The novel function of nesfatin-1 as an anti-inflammatory and antiapoptotic peptide in subarachnoid hemorrhage-induced oxidative brain damage in rats

Neurosurgery

Volumn 68, Issue 6, 2011, Pages 1699-1708

  Özsavcí, Derya ^a   Erşahin, Mehmet ^b   Şener, Azize ^a   Özakpinar, Özlem Bingol ^a   Toklu, Hale Z ^a   Akakín, Dilek ^a   Şener, Göksel ^a   Yeǧen, Berrak Ç ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b Samsun Education and Research Hospital   (Turkey)

Author keywords

Apoptosis; Nesfatin 1; Neutrophils; Oxidative stress; Subarachnoid hemorrhage

Indexed keywords

ANOREXIGENIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; APOPTOSIS REPRESSOR WITH CASPASE RECRUITMENT DOMAIN; CASPASE 3; ENZYME; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MYELOPEROXIDASE; NESFATIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BLOOD BRAIN BARRIER; BLOOD LEVEL; BRAIN DAMAGE; BRAIN EDEMA; BRAIN WATER; CHEMICAL ANALYSIS; CISTERNA MAGNA; CONTROLLED STUDY; DRUG EFFECT; HISTOLOGY; LIPID PEROXIDATION; MALE; MORPHOLOGY; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PERMEABILITY; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RAT; SUBARACHNOID HEMORRHAGE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD-BRAIN BARRIER; HYPOXIA, BRAIN; MALE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUBARACHNOID HEMORRHAGE;

EID: 79955892182     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0b013e318210f258     Document Type: Article

References (53)

