra R.P. Basic calcium phosphate crystals activate c-fos expression through a Ras/ERK dependent signaling mechanism. Biochem. Biophys. Res. Commun. 2007, 355:654-660.
20. Tsukamoto Y., Fukutani S., Shin-Ike T., Kubota T., Sato S., Suzuki Y., et al. Mineralized nodule formation by cultures of human dental pulp-derived fibroblasts. Arch. Oral Biol. 1992, 37:1045-1055.
21. Gronthos S., Mankani M., Brahim J., Robey P.G., Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl Acad. Sci. U.S.A. 2000, 97:13625-13630.
22. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., et al. Novel regulators of bone formation: molecular clones and activities. Science 1988, 242:1528-1534.
23. Ducy P., Karsenty G. The family of bone morphogenetic proteins. Kidney Int. 2000, 57:2207-2214.
24. Huang W., Rudkin G.H., Carlsen B., Ishida K., Ghasri P., Anvar B., et al. Overexpression of BMP-2 modulates morphology, growth, and gene expression in osteoblastic cells. Exp. Cell Res. 2002, 274:226-234.
25. Chen S., Gluhak-Heinrich J., Martinez M., Li T., Wu Y., Chuang H.H., et al. Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling. J. Biol. Chem. 2008, 283:19359-19370.
26. Nakashima M. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J. Dent. Res. 1994, 73:1515-1522.
27. McKay W.F., Peckham S.M., Badura J.M. A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft). Int. Orthop. 2007, 31:729-734.
28. Tada H., Nemoto E., Kanaya S., Hamaji N., Sato H., Shimauchi H. Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells. Biochem. Biophys. Res. Commun. 2010, 394:1093-1097.
29. Nemoto E., Kanaya S., Minamibuchi M., Shimauchi H. Cleavage of PDGF receptor on periodontal ligament cells by elastase. J. Dent. Res. 2005, 84:629-633.
30. Sugiyama M., Kodama T., Konishi K., Abe K., Asami S., Oikawa S. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem. Biophys. Res. Commun. 2000, 271:688-692.
31. Butler W.T. Dentin matrix proteins. Eur. J. Oral Sci. 1998, 106:204-210.
32. MacDougall M., Gu T.T., Luan X., Simmons D., Chen J. Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. J. Bone Miner. Res. 1998, 13:422-431.
33. Seo B.M., Miura M., Gronthos S., Bartold P.M., Batouli S., Brahim J., et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004, 364:149-155.
34. Villa-Bellosta R., Bogaert Y.E., Levi M., Sorribas V. Characterization of phosphate transport in rat vascular smooth muscle cells: implications for vascular calcification. Arterioscler. Thromb. Vasc. Biol. 2007, 27:1030-1036.
35. Villa-Bellosta R., Sorribas V. Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition. Arterioscler. Thromb. Vasc. Biol. 2009, 29:761-766.
36. Ravera S., Virkki L.V., Murer H., Forster I.C. Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements. Am. J. Physiol. Cell Physiol. 2007, 293:C606-C620.
37. Ghosh-Choudhury N., Mandal C.C., Choudhury G.G. Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. J. Biol. Chem. 2007, 282:4983-4993.
38. Tang C.H., Yang R.S., Chien M.Y., Chen C.C., Fu W.M. Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts. Eur. J. Pharmacol. 2008, 579:40-49.
39. Gerits N., Kostenko S., Shiryaev A., Johannessen M., Moens U. Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: comradeship and hostility. Cell. Signal. 2008, 20:1592-1607.
40. Kavanaugh M.P., Kabat D. Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family. Kidney Int. 1996, 49:959-963.
41. Lundquist P. Odontoblast phosphate and calcium transport in dentinogenesis. Swed. Dent. J. 2002, 1-52. Suppl.
42. Suzuki A., Ghayor C., Guicheux J., Magne D., Quillard S., Kakita A., et al. Enhanced expression of the inorganic phosphate transporter Pit-1 is involved in BMP-2-induced matrix mineralization in osteoblast-like cells. J. Bone Miner. Res. 2006, 21:674-683.
43. Yoshiko Y., Candeliere G.A., Maeda N., Aubin J.E. Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization. Mol. Cell. Biol. 2007, 27:4465-4474.
44. Nielsen L.B., Pedersen F.S., Pedersen L. Expression of type III sodium-dependent phosphate transporters/retroviral receptors mRNAs during osteoblast differentiation. Bone 2001, 28:160-166.
45. Zhao M., Xiao G., Berry J.E., Franceschi R.T., Reddi A., Somerman M.J. Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J. Bone Miner. Res. 2002, 17:1441-1451.
46. Saito Y., Yoshizawa T., Takizawa F., Ikegame M., Ishibashi O., Okuda K., et al. A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J. Cell Sci. 2002, 115:4191-4200.
47. Kobayashi M., Takiguchi T., Suzuki R., Yamaguchi A., Deguchi K., Shionome M., et al. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament. J. Dent. Res. 1999, 78:1624-1633.
48. Wu J.B., Fong Y.C., Tsai H.Y., Chen Y.F., Tsuzuki M., Tang C.H. Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. Eur. J. Pharmacol. 2008, 588:333-341.
49. Verron E., Khairoun I., Guicheux J., Bouler J.M. Calcium phosphate biomaterials as bone drug delivery systems: a review. Drug Discov. Today 2010, 15:547-552.
50. Honda Y., Anada T., Kamakura S., Nakamura M., Sugawara S., Suzuki O. Elevated extracellular calcium stimulates secretion of bone morphogenetic protein 2 by a macrophage cell line. Biochem. Biophys. Res. Commun. 2006, 345:1155-1160.