Dysfunction of nitric oxide induces protein kinase C activation resulting in vasospasm after subarachnoid hemorrhage

Neurological Research

Volumn 19, Issue 5, 1997, Pages 558-562

  Nishizawa, Shigeru ^a   Yamamoto, Seiji ^a   Yokoyama, Tetsuo ^a   Uemura, Kenichi ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Nitric oxide; Protein kinase C; Subarachnoid hemorrhage; Vasospasm

Indexed keywords

NITRIC OXIDE; PROTEIN KINASE C;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BASILAR ARTERY; BLOOD VESSEL TONE; BRAIN VASOSPASM; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; FEMALE; MALE; NONHUMAN; SUBARACHNOID HEMORRHAGE;

EID: 0030884204     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1997.11740858     Document Type: Article

References (10)

1. Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 1984; 308: 693-698
2. Nishizawa S, Peterson JW, Uemura K. The relation between protein kinase C and endothelium-dependent vasodilatation in development of vasospasm. In: Sano K, Takakura K, Kassell NF, Sasaki T (eds): Cerebral Vasospasm. Tokyo: University Tokyo Press, 1990: pp. 115-117
3. Nishizawa S, Peterson JW, Shimoyama I, Uemura K. Relation between protein kinase C and calmodulin systems in cerebro-vascular contraction: Investigation of the pathogenesis of vaso-spasm after subarachnoid hemorrhage. Neurosurgery 1992; 31: 711-716
4. Nishizawa S, Nezu N, Uemura K. Direct evidence for a key role of protein kinase C in the development of vasospasm after sub-arachnoid hemorrhage. J Neurosurg 1992; 76: 635-639
5. Ignaro LJ. Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Ore Res 1989; 65: 1-21
6. Palmer RM, Ferrige AC, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-529
7. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376
8. Furchgott RF. Role of endothelium in responses of vascular smooth muscle. Circ Res 1983; 53: 557-573
9. Lincoln TM. Effects of nitroprusside and 8-bromo-cyclic CMP on the contractile activity of the rat aorta. J Pharmacol Exp Ther 1983; 224: 100-107
10. Nguyen BL, Saitoh M, Ware JA. Interaction of nitric oxide and cGMP with signal transduction in activated platelets. Am J Physiot 1991; 261: H1043-H1052