1. Grote E, Hassler W. The critical first minutes after subarachnoid hemorrhage. Neurosurgery. 1988;22(4):654-661.
2. Nornes H. The role of intracranial pressure in the arrest of hemorrhage in patients with ruptured intracranial aneurysm. J Neurosurg. 1973;39(2):226-234.
3. del Zoppo GJ, Hallenbeck JM. Advances in the vascular pathophysiology of ischemic stroke. Thromb Res. 2000;98(3):73-81.
4. Tonnesen E, Wahlgreen C. Influence of extradural and general anaesthesia on natural killer cell activity and lymphocyte subpopulations in patients undergoing hysterectomy. Br J Anaesth. 1988;60(5):500-507.
5. Wedmore CV, Williams TJ. Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature. 1981;289(5799):646-650. (Pubitemid 11145328)
6. Kaptain GJ, Lanzino G, Kassell NF. Subarachnoid haemorrhage: epidemiology, risk factors, and treatment options. Drugs Aging. 2000;17(3):183-199.
7. Edwards DH, Byrne JV, Griffith TM. The effect of chronic subarachnoid hemorrhage on basal endothelium-derived relaxing factor activity in intrathecal cerebral arteries. J Neurosurg. 1992;76(5):830-837.
8. Nishizawa S, Yamamoto S, Yokoyama T, Uemura K. Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage. Neurol Res. 1997;19(5):558-562. (Pubitemid 27419431)
9. Colmers WF. Less fat with nesfatin. Trends Endocrinol Metab. 2007;18(4):131-132. (Pubitemid 46617270)
10. Merali Z, Cayer C, Kent P, Anisman H. Nesfatin-1 increases anxiety- and fearrelated behaviors in the rat. Psychopharmacology (Berl). 2008;201(1):115-123.
11. Stengel A, Goebel M, Yakubov I, et al. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology. 2009;150(1):232-238.
12. Gonzalez R, Tiwari A, Unniappan S. Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents. Biochem Biophys Res Commun. 2009;381(4):643-648.
13. Oh IS, Shimizu H, Satoh T, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature. 2006;443(7112):709-712. (Pubitemid 44564715)
14. Shimizu H, Oh IS, Hashimoto K, et al. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology. 2009;150(2):662-671.
15. Brailoiu GC, Dun SL, Brailoiu E, et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology. 2007;148(10):5088-5094. (Pubitemid 47481535)
16. Bonnet MS, Pecchi E, Trouslard J, Jean A, Dallaporta M, Troadec JD. Central nesfatin-1-expressing neurons are sensitive to peripheral inflammatory stimulus. J Neuroinflammation. 2009;6:27.
17. Stenhel A, Goebel M, Rivier J, et al. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology. 2009;150(11):4911-4919.
18. Delgado TJ BJ, Svendgaard NA. Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries. Stroke. 1985;16(4):595-602. (Pubitemid 15007231)
19. Toklu HZ, Uysal MK, Kabasakal L, Sirvanci S, Ercan F, Kaya M. The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. J Surg Res. 2009;152(2):238-248.
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351-358. (Pubitemid 9194347)
21. Levine RL, Garland D, Oliver CN, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464-478. (Pubitemid 20279989)
22. Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Methods. 1990;24(4): 285-295.
23. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25(1):192-205.
24. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882-888.
25. Szasz G. A kinetic photometric method for serum gamma-glutamyl transpeptidase. Clin Chem. 1969;15(2):124-136.
26. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing of protein-dye binding. Anal Biochem. 1976;72:248-254.
27. Mylroie AA, Collins H, Umbles C, Kyle J. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate. Toxicol Appl Pharmacol. 1986;82(3):512-520. (Pubitemid 16162421)
28. Aebi H. Catalase in vitro. In: Methods of Enzymol. 1984;105:121-126.
29. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126(1):131-138. (Pubitemid 13203451)
30. Findlay JM, Deagle GM. Causes of morbidity and mortality following intracranial aneurysm rupture. Can J Neurol Sci. 1998;25(3):209-215. (Pubitemid 28368796)
31. Rabinstein AA, Pichelmann MA, Friedman JA, et al. Symptomatic vasospasm and outcomes following aneurysmal subarachnoid hemorrhage: a comparison between surgical repair and endovascular coil occlusion. J Neurosurg. 2003;98(2):319-325. (Pubitemid 36151027)
32. Matz PG, FujimuraM, Lewen A, Morita-Fujimura Y, Chan PH. Increased cytochrome c-mediated DNA fragmentation and cell death in manganese-superoxide dismutasedeficient mice after exposure to subarachnoid hemolysate. Stroke. 2001;32(2):506-515. (Pubitemid 32155243)
33. Meguro T, Chen B, Parent AD, Zhang JH. Caspase inhibitors attenuate oxyhemoglobin- induced apoptosis in endothelial cells. Stroke. 2001;32(2):561-566. (Pubitemid 32155251)
34. Park S, Yamaguchi M, Zhou C, Calvert JW, Tang J, Zhang JH. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke. 2004;35(10):2412-2417. (Pubitemid 39311273)
35. Yosten GL, Samson WK. Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol. 2009;297(2):R330-R336.
36. Su Y, Zhang J, Tang Y, Bi F, Liu JN. The novel function of nesfatin-1: antihyperglycemia. Biochem Biophys Res Commun. 2010;391(1):1039-1042.
37. PanW, Hsuchou H, Kastin AJ. Nesfatin-1 crosses the blood-brain barrier without saturation. Peptides. 2007;28(11):2223-2228. (Pubitemid 47600423)
38. Price CJ, Samson WK, Ferguson AV. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res. 2008;1230:99-106.
39. Belayev L BR, Zhao W, Ginsberg MD. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 1996;739(1-2):88-96. (Pubitemid 26387366)
40. Huber JD, Egleton RD, Davis TP. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 2001;24(12):719-725. (Pubitemid 33097539)
41. Panikashvili D, Shein NA, Mechoulam R, et al. The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. Neurobiol Dis. 2006;22(2):257-264.
42. Sercombe R, Dinh YR, Gomis P. Cerebrovascular inflammation following subarachnoid hemorrhage. Jpn J Pharmacol. 2002;88(3):227-249. (Pubitemid 34302973)
43. Ersahin M, Toklu HZ, Cetinel S, Yuksel M, Yegen BC, Sener G. Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms. J Pineal Res. 2009;46(3):324-332.
44. Schoch B, Regel JP, Wichert M, Gasser T, Volbracht L, Stolke D. Analysis of intrathecal interleukin-6 as a potential predictive factor for vasospasm in subarachnoid hemorrhage. Neurosurgery. 2007;60(5):828-836.
45. Qureshi AR, Alvestrand A, Divino-Filho JC, et al. Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol. 2002;13(suppl 1):S28-S36.
46. Scarlett JM, Jobst EE, Enriori PJ, et al. Regulation of central melanocortin signaling by interleukin-1 beta. Endocrinology. 2007;148(9):4217-4225. (Pubitemid 47295678)
47. Cheunsuang O, Morris R. Astrocytes in the arcuate nucleus and median eminence that take up a fluorescent dye from the circulation express leptin receptors and neuropeptide Y Y1 receptors. Glia. 2005;52(3):228-233. (Pubitemid 43076153)
48. Foo KS, Brismar H, Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience. 2008;156(3):563-579.
49. Goebel M, Stengel A,Wang L, LambrechtNW, Tache Y.Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei. Neurosci Lett. 2009;452(3):241-246.
50. Goebel M, Stengel A, Wang L, Tache Y. Restraint stress activates nesfatin- 1-immunoreactive brain nuclei in rats. Brain Res. 2009;1300:114-124.
51. Matsunaga W, Miyata S, Takamata A, Bun H, Nakashima T, Kiyohara T. LPSinduced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus. Brain Res. 2000;858(1):9-18. (Pubitemid 30105775)
52. Ersahin M, Toklu HZ, Erzik C, et al. The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats. J Neurotrauma. 2010;27(6):1143-1155.
53. Pyne-Geithman GJ, Caudell DN, Prakash P, Clark JF. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurol Res. 2009;31(2):195-199.